Detailed information for compound 1826174

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 201.225 | Formula: C11H11N3O
  • H donors: 1 H acceptors: 2 LogP: 2.09 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O/N=C/c1nccn1c1ccc(cc1)C
  • InChi: 1S/C11H11N3O/c1-9-2-4-10(5-3-9)14-7-6-12-11(14)8-13-15/h2-8,15H,1H3/b13-8+
  • InChiKey: NLTUBOURFYRBMM-MDWZMJQESA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii 5'-nucleotidase, C-terminal domain-containing protein 0.0094 0.3431 0.3406
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0035 0.1075 0.2905
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0035 0.1075 0.172
Trichomonas vaginalis immunophilin, putative 0.0073 0.258 0.3915
Echinococcus multilocularis jumonji domain containing protein 0.0029 0.084 0.084
Toxoplasma gondii carbamoylphosphate synthetase 0.0022 0.0565 0.0529
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0044 0.1437 0.5321
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0035 0.1075 0.2905
Trypanosoma brucei acetyl-CoA carboxylase 0.0259 1 1
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.0259 1 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.008 0.2865 0.2969
Leishmania major fk506-binding protein 1-like protein 0.0073 0.258 0.2552
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0099 0.3609 0.3584
Leishmania major carbonic anhydrase-like protein 0.0148 0.5564 0.5547
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0035 0.1075 0.2905
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0012 0.0166 0.0165
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.001 0.0076 0.0106
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0099 0.3609 0.3608
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0009 0.0038 0.0038
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.001 0.0076 0.0038
Mycobacterium ulcerans hypothetical protein 0.001 0.0076 0.0106
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.001 0.0076 0.0038
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0009 0.0038 0.0037
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0009 0.0038 0.0037
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.001 0.0076 0.0063
Trichomonas vaginalis fk506-binding protein, putative 0.0073 0.258 0.3915
Leishmania major peptidylprolyl isomerase-like protein 0.0073 0.258 0.2552
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0044 0.1437 0.5435
Echinococcus multilocularis carbonic anhydrase II 0.0148 0.5564 0.5564
Schistosoma mansoni acetyl-CoA carboxylase 0.0259 1 1
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0022 0.0565 0.0565
Onchocerca volvulus 0.0171 0.6472 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.1389 0.1389
Loa Loa (eye worm) bromodomain containing protein 0.0013 0.0183 0.0185
Loa Loa (eye worm) hypothetical protein 0.0036 0.111 0.1148
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0033 0.0989 0.0988
Echinococcus multilocularis carbonic anhydrase 0.008 0.2865 0.2864
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0513 0.0668
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0033 0.0989 0.1022
Trypanosoma cruzi PAB1-binding protein , putative 0.0018 0.04 0.06
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0989 0.0989
Brugia malayi hypothetical protein 0.0012 0.0143 0.0144
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.0513 0.0477
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0148 0.5564 0.5771
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0073 0.258 0.7119
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0022 0.0533 0.0532
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0073 0.258 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0148 0.5564 0.5771
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0188 0.7147 1
Onchocerca volvulus Alhambra homolog 0.0021 0.0513 0.0683
Trypanosoma brucei ISWI complex protein 0.0011 0.0115 0.0078
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0033 0.0989 0.0988
Giardia lamblia Hypothetical protein 0.0039 0.1211 0.4533
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0026 0.0707 0.0707
Schistosoma mansoni hypothetical protein 0.001 0.0076 0.0076
Plasmodium falciparum phd finger protein, putative 0.0021 0.0513 0.0668
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0099 0.3609 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0513 0.0528
Brugia malayi Bromodomain containing protein 0.0054 0.1828 0.1893
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.001 0.0076 0.0118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0989 0.0989
Mycobacterium ulcerans pyruvate carboxylase 0.0099 0.3609 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0021 0.0513 0.0512
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0035 0.1075 0.2905
Trypanosoma brucei PAB1-binding protein , putative 0.0018 0.04 0.0363
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.1022 0.1022
Schistosoma mansoni hypothetical protein 0.0021 0.0513 0.0513
Leishmania major acetyl-CoA carboxylase, putative 0.0259 1 1
Trypanosoma brucei hypothetical protein, conserved 0.001 0.0076 0.0038
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.008 0.2865 0.2969
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0099 0.3609 0.3584
Loa Loa (eye worm) hypothetical protein 0.0018 0.04 0.041
