Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | disco interacting protein 2 | 0.0047 | 0.0981 | 0.224 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.438 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.438 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.438 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.438 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0102 | 1 | 0.5 |
Echinococcus granulosus | disco interacting protein 2 | 0.0047 | 0.0981 | 0.224 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.438 | 1 |
Brugia malayi | Disco-interacting protein 2 homolog | 0.0047 | 0.0981 | 0.224 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.438 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.438 | 1 |
Onchocerca volvulus | 0.0047 | 0.0981 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0981 | 0.224 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.438 | 1 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.438 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.438 | 1 |
Schistosoma mansoni | disco-interacting protein 2 (dip2) | 0.0047 | 0.0981 | 0.224 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.438 | 1 |
Brugia malayi | RNA binding protein | 0.0067 | 0.438 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.438 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 27.9 uM | Inhibition of human N-terminal 600 residues-deleted DNMT1 using poly(dI-dC) as substrate in presence of AdoMet | ChEMBL. | 24387159 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.