Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0179 | 0.2877 | 1 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Schistosoma mansoni | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0135 | 0.1628 | 0.566 |
Onchocerca volvulus | 0.0109 | 0.0905 | 0.3301 | |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Brugia malayi | hexokinase | 0.0174 | 0.2742 | 0.9533 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Trypanosoma cruzi | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0431 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0179 | 0.2877 | 1 |
Onchocerca volvulus | 0.0174 | 0.2742 | 1 | |
Trypanosoma brucei | hexokinase | 0.0174 | 0.2742 | 0.9058 |
Brugia malayi | MAP kinase sur-1 | 0.0179 | 0.2877 | 1 |
Onchocerca volvulus | 0.0174 | 0.2742 | 1 | |
Brugia malayi | Cell death protein 3 precursor | 0.0171 | 0.2656 | 0.9232 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.2656 | 0.9232 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0179 | 0.2877 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0135 | 0.1628 | 0.566 |
Loa Loa (eye worm) | hexokinase | 0.0174 | 0.2742 | 0.9533 |
Echinococcus multilocularis | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Echinococcus granulosus | caspase 2 | 0.0171 | 0.2656 | 0.141 |
Echinococcus multilocularis | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Echinococcus multilocularis | hexokinase type 2 | 0.0174 | 0.2742 | 0.1511 |
Leishmania major | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0129 | 0.1451 | 0.5043 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0179 | 0.2877 | 1 |
Plasmodium falciparum | hexokinase | 0.0174 | 0.2742 | 1 |
Echinococcus granulosus | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Loa Loa (eye worm) | hexokinase | 0.0174 | 0.2742 | 0.9533 |
Echinococcus multilocularis | caspase | 0.0431 | 1 | 1 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0135 | 0.1628 | 0.566 |
Echinococcus granulosus | caspase 3 | 0.0302 | 0.6362 | 0.5745 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0179 | 0.2877 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0179 | 0.2877 | 0.1668 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0179 | 0.2877 | 0.1668 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0179 | 0.2877 | 0.1668 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0179 | 0.2877 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0174 | 0.2742 | 0.1511 |
Echinococcus multilocularis | caspase 3 | 0.0302 | 0.6362 | 0.5745 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.1628 | 0.566 |
Trypanosoma brucei | hexokinase | 0.0174 | 0.2742 | 0.9058 |
Echinococcus granulosus | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Toxoplasma gondii | hexokinase | 0.0174 | 0.2742 | 0.9058 |
Brugia malayi | Hexokinase family protein | 0.0174 | 0.2742 | 0.9533 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0431 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0179 | 0.2877 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0179 | 0.2877 | 0.1668 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Leishmania major | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1451 | 0.5043 |
Entamoeba histolytica | hexokinase 1 | 0.0174 | 0.2742 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0179 | 0.2877 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1175 | 0.4085 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0179 | 0.2877 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0179 | 0.2877 | 1 |
Echinococcus multilocularis | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0179 | 0.2877 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0174 | 0.2742 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Echinococcus granulosus | caspase | 0.0431 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0179 | 0.2877 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Onchocerca volvulus | 0.0174 | 0.2742 | 1 | |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0171 | 0.2656 | 0.9684 |
Plasmodium vivax | hexokinase, putative | 0.0174 | 0.2742 | 1 |
Onchocerca volvulus | Hexokinase homolog | 0.0109 | 0.0905 | 0.3301 |
Brugia malayi | Hexokinase family protein | 0.0109 | 0.0905 | 0.3147 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0171 | 0.2656 | 0.141 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0179 | 0.2877 | 0.1668 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0179 | 0.2877 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0109 | 0.0905 | 0.3147 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0179 | 0.2877 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0174 | 0.2742 | 0.5 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0179 | 0.2877 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0431 | 1 | 1 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0135 | 0.1628 | 0.566 |
Echinococcus multilocularis | caspase 2 | 0.0171 | 0.2656 | 0.141 |
Loa Loa (eye worm) | hexokinase type II | 0.0174 | 0.2742 | 0.9533 |
Echinococcus granulosus | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.