Detailed information for compound 1825373

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 349.38 | Formula: C21H19NO4
  • H donors: 2 H acceptors: 4 LogP: 4.48 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(OC(=O)/C(=C/c1ccc(c(c1)O)O)/C#N)/C=C/c1ccccc1
  • InChi: 1S/C21H19NO4/c1-2-18(10-8-15-6-4-3-5-7-15)26-21(25)17(14-22)12-16-9-11-19(23)20(24)13-16/h3-13,18,23-24H,2H2,1H3/b10-8+,17-12+
  • InChiKey: BBISGANYDGKLDE-WJISXQBPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0302 0.0885
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0015 0.007 0.018
Echinococcus granulosus thioredoxin glutathione reductase 0.003 0.03 0.03
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Echinococcus granulosus roundabout 2 0.0015 0.007 0.007
Onchocerca volvulus 0.0018 0.0123 0.0151
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0294 0.0861
Echinococcus multilocularis anosmin 1 0.0015 0.007 0.007
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0089 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0961 1
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0961 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0073 0.0961 0.0961
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0123 0.0123
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0625 0.0625
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0033 0.0349 0.0349
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0031 0.0326 0.0953
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0015 0.007 0.0112
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0073 0.0961 0.258
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Mycobacterium ulcerans hypothetical protein 0.003 0.0302 0.1752
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0027 0.0252 0.0908
Echinococcus multilocularis titin 0.0015 0.007 0.007
Brugia malayi jmjC domain containing protein 0.0012 0.0029 0.0076
Onchocerca volvulus 0.0018 0.0123 0.0151
Echinococcus multilocularis lysine specific demethylase 5A 0.0045 0.0539 0.0539
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0381 0.0974
Giardia lamblia Protein tyrosine phosphatase 0.0018 0.0123 0.128
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Trichomonas vaginalis myo inositol monophosphatase, putative 0.003 0.0299 0.3115
Plasmodium falciparum ataxin-2 like protein, putative 0.0019 0.0142 0.4363
Brugia malayi beta-lactamase family protein 0.003 0.0302 0.0782
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0961 1
Schistosoma mansoni hypothetical protein 0.0015 0.007 0.007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0028 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0073 0.0073
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0625 0.0625
Brugia malayi hypothetical protein 0.0018 0.0123 0.0318
Toxoplasma gondii hypothetical protein 0.0038 0.042 0.2234
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.007 0.018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0082 0.0858
Brugia malayi glutathione reductase 0.0029 0.0294 0.0761
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0381 0.0381
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0018 0.0123 0.0123
Brugia malayi hypothetical protein 0.0126 0.1768 0.4572
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0302 0.3146
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.001 0 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0961 0.0961
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Trichomonas vaginalis penicillin-binding protein, putative 0.003 0.0302 0.3146
Trichomonas vaginalis penicillin-binding protein, putative 0.003 0.0302 0.3146
Schistosoma mansoni myosin-binding protein-related 0.0015 0.007 0.007
Schistosoma mansoni jumonji domain containing protein 0.0012 0.0029 0.0029
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0045 0.0539 0.0539
Treponema pallidum exodeoxyribonuclease (exoA) 0.0031 0.0326 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Schistosoma mansoni aldehyde dehydrogenase 0.0098 0.134 0.134
Loa Loa (eye worm) hypothetical protein 0.0231 0.337 0.9252
Echinococcus multilocularis phd:f box containing protein 0.0012 0.0029 0.0029
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0018 0.0123 0.0318
Entamoeba histolytica acetyltransferase, GNAT family 0.003 0.0306 0.2184
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0098 0.134 0.134
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.007 0.018
Plasmodium falciparum JmjC domain-containing protein, putative 0.0012 0.0029 0.0904
Echinococcus granulosus Fibronectin type III 0.0015 0.007 0.007
Echinococcus granulosus titin 0.0015 0.0073 0.0073
Brugia malayi Fibronectin type III domain containing protein 0.0015 0.007 0.018
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0015 0.007 0.018
Brugia malayi hypothetical protein 0.0018 0.0123 0.0318
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0123 0.0259
Echinococcus multilocularis transfer RNA-Phe 0.0015 0.007 0.007
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0028 0.0269 0.0269
Schistosoma mansoni jumonji/arid domain-containing protein 0.0049 0.0599 0.0599
