TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 435.53 | Formula: C27H30FNO3
H donors: 1 H acceptors: 3 LogP: 4.88 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]1[C@H]([C@H]2/C=C/c2ccc(cn2)c2cccc(c2)F)[C@H](OC1=O)C
InChi: 1S/C27H30FNO3/c1-16-26-24(23-9-5-17(15-30)11-20(23)13-25(26)27(31)32-16)10-8-22-7-6-19(14-29-22)18-3-2-4-21(28)12-18/h2-4,6-8,10,12,14,16-17,20,23-26,30H,5,9,11,13,15H2,1H3/b10-8+/t16-,17-,20+,23-,24+,25-,26+/m1/s1
InChiKey: FRZNWHFNZFIWLA-FCZDYQSRSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	coagulation factor II (thrombin) receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	AGC family protein kinase	0.0107	0.0427	0.3138
Echinococcus granulosus	programmed cell death protein 2	0.0016	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.023	0.0199
Loa Loa (eye worm)	hypothetical protein	0.2274	0.9744	0.9744
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0013	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0013	0.0022	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Leishmania major		0.2334	1	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Trypanosoma brucei	sedoheptulose-1,7-bisphosphatase	0.0868	0.3698	0.3678
Loa Loa (eye worm)	hypothetical protein	0.013	0.0525	0.0517
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0038	0.0132	0.0101
Schistosoma mansoni	cpg binding protein	0.0032	0.0105	0.0105
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0013	0.0022	0.0022
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0013	0.0022	0.0022
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0308	0.1292	1
Trypanosoma brucei	hypothetical protein, conserved	0.0016	0.0038	0.0006
Schistosoma mansoni	cpg binding protein	0.003	0.0098	0.0098
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0013	0.0022	0.0015
Brugia malayi	follicle stimulating hormone receptor	0.0013	0.0022	0.0015
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0111	0.0446	0.3284
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.015	0.0615	0.5
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0013	0.0022	0.0022
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0022	0.0022
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0308	0.1292	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0079	0.0306	0.2175
Schistosoma mansoni	neuropeptide f receptor 76f	0.0013	0.0022	0.0022
Echinococcus multilocularis	neuropeptide receptor	0.0013	0.0022	0.0022
Echinococcus multilocularis	orexin receptor type 2	0.0013	0.0022	0.0022
Echinococcus multilocularis	serotonin receptor	0.0013	0.0022	0.0022
Echinococcus granulosus	G protein coupled receptor 139	0.0013	0.0022	0.0022
Echinococcus granulosus	7tm_1 domain containing protein	0.0013	0.0022	0.0022
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0013	0.0022	0.0022
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0015	0.0032	0.0024
Trypanosoma cruzi	hypothetical protein	0.0016	0.0038	0.0006
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0115	0.046	0.043
Schistosoma mansoni	hypothetical protein	0.0016	0.0038	0.0038
Schistosoma mansoni	opsin-like receptor	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0153	0.0624	0.0624
Echinococcus multilocularis	neuropeptide Y receptor	0.0013	0.0022	0.0022
Loa Loa (eye worm)	MYND finger family protein	0.0016	0.0038	0.003
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0013	0.0022	0.0022
Brugia malayi	Serotonin receptor	0.0013	0.0022	0.0015
Echinococcus multilocularis	neuropeptide receptor A26	0.0013	0.0022	0.0022
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	0.0107	0.0427	0.0427
Brugia malayi	Dopamine receptor protein 1	0.0013	0.0022	0.0015
Trypanosoma cruzi	MYND finger, putative	0.0016	0.0038	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0013	0.0022	0.0022
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0308	0.1292	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0013	0.0022	0.0014
Brugia malayi	hypothetical protein	0.0013	0.0022	0.0015
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0045	0.0161	0.0161
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0022	0.0022
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	0.0107	0.0427	0.0427
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0308	0.1292	1
Brugia malayi	hypothetical protein	0.0041	0.0143	0.0136
Schistosoma mansoni	hypothetical protein	0.0431	0.1821	0.1821
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0013	0.0022	0.0022
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0022	0.0022
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0013	0.0022	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0115	0.046	0.043
