TDR Targets

Basic information

Technical information

TDR Targets ID: 1823532
Name: 2-[2-(4-fluorophenyl)morpholin-4-yl]-3-methyl -6-pyridin-4-ylpyrimidin-4-one
MW: 366.389 | Formula: C20H19FN4O2
H donors: 0 H acceptors: 2 LogP: 1.29 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)C1OCCN(C1)c1nc(cc(=O)n1C)c1ccncc1
InChi: 1S/C20H19FN4O2/c1-24-19(26)12-17(14-6-8-22-9-7-14)23-20(24)25-10-11-27-18(13-25)15-2-4-16(21)5-3-15/h2-9,12,18H,10-11,13H2,1H3
InChiKey: FZPYWVVOFIWWAQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[2-(4-fluorophenyl)morpholin-4-yl]-3-methyl-6-(4-pyridyl)pyrimidin-4-one
2-[2-(4-fluorophenyl)-4-morpholinyl]-3-methyl-6-(4-pyridyl)-4-pyrimidinone
2-[2-(4-fluorophenyl)morpholin-4-yl]-3-methyl-6-pyridin-4-yl-pyrimidin-4-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycogen synthase kinase 3 beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium vivax	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium parvum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	ko:K08822 glycogen synthase kinase 3 alpha, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Neospora caninum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium falciparum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium berghei	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	intracellular kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Theileria parva	glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	Serine/threonine protein kinase required for induction of IME2 by Ime1p	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma cruzi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania mexicana	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania donovani	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei gambiense	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania braziliensis	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania infantum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Onchocerca volvulus		Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium knowlesi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	AGC family protein kinase	0.0369	0.2173	0.2173
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0369	0.2173	0.3243
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0369	0.2173	0.3243
Onchocerca volvulus	Tyrosine kinase homolog	0.0369	0.2173	1
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Entamoeba histolytica	hypothetical protein, conserved	0.0369	0.2173	0.2173
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0369	0.2173	0.3243
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.1365	0.9353	0.9353
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Onchocerca volvulus		0.0369	0.2173	1
Echinococcus multilocularis	nervana 2	0.0897	0.5977	0.8919
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.01	0.0233	0.0385
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.2173	0.2173
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Schistosoma mansoni	hypothetical protein	0.009	0.0156	0.0233
Echinococcus multilocularis	tyrosine kinase	0.0369	0.2173	0.3243
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0369	0.2173	0.2173
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0369	0.2173	0.2173
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0908	0.6053	0.9034
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.2173	0.2173
Loa Loa (eye worm)	TK/INSR protein kinase	0.0369	0.2173	0.2173
Entamoeba histolytica	protein kinase, putative	0.0369	0.2173	0.2173
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.2173	0.2173
Trypanosoma cruzi	hypothetical protein	0.009	0.0156	0.0233
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0369	0.2173	0.2173
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0156	0.0156
Toxoplasma gondii	protein kinase domain-containing protein	0.0369	0.2173	0.2324
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0369	0.2173	0.2173
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0369	0.2173	0.3243
Entamoeba histolytica	receptor protein kinase, putative	0.0369	0.2173	0.2173
Echinococcus granulosus	tyrosine kinase	0.0369	0.2173	0.3243
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Entamoeba histolytica	tyrosine kinase, putative	0.0369	0.2173	0.2173
Trichomonas vaginalis	alpha chimerin, putative	0.009	0.0156	0.0156
Brugia malayi	hypothetical protein	0.009	0.0156	0.0156
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Schistosoma mansoni	goodpasture antigen-binding protein	0.009	0.0156	0.0233
Schistosoma mansoni	goodpasture antigen-binding protein	0.009	0.0156	0.0233
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.009	0.0156	0.0156
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Plasmodium falciparum	tyrosine kinase-like protein	0.0369	0.2173	0.359
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Brugia malayi	Protein kinase domain containing protein	0.0468	0.2885	0.2885
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.009	0.0156	0.0156
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.009	0.0156	0.0156
Echinococcus granulosus	epidermal growth factor receptor	0.0369	0.2173	0.3243
Trypanosoma cruzi	hypothetical protein	0.009	0.0156	0.0233
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0369	0.2173	0.3243
Entamoeba histolytica	hypothetical protein	0.009	0.0156	0.0156
Entamoeba histolytica	hypothetical protein	0.01	0.0233	0.0233
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Echinococcus granulosus	tyrosine protein kinase Srms	0.0369	0.2173	0.3243
Onchocerca volvulus		0.0369	0.2173	1
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Trypanosoma cruzi	PH domain containing protein, putative	0.009	0.0156	0.0233
Entamoeba histolytica	hypothetical protein	0.009	0.0156	0.0156
Schistosoma mansoni	protein kinase	0.0369	0.2173	0.3243
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0468	0.2885	0.4305
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Schistosoma mansoni	zinc finger protein	0.009	0.0156	0.0233
Echinococcus granulosus	tyrosine protein kinase csk	0.0369	0.2173	0.3243
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.009	0.0156	0.0233
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Trypanosoma brucei	protein kinase, putative	0.038	0.225	0.225
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Echinococcus multilocularis	epidermal growth factor receptor	0.0369	0.2173	0.3243
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0369	0.2173	0.2173
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Echinococcus granulosus	ephrin type A receptor 4 A	0.0369	0.2173	0.3243
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	AGC family protein kinase	0.1455	1	1
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.01	0.0233	0.0348
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.038	0.225	0.2406
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Entamoeba histolytica	protein kinase, putative	0.0369	0.2173	0.2173