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0015 0.007 0.007
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0112 0.1558 0.1558
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0961 1
Mycobacterium leprae Probable lipase LipE 0.003 0.0302 0.069
Toxoplasma gondii histone lysine methyltransferase SET1 0.0133 0.188 1
Brugia malayi hypothetical protein 0.0013 0.0036 0.0094
Entamoeba histolytica hypothetical protein 0.0028 0.0269 0.1747
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Onchocerca volvulus Serine\/threonine kinase homolog 0.0073 0.0961 0.2534
Plasmodium vivax ataxin-2 like protein, putative 0.0019 0.0142 0.4082
Mycobacterium ulcerans aldehyde dehydrogenase 0.0098 0.134 0.7766
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0018 0.0123 0.0123
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0015 0.007 0.007
Plasmodium falciparum ataxin-2 like protein, putative 0.0019 0.0142 0.4363
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0123 0.0259
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0018 0.0123 0.0123
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.007 0.018
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0075 0.0986 0.3555
Echinococcus multilocularis GPCR, family 2 0.0035 0.0381 0.0381
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0625 0.0625
Schistosoma mansoni protein tyrosine phosphatase 0.0033 0.0349 0.0349
Echinococcus granulosus tar DNA binding protein 0.0051 0.0625 0.0625
Loa Loa (eye worm) hypothetical protein 0.0248 0.364 1
Plasmodium vivax thioredoxin reductase, putative 0.0029 0.0294 0.8454
Echinococcus multilocularis anosmin 1 0.0015 0.007 0.007
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0031 0.0326 0.3388
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0018 0.0123 0.0123
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0019 0.0142 0.0312
Giardia lamblia Histone acetyltransferase GCN5 0.003 0.0306 0.3184
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0033 0.0348 0.1851
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.003 0.0302 0.1752
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0105 0.0105
Trichomonas vaginalis inositol monophosphatase, putative 0.003 0.0299 0.3115
Trichomonas vaginalis myo inositol monophosphatase, putative 0.003 0.0299 0.3115
Mycobacterium ulcerans hypothetical protein 0.0123 0.1725 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0073 0.0961 0.2486
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0018 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0082 0.0858
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0033 0.0349 0.0349
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0031 0.0326 0.0326
Schistosoma mansoni nephrin 0.0015 0.007 0.007
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0397 0.413
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0033 0.0349 0.0349
Loa Loa (eye worm) CAMK protein kinase 0.0015 0.0073 0.0122
Trypanosoma cruzi PAB1-binding protein , putative 0.0019 0.0142 0.0416
Loa Loa (eye worm) protein tyrosine phosphatase 0.0018 0.0123 0.0259
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0018 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0035 0.0381 0.0974
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0018 0.0123 0.0123
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0015 0.007 0.007
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0045 0.0539 0.0539
Echinococcus granulosus usherin 0.0015 0.007 0.007
Mycobacterium tuberculosis Conserved hypothetical protein 0.0123 0.1725 0.6223
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Echinococcus granulosus titin 0.0015 0.0073 0.0073
Mycobacterium ulcerans aldehyde dehydrogenase 0.0098 0.134 0.7766
Schistosoma mansoni cell adhesion molecule 0.0015 0.007 0.007
Loa Loa (eye worm) UNCoordinated family member 0.0015 0.007 0.0112
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0012 0.0029 0.0157
Schistosoma mansoni microtubule-associated protein tau 0.046 0.6881 0.6881
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0033 0.0348 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.003 0.0302 0.1091
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.011 0.1534 0.4492
Schistosoma mansoni cpg binding protein 0.0069 0.0897 0.0897
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0123 0.0259
Echinococcus granulosus microtubule associated protein 2 0.046 0.6881 0.6881
Trypanosoma brucei protein tyrosine phosphatase 1 0.0018 0.0123 0.036
Echinococcus multilocularis beta LACTamase domain containing family member 0.003 0.0302 0.0302
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0381 0.0381
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0123 0.0123
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0018 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Onchocerca volvulus 0.0018 0.0123 0.0151
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0123 0.0259
Loa Loa (eye worm) hypothetical protein 0.023 0.3361 0.9227
Brugia malayi jmjC domain containing protein 0.0045 0.0539 0.1395
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.007 0.018
