TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 391.509 | Formula: C23H29N5O
H donors: 1 H acceptors: 2 LogP: 4.32 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cc(ccc1Nc1ncc2c(n1)n(cc2)C1CCCCC1)N1CCOCC1
InChi: 1S/C23H29N5O/c1-17-15-20(27-11-13-29-14-12-27)7-8-21(17)25-23-24-16-18-9-10-28(22(18)26-23)19-5-3-2-4-6-19/h7-10,15-16,19H,2-6,11-14H2,1H3,(H,24,25,26)
InChiKey: CVJSDHYWXPUABU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TTK protein kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus	Dual specificity protein kinase TTK homolog	Get druggable targets OG5_129339	All targets in OG5_129339
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_129339	All targets in OG5_129339
Giardia lamblia	Kinase, TTK	Get druggable targets OG5_129339	All targets in OG5_129339
Schistosoma japonicum	ko:K05501 TetR/AcrR family transcriptional regulator, putative	Get druggable targets OG5_129339	All targets in OG5_129339
Loa Loa (eye worm)	TTK protein kinase	Get druggable targets OG5_129339	All targets in OG5_129339
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_129339	All targets in OG5_129339
Echinococcus multilocularis	dual specificity serine:threonine tyrosine	Get druggable targets OG5_129339	All targets in OG5_129339
Schistosoma mansoni	dual specificity serine/threonine tyrosine kinase	Get druggable targets OG5_129339	All targets in OG5_129339
Echinococcus granulosus	dual specificity serine:threonine tyrosine	Get druggable targets OG5_129339	All targets in OG5_129339
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_129339	All targets in OG5_129339
Candida albicans	protein threonine/tyrosine kinase	Get druggable targets OG5_129339	All targets in OG5_129339

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0229	0.0813
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0265	0.1565	0.1565
Loa Loa (eye worm)	G-protein coupled receptor	0.0265	0.1565	1
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0067	0.0359	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0136	0.0781	0.1825
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0229	0.0813
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0067	0.0359	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Brugia malayi	ORL1-like opioid receptor	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Onchocerca volvulus		0.0265	0.1565	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.04	0.0668
Echinococcus granulosus	hypothetical protein	0.0265	0.1565	0.3658
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0047	0.0078
Brugia malayi	RE15519p	0.0265	0.1565	1
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0229	0.0307
Schistosoma mansoni	biogenic amine receptor	0.0265	0.1565	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0265	0.1565	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0041	0.0201	0.0471
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0104	0.0586	0.0979
Echinococcus multilocularis	g protein coupled receptor	0.0265	0.1565	0.1565
Brugia malayi	Thioredoxin reductase	0.0046	0.0229	0.1346
Echinococcus multilocularis	serotonin receptor	0.0265	0.1565	0.1565
Echinococcus multilocularis	geminin	0.0179	0.1042	0.1042
Onchocerca volvulus		0.0231	0.1362	0.8586
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0067	0.0359	0.0599
Echinococcus multilocularis	neuropeptides capa receptor	0.0265	0.1565	0.1565
Echinococcus granulosus	neuropeptide receptor A26	0.0709	0.4279	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0067	0.0359	0.0599
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0067	0.0359	0.0599
Echinococcus granulosus	7tm_1 domain containing protein	0.0265	0.1565	0.3658
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0265	0.1565	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0265	0.1565	0.3658
Schistosoma mansoni	opsin-like receptor	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0067	0.0359	0.0839
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0265	0.1565	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0265	0.1565	1
Echinococcus multilocularis	dual specificity serine:threonine tyrosine	0.0087	0.0482	0.0482
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0067	0.0359	0.0599
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0041	0.0201	0.026
Brugia malayi	GnHR receptor homolog	0.0265	0.1565	1
Onchocerca volvulus		0.0074	0.04	0.1892
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0116	0.0657	0.1097
Brugia malayi	neuropeptide F receptor	0.0265	0.1565	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0265	0.1565	0.1565
Echinococcus granulosus	beta LACTamase domain containing family member	0.0074	0.04	0.0935
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Mycobacterium tuberculosis	Conserved protein	0.0074	0.04	0.0668
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0989	0.599	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0128	0.0817
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0047	0.0166
Mycobacterium ulcerans	esterase/lipase LipP	0.0074	0.04	0.0668
Onchocerca volvulus		0.0265	0.1565	1
