Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | Starlite/ChEMBL | References |
Homo sapiens | TANK-binding kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | IKK protein kinase | Get druggable targets OG5_132247 | All targets in OG5_132247 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_132247 | All targets in OG5_132247 |
Onchocerca volvulus | Get druggable targets OG5_132247 | All targets in OG5_132247 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1366 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1366 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1366 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1366 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1366 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1366 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1366 | 1 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.1366 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1366 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1366 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1366 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1366 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1366 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1366 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1366 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1366 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1366 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1366 | 1 | 1 |
Onchocerca volvulus | 0.1125 | 0 | 0.5 | |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1366 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1366 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.256 uM | Inhibition of recombinant full-length TBK1 (unknown origin) using CK1tide as substrate by microfluidic mobility shift assay | ChEMBL. | 24462666 |
IC50 (binding) | = 0.867 uM | Inhibition of IKK-epsilon (unknown origin) using 5FAM-AKELDQGSLCTpSFVGTLQ-NH2 as substrate by microfluidic mobility shift assay | ChEMBL. | 24462666 |
IC50 (binding) | > 30 uM | Inhibition of TBK1 in HEK293 cells after 4.5 hrs by ISRE-luciferase reporter gene assay in presence of poly I:C | ChEMBL. | 24462666 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.