TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 462.519 | Formula: C21H26N4O6S
H donors: 2 H acceptors: 7 LogP: 1.28 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C([C@@H](n1cnc(c1)S(=O)(=O)C1CCC1)CC1CCOCC1)Nc1ccc(cn1)C(=O)O
InChi: 1S/C21H26N4O6S/c26-20(24-18-5-4-15(11-22-18)21(27)28)17(10-14-6-8-31-9-7-14)25-12-19(23-13-25)32(29,30)16-2-1-3-16/h4-5,11-14,16-17H,1-3,6-10H2,(H,27,28)(H,22,24,26)/t17-/m0/s1
InChiKey: BMHNAEAUCLFHMD-KRWDZBQOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucokinase (hexokinase 4)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium berghei	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania infantum	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Entamoeba histolytica	hexokinase 2	Get druggable targets OG5_126743	All targets in OG5_126743
Theileria parva	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium knowlesi	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania donovani	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Cryptosporidium hominis	hexokinase i	Get druggable targets OG5_126743	All targets in OG5_126743
Cryptosporidium parvum	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma cruzi	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Brugia malayi	Hexokinase family protein	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hexokinase type II	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus multilocularis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Babesia bovis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania mexicana	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Theileria parva	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Entamoeba histolytica	hexokinase 1	Get druggable targets OG5_126743	All targets in OG5_126743
Brugia malayi	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Toxoplasma gondii	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Schistosoma mansoni	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Neospora caninum	cDNA FLJ57348, highly similar to Homo sapiens hexokinase domain containing 1 (HKDC1), mRNA, related	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium falciparum	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose	Get druggable targets OG5_126743	All targets in OG5_126743
Onchocerca volvulus		Get druggable targets OG5_126743	All targets in OG5_126743
Onchocerca volvulus		Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania infantum	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus multilocularis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Onchocerca volvulus		Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania major	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania major	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma congolense	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma cruzi	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium yoelii	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei gambiense	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Treponema pallidum	hexokinase (hxk)	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus multilocularis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium vivax	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Schistosoma japonicum	ko:K00844 hexokinase [EC2.7.1.1], putative	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus multilocularis	hexokinase type 2	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei gambiense	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania mexicana	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania braziliensis	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase type 2	Get druggable targets OG5_126743	All targets in OG5_126743

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hexokinase family protein	glucokinase (hexokinase 4)	465 aa	470 aa	30.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	serine/threonine kinase, putative	0.0465	0.8841	0.8743
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0465	0.8841	1
Loa Loa (eye worm)	TK protein kinase	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0465	0.8841	1
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Echinococcus multilocularis	protein kinase	0.0465	0.8841	1
Entamoeba histolytica	protein kinase, putative	0.0465	0.8841	0.8743
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0465	0.8841	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0465	0.8841	0.8743
Loa Loa (eye worm)	TK/FER protein kinase	0.0465	0.8841	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0465	0.8841	1
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0465	0.8841	1
Entamoeba histolytica	hypothetical protein	0.0465	0.8841	0.8743
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Loa Loa (eye worm)	TK protein kinase	0.0465	0.8841	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0465	0.8841	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0465	0.8841	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0465	0.8841	1
Entamoeba histolytica	receptor protein kinase, putative	0.0465	0.8841	0.8743
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0465	0.8841	1
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Trichomonas vaginalis	AGC family protein kinase	0.0465	0.8841	0.5
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0465	0.8841	1
Plasmodium falciparum	protein kinase, putative	0.0465	0.8841	1
Onchocerca volvulus		0.0096	0.0784	0.0887
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0465	0.8841	0.8743
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0465	0.8841	0.8743
Echinococcus granulosus	activated cdc42 kinase 1	0.0465	0.8841	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0465	0.8841	1
Brugia malayi	hypothetical protein	0.0465	0.8841	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0465	0.8841	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0465	0.8841	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0465	0.8841	1
