Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | fatty acid synthase | 0.1074 | 0.5102 | 0.5772 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0123 | 0.0391 | 0.1941 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase | 0.0068 | 0.0118 | 0.0032 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0706 | 0.328 | 0.5927 |
Leishmania major | zinc-binding dehydrogenase-like protein | 0.0068 | 0.0118 | 0.019 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0273 | 0.1136 | 0.1346 |
Mycobacterium ulcerans | oxidoreductase FadB5 | 0.0068 | 0.0118 | 0.0032 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0068 | 0.0118 | 0.0032 |
Onchocerca volvulus | 0.0255 | 0.1048 | 0.0991 | |
Echinococcus multilocularis | snurportin 1 | 0.0336 | 0.1446 | 0.1665 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0876 | 0.412 | 0.5183 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.1776 | 0.8579 | 1 |
Echinococcus granulosus | Malonyl coenzyme A acyl carrier protein transacylase | 0.0069 | 0.0124 | 0.0537 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.0273 | 0.1136 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0051 | 0.0121 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0068 | 0.0118 | 0.0067 |
Onchocerca volvulus | Acyl carrier protein, mitochondrial homolog | 0.011 | 0.0328 | 0.0223 |
Mycobacterium ulcerans | thioesterase TesA | 0.0907 | 0.4275 | 0.5398 |
Mycobacterium tuberculosis | S-nitrosomycothiol reductase MscR | 0.0068 | 0.0118 | 0.0032 |
Trichomonas vaginalis | set domain proteins, putative | 0.0255 | 0.1048 | 0.7376 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0067 | 0.0115 | 0.0028 |
Schistosoma mansoni | [ACP] S-malonyltransferase | 0.0069 | 0.0124 | 0.0358 |
Onchocerca volvulus | 0.1017 | 0.4819 | 0.5011 | |
Chlamydia trachomatis | acyl carrier protein | 0.011 | 0.0328 | 0.2016 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.0688 | 0.2206 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0273 | 0.1136 | 1 |
Mycobacterium tuberculosis | Probable alcohol dehydrogenase Adh | 0.0068 | 0.0118 | 0.0032 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0081 | 0.0185 | 0.0192 |
Mycobacterium tuberculosis | Acyl carrier protein (ACP) MbtL | 0.011 | 0.0328 | 0.0303 |
Loa Loa (eye worm) | acyl carrier protein | 0.011 | 0.0328 | 0.0371 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.0273 | 0.1136 | 1 |
Brugia malayi | Alcohol dehydrogenase class III | 0.0068 | 0.0118 | 0.0067 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.011 | 0.0328 | 0.0278 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.0068 | 0.0118 | 0.0134 |
Schistosoma mansoni | hypothetical protein | 0.0336 | 0.1446 | 0.4691 |
Brugia malayi | Phosphopantetheine attachment site family protein | 0.011 | 0.0328 | 0.0278 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.011 | 0.0328 | 0.0303 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD-dependent AdhB | 0.0068 | 0.0118 | 0.0032 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1156 | 0.5508 | 0.6991 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0108 | 0.0317 | 0.1553 |
Echinococcus granulosus | geminin | 0.0183 | 0.0688 | 0.35 |
Treponema pallidum | acyl carrier protein | 0.011 | 0.0328 | 0.5 |
Toxoplasma gondii | acyl carrier protein ACP | 0.011 | 0.0328 | 0.0531 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0071 | 0.0134 | 0.0391 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0068 | 0.0118 | 0.0032 |
Trypanosoma brucei | beta-ketoacyl-ACP synthase | 0.0273 | 0.1136 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0118 | 0.0134 |
Loa Loa (eye worm) | acyl carrier protein | 0.05 | 0.2262 | 0.2559 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.1627 | 0.7839 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1088 | 0.5174 | 0.6559 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0071 | 0.0134 | 0.0391 |
Echinococcus multilocularis | AMP dependent ligase | 0.011 | 0.0328 | 0.0358 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.072 | 0.3348 | 0.4183 |
Echinococcus granulosus | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0068 | 0.0118 | 0.0508 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.011 | 0.0328 | 0.0303 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0273 | 0.1136 | 1 |