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.001 0.0076 0.0063
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.001 0.0076 0.0106
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0099 0.3609 0.3609
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0148 0.5564 0.9165
Loa Loa (eye worm) hypothetical protein 0.008 0.2865 0.2969
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0073 0.258 0.2673
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0074 0.2634 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0021 0.0513 0.0512
Schistosoma mansoni carbonic anhydrase-related 0.008 0.2865 0.2865
Schistosoma mansoni methyl-cpg binding protein mbd 0.0012 0.0166 0.0166
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0073 0.258 0.4216
Schistosoma mansoni immunophilin 0.0064 0.2234 0.2234
Echinococcus multilocularis carbonic anhydrase 0.008 0.2865 0.2864
Loa Loa (eye worm) hypothetical protein 0.008 0.2865 0.2969
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0073 0.258 0.4216
Trypanosoma cruzi PAB1-binding protein , putative 0.0018 0.04 0.06
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.1022 0.1021
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0035 0.1075 0.1075
Onchocerca volvulus 0.0022 0.0533 0.0714
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.001 0.0076 0.0038
Toxoplasma gondii pyruvate carboxylase 0.0099 0.3609 0.3584
Loa Loa (eye worm) hypothetical protein 0.0063 0.2189 0.2267
Schistosoma mansoni pyruvate carboxylase 0.0099 0.3609 0.3609
Echinococcus granulosus carbonic anhydrase 0.008 0.2865 0.2864
Echinococcus granulosus jumonji domain containing protein 0.0029 0.084 0.084
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0099 0.3609 0.3584
Loa Loa (eye worm) PHD-finger family protein 0.0015 0.0268 0.0274
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0033 0.0989 0.0988
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0188 0.7147 1
Schistosoma mansoni zinc finger protein 0.0014 0.0238 0.0238
Schistosoma mansoni carbonic anhydrase-related 0.008 0.2865 0.2865
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0035 0.1075 0.2905
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0076 0.0038
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0035 0.1075 0.1041
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0009 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.0009 0.0038 0.0035
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0099 0.3609 1
Toxoplasma gondii LsmAD domain-containing protein 0.0018 0.04 0.0363
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.1404 0.1452
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0035 0.1075 0.1041
Echinococcus granulosus lysine specific demethylase 5A 0.0027 0.0744 0.0743
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0073 0.258 0.4216
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0074 0.2634 0.2633
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0035 0.1075 0.1041
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.001 0.0076 0.0074
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0035 0.1075 0.2905
Toxoplasma gondii 5'-nucleotidase, C-terminal domain-containing protein 0.0039 0.1222 0.1188
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.1022 0.1021
Plasmodium falciparum carbamoyl phosphate synthetase 0.0022 0.0565 0.0742
Loa Loa (eye worm) hypothetical protein 0.0009 0.0038 0.0035
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0076 0.0038
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0021 0.0513 0.0513
Brugia malayi Pre-SET motif family protein 0.0022 0.0533 0.0548
Trypanosoma cruzi ISWI complex protein 0.0011 0.0115 0.0128
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0074 0.2634 1
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0073 0.258 0.3576
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0009 0.0038 0.0037
Echinococcus granulosus methyl CpG binding domain protein 2 0.0012 0.0166 0.0165
Echinococcus multilocularis fk506 binding protein 0.0073 0.258 0.2579
Schistosoma mansoni bromodomain containing protein 0.0046 0.1492 0.1492
Trypanosoma brucei unspecified product 0.0065 0.2262 0.2232
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0073 0.258 0.7492
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0099 0.3609 1
Trichomonas vaginalis set domain proteins, putative 0.0171 0.6472 1
Brugia malayi hypothetical protein 0.0018 0.04 0.041
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.001 0.0076 0.0038
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0744 0.0767
Brugia malayi jmjC domain containing protein 0.0069 0.2416 0.2503
Leishmania major hypothetical protein, conserved 0.0011 0.0115 0.0078
Echinococcus granulosus fetal alzheimer antigen falz 0.0016 0.0323 0.0322
Schistosoma mansoni 23-cyclic-nucleotide 2-phosphodiesterase 0.0094 0.3431 0.3431
Schistosoma mansoni zinc finger protein 0.0011 0.0115 0.0115
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0022 0.0565 0.0874
Schistosoma mansoni hypothetical protein 0.0015 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.001 0.0076 0.0074
Brugia malayi Bromodomain containing protein 0.0023 0.0581 0.0598
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.001 0.0076 0.0106
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.008 0.2865 0.2969
Plasmodium vivax ataxin-2 like protein, putative 0.0018 0.04 0.0509
