Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | enteropeptidase | 0.0229 | 0.4827 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0229 | 0.4827 | 1 |
Echinococcus multilocularis | enteropeptidase | 0.0229 | 0.4827 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0229 | 0.4827 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0229 | 0.4827 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0229 | 0.4827 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.9282 | 0.8612 |
Onchocerca volvulus | 0.0229 | 0.4827 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0229 | 0.4827 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0229 | 0.4827 | 1 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0229 | 0.4827 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0229 | 0.4827 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0229 | 0.4827 | 1 |
Onchocerca volvulus | 0.0229 | 0.4827 | 0.5 | |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0229 | 0.4827 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0176 | 0.1523 | 0.3154 |
Onchocerca volvulus | 0.0229 | 0.4827 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0229 | 0.4827 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0229 | 0.4827 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0229 | 0.4827 | 1 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0229 | 0.4827 | 1 |
Echinococcus multilocularis | Mastin | 0.0229 | 0.4827 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0229 | 0.4827 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0229 | 0.4827 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1523 | 0.3154 |
Onchocerca volvulus | 0.0229 | 0.4827 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0229 | 0.4827 | 1 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0229 | 0.4827 | 1 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0229 | 0.4827 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0229 | 0.4827 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0229 | 0.4827 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0229 | 0.4827 | 1 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0229 | 0.4827 | 1 |
Onchocerca volvulus | 0.0229 | 0.4827 | 0.5 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1523 | 0.3154 |
Echinococcus granulosus | Mastin | 0.0229 | 0.4827 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0229 | 0.4827 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0229 | 0.4827 | 1 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0229 | 0.4827 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.9282 | 0.8612 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.9196 | 0.9807 |
Onchocerca volvulus | 0.0229 | 0.4827 | 0.5 | |
Mycobacterium ulcerans | hypothetical protein | 0.0229 | 0.4827 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0229 | 0.4827 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.9282 | 1 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0229 | 0.4827 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0229 | 0.4827 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 1.3 uM | Agonist activity at human recombinant TRbeta1 transfected in human HepG2 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assay | ChEMBL. | 24290064 |
EC50 (binding) | = 3.1 uM | Agonist activity at human recombinant TRbeta1 transfected in CV-1 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assay | ChEMBL. | 24290064 |
IC50 (binding) | = 0.24 uM | Displacement of [125I]-Triiodothyronine from human recombinant TRbeta1 ligand binding domain after 2 to 3 hrs by beta counting | ChEMBL. | 24290064 |
IC50 (binding) | = 5.2 uM | Displacement of [125I]-Triiodothyronine from human recombinant TRalpha1 ligand binding domain after 2 to 3 hrs by beta counting | ChEMBL. | 24290064 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.