Detailed information for compound 1825671

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 330.421 | Formula: C19H26N2O3
  • H donors: 0 H acceptors: 1 LogP: 4.21 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c1cnc(n1C)OCCCCCCCCO2
  • InChi: 1S/C19H26N2O3/c1-21-17-14-20-19(21)24-12-8-6-4-3-5-7-11-23-18-10-9-15(22-2)13-16(17)18/h9-10,13-14H,3-8,11-12H2,1-2H3
  • InChiKey: JHFXITBLDXDDDM-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0015 0.0269 0.0424
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0099 0.0083
Schistosoma mansoni cell adhesion molecule 0.0015 0.0269 0.0269
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0148 0.0213
Schistosoma mansoni smad 0.0008 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0148 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0148 0.0213
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0074 0.0059
Schistosoma mansoni coup transcription factor 0.001 0.0148 0.0148
Brugia malayi Fibronectin type III domain containing protein 0.0015 0.0269 0.04
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0356 0.0567
Loa Loa (eye worm) projectin 0.0015 0.0269 0.0424
Echinococcus multilocularis cell adhesion molecule 0.0015 0.0269 0.0253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Onchocerca volvulus 0.0018 0.0356 0.0565
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Echinococcus granulosus anosmin 1 0.0015 0.0269 0.0253
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0016 0.001
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Schistosoma mansoni nephrin 0.0015 0.0269 0.0269
Schistosoma mansoni hypothetical protein 0.0398 1 1
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0018 0.0356 0.0356
Onchocerca volvulus 0.0015 0.0269 0.042
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0033 0.0727 0.0712
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.0356 1
Schistosoma mansoni titin 0.0015 0.0269 0.0269
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0118 0.0177
Schistosoma mansoni Smad4 0.0008 0.0099 0.0099
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0074 0.0074
Schistosoma mansoni hemicentin 0.0015 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0148 0.0226
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0148 0.0226
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0269 0.0424
Onchocerca volvulus 0.0018 0.0356 0.0565
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0269 0.04
Echinococcus multilocularis roundabout 2 0.0015 0.0269 0.0253
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0016 0.0016
Brugia malayi orphan nuclear receptor NR2E1 0.0005 0.0016 0.001
Brugia malayi Fibronectin type III domain containing protein 0.0015 0.0269 0.04
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0018 0.0356 0.0534
Brugia malayi Fibronectin type III domain containing protein 0.0015 0.0269 0.04
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0356 0.0341
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0356 0.0341
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Loa Loa (eye worm) hypothetical protein 0.0145 0.3587 0.5844
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0015 0.0269 0.0253
Brugia malayi myotactin form A 0.0015 0.0269 0.04
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0015 0.0269 0.0424
Brugia malayi Protein-tyrosine phosphatase 1 0.0018 0.0356 0.0534
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0016 0.0016
Schistosoma mansoni smad1 5 8 and 0.0008 0.0099 0.0099
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0356 0.0341
Schistosoma mansoni nuclear hormone receptor 0.001 0.0148 0.0148
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0269 0.04
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Schistosoma mansoni cell adhesion molecule 0.0015 0.0269 0.0269
Echinococcus multilocularis 0.0018 0.0356 0.0341
Onchocerca volvulus 0.0018 0.0356 0.0565
Brugia malayi CXXC zinc finger family protein 0.0028 0.0608 0.0921
Onchocerca volvulus 0.0015 0.0269 0.042
Brugia malayi nuclear receptor RXR 0.0005 0.0016 0.001
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0356 0.0567
Loa Loa (eye worm) lethal protein 805 0.0015 0.0269 0.0424
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.003 0.003
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0033 0.0727 0.0727
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Schistosoma mansoni nuclear receptor 0.0005 0.0016 0.0016
Brugia malayi hypothetical protein 0.0018 0.0356 0.0534
Brugia malayi Smad1 0.0008 0.0099 0.0138
Echinococcus granulosus anosmin 1 0.0015 0.0269 0.0253
Echinococcus granulosus cell adhesion molecule 0.0015 0.0269 0.0253
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0148 0.0213
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.003 0.0034
Brugia malayi ecdysteroid receptor 0.001 0.0148 0.0213
Loa Loa (eye worm) hypothetical protein 0.0246 0.6132 1
Brugia malayi Protein-tyrosine phosphatase 0.026 0.6503 1
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0148 0.0213
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0015 0.0269 0.0253
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0018 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0356 0.0567
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0148 0.0226
Brugia malayi ecdysone receptor 0.0005 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Echinococcus multilocularis usherin 0.0015 0.0269 0.0253
Onchocerca volvulus 0.0018 0.0356 0.0565
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0269 0.0269
Onchocerca volvulus 4.1 G protein, putative homolog 0.0018 0.0356 0.0565
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0148 0.0148