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0369	0.2173	0.2173
Onchocerca volvulus		0.0369	0.2173	1
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Echinococcus granulosus	dynamin 1	0.009	0.0156	0.0233
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2173	0.2173
Entamoeba histolytica	protein kinase, putative	0.0369	0.2173	0.2173
Toxoplasma gondii	phosphatidylinositol transfer protein	0.009	0.0156	0.0167
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.009	0.0156	0.0258
Entamoeba histolytica	protein kinase, putative	0.0369	0.2173	0.2173
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0468	0.2885	0.2885
Echinococcus granulosus	tyrosine protein kinase Lyn	0.038	0.225	0.3358
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Brugia malayi	Cadps2 protein	0.009	0.0156	0.0156
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0369	0.2173	0.2173
Echinococcus granulosus	protein kinase c iota type	0.0468	0.2885	0.4305
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.009	0.0156	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2173	0.2173
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0156	0.0156
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.2173	0.2173
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0156	0.0156
Loa Loa (eye worm)	TK/EPH protein kinase	0.0369	0.2173	0.2173
Echinococcus granulosus	protein kinase c epsilon type	0.0468	0.2885	0.4305
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.01	0.0233	0.0348
Brugia malayi	Variant SH3 domain containing protein	0.009	0.0156	0.0156
Echinococcus granulosus	natriuretic peptide receptor 1	0.0369	0.2173	0.3243
Entamoeba histolytica	PH domain containing protein kinase, putative	0.01	0.0233	0.0233
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0369	0.2173	0.2173
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0369	0.2173	0.3243
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0369	0.2173	0.3243
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0369	0.2173	0.2173
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0369	0.2173	0.3243
Echinococcus granulosus	activated cdc42 kinase 1	0.0369	0.2173	0.3243
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Echinococcus granulosus	protein kinase C gamma type	0.0468	0.2885	0.4305
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.2173	0.2173
Brugia malayi	Pleckstrin Homology Domain	0.009	0.0156	0.0156
Leishmania major	protein kinase, putative	0.01	0.0233	0.1035
Schistosoma mansoni	protein kinase	0.0369	0.2173	0.3243
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0468	0.2885	0.2885
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Entamoeba histolytica	protein kinase, putative	0.0369	0.2173	0.2173
Trichomonas vaginalis	AGC family protein kinase	0.1455	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0369	0.2173	0.2173
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0369	0.2173	0.3243
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	CAMK family protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	centaurin alpha, putative	0.009	0.0156	0.0156
Toxoplasma gondii	protein kinase	0.0369	0.2173	0.2324
Loa Loa (eye worm)	TK/RYK protein kinase	0.0369	0.2173	0.2173
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0468	0.2885	0.2885
Loa Loa (eye worm)	syntrophin-1	0.009	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Trypanosoma cruzi	hypothetical protein	0.009	0.0156	0.0233
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0369	0.2173	0.3243
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0156	0.0156
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Plasmodium falciparum	tyrosine kinase-like protein	0.0369	0.2173	0.359
Entamoeba histolytica	hypothetical protein	0.0369	0.2173	0.2173
Loa Loa (eye worm)	TK protein kinase	0.0369	0.2173	0.2173
Entamoeba histolytica	protein kinase, putative	0.0369	0.2173	0.2173
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.01	0.0233	0.0233
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0369	0.2173	0.3243
Entamoeba histolytica	hypothetical protein	0.009	0.0156	0.0156
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.009	0.0156	0.0156
Schistosoma mansoni	syntrophin	0.009	0.0156	0.0233
Brugia malayi	PH domain containing protein	0.009	0.0156	0.0156
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Echinococcus granulosus	nervana 2	0.0897	0.5977	0.8919
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.009	0.0156	0.0156
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.009	0.0156	0.0156
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0369	0.2173	0.3243
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0908	0.6053	0.9034
Entamoeba histolytica	receptor protein kinase, putative	0.0369	0.2173	0.2173
Echinococcus multilocularis	protein tyrosine kinase	0.0369	0.2173	0.3243
Echinococcus granulosus	tyrosine protein kinase csk	0.0369	0.2173	0.3243
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Entamoeba histolytica	serine/threonine kinase, putative	0.0369	0.2173	0.2173
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.01	0.0233	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2173	0.2173
Brugia malayi	Protein kinase domain containing protein	0.0468	0.2885	0.2885
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0369	0.2173	0.3243
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0369	0.2173	0.3243
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.2173	0.2173
Echinococcus granulosus	Oxysterol binding protein 11	0.009	0.0156	0.0233
Loa Loa (eye worm)	TK/DDR protein kinase	0.0369	0.2173	0.2173
Echinococcus multilocularis	serine threonine protein kinase	0.0468	0.2885	0.4305
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0369	0.2173	0.3243
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.009	0.0156	0.0156
Entamoeba histolytica	protein kinase, putative	0.0369	0.2173	0.2173
Entamoeba histolytica	tyrosin kinase, putative	0.0369	0.2173	0.2173
Leishmania major	hypothetical protein, conserved	0.009	0.0156	0.0694
Brugia malayi	PH domain containing protein	0.009	0.0156	0.0156
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Echinococcus granulosus	cytohesin 1	0.009	0.0156	0.0233
Echinococcus granulosus	myotubularin protein 13	0.009	0.0156	0.0233
Giardia lamblia	Kinase	0.0369	0.2173	0.359
Echinococcus multilocularis	myotubularin protein 13	0.009	0.0156	0.0233
Echinococcus multilocularis	oxysterol binding protein 1	0.009	0.0156	0.0233
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0369	0.2173	0.3243
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0369	0.2173	0.3243
Echinococcus multilocularis	Oxysterol binding protein 11	0.009	0.0156	0.0233
Echinococcus granulosus	receptor type guanylyl cyclase	0.0369	0.2173	0.3243
Echinococcus multilocularis	tyrosine kinase	0.0369	0.2173	0.3243
Brugia malayi	Dynamin	0.009	0.0156	0.0156
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.2173	0.2173
Giardia lamblia	Protein 21.1	0.0369	0.2173	0.359