Echinococcus multilocularis peregrin 0.0023 0.0581 0.058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0033 0.0989 0.0988
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0035 0.1075 0.2905
Echinococcus multilocularis zinc finger protein 0.0014 0.0238 0.0237
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.008 0.2865 0.2969
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0011 0.013 0.0129
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0073 0.258 0.4216
Chlamydia trachomatis biotin carboxylase 0.009 0.3247 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0777 0.0802
Brugia malayi PHD-finger family protein 0.0018 0.0391 0.0401
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.001 0.0076 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0022 0.0533 0.0533
Trypanosoma cruzi acetyl-CoA carboxylase 0.016 0.6068 1
Echinococcus granulosus peregrin 0.0023 0.0581 0.058
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0064 0.2234 0.2233
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0022 0.0565 0.1476
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.001 0.0076 0.0074
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0099 0.3609 1
Echinococcus granulosus carbonic anhydrase II 0.0148 0.5564 0.5564
Schistosoma mansoni 23-cyclic-nucleotide 2-phosphodiesterase 0.0094 0.342 0.342
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0099 0.3609 1
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0076 0.0038
Loa Loa (eye worm) hypothetical protein 0.0051 0.1705 0.1765
Brugia malayi Bromodomain containing protein 0.0028 0.0775 0.08
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0076 0.0053
Loa Loa (eye worm) hypothetical protein 0.0031 0.09 0.0929
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0148 0.5564 0.5771
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0148 0.5564 0.5564
Treponema pallidum 5'-nucleotidase (ushA) 0.0094 0.3431 1
Toxoplasma gondii hypothetical protein 0.008 0.2865 0.2838
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0035 0.1075 0.172
Brugia malayi Carboxyl transferase domain containing protein 0.025 0.9638 1
Schistosoma mansoni carbonic anhydrase 0.008 0.2865 0.2865
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD) 0.001 0.0076 0.0112
Brugia malayi Pre-SET motif family protein 0.015 0.5647 0.5857
Echinococcus granulosus FK506 binding protein 2 0.001 0.0076 0.0075
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0035 0.1075 0.1075
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0073 0.258 1
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0035 0.1075 0.1075
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0148 0.5564 0.9165
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0069 0.2416 0.2415
Schistosoma mansoni hypothetical protein 0.008 0.2865 0.2865
Schistosoma mansoni jumonji/arid domain-containing protein 0.0027 0.0744 0.0744
Leishmania major carbamoyl-phosphate synthase, putative 0.0022 0.0565 0.0529
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0022 0.0565 0.0529
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0069 0.2416 0.2415
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.008 0.2865 0.2969
Loa Loa (eye worm) hypothetical protein 0.0029 0.0845 0.0872
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.001 0.0076 0.0038
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0073 0.258 0.3915
Echinococcus multilocularis 0.001 0.0076 0.0075
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0073 0.258 0.3576
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0009 0.0038 0.0037
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0099 0.3609 0.3609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0989 0.0989
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0035 0.1075 0.2905
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0076 0.0053
Brugia malayi PHD-finger family protein 0.0021 0.0513 0.0528
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0009 0.0038 0.0035
Schistosoma mansoni carbonic anhydrase-related 0.008 0.2865 0.2865
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0073 0.258 0.2552
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.0513 0.0477
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0513 0.0528
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.008 0.2865 0.2969
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.001 0.0076 0.0074
Loa Loa (eye worm) hypothetical protein 0.008 0.2865 0.2969
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.001 0.0076 0.0038
Plasmodium vivax SET domain protein, putative 0.0022 0.0533 0.0696
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0076 0.0063
Loa Loa (eye worm) hypothetical protein 0.0009 0.0038 0.0035
Loa Loa (eye worm) FKBP5 protein 0.0073 0.258 0.2673
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0035 0.1075 0.1041
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0009 0.0038 0.0038
Echinococcus granulosus carbonic anhydrase 0.008 0.2865 0.2864
Loa Loa (eye worm) carbonic anhydrase 3 0.0148 0.5564 0.5771
Echinococcus multilocularis lysine specific demethylase 5A 0.0025 0.0689 0.0688
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.0259 1 1
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0099 0.3609 0.3608
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0022 0.0565 0.0742