Mycobacterium tuberculosis | Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) | 0.0068 | 0.0118 | 0.0032 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtF | 0.011 | 0.0328 | 0.0303 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0342 | 0.1476 | 0.1786 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0069 | 0.0128 | 0.0124 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0108 | 0.0317 | 0.0992 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.1156 | 0.5508 | 0.6991 |
Schistosoma mansoni | methyltransferase-related | 0.0328 | 0.1407 | 0.4563 |
Mycobacterium leprae | Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.011 | 0.0328 | 0.0271 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.1088 | 0.5174 | 0.6559 |
Mycobacterium ulcerans | zinc-type alcohol dehydrogenase AdhD | 0.0068 | 0.0118 | 0.0032 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0619 | 0.2848 | 0.3556 |
Brugia malayi | jmjC domain containing protein | 0.0069 | 0.0128 | 0.0077 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0775 | 0.362 | 0.6549 |
Plasmodium vivax | hypothetical protein, conserved | 0.016 | 0.0577 | 0.4909 |
Mycobacterium ulcerans | dehydrogenase | 0.0068 | 0.0118 | 0.0032 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0071 | 0.0134 | 0.0589 |
Toxoplasma gondii | type I fatty acid synthase | 0.0167 | 0.061 | 0.1047 |
Leishmania major | d-xylulose reductase, putative | 0.0068 | 0.0118 | 0.019 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0058 | 0.0072 | 0.0082 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.011 | 0.0328 | 0.0303 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.011 | 0.0328 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0336 | 0.1446 | 0.7482 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0067 | 0.0115 | 0.0493 |
Giardia lamblia | Methyltransferase like 2 | 0.0328 | 0.1407 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0051 | 0.0121 |
Schistosoma mansoni | zinc binding dehydrogenase | 0.0068 | 0.0118 | 0.034 |
Toxoplasma gondii | acyl transferase domain-containing protein | 0.0069 | 0.0124 | 0.0158 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0108 | 0.0317 | 0.0359 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0108 | 0.0317 | 0.0346 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.1088 | 0.5174 | 0.6547 |
Mycobacterium ulcerans | Zn-dependent alcohol dehydrogenase, AdhX | 0.0068 | 0.0118 | 0.0032 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0162 | 0.0584 | 0.0535 |
Mycobacterium tuberculosis | Probable acyl carrier protein AcpA (ACP) | 0.011 | 0.0328 | 0.0303 |
Brugia malayi | AMP-binding enzyme family protein | 0.1017 | 0.4819 | 0.4793 |
Brugia malayi | mbt repeat family protein | 0.0108 | 0.0317 | 0.0267 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0051 | 0.0036 | 0.0075 |
Mycobacterium leprae | PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 | 0.0167 | 0.061 | 0.0637 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase | 0.011 | 0.0328 | 0.0303 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.0115 | 0.0028 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtE | 0.011 | 0.0328 | 0.0303 |
Leishmania major | oxidoreductase-like protein | 0.0068 | 0.0118 | 0.019 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0067 | 0.0115 | 0.0168 |
Leishmania major | zinc binding dehydrogenase-like protein | 0.0068 | 0.0118 | 0.019 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.1962 | 0.95 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.016 | 0.0577 | 0.4475 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0074 | 0.0149 | 0.067 |
Mycobacterium tuberculosis | Possible oxidoreductase FadB5 | 0.0068 | 0.0118 | 0.0032 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1088 | 0.5174 | 0.6559 |
Echinococcus multilocularis | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0068 | 0.0118 | 0.0113 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0167 | 0.061 | 0.0667 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0152 | 0.0535 | 0.2699 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.1055 | 0.5008 | 0.6345 |