Echinococcus granulosus	integrin linked protein kinase	0.0369	0.2173	0.3243
Schistosoma mansoni	dynamin	0.009	0.0156	0.0233
Trichomonas vaginalis	centaurin gamma, putative	0.009	0.0156	0.0156
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Loa Loa (eye worm)	cytohesin 3	0.009	0.0156	0.0156
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.01	0.0233	0.0348
Entamoeba histolytica	hypothetical protein	0.0369	0.2173	0.2173
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.009	0.0156	0.0156
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0369	0.2173	0.2173
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0156	0.0156
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.038	0.225	0.3358
Leishmania major	folate/biopterin transporter, putative	0.01	0.0233	0.1035
Echinococcus multilocularis	oxysterol binding protein 3	0.009	0.0156	0.0233
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Loa Loa (eye worm)	rho-GTPase-activating	0.009	0.0156	0.0156
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.009	0.0156	0.0233
Echinococcus multilocularis	Rho GTPase activating protein 24	0.009	0.0156	0.0233
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0369	0.2173	0.2173
Echinococcus multilocularis	cytohesin 1	0.009	0.0156	0.0233
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0369	0.2173	0.3243
Echinococcus multilocularis	tyrosine protein kinase	0.0369	0.2173	0.3243
Trichomonas vaginalis	AGC family protein kinase	0.0468	0.2885	0.2885
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.009	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Trichomonas vaginalis	AGC family protein kinase	0.1455	1	1
Entamoeba histolytica	protein kinase, putative	0.0369	0.2173	0.2173
Echinococcus granulosus	epidermal growth factor receptor	0.0369	0.2173	0.3243
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0369	0.2173	0.3243
Loa Loa (eye worm)	serine/threonine protein kinase	0.0369	0.2173	0.2173
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2173	0.2173
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0468	0.2885	0.4305
Echinococcus multilocularis	actin binding protein anillin	0.009	0.0156	0.0233
Echinococcus multilocularis	protein kinase	0.0369	0.2173	0.3243
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Loa Loa (eye worm)	Plekhf2 protein	0.009	0.0156	0.0156
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0369	0.2173	0.3243
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.2173	0.2173
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.009	0.0156	0.0156
Entamoeba histolytica	hypothetical protein	0.0369	0.2173	0.2173
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.009	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Brugia malayi	hypothetical protein	0.0369	0.2173	0.2173
Brugia malayi	Plekhf2 protein	0.009	0.0156	0.0156
Entamoeba histolytica	protein kinase, putative	0.0369	0.2173	0.2173
Schistosoma mansoni	tyrosine protein kinase	0.0369	0.2173	0.3243
Schistosoma mansoni	dynamin	0.009	0.0156	0.0233
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0369	0.2173	0.3243
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Trypanosoma cruzi	NIMA-related kinase, putative	0.01	0.0233	0.0348
Trypanosoma cruzi	hypothetical protein	0.009	0.0156	0.0233
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0369	0.2173	0.3243
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0369	0.2173	0.3243
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.009	0.0156	0.0156
Schistosoma mansoni	serine/threonine protein kinase	0.0369	0.2173	0.3243
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0369	0.2173	0.3243
Leishmania major	hypothetical protein, conserved	0.0369	0.2173	0.9659
Onchocerca volvulus		0.0369	0.2173	1
Trichomonas vaginalis	AGC family protein kinase	0.0468	0.2885	0.2885
Echinococcus granulosus	c src tyrosine kinase	0.0369	0.2173	0.3243
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Loa Loa (eye worm)	oxysterol binding protein	0.009	0.0156	0.0156
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0997	0.6701	0.6701
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0369	0.2173	0.3243
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0369	0.2173	0.2324
Trichomonas vaginalis	protein transport protein sec7, putative	0.009	0.0156	0.0156
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0874	0.5809	0.8669
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.2173	0.2173
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0369	0.2173	0.2173
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0897	0.5977	0.8919
Trichomonas vaginalis	centaurin/arf, putative	0.009	0.0156	0.0156
Echinococcus multilocularis	tyrosine protein kinase csk	0.0369	0.2173	0.3243
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Entamoeba histolytica	p21-activated kinase	0.01	0.0233	0.0233
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Loa Loa (eye worm)	TK protein kinase	0.0369	0.2173	0.2173
Brugia malayi	Oxysterol-binding protein	0.009	0.0156	0.0156
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0156	0.0156
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0369	0.2173	0.359
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0369	0.2173	0.2173
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0369	0.2173	0.2173
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.009	0.0156	0.0156
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Brugia malayi	protein-tyrosine kinase	0.0369	0.2173	0.2173
Echinococcus multilocularis	calcium dependent secretion activator 1	0.009	0.0156	0.0233
Leishmania major	protein kinase, putative	0.0369	0.2173	0.9659
Entamoeba histolytica	protein kinase, putative	0.01	0.0233	0.0233
Entamoeba histolytica	tyrosine kinase, putative	0.0369	0.2173	0.2173
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.2173	0.2173
Brugia malayi	PH domain containing protein	0.009	0.0156	0.0156
Entamoeba histolytica	hypothetical protein	0.0369	0.2173	0.2173
Onchocerca volvulus		0.0369	0.2173	1
Echinococcus multilocularis	oxysterol binding protein 9	0.009	0.0156	0.0233
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0369	0.2173	0.2173
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0908	0.6053	1
Brugia malayi	SRC-1	0.0369	0.2173	0.2173
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2173	0.2173
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0468	0.2885	0.4305
Echinococcus multilocularis	beta 1 syntrophin	0.009	0.0156	0.0233
Onchocerca volvulus		0.0369	0.2173	1
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Echinococcus granulosus	tyrosine protein kinase HCK	0.0369	0.2173	0.3243
Echinococcus granulosus	Pleckstrin y	0.009	0.0156	0.0233
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0369	0.2173	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0369	0.2173	0.3243
Onchocerca volvulus		0.009	0.0156	0.0719
Schistosoma mansoni	protein kinase	0.0369	0.2173	0.3243
Trichomonas vaginalis	AGC family protein kinase	0.1455	1	1
Brugia malayi	SH2 domain containing protein	0.0369	0.2173	0.2173
