Detailed information for compound 182549

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 308.465 | Formula: C16H32N6
  • H donors: 6 H acceptors: 0 LogP: -2.26 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: NCCC(NCc1ccc(cc1)CNC(CCN)CN)CN
  • InChi: 1S/C16H32N6/c17-7-5-15(9-19)21-11-13-1-2-14(4-3-13)12-22-16(10-20)6-8-18/h1-4,15-16,21-22H,5-12,17-20H2
  • InChiKey: BFAMLUAYNATHFN-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0422 0.0422
Echinococcus granulosus multidrug resistance protein 1 0.0014 0.0225 0.0225
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0148 0.0309
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0357 0.0748
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0159 0.4776 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0021 0.0422 0.0422
Brugia malayi ABC transporter family protein 0.0021 0.0422 0.0884
Onchocerca volvulus 0.0022 0.0458 0.3928
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0159 0.4776 0.4776
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0022 0.0458 0.0958
Loa Loa (eye worm) hypothetical protein 0.0019 0.0357 0.0357
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0557 0.1165
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0022 0.0458 0.5
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0148 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0458 0.0958
Echinococcus multilocularis importin subunit beta 1 0.003 0.0727 0.0727
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0148 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.1067 0.2233
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0011 0.0124 0.026
Schistosoma mansoni immunophilin 0.0159 0.4776 0.4776
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0458 0.0958
Echinococcus granulosus FK506 binding protein 2 0.0022 0.0458 0.0458
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0546 0.1143
Trichomonas vaginalis abcb9, putative 0.0021 0.0422 0.0884
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0159 0.4776 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0148 0.0309
Echinococcus multilocularis ATP binding cassette sub family B 0.0021 0.0415 0.0415
Plasmodium falciparum multidrug resistance protein 1 0.0021 0.0422 0.0884
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0012 0.0148 0.0148
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0148 0.0826
Trichomonas vaginalis fk506-binding protein, putative 0.0022 0.0458 0.0958
Echinococcus granulosus Chromo domain 0.0012 0.0148 0.0148
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0148 0.0309
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0557 0.1165
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0422 0.0884
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0148 0.0148
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0422 0.0884
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0474 0.0474
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0011 0.0124 0.0696
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0422 0.0422
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0148 0.0309
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0357 0.0748
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0422 0.0884
Onchocerca volvulus 0.0022 0.0458 0.3928
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0325 1 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0021 0.0422 0.2363
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0148 0.0309
Trichomonas vaginalis fk506-binding protein, putative 0.0159 0.4776 1
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0422 0.0422
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0022 0.0458 0.0958
Schistosoma mansoni immunophilin 0.0159 0.4776 0.4776
Echinococcus multilocularis fk506 binding protein 0.0159 0.4776 0.4776
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0159 0.4776 1
Leishmania major GTP-binding protein, putative 0.0022 0.0474 0.0992
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0422 0.0884
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0727 0.1522
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0422 0.0422
Schistosoma mansoni chromobox protein 0.0012 0.0148 0.0148
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0148 0.0148
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0159 0.4776 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1787 0.3741
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0422 0.0884
Leishmania major peptidylprolyl isomerase-like protein 0.0159 0.4776 1
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0422 0.0422
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0727 0.4069
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0021 0.0422 0.0422
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0022 0.0458 0.0958
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0148 0.0309
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0557 0.1165
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0557 0.1165
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0557 0.3115
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.0148
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0474 0.0992
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0022 0.0458 0.0958
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0325 0.182
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0546 0.1143
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0422 0.0884
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0422 0.0884
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0137 0.4087 0.4087
Loa Loa (eye worm) hypothetical protein 0.0022 0.0458 0.0458
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0159 0.4776 1
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0148 0.0309
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.0148
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0148 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0688 0.144
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0688 0.144
Trichomonas vaginalis chromobox protein, putative 0.0044 0.1165 0.244
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0148 0.0309