Schistosoma mansoni titin 0.0015 0.007 0.007
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.003 0.0302 0.0756
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0961 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0123 0.0123
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0166 0.0428
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.017 0.017
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0067 0.0871 0.3142
Brugia malayi RNA recognition motif domain containing protein 0.0051 0.0625 0.1617
Mycobacterium tuberculosis Probable reductase 0.0067 0.0871 0.3142
Echinococcus granulosus GPCR family 2 0.0035 0.0381 0.0381
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0018 0.0123 0.0123
Brugia malayi CXXC zinc finger family protein 0.0069 0.0897 0.2319
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0123 0.0123
Schistosoma mansoni factor for adipocyte differentiation 0.0015 0.007 0.007
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0031 0.0326 0.082
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0033 0.0349 0.0349
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0015 0.007 0.007
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0067 0.0871 0.3142
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.003 0.0299 0.0877
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0018 0.0123 0.0259
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0031 0.0326 0.0326
Schistosoma mansoni transcription factor LCR-F1 0.0028 0.0269 0.0269
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0302 0.0885
Echinococcus granulosus G1Y162 protein 0.0015 0.007 0.007
Echinococcus granulosus phd:f box containing protein 0.0012 0.0029 0.0029
Onchocerca volvulus 0.0018 0.0123 0.0151
Loa Loa (eye worm) TAR-binding protein 0.0051 0.0625 0.1649
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0123 0.0259
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0051 0.0625 0.1649
Echinococcus granulosus fibronectin type III domain-containing protein 0.0015 0.007 0.007
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.003 0.0299 0.0877
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.007 0.018
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0012 0.0029 0.0086
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.004 0.0456 0.1335
Brugia malayi Thioredoxin reductase 0.0029 0.0294 0.0761
Schistosoma mansoni cpg binding protein 0.0073 0.0957 0.0957
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0233 0.3415 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0082 0.0858
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0082 0.0858
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.003 0.0299 0.0877
Echinococcus granulosus neuropeptide s receptor 0.0357 0.5312 0.5312
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0029 0.0294 0.1061
Echinococcus granulosus geminin 0.0131 0.1848 0.1848
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0033 0.0349 0.0349
Echinococcus granulosus anosmin 1 0.0015 0.007 0.007
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0031 0.0326 0.2418
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0033 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.003 0.0302 0.0756
Toxoplasma gondii aldehyde dehydrogenase 0.0098 0.134 0.7124
Onchocerca volvulus 0.0018 0.0123 0.0151
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.003 0.0299 0.9194
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0033 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0155 0.221 0.221
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0123 0.0123
Schistosoma mansoni protein phosphatase 2C 0.0012 0.0029 0.0029
Brugia malayi SPRY domain containing protein 0.0015 0.007 0.018
Brugia malayi hypothetical protein 0.0018 0.0123 0.0318
Onchocerca volvulus 4.1 G protein, putative homolog 0.0018 0.0123 0.0151
Mycobacterium tuberculosis Conserved protein 0.003 0.0302 0.1091
Echinococcus granulosus beta LACTamase domain containing family member 0.003 0.0302 0.0302
Echinococcus multilocularis usherin 0.0015 0.007 0.007
Schistosoma mansoni jumonji domain containing protein 0.0045 0.0539 0.0539
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0098 0.134 0.3922
Brugia malayi acetyltransferase, GNAT family protein 0.0112 0.1558 0.403
Onchocerca volvulus 0.0018 0.0123 0.0151
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.011 0.1534 0.4492
Onchocerca volvulus 0.0018 0.0123 0.0151
Loa Loa (eye worm) MH2 domain-containing protein 0.0083 0.1116 0.3009
Schistosoma mansoni pcd6 interacting protein-related 0.0018 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Echinococcus multilocularis tar DNA binding protein 0.0051 0.0625 0.0625
Onchocerca volvulus 0.0018 0.0123 0.0151
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.003 0.0302 0.0302
Trichomonas vaginalis esterase, putative 0.003 0.0302 0.3146
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.2028 0.5536
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0082 0.0858
Leishmania major hypothetical protein, conserved 0.0012 0.0029 0.0086
Brugia malayi Lethal protein 805 0.0015 0.007 0.018
