Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Staphylococcus aureus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0356 | 0.77 | 0.5353 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0356 | 0.77 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0356 | 0.77 | 0.5353 |
Brugia malayi | Dihydrofolate reductase | 0.0415 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0356 | 0.77 | 0.5353 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0356 | 0.77 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0415 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0415 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0415 | 1 | 1 |
Giardia lamblia | Sodium/hydrogen exchanger 3 | 0.0356 | 0.77 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0415 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0356 | 0.77 | 0.5353 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0356 | 0.77 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0356 | 0.77 | 0.5353 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0356 | 0.77 | 0.5353 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0356 | 0.77 | 0.5353 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0415 | 1 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0356 | 0.77 | 0.5353 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0415 | 1 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0356 | 0.77 | 0.5353 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0415 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0415 | 1 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0356 | 0.77 | 0.5353 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.022 nM | Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric analysis in presence of NADPH | ChEMBL. | 24428639 |
Ki (binding) | = 0.022 nM | BindingDB_Patents: Inhibition Assay. Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known (see., e.g., National Committee for Clinical Laboratory Standards 2000 Performance standards for antimicrobial disk susceptibility tests: approved standard, 7th ed. M2-A7, vol. 20, no. 1, Committee for Clinical Laboratory Standards, Wayne, Pa.). | ChEMBL. | No reference |
Ki (binding) | = 572 nM | Inhibition of human DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric analysis in presence of NADPH | ChEMBL. | 24428639 |
Ki (binding) | = 572 nM | Inhibition Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.