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0022	0.0022
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0013	0.0022	0.0014
Brugia malayi	hypothetical protein	0.0013	0.0022	0.0015
Schistosoma mansoni	hypothetical protein	0.0013	0.0022	0.0022
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0022	0.0022
Echinococcus multilocularis	neuropeptides capa receptor	0.0013	0.0022	0.0022
Plasmodium falciparum	MYND-type zinc finger protein, putative	0.0016	0.0038	0.0553
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0017	0.0041	0.0009
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0308	0.1292	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0022	0.0022
Echinococcus multilocularis	somatostatin receptor	0.0013	0.0022	0.0022
Schistosoma mansoni	biogenic amine receptor	0.0013	0.0022	0.0022
Schistosoma mansoni	neuropeptide receptor	0.0013	0.0022	0.0022
Echinococcus granulosus	g protein coupled receptor	0.0013	0.0022	0.0022
Schistosoma mansoni	neuropeptide receptor	0.0013	0.0022	0.0022
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0045	0.0161	0.1023
Brugia malayi	hypothetical protein	0.0013	0.0022	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Toxoplasma gondii	MYND finger domain-containing protein	0.0016	0.0038	0.0006
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0038	0.0132	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.0143	0.0143
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0038	0.0132	0.0798
Echinococcus multilocularis	Zinc finger MYND domain containing protein 12	0.0016	0.0038	0.0038
Echinococcus granulosus	serotonin receptor	0.0013	0.0022	0.0022
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0035	0.0118	0.0086
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0045	0.0161	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0038	0.0132	0.0125
Toxoplasma gondii	fructose-bisphospatase I	0.0868	0.3698	0.3678
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0013	0.0022	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Toxoplasma gondii	MYND finger domain-containing protein	0.0016	0.0038	0.0006
Schistosoma mansoni	hypothetical protein	0.0013	0.0022	0.0022
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0022	0.0022
Schistosoma mansoni	hypothetical protein	0.0016	0.0038	0.0038
Echinococcus granulosus	neuropeptide Y receptor	0.0013	0.0022	0.0022
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0074	0.0287	0.0287
Echinococcus granulosus	allatostatin A receptor	0.0013	0.0022	0.0022
Echinococcus multilocularis	Zinc finger, MYND type	0.0016	0.0038	0.0038
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0868	0.3698	0.3678
Brugia malayi	Melatonin receptor type 1A	0.0013	0.0022	0.0015
Onchocerca volvulus		0.013	0.0525	1
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0101	0.0402	0.0394
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0216	0.0894	0.0894
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0013	0.0022	0.0014
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0308	0.1292	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Brugia malayi	hypothetical protein	0.0013	0.0022	0.0015
Echinococcus multilocularis	g protein coupled receptor	0.0013	0.0022	0.0022
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0216	0.0894	0.0894
Schistosoma mansoni	neuropeptide receptor	0.0013	0.0022	0.0022
Echinococcus granulosus	ankyrin repeat and MYND domain containing protein	0.0016	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Schistosoma mansoni	fructose-16-bisphosphatase-related	0.2334	1	1
Schistosoma mansoni	amine GPCR	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Echinococcus granulosus	biogenic amine 5HT receptor	0.0013	0.0022	0.0022
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.015	0.0615	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0022	0.0022
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Echinococcus granulosus	g-protein coupled receptor	0.0013	0.0022	0.0022
Schistosoma mansoni	amine GPCR	0.0013	0.0022	0.0022
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0022	0.0022
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0013	0.0022	0.0022
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0115	0.046	0.0453
Brugia malayi	GnHR receptor homolog	0.0013	0.0022	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0008	0.0008
Toxoplasma gondii	fructose-bisphospatase II	0.2334	1	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0013	0.0022	0.0022
Echinococcus granulosus	Zinc finger MYND type	0.0016	0.0038	0.0038
Brugia malayi	AKH receptor	0.0013	0.0022	0.0015
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0022	0.0022