Trichomonas vaginalis ap endonuclease, putative 0.0031 0.0326 0.3388
Entamoeba histolytica hypothetical protein 0.0028 0.0269 0.1747
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0961 1
Brugia malayi hypothetical protein 0.0015 0.007 0.018
Echinococcus granulosus JmjC domain containing protein 4 0.0012 0.0029 0.0029
Mycobacterium tuberculosis Probable lipase LipD 0.003 0.0302 0.1091
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0031 0.0326 0.1175
Leishmania major trypanothione reductase 0.0029 0.0294 0.0861
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0123 0.0123
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0015 0.007 0.0112
Brugia malayi Fibronectin type III domain containing protein 0.0015 0.007 0.018
Brugia malayi Fibronectin type III domain containing protein 0.0015 0.007 0.018
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.003 0.0302 0.1091
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0018 0.0123 0.0123
Trypanosoma brucei PAB1-binding protein , putative 0.0019 0.0142 0.0416
Onchocerca volvulus 0.003 0.0302 0.0661
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.2028 0.2028
Echinococcus granulosus cell adhesion molecule 0.0015 0.007 0.007
Onchocerca volvulus 0.0018 0.0123 0.0151
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Brugia malayi hypothetical protein 0.0028 0.0269 0.0697
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.007 0.018
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0123 0.0123
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0123 0.0259
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0082 0.0858
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0302 0.3146
Leishmania major hypothetical protein, conserved 0.0019 0.0142 0.0416
Loa Loa (eye worm) hypothetical protein 0.0104 0.1435 0.3893
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.2028 0.2028
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0075 0.0986 1
Onchocerca volvulus 0.0018 0.0123 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0302 0.0885
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0082 0.0858
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0033 0.0348 0.3621
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Brugia malayi hypothetical protein 0.0015 0.007 0.018
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.003 0.0302 0.1091
Leishmania major hypothetical protein, conserved 0.003 0.0302 0.0885
Schistosoma mansoni inositol monophosphatase 0.003 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0067 0.0871 0.3142
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0381 0.0986
Echinococcus multilocularis 0.0018 0.0123 0.0123
Brugia malayi beta-lactamase family protein 0.003 0.0302 0.0782
Schistosoma mansoni hypothetical protein 0.0076 0.1004 0.1004
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.0664 1 1
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0015 0.0073 0.0122
Echinococcus granulosus cpg binding protein 0.0073 0.0957 0.0957
Giardia lamblia Kinase, PLK 0.0073 0.0961 1
Loa Loa (eye worm) lethal protein 805 0.0015 0.007 0.0112
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0098 0.134 0.4832
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Echinococcus granulosus anosmin 1 0.0015 0.007 0.007
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.003 0.0299 0.1592
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0073 0.0961 0.0961
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0067 0.0871 0.8439
Onchocerca volvulus 0.0018 0.0123 0.0151
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0233 0.3415 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0123 0.0259
Mycobacterium leprae conserved hypothetical protein 0.003 0.0302 0.069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.2028 0.2028
Onchocerca volvulus 0.0018 0.0123 0.0151
Loa Loa (eye worm) hypothetical protein 0.003 0.0302 0.0756
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0075 0.0986 0.3555
Loa Loa (eye worm) hypothetical protein 0.0126 0.1768 0.4814
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.017 0.017
Echinococcus granulosus histone acetyltransferase KAT2B 0.0109 0.151 0.151
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.1541 0.4187
Schistosoma mansoni jumonji/arid domain-containing protein 0.0049 0.0599 0.0599
Brugia malayi Fibronectin type III domain containing protein 0.0015 0.007 0.018
Mycobacterium ulcerans beta-lactamase 0.003 0.0302 0.1752
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.007 0.0204
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0123 0.0259
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Schistosoma mansoni hypothetical protein 0.0035 0.0381 0.0381
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0012 0.0029 0.0086
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Schistosoma mansoni tripartite motif protein trim9 0.0015 0.007 0.007
Loa Loa (eye worm) histone methyltransferase 0.0021 0.017 0.0388
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.003 0.0299 0.0877
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0123 0.0123
Echinococcus multilocularis roundabout 2 0.0015 0.007 0.007
