Detailed information for compound 1822811

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 306.358 | Formula: C19H18N2O2
  • H donors: 1 H acceptors: 2 LogP: 3.55 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1[nH]c2c(c1/C=C/C(=O)c1ccncc1)cc(cc2)OC
  • InChi: 1S/C19H18N2O2/c1-3-17-15(5-7-19(22)13-8-10-20-11-9-13)16-12-14(23-2)4-6-18(16)21-17/h4-12,21H,3H2,1-2H3/b7-5+
  • InChiKey: BDPOBPHXAVPQCG-FNORWQNLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Echinococcus granulosus expressed conserved protein 0.0106 0.0414 0.1211
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0028 0.0071
Onchocerca volvulus 0.0095 0.0367 0.0396
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0079 0.2144
Onchocerca volvulus 0.0128 0.0511 0.0552
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0167 0.0683 0.1695
Schistosoma mansoni protein tyrosine phosphatase 0.0294 0.1244 0.3641
Schistosoma mansoni nephrin 0.0128 0.0511 0.1495
Echinococcus multilocularis transfer RNA-Phe 0.0128 0.0511 0.127
Echinococcus granulosus intermediate filament protein 0.0031 0.0085 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0125 0.048
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0167 0.0683 0.0683
Echinococcus granulosus cell adhesion molecule 0.0128 0.0511 0.1495
Schistosoma mansoni cell adhesion molecule 0.0128 0.0511 0.1495
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0128 0.0511 0.127
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0128 0.0511 0.1495
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0294 0.1244 0.3091
Echinococcus multilocularis musashi 0.0031 0.0085 0.0211
Echinococcus granulosus cpg binding protein 0.0035 0.0102 0.0298
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Onchocerca volvulus 0.0128 0.0511 0.0552
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Echinococcus granulosus Fibronectin type III 0.0128 0.0511 0.1495
Schistosoma mansoni protein tyrosine phosphatase 0.0167 0.0683 0.1997
Onchocerca volvulus 0.0128 0.0511 0.0552
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0167 0.0683 0.1997
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0167 0.0683 0.1997
Loa Loa (eye worm) phosphofructokinase 0.0124 0.0496 0.0525
Schistosoma mansoni hypothetical protein 0.0018 0.0028 0.0083
Echinococcus multilocularis Netrin receptor DCC 0.0128 0.0511 0.127
Echinococcus multilocularis Netrin receptor DCC 0.0128 0.0511 0.127
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0121 0.0121
Echinococcus multilocularis microtubule associated protein 2 0.0788 0.3418 0.8491
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Leishmania major hypothetical protein, conserved 0.0128 0.0511 0.7216
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0084
Schistosoma mansoni microtubule-associated protein tau 0.0788 0.3418 1
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0097 0.1602
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0294 0.1244 0.3641
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0167 0.0683 0.0723
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0097 0.1602
Echinococcus multilocularis Fibronectin, type III 0.0128 0.0511 0.127
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0079 0.0203
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0294 0.1244 0.3091
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.0254 0.0632
Echinococcus granulosus EG95 0.0128 0.0511 0.1495
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.0496 0.0525
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0254 0.0744
Echinococcus granulosus G1Y162 protein 0.0128 0.0511 0.1495
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0167 0.0683 0.1997
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0167 0.0683 0.0723
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0028 0.0083
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0294 0.1244 0.3641
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Schistosoma mansoni factor for adipocyte differentiation 0.0128 0.0511 0.1495
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0022 0.0022
Onchocerca volvulus 0.0167 0.0683 0.0737
Schistosoma mansoni ephrin receptor 0.0128 0.0511 0.1495
Echinococcus multilocularis 0.0167 0.0683 0.1695
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0167 0.0683 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Loa Loa (eye worm) hypothetical protein 0.1988 0.8705 0.9223
Loa Loa (eye worm) hypothetical protein 0.0031 0.0085 0.009
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0128 0.0511 0.0542
Onchocerca volvulus 0.0167 0.0683 0.0737
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0294 0.1244 0.3091
Echinococcus granulosus Netrin receptor DCC 0.0128 0.0511 0.1495
Schistosoma mansoni cell adhesion molecule 0.0128 0.0511 0.1495
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0124 0.0496 1
Onchocerca volvulus 0.0128 0.0511 0.0552
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0294 0.1244 0.3641
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0294 0.1244 0.3091
