Detailed information for compound 1822205

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 484.457 | Formula: C21H39Cl2N3O5
  • H donors: 2 H acceptors: 3 LogP: 2.64 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC[C@@H]1CC[C@H](CC1)C(=O)OC(C(=O)N(C)C)OC(=O)[C@@H]1CC[C@@](CC1)(C)CN.Cl.Cl
  • InChi: 1S/C21H37N3O5.2ClH/c1-21(13-23)10-8-16(9-11-21)19(27)29-20(17(25)24(2)3)28-18(26)15-6-4-14(12-22)5-7-15;;/h14-16,20H,4-13,22-23H2,1-3H3;2*1H/t14-,15-,16-,20?,21-;;
  • InChiKey: ZCNYPHQPOHBKFH-ATRQQOLHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0067 0.0727 0.2085
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0042 0.0042
Giardia lamblia Glutamate synthase 0.0067 0.0727 0.2085
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0067 0.0727 0.0727
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0254 0.3327 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0067 0.0727 0.2085
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0254 0.3327 0.3327
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0186 0.2387 0.2387
Trypanosoma cruzi trypanothione reductase, putative 0.0732 1 1
Mycobacterium ulcerans hypothetical protein 0.0067 0.0727 0.2085
Loa Loa (eye worm) programmed cell death 8 0.0067 0.0727 0.0727
Entamoeba histolytica disulphide oxidoreductase, putative 0.0067 0.0727 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0067 0.0727 0.0727
Trypanosoma cruzi trypanothione reductase, putative 0.0254 0.3327 0.3327
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0067 0.0727 0.0688
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0254 0.3327 0.3327
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0067 0.0727 0.0727
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0254 0.3327 0.3298
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0254 0.3327 0.3327
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0254 0.3327 0.3327
Mycobacterium ulcerans NADH dehydrogenase 0.0067 0.0727 0.2085
Schistosoma mansoni glutamate synthase 0.0067 0.0727 0.0727
Schistosoma mansoni glutamate synthase 0.0067 0.0727 0.0727
Entamoeba histolytica thioredoxin reductase, putative 0.0067 0.0727 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0042 0.0042
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0115 0.0115
Mycobacterium ulcerans monoxygenase 0.0067 0.0727 0.2085
Giardia lamblia TCP-1 chaperonin subunit beta 0.0023 0.0115 0.0223
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0067 0.0727 0.0727
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0067 0.0727 0.0727
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0067 0.0727 0.2085
Treponema pallidum NADH oxidase 0.0254 0.3327 1
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0067 0.0727 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0584 0.0584
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0067 0.0727 0.2085
Trichomonas vaginalis mercuric reductase, putative 0.0254 0.3327 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0254 0.3327 0.3327
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0584 0.0584
Leishmania major hypothetical protein, conserved 0.0067 0.0727 0.0727
Onchocerca volvulus 0.0067 0.0727 0.5
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0115 0.0115
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0042 0.0042
Schistosoma mansoni sulfide quinone reductase 0.0067 0.0727 0.0727
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.061 0.061
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0254 0.3327 0.3327
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0042 0.0042
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0067 0.0727 0.0727
Plasmodium falciparum glutathione reductase 0.0254 0.3327 0.3327
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0023 0.0115 0.0115
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0067 0.0727 0.0727
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0067 0.0727 0.0727
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0067 0.0727 0.2085
Plasmodium falciparum glutathione reductase 0.0732 1 1
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0067 0.0727 0.0727
Trypanosoma brucei hypothetical protein, conserved 0.0067 0.0727 0.0727
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0254 0.3327 0.3327
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0067 0.0727 0.0727
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0067 0.0727 0.1795
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0067 0.0727 0.2085
Leishmania major T-complex protein 1, beta subunit, putative 0.0023 0.0115 0.0115
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0067 0.0727 0.0688
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0254 0.3327 0.3298
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0042 0.0042
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0067 0.0727 0.1795
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0863 0.0863
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.061 0.061
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0067 0.0727 0.0688
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0023 0.0115 0.0115
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0254 0.3327 1
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0115 0.0115
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0042 0.0042
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0493 0.0452
Leishmania major hypothetical protein, conserved 0.0067 0.0727 0.0727
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0023 0.0115 0.0115
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0254 0.3327 0.3327
Loa Loa (eye worm) hypothetical protein 0.0077 0.0863 0.0863
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0254 0.3327 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0067 0.0727 0.0688
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0067 0.0727 0.2085
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0067 0.0727 0.0688
