Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetyltransferase | 0.017 | 0.5615 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0223 | 0.795 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0223 | 0.795 | 1 |
Onchocerca volvulus | 0.0042 | 0 | 0.5 | |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0165 | 0.5405 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0223 | 0.795 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0 | 0.5 |
Onchocerca volvulus | 0.0042 | 0 | 0.5 | |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.005 | 0.0341 | 0.0429 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.017 | 0.5615 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0042 | 0 | 0.5 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0046 | 0.0158 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0223 | 0.795 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0042 | 0 | 0.5 |
Onchocerca volvulus | 0.0042 | 0 | 0.5 | |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.005 | 0.0341 | 0.0631 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0223 | 0.795 | 0.5 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.017 | 0.5615 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0223 | 0.795 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0223 | 0.795 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.005 | 0.0341 | 0.0429 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.005 | 0.0341 | 0.0429 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0223 | 0.795 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.005 | 0.0341 | 0.0429 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.005 | 0.0341 | 0.0429 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.017 | 0.5615 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0046 | 0.0158 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0223 | 0.795 | 0.795 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1 uM | Inhibition of Mycobacterium tuberculosis full length biotinylated InhA (270 amino acids) using DDCoA as substrate assessed as NADH oxidation by fluorimetric analysis | ChEMBL. | 24450589 |
MIC90 (functional) | > 31 uM | Antitubercular activity against wild type Mycobacterium tuberculosis H37Rv ATCC 25618 assessed as growth inhibition after 6 days by resazurin dye-based assay | ChEMBL. | 24450589 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.