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0505 0.2173 0.6358
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0167 0.0683 0.1997
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0167 0.0683 0.0723
Brugia malayi Immunoglobulin I-set domain containing protein 0.0128 0.0511 0.0511
Leishmania major hypothetical protein, conserved 0.003 0.0079 0.0203
Schistosoma mansoni transcription factor btf3 0.004 0.0125 0.0366
Onchocerca volvulus 0.0167 0.0683 0.0737
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0167 0.0683 0.0723
Brugia malayi 6-phosphofructokinase 0.0124 0.0496 0.0496
Echinococcus multilocularis protein patched 0.0048 0.0162 0.0401
Brugia malayi 6-phosphofructokinase 0.0124 0.0496 0.0496
Schistosoma mansoni hypothetical protein 0.0018 0.0028 0.0083
Loa Loa (eye worm) myotactin form A 0.0128 0.0511 0.0542
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0128 0.0511 0.7216
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0067 0.5
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0128 0.0511 0.7159
Schistosoma mansoni lamin 0.0031 0.0085 0.0248
Brugia malayi myotactin form B 0.0128 0.0511 0.0511
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0085 0.009
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0167 0.0683 0.1695
Schistosoma mansoni lamin 0.0031 0.0085 0.0248
Brugia malayi Immunoglobulin I-set domain containing protein 0.0128 0.0511 0.0511
Schistosoma mansoni hypothetical protein 0.0039 0.0121 0.0353
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0022
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0128 0.0511 0.1495
Onchocerca volvulus 0.0167 0.0683 0.0737
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Schistosoma mansoni intermediate filament proteins 0.0031 0.0085 0.0248
Brugia malayi Immunoglobulin I-set domain containing protein 0.0128 0.0511 0.0511
Onchocerca volvulus Huntingtin homolog 0.014 0.0565 0.061
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Brugia malayi CHE-14 protein 0.0048 0.0162 0.0162
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0505 0.2173 0.2173
Echinococcus granulosus protein tyrosine phosphatase n9 0.0167 0.0683 0.1997
Leishmania major ATP-dependent phosphofructokinase 0.0124 0.0496 0.6965
Brugia malayi SPRY domain containing protein 0.0128 0.0511 0.0511
Loa Loa (eye worm) ICD-1 protein 0.004 0.0125 0.0132
Onchocerca volvulus 0.0167 0.0683 0.0737
Schistosoma mansoni cpg binding protein 0.0035 0.0102 0.0298
Echinococcus multilocularis lamin 0.0031 0.0085 0.0211
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Echinococcus granulosus microtubule associated protein 2 0.0788 0.3418 1
Plasmodium falciparum basic transcription factor 3b, putative 0.004 0.0125 1
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0167 0.0683 0.1997
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0167 0.0683 0.0723
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0496 0.6965
Entamoeba histolytica hypothetical protein 0.004 0.0125 0.0945
Onchocerca volvulus 0.2116 0.9267 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0167 0.0683 0.1997
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0254 0.4376
Echinococcus granulosus titin 0.0128 0.0511 0.1495
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0167 0.0683 0.0723
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0167 0.0683 0.1997
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0167 0.0683 0.1695
Trypanosoma brucei protein tyrosine phosphatase 1 0.0167 0.0683 1
Schistosoma mansoni myosin-binding protein-related 0.0128 0.0511 0.1495
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0124 0.0496 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0008 0.0022
Brugia malayi Fibronectin type III domain containing protein 0.0128 0.0511 0.0511
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.0511 0.1495
Onchocerca volvulus 0.0128 0.0511 0.0552
Brugia malayi Immunoglobulin I-set domain containing protein 0.0128 0.0511 0.0511
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0125 0.048
Echinococcus multilocularis dnaJ subfamily B 0.0467 0.2005 0.4982
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Echinococcus multilocularis GPCR, family 2 0.0018 0.0028 0.0071
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0167 0.0683 0.1997
Onchocerca volvulus 0.0031 0.0085 0.0091
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0079 0.2144
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0294 0.1244 0.3641
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0162 0.0473
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.02 0.02
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0167 0.0683 0.1997
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0294 0.1244 0.3091
Brugia malayi Immunoglobulin I-set domain containing protein 0.0128 0.0511 0.0511
Echinococcus granulosus roundabout 2 0.0128 0.0511 0.1495
Schistosoma mansoni tripartite motif protein trim9 0.0128 0.0511 0.1495
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0128 0.0511 0.0542
Brugia malayi Fibronectin type III domain containing protein 0.0128 0.0511 0.0511