Trypanosoma cruzi NADH dehydrogenase, putative 0.0067 0.0727 0.0727
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0863 0.25
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.061 0.1728
Schistosoma mansoni hypothetical protein 0.0067 0.0727 0.0727
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0067 0.0727 0.0727
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0067 0.0727 0.0727
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0067 0.0727 0.1795
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0254 0.3327 0.3298
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0158 0.0158
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0067 0.0727 0.0727
Echinococcus multilocularis glutamate synthase 0.0067 0.0727 0.0727
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0115 0.0115
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0042 0.0042
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0067 0.0727 0.2085
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0727 0.0727
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0115 0.0115
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0863 0.25
Toxoplasma gondii exonuclease III APE 0.0018 0.0042 0.0042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0254 0.3327 0.3327
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0067 0.0727 0.0727
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0254 0.3327 0.3327
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0158 0.0158
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0863 0.0863
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0067 0.0727 1
Mycobacterium ulcerans dehydrogenase 0.0067 0.0727 0.2085
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0493 0.0452
Giardia lamblia Thioredoxin reductase 0.0067 0.0727 0.2085
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0067 0.0727 0.0727
Trichomonas vaginalis chaperonin, putative 0.0023 0.0115 0.0223
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0067 0.0727 0.0727
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0863 0.0863
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0067 0.0727 0.0727
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0042 0.0042
Brugia malayi jmjC domain containing protein 0.0057 0.0584 0.0584
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0254 0.3327 0.3327
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0067 0.0727 0.1795
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0067 0.0727 0.0727
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.061 0.061
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.061 0.061
Schistosoma mansoni glutamate synthase 0.0067 0.0727 0.0727
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0863 0.0863
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0584 0.0584
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.061 0.1728
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0493 0.1056
Brugia malayi Probable ClpP-like protease 0.0077 0.0863 0.0863
Schistosoma mansoni sulfide quinone reductase 0.0067 0.0727 0.0727
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0863 0.0524
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0254 0.3327 0.3327
Plasmodium falciparum thioredoxin reductase 0.0254 0.3327 0.3327
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0067 0.0727 0.0688
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0254 0.3327 1
Toxoplasma gondii t-complex protein beta subunit 0.0023 0.0115 0.0115
Plasmodium falciparum thioredoxin reductase 0.0732 1 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0863 0.25
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0254 0.3327 0.3327
Mycobacterium tuberculosis Probable oxidoreductase 0.0254 0.3327 0.3298
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0067 0.0727 0.2085
Trichomonas vaginalis glutamate synthase, putative 0.0067 0.0727 0.2085
Echinococcus granulosus thioredoxin glutathione reductase 0.0732 1 1
Toxoplasma gondii thioredoxin reductase 0.0732 1 1
Toxoplasma gondii NADPH-glutathione reductase 0.0254 0.3327 0.3327
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0067 0.0727 0.2085
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0254 0.3327 0.3327
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0254 0.3327 0.3327
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0067 0.0727 0.0727
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0067 0.0727 0.0688
Trichomonas vaginalis glutathione reductase, putative 0.0254 0.3327 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0067 0.0727 0.2085
Loa Loa (eye worm) thioredoxin reductase 0.0732 1 1
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0067 0.0727 0.0727
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.061 0.061
Toxoplasma gondii hypothetical protein 0.0027 0.0158 0.0158
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0067 0.0727 0.2085
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0067 0.0727 0.0727
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0067 0.0727 0.0727
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0067 0.0727 1
Leishmania major trypanothione reductase 0.0732 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0067 0.0727 0.0688
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0067 0.0727 0.0727
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0067 0.0727 0.0727
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0067 0.0727 0.2085
Loa Loa (eye worm) T-complex protein 1 0.0023 0.0115 0.0115
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0067 0.0727 0.0727
Treponema pallidum thioredoxin reductase (trxB) 0.0067 0.0727 0.2085
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0254 0.3327 1
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0067 0.0727 0.1795
Brugia malayi glutamate synthase 0.0067 0.0727 0.0727
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0863 0.0863
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0254 0.3327 0.3327