Onchocerca volvulus | 0.0114 | 0.0349 | 0.0246 | |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0067 | 0.0115 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0258 | 0.0292 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1088 | 0.5174 | 0.6559 |
Leishmania major | hypothetical protein, conserved | 0.0069 | 0.0124 | 0.0231 |
Mycobacterium tuberculosis | Probable alcohol dehydrogenase AdhA | 0.0068 | 0.0118 | 0.0032 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0068 | 0.0118 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.061 | 0.069 |
Toxoplasma gondii | 3-oxoacyl-acyl-carrier protein synthase I/II, putative | 0.0273 | 0.1136 | 0.2009 |
Brugia malayi | Pre-SET motif family protein | 0.0224 | 0.0894 | 0.0848 |
Mycobacterium ulcerans | NADPH quinone oxidoreductase FadB4 | 0.0068 | 0.0118 | 0.0032 |
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.0068 | 0.0118 | 0.0148 |
Echinococcus multilocularis | NADH dehydrogenase | 0.011 | 0.0328 | 0.0358 |
Mycobacterium leprae | Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) | 0.011 | 0.0328 | 0.0271 |
Mycobacterium ulcerans | polyketide synthase | 0.1088 | 0.5174 | 0.6559 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0124 | 0.014 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.011 | 0.0328 | 0.0303 |
Brugia malayi | Methyltransferase-like protein 4 | 0.0328 | 0.1407 | 0.1363 |
Brugia malayi | Bromodomain containing protein | 0.009 | 0.0231 | 0.0181 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.011 | 0.0328 | 0.0303 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.1156 | 0.5508 | 0.6981 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.1088 | 0.5174 | 0.6547 |
Schistosoma mansoni | zinc finger protein | 0.0048 | 0.0021 | 0.0023 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.1156 | 0.5508 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.0037 | 0.0084 |
Brugia malayi | mbt repeat family protein | 0.0108 | 0.0317 | 0.0267 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.011 | 0.0328 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.028 | 0.0316 |
Schistosoma mansoni | [ACP] S-malonyltransferase | 0.0069 | 0.0124 | 0.0358 |
Leishmania major | hypothetical protein, conserved | 0.0328 | 0.1407 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.1627 | 0.7839 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0074 | 0.0149 | 0.0441 |
Schistosoma mansoni | hypothetical protein | 0.0663 | 0.3067 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0317 | 0.0359 |
Trypanosoma cruzi | Acyl carrier protein, mitochondrial, putative | 0.011 | 0.0328 | 0.2059 |
Schistosoma mansoni | acyl carrier protein | 0.011 | 0.0328 | 0.1027 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.0115 | 0.0331 |
Echinococcus granulosus | AMP dependent ligase | 0.011 | 0.0328 | 0.1609 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks17 | 0.0266 | 0.11 | 0.13 |
Plasmodium falciparum | acyl carrier protein | 0.011 | 0.0328 | 0.2016 |
Mycobacterium ulcerans | polyketide synthase MbtD | 0.0335 | 0.1441 | 0.1739 |
Wolbachia endosymbiont of Brugia malayi | acyl carrier protein | 0.011 | 0.0328 | 0.2059 |
Loa Loa (eye worm) | hypothetical protein | 0.1828 | 0.8838 | 1 |
Echinococcus granulosus | NADH dehydrogenase | 0.011 | 0.0328 | 0.1609 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0123 | 0.0391 | 0.0342 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.1017 | 0.4819 | 0.6101 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0391 | 0.0442 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.1017 | 0.4819 | 0.5453 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0068 | 0.0118 | 0.0067 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0167 | 0.061 | 0.0667 |
Trypanosoma cruzi | acyl transferase-like protein, putative | 0.0069 | 0.0124 | 0.0053 |
Mycobacterium ulcerans | polyketide synthase MbtC | 0.0273 | 0.1136 | 0.1346 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0068 | 0.0118 | 0.0067 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0123 | 0.0391 | 0.0432 |
Mycobacterium ulcerans | oxidoreductase | 0.0068 | 0.0118 | 0.0032 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0273 | 0.1136 | 0.1346 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0118 | 0.0134 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0273 | 0.1136 | 0.1091 |