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0067	0.0359	0.0599
Schistosoma mansoni	opsin-like receptor	0.0265	0.1565	1
Plasmodium vivax	hypothetical protein, conserved	0.0074	0.04	0.0594
Brugia malayi	Serotonin receptor	0.0265	0.1565	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0067	0.0359	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Echinococcus granulosus	geminin	0.0179	0.1042	0.2434
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0074	0.04	0.0668
Brugia malayi	G-protein coupled receptor	0.0265	0.1565	1
Schistosoma mansoni	dihydropteridine reductase	0.0067	0.0359	0.2294
Onchocerca volvulus		0.0074	0.04	0.1892
Echinococcus granulosus	7TM GPCR rhodopsin	0.0265	0.1565	0.3658
Trypanosoma brucei	pteridine reductase 1	0.0067	0.0359	0.8844
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0265	0.1565	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0067	0.0359	0.0599
Brugia malayi	beta-lactamase family protein	0.0074	0.04	0.2453
Echinococcus granulosus	g-protein coupled receptor	0.0265	0.1565	0.3658
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0111	0.1813
Echinococcus granulosus	orexin receptor type 2	0.0265	0.1565	0.3658
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0074	0.04	0.0668
Trichomonas vaginalis	CAMK family protein kinase	0.0087	0.0482	0.0804
Chlamydia trachomatis	oxoacy-ACP reductase	0.0067	0.0359	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Loa Loa (eye worm)	TTK protein kinase	0.0087	0.0482	0.2552
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0047	0.0078
Echinococcus granulosus	neuropeptide FF receptor 2	0.0265	0.1565	0.3658
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0128	0.0299
Echinococcus granulosus	rhodopsin orphan GPCR	0.0265	0.1565	0.3658
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0067	0.0359	0.0599
Echinococcus multilocularis	neuropeptide s receptor	0.0709	0.4279	0.4279
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0265	0.1565	1
Schistosoma mansoni	neuropeptide receptor	0.0265	0.1565	1
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0989	0.599	1
Schistosoma mansoni	neuropeptide receptor	0.0265	0.1565	1
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0016	0.0047	0.0078
Brugia malayi	hypothetical protein	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0067	0.0359	0.8844
Mycobacterium ulcerans	short chain dehydrogenase	0.0067	0.0359	0.0599
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0111	0.0108
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0111	0.0108
Onchocerca volvulus		0.0067	0.0359	0.1608
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0229	0.516
Brugia malayi	glutathione reductase	0.0046	0.0229	0.1346
Mycobacterium ulcerans	short chain dehydrogenase	0.0067	0.0359	0.0599
Echinococcus multilocularis	dro:myosuppressin receptor	0.0265	0.1565	0.1565
Schistosoma mansoni	myosin xvIII	0.0265	0.1565	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0265	0.1565	1
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0067	0.0359	0.0599
Mycobacterium tuberculosis	Conserved protein	0.0074	0.04	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0265	0.1565	0.1565
Echinococcus multilocularis	orexin receptor type 2	0.0265	0.1565	0.1565
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0265	0.1565	0.1565
Mycobacterium leprae	3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI	0.0067	0.0359	0.0599
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0067	0.0359	0.0599
Schistosoma mansoni	neuropeptide receptor	0.0265	0.1565	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.1191	0.7425
Loa Loa (eye worm)	hypothetical protein	0.0074	0.04	0.1988
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0016	0.0047	0.0078
Brugia malayi	G protein-coupled receptor	0.0265	0.1565	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0265	0.1565	0.3658
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.04	0.0668
Schistosoma mansoni	neuropeptide F-like receptor	0.0265	0.1565	1
Mycobacterium tuberculosis	Probable hydrolase	0.0074	0.04	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0265	0.1565	0.3658
Mycobacterium ulcerans	short chain dehydrogenase	0.0067	0.0359	0.0599
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.04	1
Schistosoma mansoni	amine GPCR	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0265	0.1565	1
Schistosoma mansoni	hypothetical protein	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0067	0.0359	0.8844
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0067	0.0359	0.0599
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.04	0.2555
Onchocerca volvulus		0.0067	0.0359	0.1608
Leishmania major	hypothetical protein, conserved	0.0026	0.0111	0.1813
Mycobacterium tuberculosis	Probable lipase LipE	0.0074	0.04	0.0668
Trichomonas vaginalis	CAMK family protein kinase	0.0087	0.0482	0.0804
Loa Loa (eye worm)	neuropeptide F receptor	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.04	0.1988
Echinococcus granulosus	neuropeptides capa receptor	0.0265	0.1565	0.3658
Trypanosoma brucei	hypothetical protein, conserved	0.0074	0.04	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0104	0.0586	0.0979
