Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | ap endonuclease, putative | 0.001 | 0.5774 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.001 | 0.5774 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.001 | 0.5774 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.001 | 0.5774 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.001 | 0.5774 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.001 | 0.5774 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.001 | 0.5774 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.001 | 0.5774 | 0.5774 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.001 | 0.5774 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.001 | 0.5774 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.001 | 0.5774 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.001 | 0.5774 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0008 | 0.4068 | 0.4068 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0008 | 0.4068 | 0.4068 |
Trichomonas vaginalis | ap endonuclease, putative | 0.001 | 0.5774 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.001 | 0.5774 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.001 | 0.5774 | 0.2876 |
Schistosoma mansoni | ap endonuclease | 0.001 | 0.5774 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0008 | 0.4068 | 0.4068 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.001 | 0.5774 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.001 | 0.5774 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.001 | 0.5774 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.001 | 0.5774 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.001 | 0.5774 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 11.1 uM | Antiprotozoal activity against Entamoeba histolytica HM-1:IMSS trophozoites after 72 hrs by microdilution method | ChEMBL. | 24530492 |
Inhibition (functional) | = 97.8 % | Antimicrobial activity against erythrocytic stage of chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation at 1 ug/ml after 24 hrs by beta-radiation counting analysis | ChEMBL. | 24530492 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Entamoeba histolytica | 24530492 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.