Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0573 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0312 | 0.3811 | 0.0423 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0573 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0573 | 1 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.058 | 0.058 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0573 | 1 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0573 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0573 | 1 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0176 | 0.058 | 0.058 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.058 | 0.058 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0573 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0573 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0573 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0573 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0573 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0573 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0573 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0573 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0573 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.3537 | 0.0051 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0573 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0573 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0573 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0573 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0573 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.1 uM | Displacement of [125I]-Triiodothyronine from human recombinant TRbeta1 ligand binding domain after 2 to 3 hrs by beta counting | ChEMBL. | 24290064 |
IC50 (binding) | > 10 uM | Displacement of [125I]-Triiodothyronine from human recombinant TRalpha1 ligand binding domain after 2 to 3 hrs by beta counting | ChEMBL. | 24290064 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.