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0294 0.1244 0.3641
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Onchocerca volvulus 0.0167 0.0683 0.0737
Echinococcus multilocularis anosmin 1 0.0128 0.0511 0.127
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Echinococcus granulosus Netrin receptor DCC 0.0128 0.0511 0.1495
Echinococcus granulosus transcription factor btf3 0.004 0.0125 0.0366
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.0496 0.0525
Plasmodium vivax basic transcription factor 3b, putative 0.004 0.0125 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.0254 1
Echinococcus granulosus nephrin 0.0128 0.0511 0.1495
Loa Loa (eye worm) UNCoordinated family member 0.0128 0.0511 0.0542
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0079 0.2144
Echinococcus granulosus lamin dm0 0.0031 0.0085 0.0248
Onchocerca volvulus 0.0128 0.0511 0.0552
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0167 0.0683 0.1997
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Schistosoma mansoni cell adhesion molecule 0.0128 0.0511 0.1495
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0254 0.4376
Echinococcus multilocularis titin 0.0128 0.0511 0.127
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.003
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0167 0.0683 0.1997
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0128 0.0511 0.0511
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0496 0.6809
Echinococcus granulosus neuroglian 0.0128 0.0511 0.1495
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0125 0.048
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0095 0.0367 0.1074
Echinococcus multilocularis Niemann Pick C1 protein 0.0161 0.0656 0.1631
Echinococcus multilocularis roundabout 2 0.0128 0.0511 0.127
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.0496 0.6965
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0008 0.0019
Echinococcus multilocularis titin 0.0128 0.0511 0.127
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0254 0.0744
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0505 0.2173 0.5399
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0167 0.0683 0.1695
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0167 0.0683 0.0723
Onchocerca volvulus 0.0167 0.0683 0.0737
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0094 0.0099
Onchocerca volvulus 0.0167 0.0683 0.0737
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0162 0.0473
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0167 0.0683 0.1997
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0097 0.5166
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0167 0.0683 0.0723
Schistosoma mansoni hypothetical protein 0.0128 0.0511 0.1495
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Echinococcus granulosus dnaJ subfamily B 0.0467 0.2005 0.5867
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0028 0.0071
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0926 0.4026 1
Onchocerca volvulus 0.0128 0.0511 0.0552
Schistosoma mansoni titin 0.0128 0.0511 0.1495
Loa Loa (eye worm) hypothetical protein 0.0112 0.0444 0.0471
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0505 0.2173 0.2303
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0128 0.0511 0.1495
Brugia malayi Protein-tyrosine phosphatase 1 0.0167 0.0683 0.0683
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0167 0.0683 0.1695
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0167 0.0683 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0255 0.0747
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0223 0.831
Onchocerca volvulus 0.0167 0.0683 0.0737
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0167 0.0683 0.1695
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0294 0.1244 0.3641
Schistosoma mansoni hemicentin 0.0128 0.0511 0.1495
Echinococcus granulosus anosmin 1 0.0128 0.0511 0.1495
Onchocerca volvulus 0.0167 0.0683 0.0737
Brugia malayi hypothetical protein 0.0167 0.0683 0.0683
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0028 0.0083
Loa Loa (eye worm) hypothetical protein 0.0048 0.0162 0.0171
Brugia malayi Immunoglobulin I-set domain containing protein 0.0128 0.0511 0.0511
Loa Loa (eye worm) lethal protein 805 0.0128 0.0511 0.0542
Echinococcus granulosus L aminoadipate semialdehyde 0.0095 0.0367 0.1074
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0128 0.0511 0.0542
Loa Loa (eye worm) CAMK protein kinase 0.0128 0.0511 0.0542
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0496 0.6965
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0167 0.0683 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0294 0.1244 0.3641
Echinococcus granulosus usherin 0.0128 0.0511 0.1495
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.0496 0.145
Loa Loa (eye worm) hypothetical protein 0.003 0.0082 0.0087
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Brugia malayi Immunoglobulin I-set domain containing protein 0.0128 0.0511 0.0511