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Entamoeba histolytica	tyrosine kinase, putative	0.0465	0.8841	0.8743
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0465	0.8841	1
Entamoeba histolytica	hypothetical protein	0.0465	0.8841	0.8743
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0465	0.8841	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0465	0.8841	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Loa Loa (eye worm)	TK/RYK protein kinase	0.0465	0.8841	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0465	0.8841	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0465	0.8841	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0465	0.8841	1
Onchocerca volvulus		0.0465	0.8841	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0465	0.8841	1
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Trichomonas vaginalis	CAMK family protein kinase	0.0465	0.8841	0.5
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Echinococcus granulosus	protein tyrosine kinase	0.0465	0.8841	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0465	0.8841	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0465	0.8841	1
Trichomonas vaginalis	conserved hypothetical protein	0.0465	0.8841	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0465	0.8841	0.8743
Brugia malayi	ephrin receptor 1 precursor	0.0465	0.8841	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0465	0.8841	0.8743
Loa Loa (eye worm)	SRC-1	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Brugia malayi	hypothetical protein	0.0465	0.8841	1
Onchocerca volvulus		0.0465	0.8841	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0465	0.8841	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0465	0.8841	1
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Entamoeba histolytica	protein kinase, putative	0.0465	0.8841	0.8743
Loa Loa (eye worm)	TK protein kinase	0.0465	0.8841	1
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Brugia malayi	hypothetical protein	0.0465	0.8841	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0465	0.8841	1
Plasmodium falciparum	protein kinase, putative	0.0465	0.8841	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0465	0.8841	1
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0465	0.8841	0.8743
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Schistosoma mansoni	tyrosine protein kinase	0.0465	0.8841	1
Entamoeba histolytica	tyrosine kinase, putative	0.0465	0.8841	0.8743
Entamoeba histolytica	hypothetical protein, conserved	0.0465	0.8841	0.8743
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0465	0.8841	1
Entamoeba histolytica	protein kinase, putative	0.0465	0.8841	0.8743
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0465	0.8841	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0465	0.8841	1
Schistosoma mansoni	protein tyrosine kinase	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0465	0.8841	0.5
Brugia malayi	Tyrosine-protein kinase PR2	0.0465	0.8841	1
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0465	0.8841	0.5
Giardia lamblia	Kinase, NEK	0.0465	0.8841	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Loa Loa (eye worm)	TK protein kinase	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0465	0.8841	1
Toxoplasma gondii	protein kinase	0.0465	0.8841	1
Toxoplasma gondii	STE kinase	0.0465	0.8841	1
Loa Loa (eye worm)	TK protein kinase	0.0465	0.8841	1
Brugia malayi	SH2 domain containing protein	0.0465	0.8841	1
Brugia malayi	C-terminal src kinase protein 1	0.0465	0.8841	1
Entamoeba histolytica	cysteine surface protein, putative	0.0465	0.8841	0.8743
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0465	0.8841	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0465	0.8841	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0465	0.8841	1
Trypanosoma cruzi	protein kinase, putative	0.0465	0.8841	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0465	0.8841	1
Entamoeba histolytica	tyrosine kinase, putative	0.0465	0.8841	0.8743
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Entamoeba histolytica	protein kinase, putative	0.0465	0.8841	0.8743
Echinococcus multilocularis	protein kinase	0.0465	0.8841	1
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0465	0.8841	1
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Entamoeba histolytica	tyrosine kinase, putative	0.0465	0.8841	0.8743
Echinococcus multilocularis	activated cdc42 kinase 1	0.0465	0.8841	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0465	0.8841	1
Echinococcus multilocularis	tyrosine protein kinase	0.0465	0.8841	1
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Echinococcus multilocularis	insulin receptor	0.0465	0.8841	1
Entamoeba histolytica	tyrosine kinase, putative	0.0465	0.8841	0.8743
Loa Loa (eye worm)	hexokinase type II	0.0096	0.0784	0.0887
Onchocerca volvulus		0.0465	0.8841	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0465	0.8841	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0465	0.8841	0.8743
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0465	0.8841	1
Echinococcus granulosus	protein kinase	0.0465	0.8841	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0465	0.8841	1
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Echinococcus multilocularis	protein tyrosine kinase	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0465	0.8841	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0465	0.8841	0.8743
Echinococcus granulosus	kinase suppressor of Ras 1	0.0465	0.8841	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0465	0.8841	1
Trypanosoma brucei	protein kinase, putative	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0465	0.8841	0.8743
Echinococcus multilocularis	tyrosine kinase	0.0465	0.8841	1
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0465	0.8841	1
Loa Loa (eye worm)	hypothetical protein	0.0465	0.8841	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0465	0.8841	1
Entamoeba histolytica	tyrosine kinase, putative	0.0465	0.8841	0.8743