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0265	0.1565	1
Echinococcus multilocularis	fmrfamide receptor	0.0265	0.1565	0.1565
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0111	0.0108
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0229	0.0535
Echinococcus granulosus	G protein coupled receptor 139	0.0265	0.1565	0.3658
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0265	0.1565	1
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.0067	0.0359	0.0526
Echinococcus granulosus	neuropeptide Y receptor	0.0265	0.1565	0.3658
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0265	0.1565	1
Onchocerca volvulus		0.0265	0.1565	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0067	0.0359	0.0599
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0265	0.1565	1
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0067	0.0359	0.0599
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.04	0.2555
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Onchocerca volvulus		0.0265	0.1565	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0265	0.1565	0.1565
Schistosoma mansoni	neuropeptide receptor	0.0265	0.1565	1
Echinococcus multilocularis	fmrfamide receptor	0.0265	0.1565	0.1565
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.018	0.0225
Echinococcus multilocularis	neuropeptide receptor	0.0265	0.1565	0.1565
Onchocerca volvulus		0.0265	0.1565	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0265	0.1565	0.3658
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0709	0.4279	0.4279
Trichomonas vaginalis	hypothetical protein	0.0989	0.599	1
Echinococcus granulosus	g protein coupled receptor	0.0265	0.1565	0.3658
Brugia malayi	hypothetical protein	0.0265	0.1565	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0229	0.0229
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0067	0.0359	0.8844
Mycobacterium tuberculosis	Probable lipase LipD	0.0074	0.04	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0074	0.04	0.1988
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0265	0.1565	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0067	0.0359	0.0599
Mycobacterium ulcerans	short chain dehydrogenase	0.0067	0.0359	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0265	0.1565	0.3658
Brugia malayi	Protein kinase domain containing protein	0.0087	0.0482	0.2985
Schistosoma mansoni	hypothetical protein	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0265	0.1565	0.3658
Leishmania major	oxidoreductase-like protein	0.0067	0.0359	0.8844
Loa Loa (eye worm)	acetyltransferase	0.014	0.0805	0.4773
Brugia malayi	sulfakinin receptor protein	0.0265	0.1565	1
Echinococcus granulosus	fmrfamide receptor	0.0265	0.1565	0.3658
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0116	0.0657	0.1097
Mycobacterium ulcerans	lipase LipD	0.0074	0.04	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Mycobacterium ulcerans	20-beta-hydroxysteroid dehydrogenase FabG3	0.0067	0.0359	0.0599
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0265	0.1565	1
Brugia malayi	G-protein coupled receptor	0.0265	0.1565	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0265	0.1565	1
Echinococcus multilocularis	serotonin receptor	0.0265	0.1565	0.1565
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0359	0.1707
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0067	0.0359	0.0599
Trypanosoma brucei	trypanothione reductase	0.0046	0.0229	0.516
Echinococcus multilocularis	neuropeptide receptor	0.0265	0.1565	0.1565
Onchocerca volvulus		0.0265	0.1565	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0067	0.0359	0.0599
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0074	0.04	0.2453
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Schistosoma mansoni	biogenic amine receptor	0.0265	0.1565	1
Brugia malayi	hypothetical protein	0.0265	0.1565	1
Onchocerca volvulus		0.0265	0.1565	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0067	0.0359	0.0599
Echinococcus granulosus	rhodopsin orphan GPCR	0.0265	0.1565	0.3658
Loa Loa (eye worm)	hypothetical protein	0.0074	0.04	0.1988
Echinococcus multilocularis	neuropeptides capa receptor	0.0265	0.1565	0.1565
Trichomonas vaginalis	set domain proteins, putative	0.0231	0.1362	0.2274
Echinococcus multilocularis	sex peptide receptor	0.0265	0.1565	0.1565
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0265	0.1565	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0111	0.0108
Echinococcus multilocularis	neuropeptide Y receptor	0.0265	0.1565	0.1565
Treponema pallidum	NADH oxidase	0.0016	0.0047	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0116	0.0657	0.1097
Brugia malayi	hypothetical protein	0.0265	0.1565	1
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] reductase, putative	0.0067	0.0359	0.0526
Brugia malayi	follicle stimulating hormone receptor	0.0265	0.1565	1
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0047	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0128	0.0119
Schistosoma mansoni	biogenic amine receptor	0.0265	0.1565	1
Brugia malayi	beta-lactamase	0.0074	0.04	0.2453