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0038	0.0132	0.0798
Onchocerca volvulus		0.003	0.0098	0.1501
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0015	0.0032	0.0024
Brugia malayi	G protein-coupled receptor	0.0013	0.0022	0.0015
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0022	0.0022
Toxoplasma gondii	sedoheptulose-1,7-bisphosphatase	0.0868	0.3698	0.3678
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0055	0.0205	0.1334
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Entamoeba histolytica	acetyltransferase, GNAT family	0.0041	0.0145	0.0896
Trypanosoma cruzi	MYND finger, putative	0.0016	0.0038	0.0006
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0013	0.0022	0.0022
Brugia malayi	Serotonin receptor	0.0013	0.0022	0.0015
Brugia malayi	G protein-coupled receptor F59B2.13	0.0013	0.0022	0.0015
Loa Loa (eye worm)	G-protein coupled receptor	0.0013	0.0022	0.0014
Trichomonas vaginalis	zinc finger protein MYND domain-containing protein, putative	0.0016	0.0038	0.005
Leishmania major	hypothetical protein, conserved	0.0016	0.0038	0.0006
Loa Loa (eye worm)	hypothetical protein	0.004	0.0141	0.0133
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0064	0.0244	0.0244
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0022	0.0022
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0045	0.0161	0.0129
Brugia malayi	ORL1-like opioid receptor	0.0013	0.0022	0.0015
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.2334	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0013	0.0022	0.0022
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0013	0.0022	0.0022
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0107	0.0427	0.042
Brugia malayi	Protein kinase domain containing protein	0.0107	0.0427	0.042
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0308	0.1292	1
Schistosoma mansoni	hypothetical protein	0.0013	0.0022	0.0022
Echinococcus multilocularis	fmrfamide receptor	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0013	0.0022	0.0022
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0038	0.0132	0.0101
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0013	0.0022	0.0022
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0015	0.0032	0.0032
Loa Loa (eye worm)	TYRA-2 protein	0.0013	0.0022	0.0014
Schistosoma mansoni	prolyl 4-hydroxylase alpha subunit 1	0.013	0.0525	0.0525
Giardia lamblia	Fructose-bisphosphate aldolase	0.0308	0.1292	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0013	0.0022	0.0022
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0074	0.0287	0.0279
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0022	0.0022
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0013	0.0022	0.0022
Trypanosoma brucei	fructose-1,6-bisphosphatase	0.2334	1	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0013	0.0022	0.0022
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0016	0.0038	0.0031
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0015	0.0032	0.0032
Echinococcus multilocularis	fmrfamide receptor	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0107	0.0427	0.042
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0013	0.0022	0.0022
Trypanosoma brucei	2OG-Fe(II) oxygenase superfamily, putative	0.013	0.0525	0.0494
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0038	0.0132	0.0798
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0015	0.0032	0.0032
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0115	0.046	0.3399
Echinococcus granulosus	prolyl 4 hydroxylase subunit alpha 1	0.013	0.0525	0.0525
Leishmania major	hypothetical protein, unknown function	0.0016	0.0038	0.0006
Schistosoma mansoni	amine GPCR	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0308	0.1292	1
Brugia malayi	hypothetical protein	0.0013	0.0022	0.0015
Plasmodium vivax	MYND finger protein, putative	0.0016	0.0038	0.0484
Echinococcus multilocularis	g protein coupled receptor	0.0013	0.0022	0.0022
Schistosoma mansoni	hypothetical protein	0.0041	0.0143	0.0143
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0308	0.1292	1
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	0.2334	1	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0013	0.0022	0.0015
Echinococcus multilocularis	sex peptide receptor	0.0013	0.0022	0.0022
Brugia malayi	Programmed cell death protein 2, C-terminal domain containing protein	0.0016	0.0038	0.0031
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0022	0.0022
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0091	0.036	0.2601
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Echinococcus multilocularis	ankyrin repeat and MYND domain containing protein	0.0016	0.0038	0.0038