Onchocerca volvulus		0.0465	0.8841	1
Echinococcus granulosus	insulin receptor	0.0465	0.8841	1
Entamoeba histolytica	protein kinase, putative	0.0465	0.8841	0.8743
Onchocerca volvulus		0.0465	0.8841	1
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Onchocerca volvulus		0.0096	0.0784	0.0887
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0465	0.8841	1
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Onchocerca volvulus		0.0465	0.8841	1
Echinococcus multilocularis	FL cytokine receptor	0.0465	0.8841	1
Entamoeba histolytica	ankyrin repeat protein	0.0465	0.8841	0.8743
Echinococcus granulosus	tyrosine protein kinase csk	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0465	0.8841	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Onchocerca volvulus		0.0096	0.0784	0.0887
Loa Loa (eye worm)	TK/DDR protein kinase	0.0465	0.8841	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0465	0.8841	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0465	0.8841	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0465	0.8841	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0465	0.8841	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0465	0.8841	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0465	0.8841	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0465	0.8841	1
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Loa Loa (eye worm)	hypothetical protein	0.0465	0.8841	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0465	0.8841	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0465	0.8841	1
Echinococcus granulosus	tyrosine kinase	0.0465	0.8841	1
Schistosoma mansoni	protein kinase	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0465	0.8841	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0465	0.8841	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0465	0.8841	0.8743
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0465	0.8841	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0465	0.8841	1
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Brugia malayi	hexokinase	0.0096	0.0784	0.0887
Entamoeba histolytica	protein kinase, putative	0.0465	0.8841	0.8743
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0465	0.8841	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0465	0.8841	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0465	0.8841	1
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Loa Loa (eye worm)	hexokinase	0.0096	0.0784	0.0887
Echinococcus granulosus	activin receptor type	0.0465	0.8841	1
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0465	0.8841	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0465	0.8841	1
Loa Loa (eye worm)	TK protein kinase	0.0465	0.8841	1
Schistosoma mansoni	serine/threonine protein kinase	0.0465	0.8841	1
Entamoeba histolytica	tyrosine kinase, putative	0.0465	0.8841	0.8743
Entamoeba histolytica	protein kinase, putative	0.0465	0.8841	0.8743
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Loa Loa (eye worm)	hypothetical protein	0.0465	0.8841	1
Schistosoma mansoni	serine/threonine protein kinase	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Loa Loa (eye worm)	hypothetical protein	0.0465	0.8841	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0465	0.8841	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0465	0.8841	1
Trichomonas vaginalis	TK family protein kinase	0.0465	0.8841	0.5
Loa Loa (eye worm)	hypothetical protein	0.0465	0.8841	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0518	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0465	0.8841	1
Schistosoma mansoni	ephrin receptor	0.0465	0.8841	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0465	0.8841	0.8743
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Entamoeba histolytica	protein kinase, putative	0.0465	0.8841	0.8743
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0465	0.8841	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0465	0.8841	0.8743
Entamoeba histolytica	hypothetical protein	0.0465	0.8841	0.8743
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0465	0.8841	0.8743
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0465	0.8841	0.8743
Entamoeba histolytica	hypothetical protein	0.0465	0.8841	0.8743
Echinococcus granulosus	ephrin type A receptor 4 A	0.0465	0.8841	1
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0465	0.8841	1
Echinococcus multilocularis	activin receptor type	0.0465	0.8841	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0465	0.8841	0.5
Brugia malayi	protein-tyrosine kinase	0.0465	0.8841	1
Schistosoma mansoni	protein kinase	0.0465	0.8841	1
Loa Loa (eye worm)	hexokinase	0.0096	0.0784	0.0887
Loa Loa (eye worm)	hypothetical protein	0.0465	0.8841	1
Entamoeba histolytica	tyrosine kinase, putative	0.0465	0.8841	0.8743
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0465	0.8841	0.8743
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0465	0.8841	1
Brugia malayi	SH2 domain containing protein	0.0465	0.8841	1
Onchocerca volvulus		0.0465	0.8841	1
Trichomonas vaginalis	conserved hypothetical protein	0.0465	0.8841	0.5
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Schistosoma mansoni	protein kinase	0.0465	0.8841	1
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0465	0.8841	1
Giardia lamblia	Kinase, NEK	0.0465	0.8841	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0465	0.8841	0.8743
Echinococcus granulosus	raf serine:threonine protein kinase	0.0465	0.8841	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Schistosoma mansoni	hypothetical protein	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0465	0.8841	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0465	0.8841	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0465	0.8841	1
Treponema pallidum	hexokinase (hxk)	0.0096	0.0784	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0465	0.8841	1
Schistosoma mansoni	serine/threonine RGC	0.0465	0.8841	1
Entamoeba histolytica	protein kinase, putative	0.0465	0.8841	0.8743
