Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.4694 | 0.8448 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.4694 | 0.8448 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.4694 | 0.8448 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.4694 | 0.8448 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.4694 | 0.8448 | 0.8678 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.2871 | 0.461 | 0.4666 |
Trichomonas vaginalis | CMGC family protein kinase | 0.4694 | 0.8448 | 0.5 |
Echinococcus granulosus | WGR domain containing protein | 0.1623 | 0.1982 | 0.1839 |
Onchocerca volvulus | DNA ligase 3 homolog | 0.0682 | 0 | 0.5 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.2871 | 0.461 | 0.5456 |
Brugia malayi | WGR domain containing protein | 0.5226 | 0.9569 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.4694 | 0.8448 | 0.774 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.5226 | 0.9569 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.4694 | 0.8448 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.4694 | 0.8448 | 0.8794 |
Giardia lamblia | Kinase, CMGC MAPK | 0.4694 | 0.8448 | 0.5 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.5226 | 0.9569 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.4694 | 0.8448 | 0.8678 |
Loa Loa (eye worm) | hypothetical protein | 0.3978 | 0.6941 | 0.8216 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.2871 | 0.461 | 0.5456 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.4694 | 0.8448 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.2871 | 0.461 | 0.1413 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.2871 | 0.461 | 0.5456 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.5226 | 0.9569 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.4694 | 0.8448 | 0.8794 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.1623 | 0.1982 | 0.1839 |
Trypanosoma brucei | protein kinase, putative | 0.4694 | 0.8448 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.4694 | 0.8448 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.4694 | 0.8448 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.4694 | 0.8448 | 0.8059 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.4694 | 0.8448 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.4694 | 0.8448 | 1 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.2871 | 0.461 | 0.4152 |
Loa Loa (eye worm) | poly(ADP-ribose) polymerase | 0.206 | 0.29 | 0.3433 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.4694 | 0.8448 | 1 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.5226 | 0.9569 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2871 | 0.461 | 0.5456 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1 nM | Cytotoxicity against human MCF-7 cells assessed as growth inhibition after 72 hrs by WST-1 assay | ChEMBL. | 24164086 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24164086 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.