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0013	0.0022	0.0014
Entamoeba histolytica	hypothetical protein	0.0041	0.0143	0.0884
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0308	0.1292	1
Echinococcus multilocularis	prolyl 4 hydroxylase subunit alpha 1	0.013	0.0525	0.0525
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0115	0.046	0.3399
Schistosoma mansoni	amine GPCR	0.0013	0.0022	0.0022
Echinococcus granulosus	neuropeptide receptor	0.0013	0.0022	0.0022
Schistosoma mansoni	neuropeptide F-like receptor	0.0013	0.0022	0.0022
Schistosoma mansoni	growth hormone secretagogue receptor	0.0013	0.0022	0.0022
Brugia malayi	MYND finger family protein	0.0016	0.0038	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Brugia malayi	neuropeptide F receptor	0.0013	0.0022	0.0015
Brugia malayi	MYND finger family protein	0.0016	0.0038	0.0031
Entamoeba histolytica	hypothetical protein	0.0041	0.0143	0.0884
Echinococcus granulosus	g protein coupled receptor	0.0013	0.0022	0.0022
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0022	0.0022
Plasmodium falciparum	histone-lysine N-methyltransferase, putative	0.0017	0.0041	0.0805
Echinococcus multilocularis	dro:myosuppressin receptor	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Leishmania major	MYND finger domain-like protein	0.0016	0.0038	0.0006
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0038	0.0006
Loa Loa (eye worm)	MYND finger family protein	0.0016	0.0038	0.003
Echinococcus granulosus	hypothetical protein	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Loa Loa (eye worm)	neuropeptide F receptor	0.0013	0.0022	0.0014
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0022	0.0022
Schistosoma mansoni	pcdc2/rp-8 (programmed cell death protein 2)	0.0016	0.0038	0.0038
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.015	0.0615	0.5
Entamoeba histolytica	protein kinase, putative	0.0107	0.0427	0.3138
Echinococcus granulosus	neuropeptide receptor	0.0013	0.0022	0.0022
Schistosoma mansoni	myosin xvIII	0.0013	0.0022	0.0022
Loa Loa (eye worm)	neuropeptide F receptor	0.0013	0.0022	0.0014
Schistosoma mansoni	biogenic amine receptor	0.0013	0.0022	0.0022
Echinococcus granulosus	g protein coupled receptor	0.0013	0.0022	0.0022
Onchocerca volvulus	Buzidau homolog	0.0016	0.0038	0.0312
Brugia malayi	CXXC zinc finger family protein	0.003	0.0098	0.009
Schistosoma mansoni	hypothetical protein	0.0013	0.0022	0.0022
Leishmania major	hypothetical protein, conserved	0.0016	0.0038	0.0006
Toxoplasma gondii	hypoxia- inducible factor prolyl hydroxylase (phd2), putative	0.013	0.0525	0.0494
Brugia malayi	G-protein coupled receptor	0.0013	0.0022	0.0015
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0013	0.0022	0.0022
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0013	0.0022	0.0022
Treponema pallidum	fructose-bisphosphate aldolase	0.0308	0.1292	0.5
Schistosoma mansoni	biogenic amine receptor	0.0013	0.0022	0.0022
Schistosoma mansoni	cpg binding protein	0.0032	0.0105	0.0105
Echinococcus multilocularis	dnaJ subfamily B	0.0431	0.1821	0.1821
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0115	0.046	0.3399
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0027	0.0083	0.0357
Echinococcus multilocularis	Zinc finger, PHD finger	0.0015	0.0032	0.0032
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0013	0.0022	0.0022
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0013	0.0022	0.0022
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0038	0.0132	0.0798
Brugia malayi	larval opioid receptor	0.0013	0.0022	0.0015
Trypanosoma cruzi	2OG-Fe(II) oxygenase superfamily, putative	0.013	0.0525	0.0494
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0115	0.046	0.3399
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0022	0.0022
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0013	0.0022	0.0015
Brugia malayi	neuropeptide F receptor	0.0013	0.0022	0.0015
Leishmania major	MYND zinc finger (ZnF) domain-like protein	0.0016	0.0038	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Brugia malayi	putative neuropeptide receptor	0.0013	0.0022	0.0015
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0051	0.0186	0.1224
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0098	0.009
Schistosoma mansoni	hypothetical protein	0.0016	0.0038	0.0038
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.0143	0.0143
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0045	0.0161	0.0129
Brugia malayi	Dopamine receptor protein 2	0.0013	0.0022	0.0015
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0074	0.0287	0.0287
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0013	0.0022	0.0022