Mycobacterium ulcerans 6-phosphofructokinase 0.0124 0.0496 1
Onchocerca volvulus 0.0128 0.0511 0.0552
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0167 0.0683 0.1997
Brugia malayi phosphofructokinase 0.0124 0.0496 0.0496
Echinococcus granulosus GPCR family 2 0.0018 0.0028 0.0083
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0167 0.0683 0.1695
Echinococcus multilocularis roundabout 2 0.0128 0.0511 0.127
Echinococcus granulosus lamin 0.0031 0.0085 0.0248
Echinococcus granulosus roundabout 2 0.0128 0.0511 0.1495
Onchocerca volvulus 0.0167 0.0683 0.0737
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0167 0.0683 0.1997
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0167 0.0683 0.1695
Onchocerca volvulus Huntingtin homolog 0.014 0.0565 0.061
Loa Loa (eye worm) hypothetical protein 0.0095 0.0367 0.0389
Schistosoma mansoni patched 1 0.0048 0.0162 0.0473
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0097 0.5166
Schistosoma mansoni cpg binding protein 0.0035 0.0102 0.0298
Giardia lamblia Protein tyrosine phosphatase 0.0167 0.0683 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0095 0.0367 0.0912
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0097 0.5166
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Brugia malayi Immunoglobulin I-set domain containing protein 0.0128 0.0511 0.0511
Echinococcus multilocularis hypothetical protein 0.0167 0.0683 0.1695
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0128 0.0511 0.0542
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0097 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0167 0.0683 0.1695
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0097 1
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0125 0.0758
Schistosoma mansoni cell adhesion molecule 0.0128 0.0511 0.1495
Trichomonas vaginalis pten, drome, putative 0.0167 0.0683 1
Schistosoma mansoni hypothetical protein 0.0046 0.0154 0.045
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0085 0.009
Schistosoma mansoni titin 0.0128 0.0511 0.1495
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Loa Loa (eye worm) hypothetical protein 0.2155 0.9438 1
Brugia malayi Fibronectin type III domain containing protein 0.0128 0.0511 0.0511
Onchocerca volvulus 0.0128 0.0511 0.0552
Echinococcus granulosus contactin 0.0128 0.0511 0.1495
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0167 0.0683 0.1997
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0167 0.0683 0.0723
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0162 0.0401
Echinococcus granulosus fibronectin type III domain-containing protein 0.0128 0.0511 0.1495
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0128 0.0511 0.0542
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0167 0.0683 0.1997
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0128 0.0511 0.127
Brugia malayi Fibronectin type III domain containing protein 0.0128 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0013
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0079 0.0665
Onchocerca volvulus 0.0167 0.0683 0.0737
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0128 0.0511 0.127
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.0254 0.3048
Leishmania major basic transcription factor 3a, putative 0.004 0.0125 0.0945
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0128 0.0511 0.7159
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0128 0.0511 0.0542
Brugia malayi Immunoglobulin I-set domain containing protein 0.0128 0.0511 0.0511
Brugia malayi Fibronectin type III domain containing protein 0.0128 0.0511 0.0511
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0505 0.2173 0.6358
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0167 0.0683 0.1997
Brugia malayi hypothetical protein 0.0167 0.0683 0.0683
Onchocerca volvulus 0.0167 0.0683 0.0737
Onchocerca volvulus 4.1 G protein, putative homolog 0.0167 0.0683 0.0737
Onchocerca volvulus 0.0167 0.0683 0.0737
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0128 0.0511 0.0511
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.0496 0.6902
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0167 0.0683 0.1695
Leishmania major tyrosine specific protein phosphatase, putative 0.0167 0.0683 1
Schistosoma mansoni neuroglian 0.0128 0.0511 0.1495
Brugia malayi CXXC zinc finger family protein 0.0033 0.0094 0.0094
Trypanosoma cruzi hypothetical protein, conserved 0.0128 0.0511 0.7159
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0496 0.6965
Loa Loa (eye worm) projectin 0.0128 0.0511 0.0542
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0167 0.0683 0.0683
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.0097 0.0701
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0128 0.0511 0.0542
Brugia malayi intermediate filament protein 0.0031 0.0085 0.0085
Echinococcus multilocularis cpg binding protein 0.0035 0.0102 0.0253
Echinococcus granulosus roundabout 2 0.0128 0.0511 0.1495
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0028 0.003
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0015 0.0036