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Echinococcus multilocularis	tyrosine kinase	0.0465	0.8841	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0465	0.8841	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0465	0.8841	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0465	0.8841	1
Loa Loa (eye worm)	TK protein kinase	0.0465	0.8841	1
Brugia malayi	Raf kinase	0.0465	0.8841	1
Loa Loa (eye worm)	TK protein kinase	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Entamoeba histolytica	tyrosine kinase, putative	0.0465	0.8841	0.8743
Loa Loa (eye worm)	TK/FER protein kinase	0.0465	0.8841	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0465	0.8841	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0465	0.8841	1
Echinococcus granulosus	tyrosine kinase	0.0465	0.8841	1
Schistosoma mansoni	ephrin receptor	0.0465	0.8841	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0465	0.8841	1
Brugia malayi	integrin-linked kinase	0.0465	0.8841	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0465	0.8841	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0465	0.8841	0.8743
Entamoeba histolytica	tyrosine kinase, putative	0.0465	0.8841	0.8743
Entamoeba histolytica	protein kinase, putative	0.0465	0.8841	0.8743
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Loa Loa (eye worm)	hypothetical protein	0.0465	0.8841	1
Entamoeba histolytica	protein kinase, putative	0.0518	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0465	0.8841	0.8743
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Entamoeba histolytica	protein kinase, putative	0.0465	0.8841	0.8743
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0465	0.8841	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0465	0.8841	1
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0465	0.8841	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0465	0.8841	1
Onchocerca volvulus		0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0465	0.8841	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0465	0.8841	1
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Plasmodium falciparum	protein kinase, putative	0.0465	0.8841	1
Echinococcus granulosus	tyrosine protein kinase	0.0465	0.8841	1
Entamoeba histolytica	protein kinase, putative	0.0465	0.8841	0.8743
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0465	0.8841	1
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Entamoeba histolytica	tyrosine kinase, putative	0.0465	0.8841	0.8743
Entamoeba histolytica	protein kinase, putative	0.0465	0.8841	0.8743
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0465	0.8841	1
Entamoeba histolytica	protein kinase, putative	0.0465	0.8841	0.8743
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0465	0.8841	1
Echinococcus granulosus	epidermal growth factor receptor	0.0465	0.8841	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0465	0.8841	1
Echinococcus multilocularis	integrin linked protein kinase	0.0465	0.8841	1
Trichomonas vaginalis	STE family protein kinase	0.0465	0.8841	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0465	0.8841	0.8743
Echinococcus granulosus	integrin linked protein kinase	0.0465	0.8841	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0465	0.8841	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0465	0.8841	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0465	0.8841	1
Schistosoma mansoni	protein kinase	0.0465	0.8841	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0465	0.8841	1
Leishmania major	hypothetical protein, conserved	0.0465	0.8841	1
Entamoeba histolytica	tyrosine kinase, putative	0.0465	0.8841	0.8743
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0465	0.8841	1
Echinococcus granulosus	c src tyrosine kinase	0.0465	0.8841	1
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Onchocerca volvulus		0.0465	0.8841	1
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Trichomonas vaginalis	conserved hypothetical protein	0.0465	0.8841	0.5
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Entamoeba histolytica	tyrosin kinase, putative	0.0465	0.8841	0.8743
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0465	0.8841	0.8743
Schistosoma mansoni	protein kinase	0.0465	0.8841	1
Entamoeba histolytica	hypothetical protein	0.0465	0.8841	0.8743
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0465	0.8841	1
Entamoeba histolytica	hypothetical protein	0.0465	0.8841	0.8743
Giardia lamblia	Kinase	0.0465	0.8841	0.5
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0465	0.8841	1
Leishmania major	protein kinase, putative	0.0465	0.8841	1
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Giardia lamblia	Protein 21.1	0.0465	0.8841	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.0465	0.8841	1
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0465	0.8841	1
Entamoeba histolytica	receptor protein kinase, putative	0.0465	0.8841	0.8743
Onchocerca volvulus		0.0465	0.8841	1
Entamoeba histolytica	protein kinase, putative	0.0465	0.8841	0.8743
Onchocerca volvulus		0.0465	0.8841	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0465	0.8841	1
Plasmodium vivax	protein kinase, putative	0.0465	0.8841	1
Onchocerca volvulus		0.0465	0.8841	1
Loa Loa (eye worm)	hypothetical protein	0.0465	0.8841	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0465	0.8841	1
Brugia malayi	Hexokinase family protein	0.0096	0.0784	0.0887
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0465	0.8841	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0465	0.8841	1
Entamoeba histolytica	tyrosine kinase, putative	0.0465	0.8841	0.8743
Trichomonas vaginalis	conserved hypothetical protein	0.0465	0.8841	0.5
Loa Loa (eye worm)	hypothetical protein	0.0465	0.8841	1
Trypanosoma brucei	Pseudokinase, putative	0.0465	0.8841	1
Entamoeba histolytica	tyrosin kinase, putative	0.0465	0.8841	0.8743
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0465	0.8841	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Onchocerca volvulus		0.0465	0.8841	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0465	0.8841	1