Plasmodium vivax	hypothetical protein, conserved	0.0016	0.0038	0.0484
Brugia malayi	Dopamine receptor	0.0013	0.0022	0.0015
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0148	0.0606	0.0606
Brugia malayi	phosphoinositide-dependent protein kinase I	0.0107	0.0427	0.042
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Echinococcus granulosus	neuropeptides capa receptor	0.0013	0.0022	0.0022
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0022	0.0022
Echinococcus granulosus	dnaJ subfamily B	0.0431	0.1821	0.1821
Loa Loa (eye worm)	phosphatidylinositol 3	0.0192	0.0794	0.0786
Echinococcus multilocularis	allatostatin A receptor	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Echinococcus multilocularis	serotonin receptor	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Plasmodium vivax	histone-lysine N-methyltransferase, putative	0.0017	0.0041	0.0704
Echinococcus granulosus	neuropeptide s receptor	0.0013	0.0022	0.0022
Leishmania major	hypothetical protein, conserved	0.013	0.0525	0.0494
Brugia malayi	hypothetical protein	0.0013	0.0022	0.0015
Toxoplasma gondii	oxidoreductase, 2OG-Fe(II) oxygenase family protein	0.013	0.0525	0.0494
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0022	0.0022
Echinococcus granulosus	sex peptide receptor	0.0013	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0013	0.0022	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0287	0.0279
Trypanosoma brucei	MYND finger, putative	0.0016	0.0038	0.0006
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0216	0.0894	0.0894
Echinococcus multilocularis	neuropeptides capa receptor	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Leishmania major	hypothetical protein, unknown function	0.013	0.0525	0.0494
Loa Loa (eye worm)	prolyl 4-hydroxylase 2	0.013	0.0525	0.0517
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0015	0.0032	0.0032
Loa Loa (eye worm)	programmed cell death protein 2 domain-containing protein	0.0016	0.0038	0.003
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.0143	0.0143
Echinococcus multilocularis	SET and MYND domain containing protein 3	0.0016	0.0038	0.0038
Echinococcus granulosus	cpg binding protein	0.0032	0.0105	0.0105
Echinococcus granulosus	fmrfamide receptor	0.0013	0.0022	0.0022
Echinococcus granulosus	neuropeptide Y receptor	0.0013	0.0022	0.0022
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0013	0.0022	0.0022
Echinococcus multilocularis	neuropeptide Y receptor	0.0013	0.0022	0.0022
Echinococcus multilocularis	g protein coupled receptor	0.0013	0.0022	0.0022
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0013	0.0022	0.0014
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0045	0.0161	0.1023
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0022	0.0022
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Echinococcus multilocularis	programmed cell death protein 2	0.0016	0.0038	0.0038
Echinococcus granulosus	biogenic amine 5HT receptor	0.0013	0.0022	0.0022
Brugia malayi	G-protein coupled receptor	0.0013	0.0022	0.0015
Echinococcus granulosus	SET and MYND domain containing protein 3	0.0016	0.0038	0.0038
Toxoplasma gondii	MYND finger domain-containing protein	0.0016	0.0038	0.0006
Echinococcus multilocularis	neuropeptide s receptor	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Schistosoma mansoni	neuropeptide receptor	0.0013	0.0022	0.0022
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0013	0.0022	0.0022
Echinococcus multilocularis	neuropeptide receptor	0.0013	0.0022	0.0022
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0038	0.0006
Plasmodium falciparum	MYND-type zinc finger protein, putative	0.0016	0.0038	0.0553
Giardia lamblia	Histone acetyltransferase GCN5	0.0041	0.0145	0.085
Toxoplasma gondii	tetratricopeptide repeat-containing protein	0.013	0.0525	0.0494
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0153	0.0624	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0022	0.0022
Trypanosoma cruzi	MYND finger, putative	0.0016	0.0038	0.0006
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0022	0.0022
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0008	0.0008
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0013	0.0022	0.0022
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	0.2334	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0013	0.0022	0.0015
Trypanosoma cruzi	2OG-Fe(II) oxygenase superfamily, putative	0.013	0.0525	0.0494
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0013	0.0022	0.0022
Entamoeba histolytica	hypothetical protein	0.0041	0.0143	0.0884
Echinococcus granulosus	fructose 16 bisphosphatase 1	0.2334	1	1
Trypanosoma cruzi	hypothetical protein	0.0016	0.0038	0.0006