Onchocerca volvulus 0.0018 0.0356 0.0565
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0005 0.0016 0.0011
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0148 0.0132
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0356 0.0341
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0148 0.0219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0148 0.0132
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0356 0.0567
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Onchocerca volvulus 0.0018 0.0356 0.0565
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0018 0.0356 1
Brugia malayi nuclear hormone receptor 0.0005 0.0016 0.001
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0099 0.0083
Schistosoma mansoni cpg binding protein 0.0028 0.0608 0.0608
Echinococcus multilocularis cpg binding protein 0.003 0.0648 0.0633
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0356 0.0341
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0356 0.0567
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0148 0.0226
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0356 0.0567
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0356 0.0341
Echinococcus granulosus EG95 0.0015 0.0269 0.0253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Brugia malayi MH1 domain containing protein 0.0008 0.0099 0.0138
Schistosoma mansoni titin 0.0015 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Brugia malayi Protein-tyrosine phosphatase 0.0018 0.0356 0.0534
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0018 0.0356 0.0534
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Echinococcus multilocularis roundabout 2 0.0015 0.0269 0.0253
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0148 0.0148
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0608 0.0977
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Schistosoma mansoni cell adhesion molecule 0.0015 0.0269 0.0269
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2847 0.4634
Echinococcus multilocularis anosmin 1 0.0015 0.0269 0.0253
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0033 0.0727 0.0712
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0015 0.0269 0.0424
Brugia malayi protein unc-22 0.0015 0.0269 0.04
Onchocerca volvulus 0.0018 0.0356 0.0565
Schistosoma mansoni ephrin receptor 0.0015 0.0269 0.0269
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0005 0.0016 0.001
Schistosoma mansoni nuclear receptor 0.0005 0.0016 0.0016
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0016 0.001
Loa Loa (eye worm) CAMK protein kinase 0.0015 0.0269 0.0424
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0269 0.04
Echinococcus granulosus anosmin 1 0.0015 0.0269 0.0253
Schistosoma mansoni factor for adipocyte differentiation 0.0015 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0018 0.0356 0.0341
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0148 0.0148
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0033 0.0727 0.0712
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0269 0.04
Loa Loa (eye worm) hypothetical protein 0.0005 0.003 0.0034
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0018 0.0356 0.0341
Onchocerca volvulus 0.0018 0.0356 0.0565
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0269 0.0424
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Schistosoma mansoni neuroglian 0.0015 0.0269 0.0269
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0356 0.0341
Echinococcus multilocularis smad 0.0008 0.0099 0.0083
Loa Loa (eye worm) protein tyrosine phosphatase 0.0018 0.0356 0.0567
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Onchocerca volvulus 0.0018 0.0356 0.0565
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0356 0.0567
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0356 0.0341
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0148 0.0132
Echinococcus granulosus smad 0.0008 0.0099 0.0083
Onchocerca volvulus 0.0015 0.0269 0.042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0148 0.0132
Echinococcus granulosus fibronectin type III domain-containing protein 0.0015 0.0269 0.0253
Schistosoma mansoni nephrin 0.0015 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Schistosoma mansoni titin 0.0015 0.0269 0.0269
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0015 0.0269 0.0253
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0018 0.0356 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0148 0.0226
Onchocerca volvulus 0.0018 0.0356 0.0565
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Echinococcus granulosus Smad4 0.0008 0.0099 0.0083
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0148 0.0132
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0074 0.0059
Onchocerca volvulus 0.0015 0.0269 0.042
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0356 0.0341
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0356 0.0567
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.0356 1
Brugia malayi Lethal protein 805 0.0015 0.0269 0.04
Onchocerca volvulus 0.0015 0.0269 0.042
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0148 0.0219
Brugia malayi hypothetical protein 0.0018 0.0356 0.0534
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0148 0.0226
Onchocerca volvulus 0.0018 0.0356 0.0565
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0016 0.0016
Echinococcus granulosus Netrin receptor DCC 0.0015 0.0269 0.0253
Onchocerca volvulus 0.0028 0.0608 0.0981
Loa Loa (eye worm) myotactin form A 0.0015 0.0269 0.0424
Echinococcus multilocularis transfer RNA-Phe 0.0015 0.0269 0.0253