Brugia malayi	Dopamine receptor protein 2	0.0265	0.1565	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0265	0.1565	1
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0067	0.0359	0.2294
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0265	0.1565	0.1565
Toxoplasma gondii	ABC1 family protein	0.0074	0.04	0.0594
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0067	0.0359	0.0599
Echinococcus multilocularis	g-protein coupled receptor	0.0265	0.1565	0.1565
Onchocerca volvulus		0.0265	0.1565	1
Leishmania major	trypanothione reductase	0.0046	0.0229	0.516
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0067	0.0359	0.8844
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0265	0.1565	0.3658
Onchocerca volvulus		0.0265	0.1565	1
Echinococcus multilocularis	allatostatin A receptor	0.0265	0.1565	0.1565
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0265	0.1565	0.1565
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0067	0.0359	0.1707
Echinococcus granulosus	neuropeptide Y receptor	0.0265	0.1565	0.3658
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0265	0.1565	1
Giardia lamblia	Kinase, TTK	0.0087	0.0482	1
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0067	0.0359	0.0599
Mycobacterium ulcerans	short chain dehydrogenase	0.0067	0.0359	0.0599
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0074	0.04	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.0067	0.0359	0.0526
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0265	0.1565	0.1565
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0989	0.599	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0265	0.1565	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0265	0.1565	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0265	0.1565	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0265	0.1565	1
Mycobacterium leprae	POSSIBLE OXIDOREDUCTASE	0.0067	0.0359	0.0599
Echinococcus granulosus	serotonin receptor	0.0265	0.1565	0.3658
Brugia malayi	Serotonin receptor	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0265	0.1565	0.1565
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0041	0.0201	0.0336
Echinococcus granulosus	neuropeptide receptor	0.0265	0.1565	0.3658
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0067	0.0359	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Mycobacterium ulcerans	oxidoreductase	0.0067	0.0359	0.0599
Brugia malayi	beta-lactamase family protein	0.0074	0.04	0.2453
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.04	0.0668
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0265	0.1565	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0111	0.1813
Mycobacterium tuberculosis	Probable reductase	0.0104	0.0586	0.0979
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0067	0.0359	0.0599
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0067	0.0359	0.0599
Onchocerca volvulus		0.0265	0.1565	1
Schistosoma mansoni	amine GPCR	0.0265	0.1565	1
Brugia malayi	hypothetical protein	0.0026	0.0111	0.0581
Brugia malayi	hypothetical protein	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Echinococcus granulosus	g protein coupled receptor	0.0265	0.1565	0.3658
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0265	0.1565	0.1565
Loa Loa (eye worm)	hypothetical protein	0.0074	0.04	0.1988
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0265	0.1565	0.1565
Leishmania major	hypothetical protein, conserved	0.0074	0.04	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0067	0.0359	0.0599
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0265	0.1565	0.3658
Schistosoma mansoni	hypothetical protein	0.0179	0.1042	0.6654
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0265	0.1565	1
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0067	0.0359	1
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0067	0.0359	0.0599
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0265	0.1565	1
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0989	0.599	1
Schistosoma mansoni	histamine h1 receptor	0.0265	0.1565	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0265	0.1565	0.1565
Echinococcus multilocularis	g protein coupled receptor	0.0265	0.1565	0.1565
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.04	1
Schistosoma mansoni	amine GPCR	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0067	0.0359	0.8844
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0265	0.1565	1
Trichomonas vaginalis	esterase, putative	0.0074	0.04	0.0668
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0104	0.0586	0.0979
Brugia malayi	larval opioid receptor	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0265	0.1565	0.1565
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0016	0.0047	0.0078
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0265	0.1565	1
Brugia malayi	Pre-SET motif family protein	0.0203	0.1191	0.7574
Mycobacterium tuberculosis	Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase)	0.0067	0.0359	0.0599
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0229	0.0307
Trichomonas vaginalis	mercuric reductase, putative	0.0016	0.0047	0.0078