Mycobacterium ulcerans hypothetical protein 0.0025 0.0557 0.1165
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0148 0.0148
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0022 0.0458 0.0458
Mycobacterium ulcerans hypothetical protein 0.0022 0.0458 0.0958
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0474 0.0474
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0148 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0148 0.0309
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0159 0.4776 1
Leishmania major p-glycoprotein 0.0021 0.0422 0.0884
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0422 0.0884
Onchocerca volvulus 0.0012 0.0148 0.1267
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0022 0.0458 0.0958
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0422 0.0884
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0557 0.1165
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0148 0.0309
Trichomonas vaginalis ran, putative 0.0022 0.0474 0.0992
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0474 0.0992
Schistosoma mansoni hypothetical protein 0.0325 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0422 0.0884
Loa Loa (eye worm) hypothetical protein 0.0032 0.0786 0.0786
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0022 0.0458 0.0958
Brugia malayi SWIB/MDM2 domain containing protein 0.0011 0.0124 0.026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0325 0.182
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0557 0.1165
Trichomonas vaginalis chromobox protein, putative 0.0074 0.2084 0.4364
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.1067 0.9154
Loa Loa (eye worm) hypothetical protein 0.0025 0.0557 0.0557
Echinococcus multilocularis multidrug resistance protein 1 0.0014 0.0225 0.0225
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0422 0.0884
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0012 0.0148 0.0148
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0557 0.1165
Entamoeba histolytica P-glycoprotein-5 0.0021 0.0422 0.0884
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0159 0.4776 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0022 0.0458 0.0458
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0159 0.4776 0.4776
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0148 0.0309
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0124 0.026
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1787 0.3741
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0148 0.0309
Brugia malayi SET domain containing protein 0.0012 0.0148 0.0309
Loa Loa (eye worm) hypothetical protein 0.0019 0.0357 0.0357
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0422 0.0884
Brugia malayi Importin beta-1 subunit 0.003 0.0727 0.1522
Schistosoma mansoni ran 0.0022 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.0019 0.0357 0.0357
Echinococcus multilocularis Chromo domain 0.0012 0.0148 0.0148
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0474 0.0992
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0022 0.0458 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0148 0.0309
Brugia malayi chromobox protein homolog 3 0.0041 0.1067 0.2233
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0124 0.0124
Entamoeba histolytica P-glyco protein 6, putative 0.0021 0.0422 0.0884
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0474 0.0992
Echinococcus granulosus chromobox protein 1 0.0074 0.2084 0.2084
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0137 0.4087 0.4087
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0422 0.0884
Trichomonas vaginalis hypothetical protein 0.0012 0.0148 0.0309
Leishmania major importin beta-1 subunit, putative 0.0025 0.0546 0.1143
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0148 0.0309
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0557 0.3115
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0557 1
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0022 0.0458 0.0958
Loa Loa (eye worm) hypothetical protein 0.0021 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0019 0.0357 0.0357
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.1787 0.1787
Brugia malayi hypothetical protein 0.0012 0.0148 0.0309
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0159 0.4776 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0159 0.4776 1
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0422 0.0884
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.0148
Schistosoma mansoni fk506 binding protein 0.0022 0.0458 0.0458
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.0148
Trichomonas vaginalis chromobox protein, putative 0.0074 0.2084 0.4364
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0474 0.2653
Trichomonas vaginalis taga, putative 0.0021 0.0422 0.0884
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0022 0.0458 0.0958
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0022 0.0458 0.0958
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0422 0.0422
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0557 0.1165
Loa Loa (eye worm) FKBP5 protein 0.0159 0.4776 0.4776
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0422 0.0884
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0022 0.0458 0.2562
Onchocerca volvulus 0.0025 0.0557 0.4777
Onchocerca volvulus 0.0012 0.0148 0.1267
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0022 0.0458 0.0958
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.0148
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0159 0.4776 1
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0148 0.0309
Echinococcus granulosus SWI:SNF matrix associated 0.0011 0.0124 0.0124
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0124 0.026
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.1787 1
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0422 0.0884
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0422 0.0884
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0148 0.0826
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0325 0.182
Echinococcus multilocularis chromobox protein 1 0.0074 0.2084 0.2084