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Schistosoma mansoni cell adhesion molecule 0.0015 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.003 0.0302 0.0756
Echinococcus multilocularis muscleblind protein 1 0.0104 0.1435 0.1435
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.2028 0.5247
Brugia malayi myotactin form A 0.0015 0.007 0.018
Echinococcus multilocularis cpg binding protein 0.0073 0.0957 0.0957
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0033 0.0349 0.0349
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0031 0.0326 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0073 0.0961 0.2814
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0031 0.0326 0.0953
Onchocerca volvulus 0.0015 0.0073 0.001
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.1541 0.3987
Echinococcus granulosus protein tyrosine phosphatase n9 0.0018 0.0123 0.0123
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0033 0.0346 0.1014
Loa Loa (eye worm) hypothetical protein 0.0076 0.1004 0.27
Echinococcus multilocularis jumonji domain containing 1A 0.0012 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.003 0.0302 0.0756
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0031 0.0326 0.0953
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Schistosoma mansoni hypothetical protein 0.0015 0.007 0.007
Echinococcus multilocularis roundabout 2 0.0015 0.007 0.007
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0031 0.0326 0.1887
Onchocerca volvulus 0.0018 0.0123 0.0151
Schistosoma mansoni cell adhesion molecule 0.0015 0.007 0.007
Schistosoma mansoni ap endonuclease 0.0031 0.0326 0.0326
Schistosoma mansoni inositol monophosphatase 0.003 0.0299 0.0299
Schistosoma mansoni hypothetical protein 0.0035 0.0381 0.0381
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Echinococcus granulosus EG95 0.0015 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0625 0.0625
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0599 0.1579
Plasmodium falciparum glutathione reductase 0.0029 0.0294 0.9036
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.2028 0.2028
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0012 0.0029 0.0157
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0123 0.0259
Mycobacterium ulcerans lipase LipD 0.003 0.0302 0.1752
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Schistosoma mansoni hypothetical protein 0.0035 0.0381 0.0381
Loa Loa (eye worm) RNA binding protein 0.0051 0.0625 0.1649
Brugia malayi Muscleblind-like protein 0.0104 0.1435 0.3713
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0123 0.0259
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0123 0.0123
Echinococcus granulosus Fibronectin type III domain containing protein 0.0015 0.007 0.007
Mycobacterium tuberculosis Conserved protein 0.003 0.0302 0.1091
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.007 0.018
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0123 0.0259
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Brugia malayi RNA binding protein 0.0051 0.0625 0.1617
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0033 0.0346 0.1014
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0033 0.0349 0.0349
Echinococcus granulosus Netrin receptor DCC 0.0015 0.007 0.007
Onchocerca volvulus 0.003 0.0302 0.0661
Schistosoma mansoni cell adhesion molecule 0.0015 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0035 0.0381 0.0381
Onchocerca volvulus 0.0018 0.0123 0.0151
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Toxoplasma gondii thioredoxin reductase 0.0029 0.0294 0.1565
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0112 0.1558 0.1558
Entamoeba histolytica myo-inositol monophosphatase, putative 0.003 0.0299 0.2105
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0033 0.0349 0.0884
Brugia malayi hypothetical protein 0.0018 0.0123 0.0318
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.0123 0.0123
Brugia malayi hypothetical protein 0.0018 0.0123 0.0318
Plasmodium falciparum histone acetyltransferase GCN5 0.003 0.0306 0.9398
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.0123 0.036
Echinococcus multilocularis dnaJ subfamily B 0.0664 1 1
Echinococcus granulosus roundabout 2 0.0015 0.007 0.007
Brugia malayi myotactin form B 0.0015 0.007 0.018
Echinococcus multilocularis thioredoxin glutathione reductase 0.003 0.03 0.03
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0123 0.0123
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0123 0.0123
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.007 0.018
Echinococcus multilocularis Fibronectin, type III 0.0015 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Schistosoma mansoni phd/f-box containing protein 0.0012 0.0029 0.0029
Echinococcus granulosus lysine specific demethylase 5A 0.0049 0.0599 0.0599
Trypanosoma cruzi PAB1-binding protein , putative 0.0019 0.0142 0.0416
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0123 0.0123
Plasmodium vivax glutathione reductase, putative 0.0029 0.0294 0.8454
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0067 0.0871 0.3142
