Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0223 | 1 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.2692 | 0.2692 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.2692 | 0.2692 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.6923 | 1 |
Giardia lamblia | Kinase, PLK | 0.0094 | 0.2692 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.2692 | 0.2692 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0094 | 0.2692 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0223 | 1 | 0.5 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0094 | 0.2692 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0094 | 0.2692 | 0.5 |
Echinococcus multilocularis | geminin | 0.0169 | 0.6923 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.2692 | 0.2692 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0094 | 0.2692 | 0.5 |
Trypanosoma brucei | polo-like protein kinase | 0.0094 | 0.2692 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0223 | 1 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0223 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.6923 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0094 | 0.2692 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0223 | 1 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.2692 | 0.2692 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0223 | 1 | 0.5 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0094 | 0.2692 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.2692 | 0.3825 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0094 | 0.2692 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0223 | 1 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.2692 | 0.2692 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.2692 | 0.2692 |
Echinococcus granulosus | geminin | 0.0169 | 0.6923 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0223 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.046 uM | Inhibition of Mycobacterium tuberculosis full length biotinylated InhA (270 amino acids) using DDCoA as substrate assessed as NADH oxidation by fluorimetric analysis | ChEMBL. | 24450589 |
MIC90 (functional) | = 4 uM | Antitubercular activity against wild type Mycobacterium tuberculosis H37Rv ATCC 25618 assessed as growth inhibition after 6 days by resazurin dye-based assay | ChEMBL. | 24450589 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.