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0989	0.599	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0265	0.1565	0.3658
Onchocerca volvulus		0.0265	0.1565	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0265	0.1565	0.1565
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0067	0.0359	0.0599
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.014	0.0805	0.5142
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0041	0.0201	0.026
Loa Loa (eye worm)	oxidoreductase	0.0067	0.0359	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0067	0.0359	0.2189
Schistosoma mansoni	neuropeptide f receptor 76f	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0067	0.0359	0.2189
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0022	0.0022
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0265	0.1565	0.3658
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0111	0.1813
Brugia malayi	Dopamine receptor protein 1	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0265	0.1565	0.3658
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Echinococcus multilocularis	g protein coupled receptor	0.0265	0.1565	0.1565
Loa Loa (eye worm)	hypothetical protein	0.0074	0.04	0.1988
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0116	0.0657	0.1097
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0047	0.0047
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0229	0.0307
Echinococcus granulosus	somatostatin receptor	0.0265	0.1565	0.3658
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0265	0.1565	0.1565
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Loa Loa (eye worm)	TYRA-2 protein	0.0265	0.1565	1
Onchocerca volvulus		0.0265	0.1565	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0265	0.1565	0.3658
Echinococcus granulosus	dual specificity serine:threonine tyrosine	0.0087	0.0482	0.1126
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0067	0.0359	0.0599
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0047	0.0298
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0128	0.0817
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0067	0.0359	0.1707
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0067	0.0359	0.0599
Mycobacterium ulcerans	short chain dehydrogenase	0.0067	0.0359	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Onchocerca volvulus		0.0265	0.1565	1
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0989	0.599	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0265	0.1565	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0265	0.1565	0.1565
Mycobacterium leprae	conserved hypothetical protein	0.0074	0.04	0.0668
Schistosoma mansoni	amine GPCR	0.0265	0.1565	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.04	0.0668
Echinococcus granulosus	rhodopsin orphan GPCR	0.0265	0.1565	0.3658
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0104	0.0586	0.0979
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0121	0.0284
Echinococcus granulosus	rhodopsin orphan GPCR	0.0265	0.1565	0.3658
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0265	0.1565	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0265	0.1565	1
Onchocerca volvulus		0.0074	0.04	0.1892
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0128	0.0137
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0265	0.1565	0.1565
Onchocerca volvulus	Dual specificity protein kinase TTK homolog	0.0087	0.0482	0.2463
Echinococcus granulosus	rhodopsin orphan GPCR	0.0265	0.1565	0.3658
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Brugia malayi	neuropeptide F receptor	0.0265	0.1565	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0265	0.1565	0.3658
Brugia malayi	hypothetical protein	0.0017	0.0054	0.0212
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0265	0.1565	0.1565
Echinococcus multilocularis	G protein coupled receptor 139	0.0265	0.1565	0.1565
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0074	0.04	0.0668
Echinococcus granulosus	tm gpcr rhodopsin	0.0265	0.1565	0.3658
Brugia malayi	Dopamine receptor	0.0265	0.1565	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0265	0.1565	0.1565
Mycobacterium tuberculosis	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)	0.0067	0.0359	0.0599
Schistosoma mansoni	hypothetical protein	0.0012	0.0022	0.0141
Trichomonas vaginalis	glutathione reductase, putative	0.0016	0.0047	0.0078
Brugia malayi	hypothetical protein	0.0265	0.1565	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0128	0.0128
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0265	0.1565	0.3658
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0265	0.1565	1
Mycobacterium tuberculosis	Possible oxidoreductase	0.0067	0.0359	0.0599
Schistosoma mansoni	opsin-like receptor	0.0265	0.1565	1
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0067	0.0359	0.8844
Schistosoma mansoni	dual specificity serine/threonine tyrosine kinase	0.0087	0.0482	0.3079
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.018	0.3074
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0265	0.1565	0.1565
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0074	0.04	0.1988
Brugia malayi	G protein-coupled receptor F59B2.13	0.0265	0.1565	1