Echinococcus granulosus	tyrosine kinase	0.0369	0.2173	0.3243
Entamoeba histolytica	tyrosine kinase, putative	0.0369	0.2173	0.2173
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.009	0.0156	0.0156
Entamoeba histolytica	serine/threonine kinase, putative	0.0369	0.2173	0.2173
Entamoeba histolytica	tyrosin kinase, putative	0.0369	0.2173	0.2173
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.009	0.0156	0.0719
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.2173	0.2173
Echinococcus multilocularis	DCC interacting protein 13 beta	0.009	0.0156	0.0233
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0468	0.2885	0.2885
Entamoeba histolytica	hypothetical protein	0.0369	0.2173	0.2173
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0369	0.2173	0.2173
Echinococcus granulosus	Glutaredoxin protein 5	0.0897	0.5977	0.8919
Entamoeba histolytica	tyrosine kinase, putative	0.0369	0.2173	0.2173
Echinococcus multilocularis	Glutaredoxin protein 5	0.0897	0.5977	0.8919
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Entamoeba histolytica	protein kinase, putative	0.0369	0.2173	0.2173
Entamoeba histolytica	protein kinase, putative	0.0468	0.2885	0.2885
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Loa Loa (eye worm)	TK/FAK protein kinase	0.0369	0.2173	0.2173
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2173	0.2173
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0908	0.6053	0.9034
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Schistosoma mansoni	oxysterol-binding protein 1	0.009	0.0156	0.0233
Entamoeba histolytica	ARF GTPase activating protein, putative	0.009	0.0156	0.0156
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0369	0.2173	0.2173
Entamoeba histolytica	PH domain containing protein kinase, putative	0.01	0.0233	0.0233
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0369	0.2173	0.2173
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0369	0.2173	0.3243
Entamoeba histolytica	serine/threonine kinase, putative	0.0369	0.2173	0.2173
Entamoeba histolytica	protein kinase domain containing protein	0.038	0.225	0.225
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Toxoplasma gondii	AtPH1 family protein	0.009	0.0156	0.0167
Brugia malayi	hypothetical protein	0.0369	0.2173	0.2173
Schistosoma mansoni	ephrin receptor	0.0369	0.2173	0.3243
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Loa Loa (eye worm)	TK/CSK protein kinase	0.0369	0.2173	0.2173
Loa Loa (eye worm)	TK protein kinase	0.0369	0.2173	0.2173
Entamoeba histolytica	tyrosin kinase, putative	0.0369	0.2173	0.2173
Onchocerca volvulus	outspread protein homolog	0.009	0.0156	0.0719
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.009	0.0156	0.0233
Echinococcus granulosus	GRB2 associated binding protein 3	0.009	0.0156	0.0233
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.009	0.0156	0.0233
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Schistosoma mansoni	oxysterol-binding protein 1	0.009	0.0156	0.0233
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.009	0.0156	0.0156
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.2173	0.2173
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.009	0.0156	0.0258
Onchocerca volvulus		0.009	0.0156	0.0719
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0369	0.2173	0.3243
Entamoeba histolytica	tyrosine kinase, putative	0.0369	0.2173	0.2173
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0369	0.2173	0.3243
Entamoeba histolytica	protein kinase 2, putative	0.0908	0.6053	0.6053
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Giardia lamblia	Kinase, NEK	0.0369	0.2173	0.359
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0369	0.2173	0.2173
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0369	0.2173	0.2173
Brugia malayi	PH domain containing protein	0.009	0.0156	0.0156
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0369	0.2173	0.2173
Entamoeba histolytica	protein kinase, putative	0.0369	0.2173	0.2173
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.009	0.0156	0.0233
Entamoeba histolytica	protein kinase, putative	0.0369	0.2173	0.2173
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Entamoeba histolytica	tyrosine kinase, putative	0.0369	0.2173	0.2173
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0156	0.0156
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Brugia malayi	TBC domain containing protein	0.009	0.0156	0.0156
Onchocerca volvulus		0.0369	0.2173	1
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2173	0.2173
Echinococcus granulosus	tyrosine kinase	0.0369	0.2173	0.3243
Schistosoma mansoni	hypothetical protein	0.009	0.0156	0.0233
Toxoplasma gondii	Oxysterol-binding protein	0.009	0.0156	0.0167
Trichomonas vaginalis	STE family protein kinase	0.0369	0.2173	0.2173
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0997	0.6701	0.6701
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.009	0.0156	0.0233
Schistosoma mansoni	protein kinase	0.0369	0.2173	0.3243
Echinococcus multilocularis	tyrosine protein kinase shark	0.0369	0.2173	0.3243
Echinococcus multilocularis	Pleckstrin y	0.009	0.0156	0.0233
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.009	0.0156	0.0233
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0369	0.2173	0.3243
Entamoeba histolytica	tyrosine kinase, putative	0.0369	0.2173	0.2173
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0369	0.2173	0.3243
Onchocerca volvulus		0.0369	0.2173	1
Trypanosoma brucei	Pseudokinase, putative	0.0369	0.2173	0.2173
Schistosoma mansoni	serine/threonine RGC	0.0369	0.2173	0.3243
Brugia malayi	Guanylyl cyclase protein 23	0.0369	0.2173	0.2173
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Echinococcus multilocularis	rac serine:threonine kinase	0.0997	0.6701	1
Entamoeba histolytica	protein kinase, putative	0.0369	0.2173	0.2173
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0369	0.2173	0.3243
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Echinococcus multilocularis	GRB2 associated binding protein 3	0.009	0.0156	0.0233
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.009	0.0156	0.0233
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.2173	0.2173
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.009	0.0156	0.0719
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.2173	0.2173
Schistosoma mansoni	serine/threonine protein kinase	0.0369	0.2173	0.3243
Brugia malayi	Oxysterol binding protein	0.009	0.0156	0.0156
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.009	0.0156	0.0233
Onchocerca volvulus		0.0369	0.2173	1
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Echinococcus granulosus	protein kinase	0.0369	0.2173	0.3243
Entamoeba histolytica	hypothetical protein	0.0369	0.2173	0.2173
Onchocerca volvulus		0.009	0.0156	0.0719
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0369	0.2173	0.3243
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0156	0.0156
Schistosoma mansoni	serine/threonine protein kinase	0.0468	0.2885	0.4305
