Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0705 | 0.4649 | 0.6261 |
Onchocerca volvulus | 0.119 | 0.9202 | 0.9285 | |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0276 | 0.0622 | 0.0838 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0639 | 0.4025 | 0.3989 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0214 | 0.0036 | 0.0049 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0705 | 0.4649 | 0.6239 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0389 | 0.1676 | 0.2257 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.1001 | 0.7426 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.1001 | 0.7426 | 1 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0444 | 0.2191 | 0.2724 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0487 | 0.2597 | 0.3924 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0663 | 0.425 | 0.5723 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0663 | 0.425 | 0.5723 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0663 | 0.425 | 0.5723 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0491 | 0.2639 | 0.3553 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0663 | 0.425 | 0.5723 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0705 | 0.4649 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0663 | 0.425 | 0.5723 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.1001 | 0.7426 | 1 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0705 | 0.4649 | 0.6261 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0639 | 0.4025 | 0.542 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0663 | 0.425 | 0.5699 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0431 | 0.2075 | 0.2794 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0705 | 0.4649 | 0.6239 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.1427 | 0.0587 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0705 | 0.4649 | 0.6261 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0215 | 0.0043 | 0.0058 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0431 | 0.2075 | 0.2794 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0663 | 0.425 | 0.5723 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0663 | 0.425 | 0.425 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0538 | 0.308 | 0.4148 |
Mycobacterium ulcerans | thioesterase | 0.057 | 0.3377 | 0.4547 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.1001 | 0.7426 | 1 |
Loa Loa (eye worm) | fatty acid synthase | 0.0675 | 0.4362 | 0.4429 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0529 | 0.2996 | 0.4034 |
Brugia malayi | AMP-binding enzyme family protein | 0.0639 | 0.4025 | 0.4025 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0705 | 0.4649 | 0.6261 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0663 | 0.425 | 0.5723 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0663 | 0.425 | 0.5723 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0663 | 0.425 | 0.5723 |
Mycobacterium ulcerans | thioesterase TesA | 0.057 | 0.3377 | 0.4547 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.1233 | 0.9601 | 1 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.057 | 0.3377 | 0.4547 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0705 | 0.4649 | 0.6239 |
Loa Loa (eye worm) | hypothetical protein | 0.1128 | 0.8616 | 1 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0215 | 0.0043 | 0.0058 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0663 | 0.425 | 0.5699 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0529 | 0.2996 | 0.3999 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0431 | 0.2075 | 0.2753 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0529 | 0.2996 | 0.4034 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0663 | 0.425 | 0.5723 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0705 | 0.4649 | 0.6261 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.057 | 0.3377 | 0.4515 |
Mycobacterium ulcerans | polyketide synthase | 0.0705 | 0.4649 | 0.6261 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.