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Schistosoma mansoni smad1 5 8 and 0.0008 0.0099 0.0099
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0356 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0148 0.0213
Schistosoma mansoni thyroid hormone receptor 0.001 0.0148 0.0148
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0015 0.0269 0.0424
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0148 0.0148
Brugia malayi Fibronectin type III domain containing protein 0.0015 0.0269 0.04
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0018 0.0356 0.0341
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0018 0.0356 0.0356
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0148 0.0132
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Brugia malayi Fibronectin type III domain containing protein 0.0015 0.0269 0.04
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0015 0.0269 0.0253
Brugia malayi hypothetical protein 0.0018 0.0356 0.0534
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Brugia malayi hypothetical protein 0.0015 0.0269 0.04
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0033 0.0727 0.0712
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0148 0.0213
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0148 0.0226
Loa Loa (eye worm) hypothetical protein 0.001 0.0148 0.0226
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0356 0.0341
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1403 0.1403
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0018 0.0356 0.0567
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0356 0.0567
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0018 0.0356 0.0356
Brugia malayi steroid hormone receptor 0.001 0.0148 0.0213
Brugia malayi nuclear receptor NHR-88 0.001 0.0148 0.0213
Echinococcus granulosus FTZ F1 alpha 0.001 0.0148 0.0132
Onchocerca volvulus 0.0018 0.0356 0.0565
Loa Loa (eye worm) hypothetical protein 0.001 0.0148 0.0226
Onchocerca volvulus 0.0015 0.0269 0.042
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0356 0.0356
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0015 0.0269 0.0253
Echinococcus granulosus roundabout 2 0.0015 0.0269 0.0253
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Onchocerca volvulus 0.0015 0.0269 0.042
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0099 0.0147
Brugia malayi nuclear receptor RXR 0.0005 0.003 0.0032
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0033 0.0727 0.0727
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0118 0.0102
Brugia malayi hypothetical protein 0.0005 0.003 0.0032
Echinococcus granulosus roundabout 2 0.0015 0.0269 0.0253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0033 0.0727 0.0727
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Echinococcus granulosus titin 0.0015 0.0269 0.0253
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0148 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0148 0.0213
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0356 0.0341
Brugia malayi conserved hypotetical protein 0.0005 0.0016 0.001
Echinococcus multilocularis roundabout 2 0.0015 0.0269 0.0253
Loa Loa (eye worm) hypothetical protein 0.0228 0.5674 0.9252
Brugia malayi MH1 domain containing protein 0.0008 0.0099 0.0138
Echinococcus multilocularis Netrin receptor DCC 0.0015 0.0269 0.0253
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Brugia malayi nuclear hormone receptor family member nhr-6 0.0005 0.0016 0.001
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Onchocerca volvulus 0.0018 0.0356 0.0565
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0356 0.0341
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0018 0.0356 0.0356
Onchocerca volvulus 0.0018 0.0356 0.0565
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0148 0.0213
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0356 0.0567
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.0356 0.0356
Echinococcus granulosus neuroglian 0.0015 0.0269 0.0253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Brugia malayi hypothetical protein 0.0018 0.0356 0.0534
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0148 0.0219
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0033 0.0727 0.0727
Onchocerca volvulus 0.0015 0.0269 0.042
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0018 0.0356 0.0341
Brugia malayi MH2 domain containing protein 0.0008 0.0099 0.0138
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0269 0.04
Echinococcus multilocularis neuroglian 0.0015 0.0269 0.0253
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0074 0.0059
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0033 0.0727 0.0712
Echinococcus granulosus muscleblind protein 0.0145 0.3587 0.3577
Brugia malayi hypothetical protein 0.0005 0.0016 0.001
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.0356 1
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0015 0.0269 0.0253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Echinococcus granulosus Fibronectin type III domain containing protein 0.0015 0.0269 0.0253
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0018 0.0356 0.5
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0033 0.0727 0.0712
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0269 0.04
Loa Loa (eye worm) nuclear hormone receptor 0.0005 0.0016 0.0011
Echinococcus granulosus roundabout 2 0.0015 0.0269 0.0253
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0018 0.0356 0.0356
Loa Loa (eye worm) DR-78 0.0005 0.0016 0.0011
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0018 0.0356 0.0356
Brugia malayi Lethal protein 805 0.0015 0.0269 0.04
Loa Loa (eye worm) hypothetical protein 0.001 0.0148 0.0226