Brugia malayi	sulfakinin receptor protein	0.0013	0.0022	0.0015
Trichomonas vaginalis	AGC family protein kinase	0.0107	0.0427	0.3138
Schistosoma mansoni	ankyrin repeat and mynd domain containing	0.0016	0.0038	0.0038
Echinococcus granulosus	7TM GPCR rhodopsin	0.0013	0.0022	0.0022
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0013	0.0022	0.0022
Brugia malayi	RE15519p	0.0013	0.0022	0.0015
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0015	0.0032	0.0032
Schistosoma mansoni	adenoreceptor	0.0013	0.0022	0.0022
Trypanosoma brucei	hypothetical protein, conserved	0.0016	0.0038	0.0006
Toxoplasma gondii	hypothetical protein	0.0016	0.0038	0.0006
Entamoeba histolytica	hypothetical protein	0.0041	0.0143	0.0884
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0013	0.0022	0.0022
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0038	0.0006
Brugia malayi	hypothetical protein	0.0013	0.0022	0.0015
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0013	0.0022	0.0015
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0013	0.0022	0.0022
Schistosoma mansoni	serine/threonine protein kinase	0.0107	0.0427	0.0427
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0038	0.0006
Echinococcus multilocularis	zinc finger MYND domain containing protein	0.0016	0.0038	0.0038
Loa Loa (eye worm)	acetyltransferase	0.0153	0.0624	0.0617
Echinococcus granulosus	somatostatin receptor	0.0013	0.0022	0.0022
Toxoplasma gondii	oxidoreductase, 2OG-Fe(II) oxygenase family protein	0.013	0.0525	0.0494
Brugia malayi	hypothetical protein	0.0013	0.0022	0.0015
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0013	0.0022	0.0022
Echinococcus granulosus	neuropeptide receptor A26	0.0013	0.0022	0.0022
Entamoeba histolytica	hypothetical protein	0.0091	0.036	0.2601
Echinococcus granulosus	tm gpcr rhodopsin	0.0013	0.0022	0.0022
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0013	0.0022	0.0022
Brugia malayi	prolyl 4-hydroxylase	0.013	0.0525	0.0518
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0013	0.0022	0.0022
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0013	0.0022	0.0022
Echinococcus multilocularis	G protein coupled receptor 139	0.0013	0.0022	0.0022
Plasmodium falciparum	histone acetyltransferase GCN5	0.0041	0.0145	1
Echinococcus granulosus	Zinc finger MYND domain containing protein 12	0.0016	0.0038	0.0038
Schistosoma mansoni	histamine h1 receptor	0.0013	0.0022	0.0022
Echinococcus multilocularis	g-protein coupled receptor	0.0013	0.0022	0.0022
Schistosoma mansoni	opsin-like receptor	0.0013	0.0022	0.0022
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.2334	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0107	0.0427	0.3138
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0013	0.0022	0.0022
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0022	0.0022
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0079	0.0306	0.2175
Trypanosoma brucei	MYND finger, putative	0.0016	0.0038	0.0006
Echinococcus granulosus	tm gpcr rhodopsin	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Loa Loa (eye worm)	G-protein coupled receptor	0.0013	0.0022	0.0014
Brugia malayi	acetyltransferase, GNAT family protein	0.0153	0.0624	0.0617
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0013	0.0022	0.0022
Schistosoma mansoni	amine GPCR	0.0013	0.0022	0.0022
Echinococcus granulosus	tm gpcr rhodopsin	0.0013	0.0022	0.0022
Echinococcus granulosus	orexin receptor type 2	0.0013	0.0022	0.0022
Loa Loa (eye worm)	melatonin receptor type 1A	0.0013	0.0022	0.0014
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0038	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014
Schistosoma mansoni	opsin-like receptor	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0038	0.003
Loa Loa (eye worm)	phosphatidylinositol 3	0.0035	0.0118	0.011
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0013	0.0022	0.0022
Leishmania major	hypothetical protein, conserved	0.0017	0.0041	0.0009
Echinococcus multilocularis	cpg binding protein	0.0032	0.0105	0.0105
Echinococcus granulosus	zinc finger MYND domain containing protein	0.0016	0.0038	0.0038
Brugia malayi	MYND finger family protein	0.0016	0.0038	0.0031
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0038	0.0132	0.0798
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0868	0.3698	0.3678
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0014

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 8 nM	Displacement of [3H]haTRAP from PAR-1 isolated from human platelets by liquid scintillation counting analysis	ChEMBL.	24900795

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3109579

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1825281