Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Cholinesterase | Starlite/ChEMBL | References |
Homo sapiens | monoamine oxidase B | Starlite/ChEMBL | References |
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Putative nuclear protein | Cholinesterase | 574 aa | 572 aa | 40.9 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 538 aa | 31.4 % |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 578 aa | 25.3 % | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Cholinesterase | 574 aa | 577 aa | 36.9 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Echinococcus granulosus | neuroligin | Cholinesterase | 574 aa | 492 aa | 24.4 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Cholinesterase | 574 aa | 554 aa | 36.1 % |
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase B | 520 aa | 462 aa | 19.7 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 551 aa | 29.9 % | |
Schistosoma mansoni | gliotactin | Cholinesterase | 574 aa | 587 aa | 27.9 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.0052 | 0 | 0.5 |
Giardia lamblia | 5-AMP-activated protein kinase, gamma-1 subunit | 0.0396 | 0.7907 | 1 |
Schistosoma mansoni | protein kinase subunit gamma | 0.0396 | 0.7907 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0488 | 1 | 1 |
Schistosoma mansoni | protein kinase subunit beta | 0.007 | 0.0399 | 0.0505 |
Brugia malayi | 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein | 0.013 | 0.1779 | 0.1779 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.2561 | 0.3239 |
Toxoplasma gondii | 5'-AMP-activated protein kinase subunit beta-1 family protein, putative | 0.0077 | 0.0558 | 1 |
Trypanosoma cruzi | SNF1-related protein kinase regulatory subunit beta, putative | 0.013 | 0.1779 | 1 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.0364 | 0.7171 | 0.9069 |
Echinococcus granulosus | 5' AMP activated protein kinase catalytic | 0.0272 | 0.5048 | 0.6385 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0 | 0.5 |
Onchocerca volvulus | Alicorn homolog | 0.0113 | 0.1402 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0333 | 0.6456 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.2561 | 0.3239 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.2561 | 0.2561 |
Giardia lamblia | 5-AMP-activated protein kinase, beta-1 subunit | 0.013 | 0.1779 | 0.225 |
Brugia malayi | EST embl|AI107989|AI107989 comes from the 3' UTR, putative | 0.0272 | 0.5048 | 0.5048 |
Plasmodium falciparum | serine/threonine protein kinase KIN | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.2561 | 0.2561 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.2561 | 0.2561 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.2561 | 0.2561 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.2561 | 0.3239 |
Loa Loa (eye worm) | hypothetical protein | 0.0475 | 0.9704 | 0.9704 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.2561 | 0.3239 |
Brugia malayi | loechrig isoform VII | 0.0396 | 0.7907 | 0.7907 |
Brugia malayi | 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein | 0.013 | 0.1779 | 0.1779 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.2561 | 0.3239 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0 | 0.5 |
Trypanosoma cruzi | 5'-AMP-activated protein kinase subunit beta, putative | 0.013 | 0.1779 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.2561 | 0.3239 |
Loa Loa (eye worm) | 5'-AMP-activated protein kinase | 0.013 | 0.1779 | 0.1779 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.2561 | 0.2561 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.0396 | 0.7907 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | loechrig isoform VII | 0.0396 | 0.7907 | 0.7907 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0.7036 | 0.5 |
Echinococcus multilocularis | 5' AMP activated protein kinase catalytic | 0.0272 | 0.5048 | 0.6385 |
Echinococcus granulosus | 5' AMP activated protein kinase subunit beta 1 | 0.007 | 0.0399 | 0.0505 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0.7036 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.013 | 0.1779 | 1 |
Schistosoma mansoni | protein kinase subunit beta | 0.013 | 0.1779 | 0.225 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.2561 | 0.2561 |
Loa Loa (eye worm) | CAMK/CAMKL/AMPK protein kinase | 0.0272 | 0.5048 | 0.5048 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit beta 1 | 0.007 | 0.0399 | 0.0505 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | 5' AMP activated protein kinase subunit gamma | 0.0396 | 0.7907 | 1 |
Echinococcus granulosus | AMPK beta subunit | 0.013 | 0.1779 | 0.225 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.2561 | 0.3239 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0272 | 0.5048 | 0.6385 |
Echinococcus multilocularis | AMPK beta subunit | 0.013 | 0.1779 | 0.225 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0 | 0.5 |
Trypanosoma brucei | 5'-AMP-activated protein kinase subunit beta | 0.013 | 0.1779 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 65.7 nM | Inhibition of horse serum BuChE using butylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 1 min by Ellman method | ChEMBL. | 24128814 |
IC50 (binding) | = 115.4 nM | Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 1 min by Ellman method | ChEMBL. | 24128814 |
IC50 (binding) | = 1.03 uM | Inhibition of human recombinant MAO-B using benzylamine as substrate preincubated for 15 mins under dark condition followed by substrate addition measured after 20 mins by fluorescence assay | ChEMBL. | 24128814 |
Inhibition (binding) | = 31.5 % | Inhibition of human recombinant MAO-A using p-tyramine as substrate assessed as formation of H2O2 at 100 uM preincubated for 15 mins under dark condition followed by substrate addition measured after 20 mins by fluorescence assay relative to control | ChEMBL. | 24128814 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.