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Schistosoma mansoni	zinc finger protein	0.009	0.0156	0.0233
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0369	0.2173	0.2173
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Entamoeba histolytica	protein kinase, putative	0.0369	0.2173	0.2173
Toxoplasma gondii	hypothetical protein	0.009	0.0156	0.0167
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0369	0.2173	0.2173
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Entamoeba histolytica	PH domain containing protein kinase, putative	0.01	0.0233	0.0233
Schistosoma mansoni	serine/threonine-protein kinase	0.0997	0.6701	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0369	0.2173	0.3243
Trypanosoma cruzi	hypothetical protein	0.009	0.0156	0.0233
Echinococcus multilocularis	tyrosine protein kinase csk	0.0369	0.2173	0.3243
Brugia malayi	PH domain containing protein	0.009	0.0156	0.0156
Schistosoma mansoni	serine/threonine protein kinase	0.0468	0.2885	0.4305
Schistosoma mansoni	protein kinase	0.0369	0.2173	0.3243
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Echinococcus granulosus	tyrosine protein kinase pr2	0.0369	0.2173	0.3243
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.009	0.0156	0.0258
Echinococcus multilocularis	Pleckstrin y	0.009	0.0156	0.0233
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.009	0.0156	0.0156
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0369	0.2173	0.3243
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0369	0.2173	0.3243
Onchocerca volvulus		0.009	0.0156	0.0719
Trichomonas vaginalis	hypothetical protein	0.009	0.0156	0.0156
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0369	0.2173	0.3243
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2173	0.2173
Trypanosoma cruzi	hypothetical protein	0.009	0.0156	0.0233
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0369	0.2173	0.3243
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.009	0.0156	0.0233
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Brugia malayi	Furin-like cysteine rich region family protein	0.0369	0.2173	0.2173
Echinococcus multilocularis	activated cdc42 kinase 1	0.0369	0.2173	0.3243
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.009	0.0156	0.0233
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Brugia malayi	MAX-1A	0.009	0.0156	0.0156
Trypanosoma brucei	PH domain containing protein, putative	0.009	0.0156	0.0156
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0468	0.2885	0.2885
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Brugia malayi	Hr1 repeat family protein	0.0468	0.2885	0.2885
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.009	0.0156	0.0156
Brugia malayi	Dynamin	0.009	0.0156	0.0156
Entamoeba histolytica	protein kinase, putative	0.01	0.0233	0.0233
Echinococcus granulosus	raf serine:threonine protein kinase	0.0369	0.2173	0.3243
Brugia malayi	Uncoordinated protein 104	0.009	0.0156	0.0156
Trypanosoma cruzi	Protein kinase B	0.0997	0.6701	1
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Schistosoma mansoni	serine/threonine protein kinase	0.0468	0.2885	0.4305
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.01	0.0233	0.0348
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0369	0.2173	0.3243
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0369	0.2173	0.2173
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0369	0.2173	0.3243
Echinococcus granulosus	tyrosine protein kinase shark	0.0369	0.2173	0.3243
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.009	0.0156	0.0156
Plasmodium vivax	protein kinase, putative	0.0369	0.2173	0.359
Schistosoma mansoni	serine/threonine protein kinase	0.0369	0.2173	0.3243
Trichomonas vaginalis	AGC family protein kinase	0.1455	1	1
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.009	0.0156	0.0258
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Echinococcus granulosus	activin receptor type	0.038	0.225	0.3358
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0369	0.2173	0.3243
Entamoeba histolytica	tyrosine kinase, putative	0.0369	0.2173	0.2173
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0369	0.2173	0.3243
Brugia malayi	C-terminal src kinase protein 1	0.0369	0.2173	0.2173
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0369	0.2173	0.2173
Schistosoma mansoni	serine/threonine protein kinase	0.0468	0.2885	0.4305
Schistosoma mansoni	vav2	0.009	0.0156	0.0233
Echinococcus granulosus	Protein kinase C brain isozyme	0.0468	0.2885	0.4305
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Entamoeba histolytica	protein kinase, putative	0.0369	0.2173	0.2173
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Entamoeba histolytica	tyrosine kinase, putative	0.0369	0.2173	0.2173
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0369	0.2173	0.2173
Echinococcus granulosus	insulin receptor	0.0369	0.2173	0.3243
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0369	0.2173	0.2173
Loa Loa (eye worm)	TK protein kinase	0.0369	0.2173	0.2173
Echinococcus granulosus	oxysterol binding protein 9	0.009	0.0156	0.0233
Trichomonas vaginalis	centaurin beta, putative	0.009	0.0156	0.0156
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.009	0.0156	0.0233
Echinococcus granulosus	Pleckstrin y	0.009	0.0156	0.0233
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0369	0.2173	0.359
Loa Loa (eye worm)	TK protein kinase	0.0369	0.2173	0.2173
Entamoeba histolytica	hypothetical protein	0.01	0.0233	0.0233
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.009	0.0156	0.0233
Schistosoma mansoni	protein kinase	0.038	0.225	0.3358
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.01	0.0233	0.0233
Entamoeba histolytica	tyrosine kinase, putative	0.0369	0.2173	0.2173
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0369	0.2173	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0369	0.2173	0.3243
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.01	0.0233	0.0233
Onchocerca volvulus		0.009	0.0156	0.0719
Echinococcus granulosus	pdz domain containing protein	0.009	0.0156	0.0233
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	protein transport protein sec7, putative	0.009	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2173	0.2173
Entamoeba histolytica	ankyrin repeat protein	0.0369	0.2173	0.2173
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.009	0.0156	0.0233
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0369	0.2173	0.3243
Brugia malayi	Variant SH3 domain containing protein	0.009	0.0156	0.0156
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Schistosoma mansoni	serine/threonine protein kinase	0.0468	0.2885	0.4305
Toxoplasma gondii	STE kinase	0.0369	0.2173	0.2324
Toxoplasma gondii	hypothetical protein	0.009	0.0156	0.0167
Schistosoma mansoni	hypothetical protein	0.009	0.0156	0.0233
Echinococcus granulosus	DCC interacting protein 13 beta	0.009	0.0156	0.0233
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0369	0.2173	0.3243
Echinococcus granulosus	calcium dependent secretion activator 1	0.009	0.0156	0.0233