Mycobacterium leprae | PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) | 0.0342 | 0.1476 | 0.1759 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.1088 | 0.5174 | 0.5149 |
Brugia malayi | PHD-finger family protein | 0.006 | 0.0081 | 0.003 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0139 | 0.047 | 0.2358 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0123 | 0.0391 | 0.0432 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.1627 | 0.7839 | 1 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0273 | 0.1136 | 1 |
Mycobacterium ulcerans | acyl carrier protein | 0.011 | 0.0328 | 0.0303 |
Mycobacterium ulcerans | acyl carrier protein | 0.011 | 0.0328 | 0.0303 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0074 | 0.0149 | 0.0441 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0051 | 0.0036 | 0.0017 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0054 | 0.0051 | 0.0058 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0108 | 0.0317 | 0.0992 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.0115 | 0.0028 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase AdhE2 | 0.0068 | 0.0118 | 0.0032 |
Onchocerca volvulus | 0.0108 | 0.0317 | 0.0212 | |
Mycobacterium ulcerans | phenyloxazoline synthase MbtB | 0.011 | 0.0328 | 0.0303 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0328 | 0.1407 | 0.1696 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0224 | 0.0894 | 0.1012 |
Wolbachia endosymbiont of Brugia malayi | ACP S-malonyltransferase | 0.0069 | 0.0124 | 0.0053 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0335 | 0.1441 | 0.1739 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0876 | 0.412 | 0.5199 |
Leishmania major | oxidoreductase, putative | 0.0068 | 0.0118 | 0.019 |
Trypanosoma cruzi | acyl transferase-like protein | 0.0069 | 0.0124 | 0.0053 |
Schistosoma mansoni | alcohol dehydrogenase | 0.0068 | 0.0118 | 0.034 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0068 | 0.0118 | 0.0032 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0782 | 0.3655 | 0.4599 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.1156 | 0.5508 | 0.6991 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0123 | 0.0391 | 0.1234 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.0273 | 0.1136 | 0.5854 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.0115 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.061 | 0.2803 | 0.3172 |
Brugia malayi | acyl carrier protein, mitochondrial precursor, putative | 0.011 | 0.0328 | 0.0278 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0433 | 0.1926 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0139 | 0.047 | 0.0525 |
Brugia malayi | Bromodomain containing protein | 0.0173 | 0.0642 | 0.0594 |
Echinococcus multilocularis | Malonyl coenzyme A acyl carrier protein transacylase | 0.0069 | 0.0124 | 0.0119 |
Mycobacterium ulcerans | peptide synthetase Nrp (peptide synthase) | 0.011 | 0.0328 | 0.0303 |
Echinococcus multilocularis | geminin | 0.0183 | 0.0688 | 0.0779 |
Schistosoma mansoni | jumonji domain containing protein | 0.0069 | 0.0128 | 0.0371 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0162 | 0.0584 | 0.0657 |
Leishmania major | NADP-dependent alcohol dehydrogenase, putative | 0.0068 | 0.0118 | 0.019 |
Mycobacterium ulcerans | NADP-dependent oxidoreductase | 0.0068 | 0.0118 | 0.0032 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.0273 | 0.1136 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0336 | 0.1446 | 0.1636 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.072 | 0.3348 | 0.4201 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0074 | 0.0149 | 0.0169 |
Mycobacterium tuberculosis | Meromycolate extension acyl carrier protein AcpM | 0.011 | 0.0328 | 0.0303 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0108 | 0.0317 | 0.0992 |
Mycobacterium tuberculosis | Probable NADP-dependent alcohol dehydrogenase AdhC | 0.0068 | 0.0118 | 0.0032 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.1156 | 0.5508 | 0.6981 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.0051 | 0.0156 |
