Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase | 0.0096 | 0.0058 | 0.0058 |
Echinococcus multilocularis | carbonic anhydrase | 0.0096 | 0.0058 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0058 | 0.0058 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0096 | 0.0058 | 0.0058 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.4148 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0096 | 0.0058 | 0.0058 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.4148 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.4148 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0096 | 0.0058 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0058 | 0.0058 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0205 | 0.0325 | 0.0325 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.4148 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0205 | 0.0325 | 0.0325 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.4148 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0096 | 0.0058 | 0.0058 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.4148 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.4148 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.4148 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0096 | 0.0058 | 0.0058 |
Schistosoma mansoni | hypothetical protein | 0.0096 | 0.0058 | 0.0058 |
Echinococcus granulosus | carbonic anhydrase | 0.0096 | 0.0058 | 0.0058 |
Echinococcus granulosus | carbonic anhydrase II | 0.0205 | 0.0325 | 0.0325 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0096 | 0.0058 | 0.0058 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.4148 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.4148 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0096 | 0.0058 | 0.0058 |
Trichomonas vaginalis | CMGC family protein kinase | 0.4148 | 1 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.4148 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0096 | 0.0058 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.4148 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.4148 | 1 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0096 | 0.0058 | 0.0058 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.4148 | 1 | 1 |
Onchocerca volvulus | 0.0073 | 0 | 0.5 | |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0096 | 0.0058 | 0.0058 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0205 | 0.0325 | 0.0325 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0205 | 0.0325 | 0.0325 |
Schistosoma mansoni | carbonic anhydrase | 0.0096 | 0.0058 | 0.0058 |
Trichomonas vaginalis | CMGC family protein kinase | 0.4148 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0205 | 0.0325 | 0.0325 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0205 | 0.0325 | 0.0325 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.4148 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0205 | 0.0325 | 0.0325 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0096 | 0.0058 | 0.0058 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.4148 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0058 | 0.0058 |
Trichomonas vaginalis | CMGC family protein kinase | 0.4148 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0096 | 0.0058 | 0.0058 |
Echinococcus multilocularis | carbonic anhydrase | 0.0096 | 0.0058 | 0.0058 |
Trypanosoma brucei | protein kinase, putative | 0.4148 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0073 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | > 70 % | Displacement of [3H]citalopram from Sprague-Dawley rat brain stem SERT site S1 at 10 uM by scintillation counting analysis | ChEMBL. | 24237160 |
Ki (binding) | = 50.9 nM | Displacement of [3H]citalopram from Sprague-Dawley rat brain stem SERT site S1 by scintillation counting analysis | ChEMBL. | 24237160 |
T1/2 (binding) | = 24.7 min | Allosteric modulation at wild-type human SERT site S2 expressed in african green monkey COS7 cells assessed as inhibition of [3H]citalopram dissociation by measuring half life at 30 uM at 18 degC by scintillation counting analysis | ChEMBL. | 24237160 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.