Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0094 | 0.4598 | 0.3545 |
Trypanosoma brucei | polo-like protein kinase | 0.0094 | 0.4598 | 0.0163 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0166 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.4598 | 0.3953 |
Plasmodium falciparum | lysophospholipase, putative | 0.0166 | 1 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0094 | 0.4598 | 0.3545 |
Mycobacterium ulcerans | lysophospholipase | 0.0166 | 1 | 1 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0093 | 0.4508 | 0.3407 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0094 | 0.4598 | 0.0163 |
Plasmodium falciparum | esterase, putative | 0.0166 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2295 | 0.3302 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.4508 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.4598 | 0.3953 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0166 | 1 | 1 |
Plasmodium vivax | PST-A protein | 0.0166 | 1 | 1 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0093 | 0.4508 | 0.9611 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0166 | 1 | 1 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0101 | 0.5123 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0094 | 0.4598 | 0.0163 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0166 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.4598 | 0.3953 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0166 | 1 | 1 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0101 | 0.5123 | 0.1119 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0094 | 0.4598 | 0.0163 |
Leishmania major | monoglyceride lipase, putative | 0.0166 | 1 | 1 |
Onchocerca volvulus | 0.015 | 0.8791 | 1 | |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0166 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.6443 | 0.6385 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2295 | 0.3302 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.4508 | 0.3036 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2295 | 0.3302 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0101 | 0.5123 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2295 | 0.3302 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.4598 | 0.3953 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0101 | 0.5123 | 0.454 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.4598 | 0.3953 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0166 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.4598 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0166 | 1 | 1 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0166 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2295 | 0.3302 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0101 | 0.5123 | 0.454 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.4598 | 0.3953 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.8791 | 1 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0093 | 0.4508 | 0.3407 |
Brugia malayi | hypothetical protein | 0.015 | 0.8791 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0094 | 0.4598 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.6443 | 0.6385 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0166 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.6443 | 0.6385 |
Mycobacterium ulcerans | hypothetical protein | 0.0166 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 1 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0166 | 1 | 1 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0166 | 1 | 1 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.4508 | 0.974 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0101 | 0.5123 | 0.454 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0093 | 0.4508 | 0.9611 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.4508 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0094 | 0.4598 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0166 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.4598 | 0.3953 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0166 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 18 ml/min.kg | Clearance in human hepatocytes at 0.5 uM after 120 mins by LC/MS/MS analysis | ChEMBL. | 23544424 |
CL (ADMET) | = 80 ml/min.kg | Clearance in CD-1 mouse hepatocytes at 0.5 uM after 120 mins by LC/MS/MS analysis | ChEMBL. | 23544424 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.