Onchocerca volvulus 0.0128 0.0511 0.0552
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0128 0.0511 0.0542
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0167 0.0683 0.0723
Echinococcus multilocularis lamin dm0 0.0031 0.0085 0.0211
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0128 0.0511 0.0542
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0028 0.0028
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0167 0.0683 0.0723
Echinococcus multilocularis cell adhesion molecule 0.0128 0.0511 0.127
Schistosoma mansoni cpg binding protein 0.0033 0.0094 0.0274
Onchocerca volvulus 0.0033 0.0094 0.0101
Trypanosoma brucei transcription factor BTF3, putative 0.004 0.0125 0.0945
Onchocerca volvulus 0.0167 0.0683 0.0737
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0167 0.0683 0.1997
Echinococcus granulosus Niemann Pick C1 protein 0.0112 0.0444 0.1299
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0167 0.0683 1
Loa Loa (eye worm) hypothetical protein 0.1988 0.8705 0.9223
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0167 0.0683 0.0723
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0167 0.0683 0.0723
Onchocerca volvulus 0.0031 0.0085 0.0091
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0114 0.0452 0.1322
Onchocerca volvulus 0.0128 0.0511 0.0552
Echinococcus granulosus anosmin 1 0.0128 0.0511 0.1495
Loa Loa (eye worm) hypothetical protein 0.1988 0.8705 0.9223
Echinococcus granulosus 6 phosphofructokinase 0.0124 0.0496 0.145
Echinococcus multilocularis transcription factor btf3 0.004 0.0125 0.031
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0167 0.0683 0.1695
Onchocerca volvulus 0.0167 0.0683 0.0737
Brugia malayi Protein-tyrosine phosphatase 0.0167 0.0683 0.0683
Schistosoma mansoni hypothetical protein 0.0018 0.0028 0.0083
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0167 0.0683 0.1997
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.0254 0.0744
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0167 0.0683 0.1695
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0496 0.6809
Brugia malayi Niemann-Pick C1 protein precursor 0.0112 0.0444 0.0444
Schistosoma mansoni hypothetical protein 0.0018 0.0028 0.0083
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Onchocerca volvulus 0.0167 0.0683 0.0737
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0128 0.0511 0.0511
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Loa Loa (eye worm) hypothetical protein 0.014 0.0565 0.0599
Loa Loa (eye worm) hypothetical protein 0.0057 0.02 0.0212
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0167 0.0683 0.1695
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0128 0.0511 0.127
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Brugia malayi protein unc-22 0.0128 0.0511 0.0511
Brugia malayi hypothetical protein 0.0128 0.0511 0.0511
Brugia malayi beta-NAC-like protein 0.004 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Schistosoma mansoni protein tyrosine phosphatase 0.0167 0.0683 0.1997
Onchocerca volvulus 0.0167 0.0683 0.0737
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Loa Loa (eye worm) protein tyrosine phosphatase 0.0167 0.0683 0.0723
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.02 0.0212
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0496 0.6809
Brugia malayi Immunoglobulin I-set domain containing protein 0.0128 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0059 0.0209 0.0222
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0167 0.0683 0.0723
Brugia malayi Immunoglobulin I-set domain containing protein 0.0128 0.0511 0.0511
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0022 0.0023
Brugia malayi hypothetical protein 0.0019 0.0033 0.0033
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0015 0.0043
Schistosoma mansoni hypothetical protein 0.0128 0.0511 0.1495
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Schistosoma mansoni factor for adipocyte differentiation 0.0128 0.0511 0.1495
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0128 0.0511 0.0542
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0294 0.1244 0.3641
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Brugia malayi Lethal protein 805 0.0128 0.0511 0.0511
Schistosoma mansoni hypothetical protein 0.0467 0.2005 0.5867
Echinococcus granulosus Fibronectin type III domain containing protein 0.0128 0.0511 0.1495
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Echinococcus multilocularis neuroglian 0.0128 0.0511 0.127
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0167 0.0683 0.0723
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0167 0.0683 0.0723
Schistosoma mansoni hypothetical protein 0.0046 0.0154 0.045
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0162 0.0171
Onchocerca volvulus 0.0167 0.0683 0.0737
Loa Loa (eye worm) hypothetical protein 0.014 0.0565 0.0599
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0167 0.0683 0.1997
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Onchocerca volvulus 0.0128 0.0511 0.0552