Brugia malayi jmjC domain containing protein 0.0027 0.0744 0.0767
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0022 0.0565 0.1476
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.015 0.5647 0.5857
Schistosoma mansoni immunophilin 0.0074 0.2634 0.2634
Echinococcus granulosus carbonic anhydrase 0.008 0.2865 0.2864
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.1389 0.1389
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0035 0.1075 0.2905
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0074 0.2634 0.2633
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0073 0.258 0.258
Schistosoma mansoni methyl-cpg binding protein mbd 0.0012 0.0166 0.0166
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.001 0.0076 0.0075
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0076 0.0063
Schistosoma mansoni jumonji/arid domain-containing protein 0.0027 0.0744 0.0744
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0021 0.0501 0.0501
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0035 0.1075 0.2905
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.001 0.0076 0.0038
Loa Loa (eye worm) hypothetical protein 0.0034 0.1022 0.1056
Leishmania major carboxylase, putative 0.0099 0.3609 0.3584
Schistosoma mansoni aspartate carbamoyltransferase 0.0022 0.0565 0.0565
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.001 0.0076 0.0106
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0022 0.0565 0.0565
Schistosoma mansoni fk506 binding protein 0.001 0.0076 0.0076
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.001 0.0076 0.0074
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.04 0.0509
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0073 0.258 0.3915
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0073 0.258 0.2552
Plasmodium falciparum carbonic anhydrase 0.008 0.2865 0.3976
Echinococcus multilocularis carbonic anhydrase 0.008 0.2865 0.2864
Giardia lamblia PHD finger protein 15 0.0021 0.0513 0.1745
Echinococcus multilocularis Biotin lipoyl attachment 0.0009 0.0038 0.0037
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0073 0.258 0.2673
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0035 0.1075 0.2905
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0148 0.5564 0.5564
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0099 0.3609 0.5922
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0035 0.1075 0.2905
Echinococcus granulosus Biotin lipoyl attachment 0.0009 0.0038 0.0037
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0073 0.258 0.2579
Schistosoma mansoni hypothetical protein 0.0008 0.0001 0.0001
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0099 0.3609 0.5922
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.001 0.0076 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0533 0.0533
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0022 0.0533 0.0497
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0016 0.0323 0.0322
Echinococcus granulosus zinc finger protein 0.0014 0.0238 0.0237
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0026 0.0707 0.0707
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0016 0.0323 0.0323
Schistosoma mansoni hypothetical protein 0.0011 0.0115 0.0115
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0022 0.0565 0.0874
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0009 0.0038 0.0038
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0073 0.2588 0.2682
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.025 0.9638 1
Trypanosoma brucei carbonic anhydrase-like protein 0.0148 0.5564 0.5547
Leishmania major hypothetical protein, conserved 0.0018 0.04 0.0363
Trypanosoma cruzi ISWI complex protein 0.0011 0.0115 0.0128
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0064 0.2234 0.2233
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.1022 0.1022
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0035 0.1075 0.172
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.04 0.0509
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0099 0.3609 1
Schistosoma mansoni immunophilin 0.0074 0.2634 0.2634
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.0259 1 1
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0099 0.3609 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0033 0.0989 0.1022
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0036 0.0033
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0009 0.0038 0.0038
Onchocerca volvulus 0.001 0.0084 0.0013
Schistosoma mansoni jumonji domain containing protein 0.0055 0.1853 0.1853
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0009 0.0038 0.0035
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0035 0.1075 0.3233
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.001 0.0076 0.0063

Activities

Activity type Activity value Assay description Source Reference
IZ (functional) = 20.2 mm Antifungal activity against Candida albicans ATCC 10231 assessed as diameter of zone of inhibition at 250 ug/disc after 48 hrs by disc diffusion method ChEMBL. 24126094
MIC (functional) = 25 ug ml-1 Antibacterial activity against Escherichia coli FNSST 982 after 18 to 24 hrs by two-fold broth microdilution assay ChEMBL. 24126094

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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