Entamoeba histolytica	protein kinase, putative	0.1455	1	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0369	0.2173	0.3243
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0369	0.2173	0.3243
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0369	0.2173	0.3243
Echinococcus granulosus	Rho GTPase activating protein 24	0.009	0.0156	0.0233
Trichomonas vaginalis	AGC family protein kinase	0.0558	0.3532	0.3532
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.01	0.0233	0.1035
Onchocerca volvulus		0.009	0.0156	0.0719
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Echinococcus granulosus	serine/threonine protein kinase	0.0997	0.6701	1
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Brugia malayi	Cytohesin 3	0.009	0.0156	0.0156
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Schistosoma mansoni	protein kinase	0.0369	0.2173	0.3243
Entamoeba histolytica	hypothetical protein	0.009	0.0156	0.0156
Entamoeba histolytica	hypothetical protein	0.0369	0.2173	0.2173
Schistosoma mansoni	ephrin receptor	0.0369	0.2173	0.3243
Entamoeba histolytica	hypothetical protein	0.009	0.0156	0.0156
Entamoeba histolytica	PH domain containing protein	0.009	0.0156	0.0156
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Echinococcus multilocularis	protein kinase	0.0369	0.2173	0.3243
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0468	0.2885	0.4305
Toxoplasma gondii	AGC kinase	0.1365	0.9353	1
Echinococcus multilocularis	transfer RNA-Thr	0.0369	0.2173	0.3243
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0997	0.6701	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0369	0.2173	0.2173
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0156	0.0156
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Onchocerca volvulus	Putative zinc finger protein	0.009	0.0156	0.0719
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.009	0.0156	0.0156
Onchocerca volvulus		0.0369	0.2173	1
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Leishmania major	serine/threonine-protein kinase a, putative	0.01	0.0233	0.1035
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2173	0.2173
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Echinococcus granulosus	activated cdc42 kinase 1	0.0369	0.2173	0.3243
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0156	0.0156
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0369	0.2173	0.3243
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0369	0.2173	0.3243
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.009	0.0156	0.0156
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.01	0.0233	0.0249
Brugia malayi	PH domain containing protein	0.009	0.0156	0.0156
Echinococcus multilocularis	pdz domain containing protein	0.009	0.0156	0.0233
Loa Loa (eye worm)	SRC-1	0.0369	0.2173	0.2173
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.009	0.0156	0.0156
Onchocerca volvulus	Protein melted homolog	0.009	0.0156	0.0719
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	kinesin light chain, putative	0.009	0.0156	0.0156
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0369	0.2173	0.3243
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Schistosoma mansoni	protein kinase	0.038	0.225	0.3358
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.01	0.0233	0.0233
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0369	0.2173	0.3243
Echinococcus multilocularis	Ras associated and pleckstrin y	0.009	0.0156	0.0233
Loa Loa (eye worm)	PH domain-containing protein	0.009	0.0156	0.0156
Echinococcus multilocularis	heat shock protein 70	0.0369	0.2173	0.3243
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Schistosoma mansoni	hypothetical protein	0.009	0.0156	0.0233
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0369	0.2173	0.2324
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0369	0.2173	0.2173
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Echinococcus granulosus	nervana 2	0.0897	0.5977	0.8919
Entamoeba histolytica	serine/threonine kinase, putative	0.0369	0.2173	0.2173
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.009	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2173	0.2173
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0897	0.5977	0.8919
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0369	0.2173	0.2173
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.009	0.0156	0.0233
Giardia lamblia	Kinase, NEK	0.0369	0.2173	0.359
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.009	0.0156	0.0233
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Onchocerca volvulus		0.0369	0.2173	1
Onchocerca volvulus		0.0369	0.2173	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0369	0.2173	0.3243
Echinococcus multilocularis	c src tyrosine kinase	0.0369	0.2173	0.3243
Entamoeba histolytica	tyrosine kinase, putative	0.0369	0.2173	0.2173
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Entamoeba histolytica	hypothetical protein	0.0369	0.2173	0.2173
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Echinococcus multilocularis	insulin receptor	0.0369	0.2173	0.3243
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.009	0.0156	0.0258
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Brugia malayi	probable spectrin beta chain	0.009	0.0156	0.0156
Trypanosoma brucei	protein kinase, putative	0.01	0.0233	0.0233
Echinococcus multilocularis	tyrosine protein kinase csk	0.0369	0.2173	0.3243
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0369	0.2173	0.3243
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.009	0.0156	0.0233
Echinococcus granulosus	protein tyrosine kinase	0.0369	0.2173	0.3243
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0468	0.2885	0.4305
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0369	0.2173	0.2173
Echinococcus multilocularis	activin receptor type	0.038	0.225	0.3358
Echinococcus granulosus	tyrosine protein kinase csk	0.0369	0.2173	0.3243
Schistosoma mansoni	serine/threonine protein kinase	0.0468	0.2885	0.4305
Brugia malayi	hypothetical protein	0.0369	0.2173	0.2173
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Echinococcus multilocularis	dynamin 1	0.009	0.0156	0.0233
Plasmodium falciparum	protein kinase, putative	0.0369	0.2173	0.359
Trichomonas vaginalis	TK family protein kinase	0.0369	0.2173	0.2173
Schistosoma mansoni	serine/threonine protein kinase	0.0468	0.2885	0.4305
Entamoeba histolytica	protein kinase, putative	0.01	0.0233	0.0233
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0156	0.0156
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0156	0.0156
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0369	0.2173	0.3243
Leishmania major	hypothetical protein, conserved	0.009	0.0156	0.0694
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0369	0.2173	0.3243
Schistosoma mansoni	hypothetical protein	0.0369	0.2173	0.3243
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0369	0.2173	0.3243
Entamoeba histolytica	tyrosin kinase, putative	0.0369	0.2173	0.2173
