Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0943 | 0.0943 |
Onchocerca volvulus | 0.0148 | 0.0943 | 0.5 | |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0148 | 0.0943 | 0.0943 |
Schistosoma mansoni | nAChR subunit | 0.0148 | 0.0943 | 0.0943 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0943 | 0.0943 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0148 | 0.0943 | 0.0943 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0148 | 0.0943 | 0.0943 |
Onchocerca volvulus | 0.0148 | 0.0943 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0943 | 0.0943 |
Onchocerca volvulus | 0.0148 | 0.0943 | 0.5 | |
Echinococcus granulosus | glycine receptor subunit beta | 0.0148 | 0.0943 | 0.0943 |
Schistosoma mansoni | nAChR subunit | 0.0148 | 0.0943 | 0.0943 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0148 | 0.0943 | 0.0943 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0943 | 0.0943 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0287 | 1 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0148 | 0.0943 | 0.0943 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0148 | 0.0943 | 0.0943 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 1 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0148 | 0.0943 | 0.0943 |
Echinococcus granulosus | nAChR subunit | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0943 | 0.0943 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0148 | 0.0943 | 0.0943 |
Onchocerca volvulus | 0.0148 | 0.0943 | 0.5 | |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0287 | 1 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0943 | 0.0943 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0148 | 0.0943 | 0.0943 |
Schistosoma mansoni | nAChR subunit | 0.0148 | 0.0943 | 0.0943 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0148 | 0.0943 | 0.0943 |
Echinococcus multilocularis | nAChR subunit | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | ACC-1 protein | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0148 | 0.0943 | 0.0943 |
Onchocerca volvulus | Putative nachr subunit | 0.0148 | 0.0943 | 0.5 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0148 | 0.0943 | 0.0943 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 1 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | ACC-1 protein | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0943 | 0.0943 |
Echinococcus multilocularis | acetylcholinesterase | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0943 | 0.0943 |
Schistosoma mansoni | nAChR subunit | 0.0148 | 0.0943 | 0.0943 |
Onchocerca volvulus | 0.0148 | 0.0943 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0943 | 0.0943 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0148 | 0.0943 | 0.0943 |
Echinococcus granulosus | carboxylesterase 5A | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0943 | 0.0943 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0148 | 0.0943 | 0.0943 |
Echinococcus granulosus | acetylcholinesterase | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0943 | 0.0943 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0943 | 0.0943 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0287 | 1 | 1 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0943 | 0.0943 |
Onchocerca volvulus | 0.0148 | 0.0943 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0943 | 0.0943 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0148 | 0.0943 | 0.0943 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0943 | 0.0943 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0148 | 0.0943 | 0.0943 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0148 | 0.0943 | 0.0943 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0148 | 0.0943 | 0.0943 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0148 | 0.0943 | 0.0943 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0148 | 0.0943 | 0.0943 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | carboxylesterase | 0.0287 | 1 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0148 | 0.0943 | 0.0943 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0148 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | LGC-31 protein | 0.0148 | 0.0943 | 0.0943 |
Schistosoma mansoni | nAChR subunit | 0.0148 | 0.0943 | 0.0943 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0148 | 0.0943 | 0.0943 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0148 | 0.0943 | 0.0943 |
Echinococcus granulosus | acetylcholinesterase | 0.0287 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0287 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0287 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 20 microL/min/mg | Intrinsic clearance in human liver microsomes | ChEMBL. | 24410637 |
IC50 (functional) | = 3.2 nM | Antagonist activity at human histamine H3 receptor long form expressed in CHOK1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GTPgammaS binding after 3 hrs by scintillation proximity assay | ChEMBL. | 24410637 |
IC50 (binding) | > 33 uM | Inhibition of human ERG expressed in CHOK1 cells by electrophysiological analysis | ChEMBL. | 24410637 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.