Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Delta opioid receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Mu opioid receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Delta opioid receptor | 372 aa | 315 aa | 28.6 % |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 353 aa | 21.0 % | |
Onchocerca volvulus | Programmed cell death protein 5 homolog | Mu opioid receptor | 398 aa | 323 aa | 24.1 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Delta opioid receptor | 372 aa | 320 aa | 25.6 % |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 316 aa | 26.9 % | |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Delta opioid receptor | 372 aa | 330 aa | 24.2 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Delta opioid receptor | 372 aa | 353 aa | 29.2 % |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 386 aa | 22.8 % | |
Schistosoma japonicum | Rhodopsin, putative | Mu opioid receptor | 398 aa | 328 aa | 23.2 % |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 349 aa | 22.1 % | |
Echinococcus granulosus | allatostatin A receptor | Delta opioid receptor | 372 aa | 302 aa | 27.8 % |
Loa Loa (eye worm) | neuropeptide F receptor | Delta opioid receptor | 372 aa | 317 aa | 23.3 % |
Schistosoma mansoni | neuropeptide F-like receptor | Mu opioid receptor | 398 aa | 335 aa | 20.6 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Mu opioid receptor | 398 aa | 397 aa | 22.7 % |
Echinococcus multilocularis | allatostatin A receptor | Delta opioid receptor | 372 aa | 302 aa | 28.5 % |
Echinococcus granulosus | thyrotropin releasing hormone receptor | Delta opioid receptor | 372 aa | 330 aa | 24.5 % |
Brugia malayi | ORL1-like opioid receptor | Delta opioid receptor | 372 aa | 300 aa | 24.7 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Mu opioid receptor | 398 aa | 334 aa | 23.1 % |
Brugia malayi | GnHR receptor homolog | Delta opioid receptor | 372 aa | 313 aa | 18.5 % |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | Delta opioid receptor | 372 aa | 366 aa | 22.7 % |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 344 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.1125 | 1 | 0.5 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0046 | 0.0034 | 0.0034 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0631 | 0.5433 | 0.5433 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.1125 | 1 | 0.5 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0046 | 0.0034 | 0.0034 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0046 | 0.0034 | 0.0034 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1125 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0117 | 0.069 | 0.069 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0366 | 0.299 | 0.299 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.2565 | 0.254 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0046 | 0.0034 | 0.0034 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0696 | 0.604 | 0.604 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0046 | 0.0034 | 0.0034 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0046 | 0.0034 | 0.0034 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1125 | 1 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.2565 | 0.254 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 0.0904 | 0.0872 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.28 | 0.2775 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.1125 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0696 | 0.604 | 0.604 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.2565 | 0.254 |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0046 | 0.0034 | 0.0034 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.1125 | 1 | 0.5 |
Onchocerca volvulus | 0.0341 | 0.2755 | 0.5 | |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0046 | 0.0034 | 0.0034 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0696 | 0.604 | 0.604 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0117 | 0.069 | 0.069 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0349 | 0.0315 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.1125 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0117 | 0.069 | 0.0658 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 0.0904 | 0.0872 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0631 | 0.5433 | 0.5433 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.1125 | 1 | 0.5 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0046 | 0.0034 | 0.0034 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1125 | 1 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.1125 | 1 | 1 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.1125 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1125 | 1 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.1125 | 1 | 0.5 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.1125 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0349 | 0.0349 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0696 | 0.604 | 0.604 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.1125 | 1 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.1125 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.014 | 0.0904 | 0.0904 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1125 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.069 | 0.0658 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.008 | 0.0349 | 0.0349 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0046 | 0.0034 | 0.0034 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.1125 | 1 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0046 | 0.0034 | 0.0034 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.0745 nM | The compound was tested In vitro for the ability to inhibit electrically induced contractions of the mouse vas deferens | ChEMBL. | 2536436 |
Ki (binding) | = 0.94 nM | The compound was tested for the ability to displace delta-receptor specific radioligand [3H]-DPDPE | ChEMBL. | 2536436 |
Ki (binding) | = 3.27 nM | The compound was tested for the ability to displace delta-receptor specific radioligand [3H]-DSLET | ChEMBL. | 2536436 |
Ki (binding) | = 14.4 nM | The compound was tested for the ability to displace Opioid receptor mu 1 specific radioligand [3H]-DAGO | ChEMBL. | 2536436 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 2536436 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.