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0474 0.0474
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0148 0.0309
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0422 0.0884
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0557 0.1165
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0022 0.0458 0.0958
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0422 0.0422
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.1165 1
Plasmodium vivax importin-beta 2, putative 0.003 0.0727 0.1522
Leishmania major fk506-binding protein 1-like protein 0.0159 0.4776 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0422 0.0884
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0148 0.0148
Echinococcus granulosus importin subunit beta 1 0.003 0.0727 0.0727
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0557 0.1165
Brugia malayi Protein cec-1. 0.0012 0.0148 0.0309
Plasmodium vivax heterochromatin protein 1, putative 0.0012 0.0148 0.0309
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0557 0.1165
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0422 0.0884
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0148 0.0309
Onchocerca volvulus 0.0011 0.0124 0.1067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0148 0.0309
Schistosoma mansoni hypothetical protein 0.0011 0.0124 0.0124
Trichomonas vaginalis abcb9, putative 0.0021 0.0422 0.0884
Entamoeba histolytica hypothetical protein 0.0012 0.0148 0.0309
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0022 0.0458 0.0458
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0022 0.0458 0.2562
Loa Loa (eye worm) hypothetical protein 0.0021 0.0422 0.0422
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0022 0.0458 0.0958
Plasmodium vivax multidrug resistance protein 1, putative 0.0021 0.0422 0.0884
Trichomonas vaginalis fk506 binding protein, putative 0.0022 0.0458 0.0958
Trichomonas vaginalis chromobox protein, putative 0.0044 0.1165 0.244
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0422 0.0884
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0022 0.0458 0.0958
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0422 0.0422
Brugia malayi RNA, U transporter 1 0.0087 0.2494 0.5222
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0422 0.0422
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0148 0.0148
Entamoeba histolytica hypothetical protein 0.0012 0.0148 0.0309
Brugia malayi CHD4 protein 0.0012 0.0148 0.0309
Echinococcus multilocularis 0.0022 0.0458 0.0458
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.2084 0.2084
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0422 0.0422
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0557 0.1165
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0148 0.0309
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0148 0.0148
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0022 0.0458 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.4087 0.4087
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0021 0.0415 0.0415
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0148 0.0826
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0011 0.0124 0.026
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0159 0.4776 1
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0021 0.0422 0.8934
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0011 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0025 0.0557 0.0557
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0422 0.0884
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0148 0.0309
Schistosoma mansoni hypothetical protein 0.0012 0.0148 0.0148
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0022 0.0458 0.0958
Loa Loa (eye worm) brahma associated protein 0.0011 0.0124 0.0124
Schistosoma mansoni multidrug resistance protein 0.0021 0.0422 0.0422
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.1787 0.1787
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0357 0.6991
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0557 0.1165
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0011 0.0124 0.026
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0148 0.0309
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0357 0.2
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0225 0.0471
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0325 0.182
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0022 0.0458 0.2562
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0422 0.0884
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0422 0.0884
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0011 0.0124 0.0124
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0159 0.4776 0.4776
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0422 0.0884
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0159 0.4776 0.4776
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0159 0.4776 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0422 0.0884
Echinococcus multilocularis chromobox protein 1 0.0074 0.2084 0.2084
Schistosoma mansoni ran 0.0022 0.0474 0.0474
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0159 0.4776 1
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0422 0.0422
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0148 0.0309
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0148 0.0309
Echinococcus granulosus multidrug resistance protein 1 0.0014 0.0225 0.0225
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.1787 1
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.0022 0.0458 0.8223
Trichomonas vaginalis fk506-binding protein, putative 0.0022 0.0458 0.0958
Brugia malayi Heterochromatin protein 1 0.0074 0.2084 0.4364
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0159 0.4776 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0022 0.0458 0.0958
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0148 0.0148
Echinococcus multilocularis chromobox protein 2 0.0012 0.0148 0.0148
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0546 0.1143
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.1787 0.1787
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0011 0.0124 0.0124
Onchocerca volvulus 0.0032 0.0786 0.6747
