Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.2656 | 0.9232 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0431 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0179 | 0.2877 | 1 |
Onchocerca volvulus | 0.0174 | 0.2742 | 1 | |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0179 | 0.2877 | 1 |
Toxoplasma gondii | hexokinase | 0.0174 | 0.2742 | 0.9058 |
Echinococcus granulosus | caspase 3 | 0.0302 | 0.6362 | 0.5745 |
Echinococcus multilocularis | hexokinase type 2 | 0.0174 | 0.2742 | 0.1511 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0179 | 0.2877 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0179 | 0.2877 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0171 | 0.2656 | 0.9232 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0179 | 0.2877 | 1 |
Echinococcus granulosus | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Echinococcus granulosus | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1451 | 0.5043 |
Onchocerca volvulus | Hexokinase homolog | 0.0109 | 0.0905 | 0.3301 |
Treponema pallidum | hexokinase (hxk) | 0.0174 | 0.2742 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0179 | 0.2877 | 1 |
Onchocerca volvulus | 0.0174 | 0.2742 | 1 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0179 | 0.2877 | 1 |
Onchocerca volvulus | 0.0174 | 0.2742 | 1 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0179 | 0.2877 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0174 | 0.2742 | 0.9533 |
Schistosoma mansoni | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0179 | 0.2877 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0179 | 0.2877 | 0.1668 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0171 | 0.2656 | 0.141 |
Loa Loa (eye worm) | hexokinase | 0.0174 | 0.2742 | 0.9533 |
Brugia malayi | hexokinase | 0.0174 | 0.2742 | 0.9533 |
Brugia malayi | Hexokinase family protein | 0.0174 | 0.2742 | 0.9533 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0179 | 0.2877 | 1 |
Echinococcus multilocularis | caspase 3 | 0.0302 | 0.6362 | 0.5745 |
Echinococcus multilocularis | caspase | 0.0431 | 1 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0431 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0174 | 0.2742 | 0.1511 |
Trypanosoma brucei | hexokinase | 0.0174 | 0.2742 | 0.9058 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0129 | 0.1451 | 0.5043 |
Echinococcus multilocularis | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Echinococcus multilocularis | caspase 2 | 0.0171 | 0.2656 | 0.141 |
Echinococcus multilocularis | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0179 | 0.2877 | 1 |
Echinococcus granulosus | caspase | 0.0431 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Entamoeba histolytica | hexokinase 2 | 0.0174 | 0.2742 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0109 | 0.0905 | 0.3147 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0179 | 0.2877 | 0.1668 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Brugia malayi | Hexokinase family protein | 0.0109 | 0.0905 | 0.3147 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0179 | 0.2877 | 0.1668 |
Trypanosoma brucei | protein kinase, putative | 0.0179 | 0.2877 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0174 | 0.2742 | 1 |
Onchocerca volvulus | 0.0109 | 0.0905 | 0.3301 | |
Echinococcus granulosus | caspase 2 | 0.0171 | 0.2656 | 0.141 |
Plasmodium falciparum | hexokinase | 0.0174 | 0.2742 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Trypanosoma brucei | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0179 | 0.2877 | 0.1668 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Echinococcus multilocularis | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Echinococcus granulosus | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Leishmania major | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Trypanosoma brucei | hexokinase | 0.0174 | 0.2742 | 0.9058 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0179 | 0.2877 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0179 | 0.2877 | 1 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0135 | 0.1628 | 0.566 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0135 | 0.1628 | 0.566 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0135 | 0.1628 | 0.566 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0171 | 0.2656 | 0.9684 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0431 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0179 | 0.2877 | 0.5 |
Brugia malayi | MAP kinase sur-1 | 0.0179 | 0.2877 | 1 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0135 | 0.1628 | 0.566 |
Loa Loa (eye worm) | hexokinase | 0.0174 | 0.2742 | 0.9533 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1175 | 0.4085 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0179 | 0.2877 | 0.1668 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.1628 | 0.566 |
Entamoeba histolytica | hexokinase 1 | 0.0174 | 0.2742 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.