Schistosoma mansoni | 3-oxoacyl-[ACP] synthase | 0.0273 | 0.1136 | 0.3675 |
Trypanosoma brucei | acyl transferase-like protein | 0.0069 | 0.0124 | 0.0053 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0433 | 0.1926 | 0.2225 |
Onchocerca volvulus | 0.1894 | 0.9165 | 0.9643 | |
Leishmania major | beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative | 0.0273 | 0.1136 | 0.7938 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0071 | 0.0134 | 0.0131 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0067 | 0.0115 | 0.011 |
Schistosoma mansoni | bromodomain containing protein | 0.0147 | 0.051 | 0.1625 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1088 | 0.5174 | 0.6559 |
Mycobacterium tuberculosis | Probable polyketide beta-ketoacyl synthase Pks3 | 0.0167 | 0.061 | 0.0667 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.011 | 0.0328 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1156 | 0.5508 | 0.6991 |
Brugia malayi | jmjC domain containing protein | 0.0074 | 0.0149 | 0.0098 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0907 | 0.4275 | 0.5384 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0328 | 0.1407 | 1 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0063 | 0.0093 | 0.0042 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0063 | 0.0093 | 0.0084 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.0068 | 0.0118 | 0.0032 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1088 | 0.5174 | 0.6559 |
Schistosoma mansoni | [ACP] S-malonyltransferase | 0.0069 | 0.0124 | 0.0358 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0118 | 0.0134 |
Mycobacterium ulcerans | hypothetical protein | 0.011 | 0.0328 | 0.0303 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase Adh | 0.0068 | 0.0118 | 0.0032 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0069 | 0.0128 | 0.0124 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.0051 | 0.0035 |
Mycobacterium tuberculosis | Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) | 0.0068 | 0.0118 | 0.0032 |
Brugia malayi | RNA, U transporter 1 | 0.0089 | 0.0226 | 0.0176 |
Echinococcus multilocularis | Acyl carrier protein, mitochondrial | 0.011 | 0.0328 | 0.0358 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0162 | 0.0584 | 0.1865 |
Mycobacterium tuberculosis | Possible dehydrogenase | 0.0068 | 0.0118 | 0.0032 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.011 | 0.0328 | 0.0303 |
Mycobacterium ulcerans | fatty-acid-CoA ligase FadD9 | 0.011 | 0.0328 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0134 | 0.0151 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0342 | 0.1476 | 0.1786 |
Loa Loa (eye worm) | beta-ketoacyl synthase domain-containing protein | 0.0273 | 0.1136 | 0.1286 |
Mycobacterium tuberculosis | Conserved protein | 0.0328 | 0.1407 | 0.1696 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0051 | 0.0036 | 0.007 |
Leishmania major | quinone oxidoreductase, putative | 0.0068 | 0.0118 | 0.019 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.0688 | 0.2206 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.0115 | 0.0331 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0063 | 0.0093 | 0.0259 |
Plasmodium vivax | malonyl CoA-acyl carrier protein transacylase precursor, putative | 0.0069 | 0.0124 | 0.0785 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.072 | 0.3348 | 0.4201 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0575 | 0.065 |
Loa Loa (eye worm) | acetyltransferase | 0.0162 | 0.0584 | 0.066 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0123 | 0.0391 | 0.1941 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.0051 | 0.0035 |
Mycobacterium ulcerans | oxidoreductase | 0.0068 | 0.0118 | 0.0032 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0907 | 0.4275 | 0.5398 |
Brugia malayi | ADP-specific Phosphofructokinase/Glucokinase conserved region family protein | 0.0069 | 0.0124 | 0.0073 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0108 | 0.0317 | 0.0212 |
Mycobacterium ulcerans | thioesterase | 0.0907 | 0.4275 | 0.5398 |
