Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.4 nM | Inhibition of human coagulation factor 10a using S-2765 as substrate measured up to 20 mins by chromogenic assay | ChEMBL. | 24175584 |
IC50 (binding) | = 126 nM | Inhibition of human thrombin using S-2238 as substrate measured up to 20 mins by chromogenic assay | ChEMBL. | 24175584 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.