Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.1632 | 0.5223 | 1 | |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.1632 | 0.5223 | 0.5223 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.1632 | 0.5223 | 0.5223 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.1632 | 0.5223 | 0.5223 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.232 | 1 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.1632 | 0.5223 | 0.5223 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.1632 | 0.5223 | 0.5223 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.232 | 1 | 0.5 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.5223 | 0.5223 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.5223 | 0.5223 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.232 | 1 | 1 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.5223 | 0.5223 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.1632 | 0.5223 | 0.5223 |
Trichomonas vaginalis | CMGC family protein kinase | 0.232 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.232 | 1 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.1632 | 0.5223 | 0.5223 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.1632 | 0.5223 | 0.5223 |
Schistosoma mansoni | nAChR subunit | 0.1632 | 0.5223 | 0.5223 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.1632 | 0.5223 | 0.5223 |
Onchocerca volvulus | 0.1632 | 0.5223 | 1 | |
Brugia malayi | Cation transporter family protein | 0.1632 | 0.5223 | 0.5223 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.5223 | 0.5223 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.232 | 1 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.1632 | 0.5223 | 0.5223 |
Schistosoma mansoni | nAChR subunit | 0.1632 | 0.5223 | 0.5223 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.1632 | 0.5223 | 0.5223 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.1632 | 0.5223 | 0.5223 |
Echinococcus granulosus | nAChR subunit | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | LGC-31 protein | 0.1632 | 0.5223 | 0.5223 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.5223 | 0.5223 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.1632 | 0.5223 | 0.5223 |
Echinococcus granulosus | glycine receptor subunit beta | 0.1632 | 0.5223 | 0.5223 |
Schistosoma mansoni | nAChR subunit | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | ACC-1 protein | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.5223 | 0.5223 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.1632 | 0.5223 | 0.5223 |
Echinococcus granulosus | mitogen activated protein kinase | 0.232 | 1 | 1 |
Brugia malayi | Cation transporter family protein | 0.1632 | 0.5223 | 0.5223 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.232 | 1 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.5223 | 0.5223 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.1632 | 0.5223 | 0.5223 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.1632 | 0.5223 | 0.5223 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.5223 | 0.5223 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.1632 | 0.5223 | 0.5223 |
Schistosoma mansoni | nAChR subunit | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.5223 | 0.5223 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.1632 | 0.5223 | 0.5223 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.232 | 1 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.1632 | 0.5223 | 0.5223 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.232 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.5223 | 0.5223 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.5223 | 0.5223 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.232 | 1 | 1 |
Schistosoma mansoni | nAChR subunit | 0.1632 | 0.5223 | 0.5223 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.1632 | 0.5223 | 0.5223 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.1632 | 0.5223 | 0.5223 |
Onchocerca volvulus | 0.1632 | 0.5223 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.1632 | 0.5223 | 0.5223 |
Giardia lamblia | Kinase, CMGC MAPK | 0.232 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.232 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.232 | 1 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.1632 | 0.5223 | 0.5223 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.1632 | 0.5223 | 0.5223 |
Echinococcus granulosus | glycine receptor subunit beta | 0.1632 | 0.5223 | 0.5223 |
Entamoeba histolytica | hypothetical protein | 0.0879 | 0 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.232 | 1 | 0.5 |
Onchocerca volvulus | Putative nachr subunit | 0.1632 | 0.5223 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.232 | 1 | 1 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.1632 | 0.5223 | 0.5223 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.1632 | 0.5223 | 0.5223 |
Onchocerca volvulus | 0.1632 | 0.5223 | 1 | |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.1632 | 0.5223 | 0.5223 |
Echinococcus multilocularis | nAChR subunit | 0.1632 | 0.5223 | 0.5223 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.232 | 1 | 0.5 |
Loa Loa (eye worm) | ACC-1 protein | 0.1632 | 0.5223 | 0.5223 |
Schistosoma mansoni | nAChR subunit | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.1632 | 0.5223 | 0.5223 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.1632 | 0.5223 | 0.5223 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.1632 | 0.5223 | 0.5223 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.1632 | 0.5223 | 0.5223 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.5223 | 0.5223 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.1632 | 0.5223 | 0.5223 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.1632 | 0.5223 | 0.5223 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.5223 | 0.5223 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.232 | 1 | 0.5 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.1632 | 0.5223 | 0.5223 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.1632 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.232 | 1 | 1 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.1632 | 0.5223 | 0.5223 |
Brugia malayi | Cation transporter family protein | 0.1632 | 0.5223 | 0.5223 |
Schistosoma mansoni | nAChR subunit | 0.1632 | 0.5223 | 0.5223 |
Onchocerca volvulus | 0.1632 | 0.5223 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.5223 | 0.5223 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.1632 | 0.5223 | 0.5223 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.1632 | 0.5223 | 0.5223 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.1632 | 0.5223 | 0.5223 |
Onchocerca volvulus | 0.1632 | 0.5223 | 1 | |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.232 | 1 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.1632 | 0.5223 | 0.5223 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
log(1/MIC) (functional) | = -0.20639 | Antitubercular activity against Mycobacterium tuberculosis H37Rv | ChEMBL. | 24246731 |
MIC (functional) | = 1.61 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv | ChEMBL. | 24246731 |
MIC (functional) | = 0.56 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by BACTEC 960 assay | ChEMBL. | 24836065 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.