Trypanosoma brucei | Acyl carrier protein, mitochondrial | 0.011 | 0.0328 | 0.2059 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0118 | 0.0134 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0047 | 0.0014 | 0.0016 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0068 | 0.0118 | 0.0032 |
Plasmodium vivax | acyl carrier protein, putative | 0.011 | 0.0328 | 0.2643 |
Mycobacterium ulcerans | quinone reductase Qor | 0.0068 | 0.0118 | 0.0032 |
Toxoplasma gondii | quinone oxidoreductase, putative | 0.0068 | 0.0118 | 0.0148 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0108 | 0.0317 | 0.0346 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0108 | 0.0317 | 0.1553 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.1055 | 0.5008 | 0.6345 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0213 | 0.0241 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1088 | 0.5174 | 0.6559 |
Mycobacterium tuberculosis | Probable polyketide beta-ketoacyl synthase Pks4 | 0.0167 | 0.061 | 0.0667 |
Leishmania major | nuclear receptor binding factor-like protein | 0.0068 | 0.0118 | 0.019 |
Loa Loa (eye worm) | phosphopantetheine attachment site family protein | 0.011 | 0.0328 | 0.0371 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.0051 | 0.0156 |
Mycobacterium tuberculosis | Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) | 0.0068 | 0.0118 | 0.0032 |
Echinococcus multilocularis | 3 oxoacyl (acyl carrier protein) synthase | 0.0273 | 0.1136 | 0.1303 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.055 | 0.2507 | 0.4515 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0069 | 0.0128 | 0.0558 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.089 | 0.4191 | 0.5291 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0068 | 0.0118 | 0.059 |
Leishmania major | acyl carrier protein, putative | 0.011 | 0.0328 | 0.1785 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase AdhC | 0.0068 | 0.0118 | 0.0032 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1156 | 0.5508 | 0.6991 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.044 | 0.1963 | 0.2414 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.061 | 0.069 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0063 | 0.0093 | 0.0377 |
Mycobacterium tuberculosis | Possible dehydrogenase | 0.0068 | 0.0118 | 0.0032 |
Echinococcus granulosus | acyl carrier protein mitochondrial | 0.011 | 0.0328 | 0.1609 |
Brugia malayi | AMP-binding enzyme family protein | 0.0335 | 0.1441 | 0.1397 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0081 | 0.0185 | 0.0862 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.0328 | 0.1027 |
Mycobacterium ulcerans | polyketide synthase | 0.1156 | 0.5508 | 0.6991 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0876 | 0.412 | 0.5199 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.1627 | 0.7839 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.1156 | 0.5508 | 0.6981 |
Mycobacterium ulcerans | short-chain dehydrogenase | 0.0072 | 0.0139 | 0.0059 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0051 | 0.0121 |
Mycobacterium ulcerans | malonyl CoA-acyl carrier protein transacylase FabD | 0.0069 | 0.0124 | 0.0039 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0374 | 0.1636 | 0.1992 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0068 | 0.0118 | 0.059 |
Mycobacterium leprae | conserved hypothetical protein | 0.011 | 0.0328 | 0.0271 |
Loa Loa (eye worm) | MBCTL1 | 0.0123 | 0.0391 | 0.0442 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 7 ug ml-1 | Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by MTS assay | ChEMBL. | 26209266 |
MIC (functional) | = 0.16 ug ml-1 | Antimicrobial activity against TolC efflux-deficient Escherichia coli K-12 after 16 to 20 hrs by broth microdilution method | ChEMBL. | 24239389 |
MIC (functional) | = 0.63 ug ml-1 | Antimicrobial activity against efflux pump-positive Escherichia coli K-12 after 16 to 20 hrs by broth microdilution method | ChEMBL. | 24239389 |
MIC (functional) | = 3.13 ug ml-1 | Antifungal activity against Cryptococcus neoformans Cn18 (Serotype C) WTBF-106 by microbroth dilution method | ChEMBL. | 26209266 |
MIC (functional) | = 16 ug ml-1 | Antifungal activity against Candida albicans WTBF-50 by microbroth dilution method | ChEMBL. | 26209266 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.