Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0421 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0421 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0421 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0421 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0421 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0421 | 1 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0421 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0421 | 1 | 0.5 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0421 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0421 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0421 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0421 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0421 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0421 | 1 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0032 | 0 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0421 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0421 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0421 | 1 | 0.5 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0421 | 1 | 0.5 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0421 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0421 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.34 uM | Inhibition of human recombinant COX2 using arachidonic acid as substrate incubated for 10 mins prior to substrate addition measured after 2 mins by enzyme immunoassay | ChEMBL. | 24607877 |
IC50 (binding) | > 50 uM | Inhibition of ovine COX1 using arachidonic acid as substrate incubated for 10 mins prior to substrate addition measured after 2 mins by enzyme immunoassay | ChEMBL. | 24607877 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.