Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0776 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.0466 | 0.0466 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0053 | 0.0053 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0519 | 0.0519 |
Echinococcus granulosus | calcium activated potassium channel | 0.001 | 0.0015 | 0.0015 |
Brugia malayi | Egg laying defective protein 4 | 0.0013 | 0.0053 | 0.0053 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0428 | 0.0428 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0776 | 1 | 1 |
Echinococcus granulosus | cGMP dependent protein kinase 1 | 0.0013 | 0.0053 | 0.0053 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0776 | 1 | 0.5 |
Echinococcus multilocularis | calcium activated potassium channel | 0.001 | 0.0015 | 0.0015 |
Echinococcus multilocularis | cGMP dependent protein kinase 1 | 0.0013 | 0.0053 | 0.0053 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0519 | 0.0519 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0776 | 1 | 1 |
Echinococcus granulosus | cGMP dependent protein kinase | 0.0013 | 0.0053 | 0.0053 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.0466 | 0.0466 |
Trypanosoma brucei | protein kinase, putative | 0.0776 | 1 | 1 |
Echinococcus granulosus | cGMP dependent protein kinase 1 | 0.0013 | 0.0053 | 0.0053 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0776 | 1 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.0466 | 0.0466 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0389 | 0.0389 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0053 | 0.0053 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0776 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0013 | 0.0053 | 0.0053 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0013 | 0.0053 | 0.0053 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0776 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0428 | 0.0428 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0776 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0053 | 0.0053 |
Plasmodium falciparum | cGMP-dependent protein kinase | 0.0013 | 0.0053 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0053 | 0.0053 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0776 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0776 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0013 | 0.0053 | 0.0053 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0776 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0053 | 0.0053 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0776 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0053 | 0.0053 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0776 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0053 | 0.0053 |
Echinococcus multilocularis | expressed conserved protein | 0.0013 | 0.0053 | 0.0053 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0053 | 0.0053 |
Echinococcus multilocularis | cGMP dependent protein kinase 1 | 0.0013 | 0.0053 | 0.0053 |
Loa Loa (eye worm) | AGC/PKG protein kinase | 0.0013 | 0.0053 | 0.0053 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0776 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.0466 | 0.0466 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0776 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0776 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0776 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0776 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0776 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.5 nM | Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis | ChEMBL. | 24224763 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.