Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acyl-CoA desaturase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase | Acyl-CoA desaturase 1 | 358 aa | 317 aa | 27.1 % |
Candida albicans | one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase | Acyl-CoA desaturase 1 | 358 aa | 317 aa | 27.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0244 | 0.1162 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.1445 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0244 | 0.1162 | 0.5 |
Leishmania major | stearic acid desaturase, putative | 0.0086 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0086 | 0 | 0.5 |
Onchocerca volvulus | 0.0244 | 0.1162 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1445 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1445 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1445 | 1 | 1 |
Onchocerca volvulus | 0.0244 | 0.1162 | 1 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.1445 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0244 | 0.1162 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0244 | 0.1162 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0244 | 0.1162 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0244 | 0.1162 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.0086 | 0 | 0.5 |
Onchocerca volvulus | 0.0244 | 0.1162 | 1 | |
Echinococcus granulosus | carboxylesterase 5A | 0.1445 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1445 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1445 | 1 | 1 |
Onchocerca volvulus | 0.0244 | 0.1162 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.1445 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1445 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1445 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1445 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0244 | 0.1162 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0086 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 347 nM | Inhibition of SCD1 in Sprague-Dawley rat liver microsomes using Stearoyl-[9,10-3H]-CoA as substrate assessed as [3H2O] generation | ChEMBL. | 24153205 |
IC50 (binding) | = 347 nM | SCD1 Enzymatic Assay | BINDINGDB. | No reference |
INH (binding) | = 76 nM | Inhibition of SCD1 in human A431 cells assessed as conversion of 13C-palmitic acid to 13C-palmitoleic acid after 4 hrs by LC/MS analysis | ChEMBL. | 24153205 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.