Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chymotrypsin C (caldecrin) | Starlite/ChEMBL | References |
Homo sapiens | elastase, neutrophil expressed | Starlite/ChEMBL | References |
Hepatitis C virus | Hepatitis C virus NS3 protease/helicase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | transmembrane protease serine 3 | elastase, neutrophil expressed | 267 aa | 236 aa | 27.5 % |
Brugia malayi | Trypsin family protein | chymotrypsin C (caldecrin) | 268 aa | 236 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.1253 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0212 | 0 | 0.5 |
Onchocerca volvulus | 0.0212 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.1253 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1253 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1253 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0212 | 0 | 0.5 |
Onchocerca volvulus | 0.0212 | 0 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0212 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1253 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0212 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1253 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1253 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1253 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0212 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0212 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1253 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1253 | 1 | 1 |
Onchocerca volvulus | 0.0212 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.1253 | 1 | 1 |
Onchocerca volvulus | 0.0212 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.1253 | 1 | 1 |
Onchocerca volvulus | 0.0212 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.075 uM | Inhibitory concentration against Human pancreatic Serine protease chymotrypsin | ChEMBL. | 12372533 |
IC50 (binding) | = 0.075 uM | Inhibitory concentration against Human pancreatic Serine protease chymotrypsin | ChEMBL. | 12372533 |
IC50 (binding) | = 3.5 uM | Inhibitory concentration against Human leukocyte Elastase | ChEMBL. | 12372533 |
IC50 (binding) | = 3.5 uM | Inhibitory concentration against Human leukocyte Elastase | ChEMBL. | 12372533 |
Ki (binding) | = 0.008 uM | Binding affinity against Hepatitis C virus NS3 protease | ChEMBL. | 12372533 |
Ki (binding) | = 0.008 uM | Binding affinity against Hepatitis C virus NS3 protease | ChEMBL. | 12372533 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.