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0148 0.0213
Loa Loa (eye worm) Smad1 0.0008 0.0099 0.0147
Trypanosoma brucei protein tyrosine phosphatase 1 0.0018 0.0356 1
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0018 0.0356 0.0567
Schistosoma mansoni cell adhesion molecule 0.0015 0.0269 0.0269
Echinococcus multilocularis hypothetical protein 0.0018 0.0356 0.0341
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0356 0.0341
Echinococcus multilocularis muscleblind protein 0.0145 0.3587 0.3577
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0033 0.0727 0.0712
Echinococcus multilocularis titin 0.0015 0.0269 0.0253
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0033 0.0727 0.0712
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.003 0.0032
Brugia malayi SPRY domain containing protein 0.0015 0.0269 0.04
Onchocerca volvulus 0.0015 0.0269 0.042
Onchocerca volvulus 0.0015 0.0269 0.042
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0148 0.0213
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Onchocerca volvulus 0.0242 0.6045 1
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0033 0.0727 0.1172
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0015 0.0269 0.04
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Onchocerca volvulus 0.0018 0.0356 0.0565
Schistosoma mansoni zinc finger protein 0.0005 0.0016 0.0016
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0015 0.0269 0.04
Schistosoma mansoni cpg binding protein 0.003 0.0648 0.0648
Brugia malayi hypothetical protein 0.0015 0.0269 0.04
Brugia malayi hypothetical protein 0.0005 0.003 0.0032
Schistosoma mansoni hypothetical protein 0.0015 0.0269 0.0269
Brugia malayi nuclear receptor NHR-88 0.0005 0.0016 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0099 0.0147
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.003 0.0032
Schistosoma mansoni cell adhesion molecule 0.0015 0.0269 0.0269
Onchocerca volvulus 0.001 0.0148 0.0219
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0015 0.0269 0.0253
Loa Loa (eye worm) hypothetical protein 0.001 0.0148 0.0226
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0016 0.0016
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0015 0.0269 0.0253
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Schistosoma mansoni smad1 5 8 and 0.0008 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0228 0.5674 0.9252
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Loa Loa (eye worm) nuclear receptor NHR-67 0.0005 0.0016 0.0011
Schistosoma mansoni pcd6 interacting protein-related 0.0018 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.001 0.0148 0.0226
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0148 0.0132
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0356 0.0341
Brugia malayi MH2 domain containing protein 0.0008 0.0099 0.0138
Schistosoma mansoni tripartite motif protein trim9 0.0015 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0005 0.003 0.0034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0356 0.0567
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0356 0.0341
Echinococcus granulosus Netrin receptor DCC 0.0015 0.0269 0.0253
Brugia malayi Muscleblind-like protein 0.0145 0.3587 0.551
Schistosoma mansoni thyroid hormone receptor 0.001 0.0148 0.0148
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0018 0.0356 0.0341
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0356 0.0341
Onchocerca volvulus 0.0018 0.0356 0.0565
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0269 0.04
Loa Loa (eye worm) hypothetical protein 0.0005 0.003 0.0034
Brugia malayi nuclear hormone receptor 0.001 0.0148 0.0213
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0015 0.0269 0.04
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Onchocerca volvulus 0.0018 0.0356 0.0565
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0099 0.0099
Echinococcus multilocularis dnaJ subfamily B 0.0398 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0148 0.0213
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0018 0.0356 0.0567
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Echinococcus granulosus Fibronectin type III 0.0015 0.0269 0.0253
Loa Loa (eye worm) hypothetical protein 0.001 0.0148 0.0226
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0018 0.0356 0.0356
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0356 0.0341
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0269 0.0424
Schistosoma mansoni protein tyrosine phosphatase 0.0033 0.0727 0.0727
Schistosoma mansoni factor for adipocyte differentiation 0.0015 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0033 0.0727 0.0712
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0018 0.0356 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0148 0.0132
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0018 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0005 0.003 0.0034
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Brugia malayi nuclear receptor NHR-67 0.0005 0.0016 0.001
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0115 0.0163
Schistosoma mansoni factor for adipocyte differentiation 0.0015 0.0269 0.0269
Onchocerca volvulus 0.0015 0.0269 0.042
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2847 0.4634
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0148 0.0213
Brugia malayi tailless protein 0.0005 0.0016 0.001
Loa Loa (eye worm) UNCoordinated family member 0.0015 0.0269 0.0424
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0269 0.04
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0148 0.0132
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0099 0.0083
