Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | pteridine reductase 1 | 0.0015 | 0.0013 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0015 | 0.0013 | 0.5 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0015 | 0.0013 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0015 | 0.0013 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0015 | 0.0013 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0015 | 0.0013 | 0.5 |
Schistosoma mansoni | dihydropteridine reductase | 0.0015 | 0.0013 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0223 | 1 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0015 | 0.0013 | 1 |
Leishmania major | pteridine reductase 1 | 0.0015 | 0.0013 | 0.5 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0015 | 0.0013 | 0.5 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0015 | 0.0013 | 1 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0015 | 0.0013 | 0.5 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0015 | 0.0013 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0223 | 1 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0015 | 0.0013 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0015 | 0.0013 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0223 | 1 | 1 |
Onchocerca volvulus | 0.0015 | 0.0013 | 1 | |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0015 | 0.0013 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0223 | 1 | 0.5 |
Onchocerca volvulus | 0.0015 | 0.0013 | 1 | |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0223 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0223 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0223 | 1 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0223 | 1 | 1 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0015 | 0.0013 | 1 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0015 | 0.0013 | 1 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0015 | 0.0013 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0013 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0015 | 0.0013 | 0.5 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0015 | 0.0013 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.025 uM | Inhibition of Mycobacterium tuberculosis full length biotinylated InhA (270 amino acids) using DDCoA as substrate assessed as NADH oxidation by fluorimetric analysis | ChEMBL. | 24450589 |
MIC90 (functional) | = 1 uM | Antitubercular activity against wild type Mycobacterium tuberculosis H37Rv ATCC 25618 assessed as growth inhibition after 6 days by resazurin dye-based assay | ChEMBL. | 24450589 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.