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0015 0.0073 0.0122
Echinococcus multilocularis anosmin 1 0.0015 0.007 0.007
Schistosoma mansoni hemicentin 0.0015 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Echinococcus granulosus neuroglian 0.0015 0.007 0.007
Entamoeba histolytica hypothetical protein 0.0028 0.0269 0.1747
Echinococcus multilocularis inositol monophosphatase 1 0.003 0.0299 0.0299
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0082 0.0858
Brugia malayi Lethal protein 805 0.0015 0.007 0.018
Mycobacterium tuberculosis Probable esterase LipL 0.003 0.0302 0.1091
Echinococcus multilocularis titin 0.0015 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0131 0.1848 0.1848
Echinococcus multilocularis neuroglian 0.0015 0.007 0.007
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0018 0.0123 0.0123
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0123 0.0259
Brugia malayi jmjC domain containing protein 0.0012 0.0029 0.0076
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0033 0.0349 0.0349
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0018 0.0123 0.0318
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0105 0.0105
Brugia malayi beta-lactamase 0.003 0.0302 0.0782
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.007 0.018
Schistosoma mansoni hypothetical protein 0.0028 0.0269 0.0269
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.0123 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0082 0.0858
Schistosoma mansoni phosphatidylserine receptor 0.0012 0.0029 0.0029
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0033 0.0346 0.1014
Echinococcus multilocularis JmjC domain containing protein 4 0.0012 0.0029 0.0029
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0073 0.0961 0.2814
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0033 0.0349 0.0349
Brugia malayi hypothetical protein 0.0019 0.0142 0.0367
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0031 0.0326 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0033 0.0349 0.0349
Brugia malayi Protein-tyrosine phosphatase 0.0018 0.0123 0.0318
Schistosoma mansoni hypothetical protein 0.0131 0.1848 0.1848
Loa Loa (eye worm) hypothetical protein 0.003 0.0302 0.0756
Schistosoma mansoni titin 0.0015 0.007 0.007
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0018 0.0123 0.0259
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.007 0.018
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0123 0.0123
Onchocerca volvulus 0.0018 0.0123 0.0151
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.003 0.0302 0.0782
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Schistosoma mansoni factor for adipocyte differentiation 0.0015 0.007 0.007
Echinococcus granulosus anosmin 1 0.0015 0.007 0.007
Schistosoma mansoni aldehyde dehydrogenase 0.0098 0.134 0.134
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Trichomonas vaginalis pten, drome, putative 0.0018 0.0123 0.128
Echinococcus multilocularis Netrin receptor DCC 0.0015 0.007 0.007
Echinococcus granulosus lysine specific demethylase 6a 0.0012 0.0029 0.0029
Mycobacterium ulcerans aldehyde dehydrogenase 0.0098 0.134 0.7766
Mycobacterium tuberculosis Probable lipase LipE 0.003 0.0302 0.1091
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0105 0.0105
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0302 0.3146
Loa Loa (eye worm) inositol-1 0.003 0.0299 0.0748
Schistosoma mansoni kinase 0.0037 0.0412 0.0412
Onchocerca volvulus 0.0018 0.0123 0.0151
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0012 0.0029 0.0086
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0155 0.221 0.221
Brugia malayi MH2 domain containing protein 0.0083 0.1116 0.2886
Echinococcus granulosus jumonji domain containing 1A 0.0012 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.2028 0.2028
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.003 0.0299 0.1735
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Loa Loa (eye worm) beta-lactamase 0.003 0.0302 0.0756
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0231 0.337 0.8718
Brugia malayi Inositol-1 0.003 0.0299 0.0774
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0082 0.0858
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0082 0.0858
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Trypanosoma cruzi polo-like protein kinase, putative 0.0073 0.0961 0.2814
Echinococcus granulosus contactin 0.0015 0.007 0.007
Leishmania major tyrosine specific protein phosphatase, putative 0.0018 0.0123 0.036
Entamoeba histolytica hypothetical protein 0.0028 0.0269 0.1747
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0018 0.0123 0.0259
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0018 0.0123 0.0123
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.003 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.007 0.018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0031 0.0326 0.9356
Onchocerca volvulus 0.0245 0.3587 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0961 1
Toxoplasma gondii LsmAD domain-containing protein 0.0019 0.0142 0.0755
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0073 0.019