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0465	0.8841	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0465	0.8841	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0465	0.8841	1
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Echinococcus multilocularis	heat shock protein 70	0.0465	0.8841	1
Entamoeba histolytica	tyrosin kinase, putative	0.0465	0.8841	0.8743
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Entamoeba histolytica	protein kinase, putative	0.0465	0.8841	0.8743
Entamoeba histolytica	protein kinase, putative	0.0465	0.8841	0.8743
Onchocerca volvulus		0.0465	0.8841	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0465	0.8841	0.8743
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0465	0.8841	1
Loa Loa (eye worm)	hypothetical protein	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Loa Loa (eye worm)	TK protein kinase	0.0465	0.8841	1
Schistosoma mansoni	protein kinase	0.0465	0.8841	1
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Schistosoma mansoni	protein kinase	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0465	0.8841	0.5
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0465	0.8841	1
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0465	0.8841	0.8743
Echinococcus granulosus	tyrosine protein kinase csk	0.0465	0.8841	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0465	0.8841	1
Entamoeba histolytica	protein kinase, putative	0.0465	0.8841	0.8743
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Entamoeba histolytica	hypothetical protein	0.0518	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0465	0.8841	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0465	0.8841	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0465	0.8841	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0465	0.8841	0.5
Schistosoma mansoni	protein kinase	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0465	0.8841	1
Schistosoma mansoni	protein kinase	0.0465	0.8841	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0465	0.8841	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0465	0.8841	1
Brugia malayi	Guanylyl cyclase protein 23	0.0465	0.8841	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0465	0.8841	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0465	0.8841	1
Entamoeba histolytica	hypothetical protein	0.0465	0.8841	0.8743
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Schistosoma mansoni	protein kinase	0.0465	0.8841	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0465	0.8841	1
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0465	0.8841	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0465	0.8841	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0115	0.013
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0465	0.8841	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0465	0.8841	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Echinococcus granulosus	tyrosine kinase	0.0465	0.8841	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0465	0.8841	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0465	0.8841	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0465	0.8841	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0465	0.8841	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0465	0.8841	1
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0465	0.8841	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0465	0.8841	1
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0465	0.8841	1
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0465	0.8841	0.8743
Entamoeba histolytica	protein kinase domain containing protein	0.0465	0.8841	0.8743
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0465	0.8841	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0465	0.8841	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Entamoeba histolytica	hypothetical protein	0.0465	0.8841	0.8743
Schistosoma mansoni	serine/threonine protein kinase	0.0465	0.8841	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0465	0.8841	1
Brugia malayi	SRC-1	0.0465	0.8841	1
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0465	0.8841	1
Schistosoma mansoni	protein kinase	0.0465	0.8841	1
Entamoeba histolytica	tyrosine kinase, putative	0.0465	0.8841	0.8743
Echinococcus granulosus	tyrosine protein kinase csk	0.0465	0.8841	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0465	0.8841	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0465	0.8841	1
Loa Loa (eye worm)	TK protein kinase	0.0465	0.8841	1
Entamoeba histolytica	hypothetical protein	0.0518	1	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0465	0.8841	0.8743
Entamoeba histolytica	ankyrin repeat protein	0.0465	0.8841	0.8743
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0465	0.8841	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0465	0.8841	1
Trypanosoma cruzi	protein kinase, putative	0.0465	0.8841	1
Onchocerca volvulus		0.0465	0.8841	1
Loa Loa (eye worm)	hypothetical protein	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0465	0.8841	1
Echinococcus granulosus	epidermal growth factor receptor	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0465	0.8841	1
Entamoeba histolytica	tyrosine kinase, putative	0.0465	0.8841	0.8743
Loa Loa (eye worm)	hypothetical protein	0.0465	0.8841	1
Loa Loa (eye worm)	hypothetical protein	0.0465	0.8841	1
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0465	0.8841	0.5
Schistosoma mansoni	tyrosine kinase	0.0465	0.8841	1
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Brugia malayi	Protein kinase domain containing protein	0.0465	0.8841	1
Leishmania major	protein kinase, putative	0.0465	0.8841	1

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	> 10000 nM	Activation of recombinant human glucokinase by G6PDH/NADP coupled assay	ChEMBL.	24239482

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3091585

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1823570