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0022 0.0458 0.0958
Schistosoma mansoni multidrug resistance protein 0.0021 0.0422 0.0422
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0148 0.0309
Schistosoma mansoni multidrug resistance protein 0.0021 0.0422 0.0422
Echinococcus granulosus chromobox protein 1 0.0074 0.2084 0.2084
Loa Loa (eye worm) hypothetical protein 0.0041 0.1067 0.1067
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0124 0.0124
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0124 0.026
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0557 0.1165
Schistosoma mansoni importin beta-1 0.003 0.0727 0.0727
Onchocerca volvulus 0.0021 0.0422 0.3623
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0422 0.0422
Onchocerca volvulus 0.0012 0.0148 0.1267
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.0148
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0159 0.4776 1
Schistosoma mansoni chromobox protein 0.0074 0.2084 0.2084
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0474 0.0992
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0022 0.0458 0.0958
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.0148
Entamoeba histolytica hypothetical protein 0.0025 0.0546 0.1143
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0159 0.4776 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0012 0.0148 0.0148
Entamoeba histolytica hypothetical protein 0.0012 0.0148 0.0309
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0422 0.2363
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0148 0.0309
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0422 0.0884
Echinococcus granulosus Chromobox protein 3 0.0012 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0022 0.0458 0.0458
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0148 0.0309
Trichomonas vaginalis abcb9, putative 0.0021 0.0422 0.0884
Entamoeba histolytica P-glycoprotein 5, putative 0.0021 0.0422 0.0884
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0557 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0022 0.0458 0.0958
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0148 0.0148
Brugia malayi multidrug resistance protein 3 0.0021 0.0422 0.0884
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0557 0.1165
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0022 0.0458 0.0458
Loa Loa (eye worm) hypothetical protein 0.0019 0.0357 0.0357
Entamoeba histolytica Ran family GTPase 0.0022 0.0474 0.0992
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0546 0.1143
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0011 0.0124 0.0696
Loa Loa (eye worm) helicase 0.0012 0.0148 0.0148
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0727 0.1522
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0148 0.0309
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0022 0.0458 0.0458
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1787 0.3741
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0474 0.0992
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.1787 0.1787
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0124 0.026
Schistosoma mansoni hypothetical protein 0.0011 0.0124 0.0124
Echinococcus multilocularis snurportin 1 0.0325 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0422 0.0422
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.1787 0.3741
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0021 0.0422 0.0884
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0557 0.1165
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0422 0.0422
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0021 0.0422 0.2363
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0022 0.0458 0.2562
Schistosoma mansoni chromobox protein 0.0074 0.2084 0.2084
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.1067 0.2233
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0159 0.4776 1
Schistosoma mansoni brg-1 associated factor 0.0011 0.0124 0.0124
Schistosoma mansoni smdr2 0.0021 0.0422 0.0422
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0124 0.0124
Plasmodium falciparum importin beta, putative 0.003 0.0727 0.1522
Schistosoma mansoni chromobox protein 0.0012 0.0148 0.0148
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0148 0.0309
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0159 0.4776 0.4776
Schistosoma mansoni hypothetical protein 0.0011 0.0124 0.0124
Entamoeba histolytica P-glycoprotein-1 0.0021 0.0422 0.0884
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0458 0.0958
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0357 0.0748
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0148 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0148 0.0309
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0422 0.0422
Echinococcus granulosus chromobox protein 2 0.0012 0.0148 0.0148
Entamoeba histolytica P-glycoprotein-2, putative 0.0021 0.0422 0.0884
Loa Loa (eye worm) hypothetical protein 0.0025 0.0557 0.0557
Trichomonas vaginalis immunophilin, putative 0.0159 0.4776 1
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0022 0.0458 0.2562
Trichomonas vaginalis Heterochromatin protein, putative 0.0012 0.0148 0.0309
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0422 0.0884
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0159 0.4776 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0474 0.0038
Loa Loa (eye worm) hypothetical protein 0.003 0.0727 0.0727
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0148 0.0309
Schistosoma mansoni immunophilin 0.0137 0.4087 0.4087
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0148 0.0309
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0148 0.0309

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 9.3 uM Inhibition of spermidine transport determined in T-47D human breast cancer cells ChEMBL. 12951106
Ki (functional) = 9.3 uM Inhibition of spermidine transport determined in T-47D human breast cancer cells ChEMBL. 12951106

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 12951106

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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