Onchocerca volvulus 0.0018 0.0123 0.0151
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0018 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Loa Loa (eye worm) projectin 0.0015 0.007 0.0112
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0123 0.0123
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0015 0.007 0.018
Mycobacterium tuberculosis Probable dehydrogenase 0.0067 0.0871 0.3142
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0015 0.007 0.0112
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.007 0.0112
Brugia malayi TAR-binding protein 0.0051 0.0625 0.1617
Echinococcus granulosus Netrin receptor DCC 0.0015 0.007 0.007
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0098 0.134 0.134
Onchocerca volvulus 0.0126 0.1768 0.4827
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0123 0.0123
Schistosoma mansoni nephrin 0.0015 0.007 0.007
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0033 0.0349 0.0349
Schistosoma mansoni neuroglian 0.0015 0.007 0.007
Loa Loa (eye worm) thioredoxin reductase 0.0029 0.0294 0.0733
Loa Loa (eye worm) hypothetical protein 0.023 0.3361 0.9227
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0012 0.0029 0.0029
Brugia malayi Protein-tyrosine phosphatase 0.0263 0.3866 1
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.1004 0.2598
Echinococcus multilocularis muscleblind protein 0.0104 0.1435 0.1435
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.007 0.0112
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0018 0.0123 0.0123
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.0123 0.036
Echinococcus granulosus inositol monophosphatase 1 0.003 0.0299 0.0299
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0033 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0104 0.1435 0.3893
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.007 0.0112
Echinococcus multilocularis hypothetical protein 0.0018 0.0123 0.0123
Trichomonas vaginalis helicase, putative 0.0016 0.0082 0.0858
Plasmodium vivax JmjC domain containing protein 0.0012 0.0029 0.0846
Brugia malayi jmjC domain containing protein 0.0012 0.0029 0.0076
Entamoeba histolytica serine/threonine protein kinase, putative 0.0073 0.0961 1
Trypanosoma brucei trypanothione reductase 0.0029 0.0294 0.0861
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0082 0.0858
Schistosoma mansoni ap endonuclease 0.0031 0.0326 0.0326
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0082 0.0858
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Loa Loa (eye worm) hypothetical protein 0.003 0.0302 0.0756
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Brugia malayi jmjC domain containing protein 0.0012 0.0029 0.0076
Mycobacterium tuberculosis Conserved protein 0.003 0.0302 0.1091
Plasmodium vivax hypothetical protein, conserved 0.003 0.0302 0.8687
Brugia malayi exodeoxyribonuclease III family protein 0.0031 0.0326 0.0842
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0031 0.0326 0.0953
Schistosoma mansoni factor for adipocyte differentiation 0.0015 0.007 0.007
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.007 0.0112
Schistosoma mansoni hypothetical protein 0.0015 0.007 0.007
Echinococcus multilocularis neuropeptide receptor A26 0.0357 0.5312 0.5312
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.0123 0.0123
Mycobacterium tuberculosis Probable hydrolase 0.003 0.0302 0.1091
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0033 0.0349 0.0349
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0625 0.0625
Brugia malayi protein unc-22 0.0015 0.0073 0.019
Toxoplasma gondii exonuclease III APE 0.0031 0.0326 0.1732
Onchocerca volvulus 0.0018 0.0123 0.0151
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.007 0.0112
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0015 0.007 0.0204
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0123 0.0259
Trypanosoma brucei polo-like protein kinase 0.0073 0.0961 0.2814
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0082 0.0858
Mycobacterium ulcerans esterase/lipase LipP 0.003 0.0302 0.1752
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.2028 0.2028
Loa Loa (eye worm) acetyltransferase 0.0112 0.1558 0.4233
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0146 0.2077 0.2077
Brugia malayi Fibronectin type III domain containing protein 0.0015 0.007 0.018
Toxoplasma gondii ABC1 family protein 0.003 0.0302 0.1608
Trichomonas vaginalis bromodomain-containing protein, putative 0.0033 0.0348 0.3621
Mycobacterium tuberculosis Probable oxidoreductase 0.0075 0.0986 0.3555
Echinococcus multilocularis lysine specific demethylase 6a 0.0012 0.0029 0.0029
Onchocerca volvulus 0.0018 0.0123 0.0151
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0123 0.0123
Echinococcus granulosus muscleblind protein 0.0104 0.1435 0.1435
Onchocerca volvulus 0.0018 0.0123 0.0151
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0082 0.0858
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.011 0.1534 0.4492
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0082 0.0858
Onchocerca volvulus 0.0069 0.0897 0.2351
