Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Echinococcus granulosus | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Leishmania major | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Trypanosoma brucei | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0179 | 0.2877 | 0.1668 |
Echinococcus multilocularis | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Trypanosoma cruzi | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0179 | 0.2877 | 1 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Trypanosoma brucei | hexokinase | 0.0174 | 0.2742 | 0.9058 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0179 | 0.2877 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0179 | 0.2877 | 1 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0135 | 0.1628 | 0.566 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0135 | 0.1628 | 0.566 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0171 | 0.2656 | 0.9684 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0135 | 0.1628 | 0.566 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0431 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0179 | 0.2877 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1175 | 0.4085 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0179 | 0.2877 | 0.1668 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.1628 | 0.566 |
Entamoeba histolytica | hexokinase 1 | 0.0174 | 0.2742 | 0.5 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0135 | 0.1628 | 0.566 |
Loa Loa (eye worm) | hexokinase | 0.0174 | 0.2742 | 0.9533 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0129 | 0.1451 | 0.5043 |
Echinococcus multilocularis | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Echinococcus multilocularis | caspase 2 | 0.0171 | 0.2656 | 0.141 |
Trypanosoma brucei | hexokinase | 0.0174 | 0.2742 | 0.9058 |
Echinococcus multilocularis | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0179 | 0.2877 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0179 | 0.2877 | 0.1668 |
Brugia malayi | Hexokinase family protein | 0.0109 | 0.0905 | 0.3147 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Echinococcus granulosus | caspase | 0.0431 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Entamoeba histolytica | hexokinase 2 | 0.0174 | 0.2742 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0109 | 0.0905 | 0.3147 |
Echinococcus granulosus | caspase 2 | 0.0171 | 0.2656 | 0.141 |
Plasmodium falciparum | hexokinase | 0.0174 | 0.2742 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Trypanosoma brucei | protein kinase, putative | 0.0179 | 0.2877 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0179 | 0.2877 | 0.1668 |
Onchocerca volvulus | 0.0109 | 0.0905 | 0.3301 | |
Plasmodium vivax | hexokinase, putative | 0.0174 | 0.2742 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0171 | 0.2656 | 0.141 |
Loa Loa (eye worm) | hexokinase type II | 0.0174 | 0.2742 | 0.9533 |
Schistosoma mansoni | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0179 | 0.2877 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0179 | 0.2877 | 0.1668 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0179 | 0.2877 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0174 | 0.2742 | 0.9533 |
Brugia malayi | hexokinase | 0.0174 | 0.2742 | 0.9533 |
Brugia malayi | Hexokinase family protein | 0.0174 | 0.2742 | 0.9533 |
Echinococcus multilocularis | caspase | 0.0431 | 1 | 1 |
Echinococcus multilocularis | caspase 3 | 0.0302 | 0.6362 | 0.5745 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0431 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0174 | 0.2742 | 0.1511 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0179 | 0.2877 | 1 |
Toxoplasma gondii | hexokinase | 0.0174 | 0.2742 | 0.9058 |
Echinococcus multilocularis | hexokinase type 2 | 0.0174 | 0.2742 | 0.1511 |
Echinococcus granulosus | caspase 3 | 0.0302 | 0.6362 | 0.5745 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0431 | 1 | 1 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.2656 | 0.9232 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0179 | 0.2877 | 1 |
Onchocerca volvulus | 0.0174 | 0.2742 | 1 | |
Brugia malayi | Cell death protein 3 precursor | 0.0171 | 0.2656 | 0.9232 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0179 | 0.2877 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0179 | 0.2877 | 1 |
Echinococcus granulosus | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1451 | 0.5043 |
Onchocerca volvulus | Hexokinase homolog | 0.0109 | 0.0905 | 0.3301 |
Echinococcus granulosus | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0179 | 0.2877 | 1 |
Onchocerca volvulus | 0.0174 | 0.2742 | 1 | |
Onchocerca volvulus | 0.0174 | 0.2742 | 1 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0179 | 0.2877 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0179 | 0.2877 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0174 | 0.2742 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0179 | 0.2877 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.