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0468	0.2885	0.4305
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0369	0.2173	0.3243
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Toxoplasma gondii	protein kinase domain-containing protein	0.01	0.0233	0.0249
Giardia lamblia	Kinase, AGC PKA	0.0908	0.6053	1
Echinococcus multilocularis	Pleckstrin y	0.009	0.0156	0.0233
Echinococcus granulosus	beta 1 syntrophin	0.009	0.0156	0.0233
Plasmodium falciparum	calcium-dependent protein kinase 7	0.01	0.0233	0.0385
Plasmodium falciparum	PH domain-containing protein, putative	0.009	0.0156	0.0258
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.009	0.0156	0.0156
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Echinococcus granulosus	tyrosine protein kinase	0.0369	0.2173	0.3243
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.009	0.0156	0.0233
Entamoeba histolytica	tyrosine kinase, putative	0.0369	0.2173	0.2173
Echinococcus multilocularis	protein kinase c epsilon type	0.0468	0.2885	0.4305
Loa Loa (eye worm)	TK/ALK protein kinase	0.0369	0.2173	0.2173
Plasmodium falciparum	protein kinase, putative	0.0369	0.2173	0.359
Entamoeba histolytica	tyrosine kinase, putative	0.0369	0.2173	0.2173
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0369	0.2173	0.2173
Brugia malayi	Receptor family ligand binding region containing protein	0.0369	0.2173	0.2173
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.038	0.225	0.3358
Trypanosoma cruzi	protein kinase, putative	0.0369	0.2173	0.3243
Entamoeba histolytica	protein kinase, putative	0.1365	0.9353	0.9353
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0369	0.2173	0.3243
Entamoeba histolytica	protein kinase, putative	0.01	0.0233	0.0233
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.01	0.0233	0.0348
Brugia malayi	PH domain containing protein	0.009	0.0156	0.0156
Entamoeba histolytica	tyrosine kinase, putative	0.0369	0.2173	0.2173
Loa Loa (eye worm)	TK protein kinase	0.0369	0.2173	0.2173
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Leishmania major	protein kinase, putative	0.038	0.225	1
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.009	0.0156	0.0156
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0369	0.2173	0.2173
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Schistosoma mansoni	hypothetical protein	0.009	0.0156	0.0233
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0369	0.2173	0.3243
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Entamoeba histolytica	protein kinase, putative	0.1455	1	1
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.01	0.0233	0.0233
Entamoeba histolytica	tyrosine kinase, putative	0.0369	0.2173	0.2173
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0369	0.2173	0.2173
Trichomonas vaginalis	AGC family protein kinase	0.0468	0.2885	0.2885
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.2173	0.2173
Entamoeba histolytica	hypothetical protein	0.0369	0.2173	0.2173
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0156	0.0156
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.038	0.225	0.225
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0369	0.2173	0.2173
Schistosoma mansoni	myotubularin-related protein	0.009	0.0156	0.0233
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.2173	0.2173
Schistosoma mansoni	serine/threonine protein kinase	0.0369	0.2173	0.3243
Brugia malayi	Raf kinase	0.0369	0.2173	0.2173
Entamoeba histolytica	protein kinase, putative	0.0369	0.2173	0.2173
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0457	0.2808	0.2808
Entamoeba histolytica	tyrosine kinase, putative	0.0369	0.2173	0.2173
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0369	0.2173	0.3243
Entamoeba histolytica	PH domain containing protein	0.009	0.0156	0.0156
Schistosoma mansoni	serine/threonine kinase	0.0468	0.2885	0.4305
Loa Loa (eye worm)	TK protein kinase	0.0369	0.2173	0.2173
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0468	0.2885	0.2885
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.2173	0.2173
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Echinococcus granulosus	pleckstrin y domain containing family A	0.009	0.0156	0.0233
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Loa Loa (eye worm)	TK protein kinase	0.0369	0.2173	0.2173
Echinococcus multilocularis	integrin linked protein kinase	0.0369	0.2173	0.3243
Entamoeba histolytica	ankyrin repeat protein	0.0369	0.2173	0.2173
Schistosoma mansoni	protein kinase	0.0369	0.2173	0.3243
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0369	0.2173	0.3243
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.2173	0.2173
Echinococcus granulosus	tyrosine protein kinase Blk	0.0369	0.2173	0.3243
Schistosoma mansoni	protein kinase	0.0369	0.2173	0.3243
Trypanosoma cruzi	PH domain containing protein, putative	0.009	0.0156	0.0233
Brugia malayi	protein kinase C II.	0.0468	0.2885	0.2885
Schistosoma mansoni	growth factor receptor-bound protein	0.009	0.0156	0.0233
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0156	0.0156
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.01	0.0233	0.0233
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.009	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2173	0.2173
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0156	0.0156
Plasmodium falciparum	protein kinase, putative	0.038	0.225	0.3717
Loa Loa (eye worm)	hypothetical protein	0.0468	0.2885	0.2885
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0468	0.2885	0.4305
Brugia malayi	ephrin receptor 1 precursor	0.0369	0.2173	0.2173
Trypanosoma cruzi	hypothetical protein	0.009	0.0156	0.0233
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0369	0.2173	0.3243
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Loa Loa (eye worm)	TK/ROR protein kinase	0.0369	0.2173	0.2173
Echinococcus granulosus	oxysterol binding protein 3	0.009	0.0156	0.0233
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.038	0.225	0.3358
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0369	0.2173	0.3243
Loa Loa (eye worm)	TK protein kinase	0.0369	0.2173	0.2173
Entamoeba histolytica	hypothetical protein	0.0369	0.2173	0.2173
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0369	0.2173	0.2173
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Echinococcus multilocularis	epidermal growth factor receptor	0.0369	0.2173	0.3243
Schistosoma mansoni	protein kinase	0.038	0.225	0.3358
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0369	0.2173	0.3243
Brugia malayi	SH2 domain containing protein	0.0369	0.2173	0.2173
Brugia malayi	Tyrosine-protein kinase PR2	0.0369	0.2173	0.2173
Echinococcus granulosus	Pleckstrin y	0.009	0.0156	0.0233
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0369	0.2173	0.2173
Trichomonas vaginalis	AGC family protein kinase	0.1455	1	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0369	0.2173	0.2173
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0369	0.2173	0.3243
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0369	0.2173	0.3243