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0033 0.0346 0.1014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Loa Loa (eye worm) hypothetical protein 0.023 0.3361 0.9227
Echinococcus granulosus roundabout 2 0.0015 0.007 0.007
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0015 0.007 0.007
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0015 0.007 0.0204
Echinococcus multilocularis roundabout 2 0.0015 0.007 0.007
Echinococcus multilocularis neuropeptide s receptor 0.0357 0.5312 0.5312
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0089 0.0089
Echinococcus multilocularis geminin 0.0131 0.1848 0.1848
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0123 0.0123
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0018 0.0123 0.036
Leishmania major hypothetical protein, conserved 0.0015 0.007 0.0204
Echinococcus multilocularis cell adhesion molecule 0.0015 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0123 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0082 0.0858
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0123 0.0123
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0123 0.0123
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0233 0.3415 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0191 0.2772 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0015 0.007 0.007
Schistosoma mansoni cpg binding protein 0.0073 0.0957 0.0957
Echinococcus multilocularis microtubule associated protein 2 0.046 0.6881 0.6881
Brugia malayi Protein-tyrosine phosphatase 1 0.0018 0.0123 0.0318
Onchocerca volvulus 0.0018 0.0123 0.0151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.2028 0.2028
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0381 0.0986
Echinococcus multilocularis Netrin receptor DCC 0.0015 0.007 0.007
Schistosoma mansoni cell adhesion molecule 0.0015 0.007 0.007
Plasmodium falciparum thioredoxin reductase 0.0029 0.0294 0.9036
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0015 0.007 0.007
Loa Loa (eye worm) glutathione reductase 0.0029 0.0294 0.0733
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0015 0.007 0.007
Schistosoma mansoni titin 0.0015 0.0073 0.0073
Echinococcus granulosus histone acetyltransferase KAT2B 0.0033 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0015 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0112
Loa Loa (eye worm) transcription factor SMAD2 0.0083 0.1116 0.3009
Loa Loa (eye worm) myotactin form A 0.0015 0.007 0.0112
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0015 0.007 0.0204
Onchocerca volvulus 0.0018 0.0123 0.0151
Onchocerca volvulus 0.0018 0.0123 0.0151
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0259
Brugia malayi Fibronectin type III domain containing protein 0.0015 0.007 0.018
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0123 0.0259
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0015 0.007 0.007
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0018 0.0123 0.0123
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0397 0.413
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0123 0.0259
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0018 0.0123 0.0123
Echinococcus granulosus neuropeptide receptor A26 0.0357 0.5312 0.5312
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0123 0.0123
Onchocerca volvulus 0.003 0.0302 0.0661
Schistosoma mansoni ephrin receptor 0.0015 0.007 0.007
Loa Loa (eye worm) CXXC zinc finger family protein 0.0069 0.0897 0.2402
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0033 0.0348 0.1851
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0105 0.0105
Trichomonas vaginalis ap endonuclease, putative 0.0031 0.0326 0.3388
Brugia malayi jmjC domain containing protein 0.0049 0.0599 0.1551
Echinococcus granulosus nephrin 0.0015 0.007 0.007
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0123 0.0318
Leishmania major mitochondrial DNA polymerase beta 0.0233 0.3415 1

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Reversible activation of TREK1 channel (unknown origin) expressed in Xenopus oocytes assessed as channel current at 20 uM incubated for 15 mins measured post compound wash-out by two-microelectrode voltage-clamp technique ChEMBL. 24561669
Inhibition (functional) = 45.3 % Antinociceptive activity in CD-1 mouse assessed as inhibition of acetic acid-induced writhing at 10 mg/kg, sc administered 15 mins before acetic acid challenge measured after 20 mins ChEMBL. 24561669
log(ratio) (binding) = 0.017 Activation of TREK1 channel (unknown origin) expressed in Xenopus oocytes assessed as ratio of current in presence of compound to current in absence of compound at 20 uM incubated for 15 mins by two-microelectrode voltage-clamp technique ChEMBL. 24561669
Ratio (binding) = 1.04 Activation of TREK1 channel (unknown origin) expressed in Xenopus oocytes assessed as ratio of current in presence of compound to current in absence of compound at 20 uM incubated for 15 mins by two-microelectrode voltage-clamp technique ChEMBL. 24561669

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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