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0067 0.0727 0.2085
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0067 0.0727 0.2085
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0863 0.0863
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0067 0.0727 0.0727
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0067 0.0727 0.0727
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0254 0.3327 0.3327
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0863 0.2225
Trichomonas vaginalis glutamate synthase, putative 0.0067 0.0727 0.2085
Brugia malayi Thioredoxin reductase 0.0732 1 1
Schistosoma mansoni disulfide oxidoreductase 0.0067 0.0727 0.0727
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0254 0.3327 0.3327
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0023 0.0115 0.0115
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0067 0.0727 0.0727
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0067 0.0727 0.0727
Echinococcus granulosus glutamate synthase 0.0067 0.0727 0.0727
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0067 0.0727 0.0688
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0042 0.0042
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0067 0.0727 0.0688
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0067 0.0727 0.2085
Toxoplasma gondii selenide, water dikinase 0.0067 0.0727 0.0727
Plasmodium vivax ferrodoxin reductase, putative 0.0067 0.0727 0.0727
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0493 0.0493
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0254 0.3327 0.3327
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0042 0.0042
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0863 0.25
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0186 0.2387 0.2387
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0067 0.0727 0.2085
Echinococcus multilocularis thioredoxin glutathione reductase 0.0732 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0254 0.3327 0.3327
Loa Loa (eye worm) glutathione reductase 0.0732 1 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0863 0.0524
Loa Loa (eye worm) hypothetical protein 0.0067 0.0727 0.0727
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0863 0.0863
Trypanosoma brucei NADH dehydrogenase 0.0067 0.0727 0.0727
Treponema pallidum oxidoreductase 0.0067 0.0727 0.2085
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0254 0.3327 0.3327
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0067 0.0727 0.0727
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0254 0.3327 0.3327
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0584 0.0584
Brugia malayi jmjC domain containing protein 0.0057 0.0584 0.0584
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0067 0.0727 0.0727
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0023 0.0115 0.0223
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0067 0.0727 0.2085
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0584 0.0584
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0067 0.0727 0.0727
Mycobacterium tuberculosis Probable dehydrogenase 0.0067 0.0727 0.0688
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0158 0.0353
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0584 0.0584
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0067 0.0727 0.0727
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0254 0.3327 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0254 0.3327 1
Schistosoma mansoni ap endonuclease 0.0018 0.0042 0.0042
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0254 0.3327 0.3327
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0254 0.3327 0.3327
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0067 0.0727 0.0727
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0584 0.0584
Plasmodium vivax thioredoxin reductase, putative 0.0732 1 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0584 0.0584
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0067 0.0727 0.0727
Leishmania major hypothetical protein, conserved 0.0067 0.0727 0.0727
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.061 0.057
Trichomonas vaginalis apoptosis inducing factor, putative 0.0067 0.0727 0.2085
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0067 0.0727 1
Plasmodium falciparum ferrodoxin reductase-like protein 0.0067 0.0727 0.0727
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.061 0.061
Plasmodium falciparum T-complex protein 1 subunit beta 0.0023 0.0115 0.0115
Plasmodium vivax glutathione reductase, putative 0.0732 1 1
Leishmania major NADH dehydrogenase, putative 0.0067 0.0727 0.0727
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0023 0.0115 0.0115
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0254 0.3327 1
Mycobacterium tuberculosis Probable reductase 0.0067 0.0727 0.0688
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0493 0.0493
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0727 0.0727
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0254 0.3327 0.3327
Trypanosoma brucei trypanothione reductase 0.0732 1 1
Schistosoma mansoni ap endonuclease 0.0018 0.0042 0.0042
Mycobacterium ulcerans glutamate synthase subunit beta 0.0067 0.0727 0.2085
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0067 0.0727 0.0727
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0067 0.0727 0.2085
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0067 0.0727 0.2085
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0067 0.0727 0.2085
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0732 1 1
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0067 0.0727 0.0727
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0023 0.0115 0.1068
Mycobacterium ulcerans ferredoxin reductase 0.0067 0.0727 0.2085
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0067 0.0727 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.061 0.1728

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.