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0041	0.0201	0.0336
Plasmodium vivax	SET domain protein, putative	0.0029	0.0128	0.0137
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0265	0.1565	1
Schistosoma mansoni	hypothetical protein	0.0179	0.1042	0.6654
Schistosoma mansoni	hypothetical protein	0.0265	0.1565	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0265	0.1565	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0265	0.1565	0.1565
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.014	0.0805	0.0805
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0265	0.1565	0.1565
Mycobacterium ulcerans	hypothetical protein	0.0074	0.04	0.0668
Echinococcus granulosus	neuropeptides capa receptor	0.0265	0.1565	0.3658
Mycobacterium tuberculosis	Probable esterase LipL	0.0074	0.04	0.0668
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0265	0.1565	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0067	0.0359	0.0599
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0265	0.1565	0.1565
Echinococcus granulosus	allatostatin A receptor	0.0265	0.1565	0.3658
Echinococcus granulosus	dro:myosuppressin receptor	0.0265	0.1565	0.3658
Loa Loa (eye worm)	beta-lactamase	0.0074	0.04	0.1988
Brugia malayi	acetyltransferase, GNAT family protein	0.014	0.0805	0.5076
Schistosoma mansoni	adenoreceptor	0.0265	0.1565	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0074	0.04	0.04
Loa Loa (eye worm)	G-protein coupled receptor	0.0265	0.1565	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0041	0.0201	0.026
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0067	0.0359	0.8844
Brugia malayi	Pre-SET motif family protein	0.0029	0.0128	0.0693
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0265	0.1565	0.1565
Brugia malayi	hypothetical protein	0.0265	0.1565	1
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0989	0.599	1
Mycobacterium leprae	Probable lipase LipE	0.0074	0.04	0.0668
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0265	0.1565	1
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	0.0067	0.0359	0.0526
Echinococcus granulosus	sex peptide receptor	0.0265	0.1565	0.3658
Brugia malayi	hypothetical protein	0.0265	0.1565	1
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0022	0.0052
Brugia malayi	hypothetical protein	0.0265	0.1565	1
Brugia malayi	Melatonin receptor type 1A	0.0265	0.1565	1
Trypanosoma brucei	oxidoreductase-like protein	0.0067	0.0359	0.8844
Brugia malayi	hypothetical protein	0.0265	0.1565	1
Brugia malayi	AKH receptor	0.0265	0.1565	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0104	0.0586	0.0979
Mycobacterium ulcerans	beta-lactamase	0.0074	0.04	0.0668
Mycobacterium tuberculosis	Possible oxidoreductase	0.0067	0.0359	0.0599
Brugia malayi	putative neuropeptide receptor	0.0265	0.1565	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0471	0.2824	0.4715
Mycobacterium tuberculosis	Conserved protein	0.0074	0.04	0.0668
Onchocerca volvulus		0.0265	0.1565	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0265	0.1565	1
Echinococcus granulosus	g protein coupled receptor	0.0265	0.1565	0.3658
Onchocerca volvulus		0.0265	0.1565	1
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0989	0.599	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0265	0.1565	1
Schistosoma mansoni	hypothetical protein	0.0265	0.1565	1
Leishmania major	pteridine reductase 1	0.0067	0.0359	0.8844
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0016	0.0047	0.0078
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0229	0.0307
Schistosoma mansoni	growth hormone secretagogue receptor	0.0265	0.1565	1
Echinococcus granulosus	neuropeptide receptor	0.0265	0.1565	0.3658
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0265	0.1565	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0128	0.0817
Echinococcus granulosus	neuropeptide s receptor	0.0709	0.4279	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0265	0.1565	0.3658
Onchocerca volvulus		0.0265	0.1565	1
Schistosoma mansoni	amine GPCR	0.0265	0.1565	1
Echinococcus multilocularis	somatostatin receptor	0.0265	0.1565	0.1565
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0265	0.1565	0.1565
Loa Loa (eye worm)	melatonin receptor type 1A	0.0265	0.1565	1
Onchocerca volvulus		0.0265	0.1565	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0128	0.0817
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.04	0.0668
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1565	1
Plasmodium falciparum	glutathione reductase	0.0046	0.0229	0.0307
Mycobacterium tuberculosis	Probable dehydrogenase	0.0104	0.0586	0.0979
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0128	0.0128
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0229	0.0382

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 22 nM	Inhibition of full-length Mps1 kinase (unknown origin)	ChEMBL.	24183538
IC50 (functional)	= 8.6 uM	Cytotoxicity against human HCT116 cells	ChEMBL.	24183538

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	24183538

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3092029

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1826682