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.009	0.0156	0.0156
Trichomonas vaginalis	centaurin/arf, putative	0.009	0.0156	0.0156
Entamoeba histolytica	hypothetical protein, conserved	0.009	0.0156	0.0156
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0468	0.2885	0.4305
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0468	0.2885	0.4305
Echinococcus multilocularis	protein kinase c iota type	0.0468	0.2885	0.4305
Loa Loa (eye worm)	TK/ACK protein kinase	0.0369	0.2173	0.2173
Brugia malayi	PH domain containing protein	0.009	0.0156	0.0156
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0156	0.0156
Plasmodium vivax	PH domain containing protein	0.009	0.0156	0.0258
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.038	0.225	0.3358
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.009	0.0156	0.0156
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.01	0.0233	0.0348
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.009	0.0156	0.0233
Schistosoma mansoni	tyrosine kinase	0.0369	0.2173	0.3243
Onchocerca volvulus		0.009	0.0156	0.0719
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0369	0.2173	0.3243
Trypanosoma cruzi	protein kinase, putative	0.0369	0.2173	0.3243
Leishmania major	protein kinase, putative	0.01	0.0233	0.1035
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.009	0.0156	0.0233
Schistosoma mansoni	serine/threonine-protein kinase	0.0997	0.6701	1
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Echinococcus granulosus	NDR protein kinase	0.0468	0.2885	0.4305
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Loa Loa (eye worm)	uncoordinated protein 104	0.009	0.0156	0.0156
Trypanosoma brucei	rac serine-threonine kinase, putative	0.1455	1	1
Entamoeba histolytica	protein kinase, putative	0.01	0.0233	0.0233
Onchocerca volvulus		0.0369	0.2173	1
Trypanosoma cruzi	PH domain containing protein, putative	0.009	0.0156	0.0233
Entamoeba histolytica	PH domain containing protein	0.009	0.0156	0.0156
Brugia malayi	Syntrophin-1	0.009	0.0156	0.0156
Brugia malayi	p70 ribosomal S6 kinase beta	0.1365	0.9353	0.9353
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0369	0.2173	0.2173
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Schistosoma mansoni	centaurin alpha	0.009	0.0156	0.0233
Plasmodium vivax	hypothetical protein, conserved	0.009	0.0156	0.0258
Schistosoma mansoni	atypical protein kinase C	0.0468	0.2885	0.4305
Trichomonas vaginalis	AGC family protein kinase	0.1455	1	1
Trypanosoma cruzi	PH domain containing protein, putative	0.009	0.0156	0.0233
Echinococcus granulosus	serine:threonine protein kinase N2	0.0468	0.2885	0.4305
Entamoeba histolytica	serine/threonine kinase, putative	0.0369	0.2173	0.2173
Schistosoma mansoni	rho gtpase activating protein	0.009	0.0156	0.0233
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.2173	0.2173
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2173	0.2173
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0369	0.2173	0.2173
Loa Loa (eye worm)	TK protein kinase	0.0369	0.2173	0.2173
Echinococcus multilocularis	pleckstrin y domain containing family A	0.009	0.0156	0.0233
Entamoeba histolytica	hypothetical protein	0.0369	0.2173	0.2173
Entamoeba histolytica	protein kinase, putative	0.0369	0.2173	0.2173
Loa Loa (eye worm)	AGC/AKT protein kinase	0.1455	1	1
Entamoeba histolytica	protein kinase, putative	0.0369	0.2173	0.2173
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0369	0.2173	0.3243
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0369	0.2173	0.3243
Echinococcus multilocularis	tyrosine protein kinase csk	0.0369	0.2173	0.3243
Brugia malayi	PH domain containing protein	0.009	0.0156	0.0156
Trichomonas vaginalis	protein kinase atn1, putative	0.0369	0.2173	0.2173
Entamoeba histolytica	PH domain containing protein kinase, putative	0.01	0.0233	0.0233
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.009	0.0156	0.0233
Entamoeba histolytica	protein kinase, putative	0.0369	0.2173	0.2173
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Plasmodium falciparum	oxysterol-binding protein, putative	0.009	0.0156	0.0258
Schistosoma mansoni	protein tyrosine kinase	0.0369	0.2173	0.3243
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0369	0.2173	0.2173
Echinococcus granulosus	serine threonine protein kinase nrc	0.0908	0.6053	0.9034
Trichomonas vaginalis	TKL family protein kinase	0.0369	0.2173	0.2173
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.01	0.0233	0.1035
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0233	0.0233
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.009	0.0156	0.0258
Loa Loa (eye worm)	hypothetical protein	0.009	0.0156	0.0156
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.2173	0.2173
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.009	0.0156	0.0156
Loa Loa (eye worm)	TK/ABL protein kinase	0.0369	0.2173	0.2173
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0369	0.2173	0.3243
Brugia malayi	integrin-linked kinase	0.0369	0.2173	0.2173
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.01	0.0233	0.0348
Entamoeba histolytica	tyrosine kinase, putative	0.0369	0.2173	0.2173
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.2173	0.2173
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0468	0.2885	0.4305
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0369	0.2173	0.2173
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0369	0.2173	0.2173
Echinococcus granulosus	oxysterol binding protein 1	0.009	0.0156	0.0233
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.2173	0.2173
Entamoeba histolytica	cysteine surface protein, putative	0.0369	0.2173	0.2173
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0908	0.6053	1
Echinococcus multilocularis	FL cytokine receptor	0.0369	0.2173	0.3243
Loa Loa (eye worm)	TK/Met protein kinase	0.0369	0.2173	0.2173
Brugia malayi	Protein kinase domain containing protein	0.0369	0.2173	0.2173
Onchocerca volvulus		0.0369	0.2173	1
Trypanosoma cruzi	NIMA-related kinase, putative	0.01	0.0233	0.0348
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0369	0.2173	0.2173
Echinococcus granulosus	kinase suppressor of Ras 1	0.0369	0.2173	0.3243
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.009	0.0156	0.0233
Entamoeba histolytica	protein kinase domain containing protein	0.0369	0.2173	0.2173
Onchocerca volvulus		0.0369	0.2173	1
Echinococcus multilocularis	nervana 2	0.0897	0.5977	0.8919

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 27 nM	Inhibition of human recombinant GSK-3beta using prephosphorylated GS1 peptide and [gamma-32P]ATP as substrate after 1 hr by liquid scintillation spectrometry	ChEMBL.	24176395
IC50 (ADMET)	= 23.9 uM	Inhibition of recombinant human CYP1A2	ChEMBL.	24176395
IC50 (ADMET)	= 35.8 uM	Inhibition of recombinant human CYP2D6	ChEMBL.	24176395
IC50 (ADMET)	> 50 uM	Inhibition of recombinant human CYP3A4	ChEMBL.	24176395

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3091547

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1823532