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0097 0.5166
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Echinococcus multilocularis anosmin 1 0.0128 0.0511 0.127
Brugia malayi Immunoglobulin I-set domain containing protein 0.0128 0.0511 0.0511
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0294 0.1244 0.3641
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Echinococcus granulosus anosmin 1 0.0128 0.0511 0.1495
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.0254 0.4376
Onchocerca volvulus 0.0167 0.0683 0.0737
Toxoplasma gondii NAC domain-containing protein 0.004 0.0125 0.3101
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0167 0.0683 1
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0128 0.0511 0.127
Brugia malayi hypothetical protein 0.0128 0.0511 0.0511
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0167 0.0683 0.1997
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Brugia malayi Fibronectin type III domain containing protein 0.0128 0.0511 0.0511
Schistosoma mansoni factor for adipocyte differentiation 0.0128 0.0511 0.1495
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0125 0.0758
Loa Loa (eye worm) hypothetical protein 0.0039 0.0121 0.0128
Onchocerca volvulus 0.0167 0.0683 0.0737
Onchocerca volvulus 0.0128 0.0511 0.0552
Schistosoma mansoni nephrin 0.0128 0.0511 0.1495
Onchocerca volvulus 0.0167 0.0683 0.0737
Brugia malayi Lethal protein 805 0.0128 0.0511 0.0511
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0095 0.0367 0.0367
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Echinococcus multilocularis expressed conserved protein 0.0106 0.0414 0.1029
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0097 0.1602
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0167 0.0683 0.1695
Echinococcus multilocularis anosmin 1 0.0128 0.0511 0.127
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0097 0.0488
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0167 0.0683 0.1997
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0167 0.0683 0.0723
Echinococcus granulosus Niemann Pick C1 protein 0.0161 0.0656 0.1921
Echinococcus multilocularis roundabout 2 0.0128 0.0511 0.127
Echinococcus granulosus titin 0.0128 0.0511 0.1495
Schistosoma mansoni cell adhesion molecule 0.0128 0.0511 0.1495
Brugia malayi hypothetical protein 0.003 0.0079 0.0079
Onchocerca volvulus 0.0167 0.0683 0.0737
Echinococcus multilocularis protein dispatched 1 0.0055 0.0192 0.0476
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Schistosoma mansoni hypothetical protein 0.0128 0.0511 0.1495
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0128 0.0511 0.1495
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Brugia malayi hypothetical protein 0.0167 0.0683 0.0683
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0254 0.4376
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0167 0.0683 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Brugia malayi myotactin form A 0.0128 0.0511 0.0511
Brugia malayi hypothetical protein 0.0167 0.0683 0.0683
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0162 0.1106
Echinococcus multilocularis 6 phosphofructokinase 0.0124 0.0496 0.1231
Echinococcus multilocularis usherin 0.0128 0.0511 0.127
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.0496 0.145
Entamoeba histolytica transcription factor BTF3, putative 0.004 0.0125 0.0945
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.02 0.02
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0128 0.0511 0.127
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0167 0.0683 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0112 0.0444 0.6128
Schistosoma mansoni hypothetical protein 0.0046 0.0154 0.045
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Loa Loa (eye worm) hypothetical protein 0.0128 0.0511 0.0542
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0013
Echinococcus multilocularis Niemann Pick C1 protein 0.0112 0.0444 0.1103
Loa Loa (eye worm) hypothetical protein 0.0167 0.0683 0.0723
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0167 0.0683 0.0683
Schistosoma mansoni hypothetical protein 0.0046 0.0154 0.045
Brugia malayi hypothetical protein 0.014 0.0565 0.0565
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0496 0.6809
Schistosoma mansoni pcd6 interacting protein-related 0.0167 0.0683 0.1997
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0294 0.1244 0.3091
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0167 0.0683 0.1695
Brugia malayi hypothetical protein 0.0167 0.0683 0.0683
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0124 0.0496 1
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0294 0.1244 0.1319
Schistosoma mansoni titin 0.0128 0.0511 0.1495

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 34.6 % Cytotoxicity against human U251 cells assessed as cell viability at 10 uM after 2 days by trypan blue dye-exclusion assay relative to control ChEMBL. 24527179

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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