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0099 0.0083
Echinococcus multilocularis Fibronectin, type III 0.0015 0.0269 0.0253
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0356 0.0341
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0269 0.04
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0269 0.0424
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1242 0.5
Schistosoma mansoni hypothetical protein 0.0015 0.0269 0.0269
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0015 0.0269 0.0424
Onchocerca volvulus 0.0018 0.0356 0.0565
Echinococcus granulosus G1Y162 protein 0.0015 0.0269 0.0253
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0148 0.0148
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0118 0.0102
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0148 0.0132
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0269 0.0424
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0356 0.0341
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0269 0.04
Giardia lamblia Protein tyrosine phosphatase 0.0018 0.0356 0.5
Brugia malayi hypothetical protein 0.0005 0.0016 0.001
Schistosoma mansoni hypothetical protein 0.0015 0.0269 0.0269
Echinococcus multilocularis Netrin receptor DCC 0.0015 0.0269 0.0253
Brugia malayi nuclear hormone receptor family member odr-7 0.0005 0.0016 0.001
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Loa Loa (eye worm) hypothetical protein 0.001 0.0148 0.0226
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0074 0.0059
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0269 0.04
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0018 0.0356 0.0341
Echinococcus multilocularis Smad4 0.0008 0.0099 0.0083
Trichomonas vaginalis pten, drome, putative 0.0018 0.0356 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0356 0.0341
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0148 0.0226
Echinococcus multilocularis muscleblind protein 1 0.0145 0.3587 0.3577
Brugia malayi hypothetical protein 0.0018 0.0356 0.0534
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0148 0.0213
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0148 0.0132
Leishmania major tyrosine specific protein phosphatase, putative 0.0018 0.0356 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Loa Loa (eye worm) hypothetical protein 0.0145 0.3587 0.5844
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0269 0.04
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0356 0.0567
Onchocerca volvulus 0.0018 0.0356 0.0565
Echinococcus multilocularis titin 0.0015 0.0269 0.0253
Onchocerca volvulus 0.0015 0.0269 0.042
Loa Loa (eye worm) hypothetical protein 0.0228 0.5674 0.9252
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0148 0.0132
Schistosoma mansoni myosin-binding protein-related 0.0015 0.0269 0.0269
Brugia malayi MH2 domain containing protein 0.0116 0.2847 0.437
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0018 0.0356 0.0341
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.003 0.0014
Echinococcus granulosus protein tyrosine phosphatase n9 0.0018 0.0356 0.0341
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0356 0.0567
Echinococcus granulosus contactin 0.0015 0.0269 0.0253
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0356 0.0567
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0356 0.0341
Brugia malayi Fibronectin type III domain containing protein 0.0015 0.0269 0.04
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0033 0.0727 0.0727
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Schistosoma mansoni cpg binding protein 0.003 0.0648 0.0648
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0148 0.0132
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0148 0.0132
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Onchocerca volvulus 0.0015 0.0269 0.042
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0148 0.0226
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0033 0.0727 0.0712
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0356 0.0341
Echinococcus granulosus usherin 0.0015 0.0269 0.0253
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0148 0.0213
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0015 0.0269 0.0253
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0148 0.0132
Echinococcus granulosus nephrin 0.0015 0.0269 0.0253
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0148 0.0132
Echinococcus multilocularis anosmin 1 0.0015 0.0269 0.0253
Onchocerca volvulus 0.0018 0.0356 0.0565
Onchocerca volvulus 0.0018 0.0356 0.0565
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0356 0.0567
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0356 0.0534
Echinococcus granulosus cpg binding protein 0.003 0.0648 0.0633
Brugia malayi myotactin form B 0.0015 0.0269 0.04
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0424
Loa Loa (eye worm) hypothetical protein 0.0005 0.003 0.0034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0567
Echinococcus multilocularis anosmin 1 0.0015 0.0269 0.0253
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0148 0.0213
Echinococcus granulosus titin 0.0015 0.0269 0.0253
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0015 0.0269 0.0253
Onchocerca volvulus 0.0018 0.0356 0.0565
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0148 0.0148
Onchocerca volvulus 0.0018 0.0356 0.0565

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 40 uM Cytotoxicity against apoptotic-sensitive human PC3 cells assessed as growth inhibition after 72 hrs by MTT-based colorimetric assay ChEMBL. 23845202

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.