Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.0006 | 0.0005 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0533 | 0.1663 | 0.1663 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0055 | 0.0145 | 0.0145 |
Onchocerca volvulus | 0.0533 | 0.1663 | 1 | |
Brugia malayi | hypothetical protein | 0.0533 | 0.1663 | 0.1662 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0504 | 0.0503 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0001 | 0.0001 |
Brugia malayi | ecdysteroid receptor | 0.0168 | 0.0504 | 0.0503 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0001 | 0.0001 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0055 | 0.0145 | 0.0143 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.002 | 0.0033 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0001 | 0.0001 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0533 | 0.1663 | 0.1662 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0001 | 0.0000066951 |
Loa Loa (eye worm) | carboxylesterase | 0.0533 | 0.1663 | 0.1662 |
Loa Loa (eye worm) | hypothetical protein | 0.0533 | 0.1663 | 0.1662 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0001 | 0.0000066951 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0533 | 0.1663 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0533 | 0.1663 | 0.1662 |
Entamoeba histolytica | recQ family DNA helicase | 0.001 | 0.0001 | 0.0381 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.0006 | 0.0005 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.002 | 0.0033 | 0.0032 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0155 | 0.0898 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0135 | 0.0397 | 0.0396 |
Treponema pallidum | ATP-dependent DNA helicase | 0.001 | 0.0001 | 0.5 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.0033 | 0.0699 |
Brugia malayi | Carboxylesterase family protein | 0.0533 | 0.1663 | 0.1662 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0397 | 0.0396 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3153 | 1 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.002 | 0.0033 | 0.0033 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0155 | 0.0155 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0001 | 0.0082 |
Schistosoma mansoni | acetylcholinesterase | 0.0533 | 0.1663 | 0.1663 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0155 | 0.0155 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0533 | 0.1663 | 0.1663 |
Brugia malayi | Bloom's syndrome protein homolog | 0.002 | 0.0033 | 0.0032 |
Schistosoma mansoni | gliotactin | 0.0533 | 0.1663 | 0.1663 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.002 | 0.0033 | 0.0032 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0533 | 0.1663 | 0.1662 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0135 | 0.0397 | 1 |
Onchocerca volvulus | 0.0533 | 0.1663 | 1 | |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0135 | 0.0397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0533 | 0.1663 | 0.1662 |
Brugia malayi | Carboxylesterase family protein | 0.0533 | 0.1663 | 0.1662 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0001 | 0.0001 |
Echinococcus multilocularis | acetylcholinesterase | 0.3153 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0063 | 0.0169 | 0.0834 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0001 | 0.0001 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.0155 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0001 | 0.0001 |
Echinococcus granulosus | bloom syndrome protein | 0.002 | 0.0033 | 0.0032 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0055 | 0.0145 | 0.0143 |
Echinococcus multilocularis | protein dispatched 1 | 0.0055 | 0.0145 | 0.0143 |
Schistosoma mansoni | DNA helicase recq5 | 0.002 | 0.0033 | 0.0033 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0055 | 0.0145 | 0.0143 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.0033 | 0.0032 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.0033 | 0.0807 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.002 | 0.0033 | 0.0032 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0533 | 0.1663 | 0.1662 |
Echinococcus multilocularis | geminin | 0.0175 | 0.0525 | 0.0524 |
Echinococcus granulosus | acetylcholinesterase | 0.3153 | 1 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.0033 | 0.0032 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0001 | 0.0001 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0055 | 0.0145 | 0.0143 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.002 | 0.0033 | 0.0032 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0533 | 0.1663 | 0.1662 |
Entamoeba histolytica | recQ family helicase, putative | 0.002 | 0.0033 | 1 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.001 | 0.0001 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0001 | 0.0001 |
Echinococcus granulosus | geminin | 0.0175 | 0.0525 | 0.0524 |
Brugia malayi | Carboxylesterase family protein | 0.0533 | 0.1663 | 0.1662 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.0033 | 0.2145 |
Brugia malayi | CHE-14 protein | 0.0055 | 0.0145 | 0.0143 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0135 | 0.0397 | 0.0396 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0055 | 0.0145 | 0.0143 |
Brugia malayi | Carboxylesterase family protein | 0.0533 | 0.1663 | 0.1662 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0063 | 0.0169 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.002 | 0.0033 | 0.0032 |
Onchocerca volvulus | 0.0533 | 0.1663 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.0525 | 0.0525 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.0155 | 0.0154 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0533 | 0.1663 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0533 | 0.1663 | 0.1663 |
Loa Loa (eye worm) | hypothetical protein | 0.0533 | 0.1663 | 0.1662 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0135 | 0.0397 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.1673 | 0.529 | 0.5289 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0055 | 0.0145 | 0.0683 |
Loa Loa (eye worm) | hypothetical protein | 0.0533 | 0.1663 | 0.1662 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0001 | 0.0001 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.0155 | 0.0154 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0533 | 0.1663 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0533 | 0.1663 | 0.1662 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0533 | 0.1663 | 0.1663 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.0006 | 0.0117 |
Loa Loa (eye worm) | carboxylesterase | 0.3153 | 1 | 1 |
Onchocerca volvulus | 0.0533 | 0.1663 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.0525 | 0.0525 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0533 | 0.1663 | 0.1662 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.0006 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0033 | 0.0032 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0533 | 0.1663 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3153 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0533 | 0.1663 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0135 | 0.0397 | 0.0396 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.0006 | 0.0005 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0168 | 0.0504 | 0.3024 |
Loa Loa (eye worm) | hypothetical protein | 0.0533 | 0.1663 | 0.1662 |
Echinococcus multilocularis | protein patched | 0.0055 | 0.0145 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0145 | 0.0143 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0533 | 0.1663 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3153 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.3153 | 1 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.0033 | 0.0699 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0135 | 0.0397 | 0.0397 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0001 | 0.0001 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0533 | 0.1663 | 0.1662 |
Echinococcus multilocularis | neuroligin | 0.0533 | 0.1663 | 0.1662 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0012 | 0.0006 | 0.0005 |
Onchocerca volvulus | 0.0533 | 0.1663 | 1 | |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.0006 | 0.0117 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0001 | 0.0001 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0533 | 0.1663 | 0.1663 |
Loa Loa (eye worm) | hypothetical protein | 0.0533 | 0.1663 | 0.1662 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0135 | 0.0397 | 1 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.002 | 0.0033 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0155 | 0.0898 |
Echinococcus granulosus | neuroligin | 0.0533 | 0.1663 | 0.1662 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.002 | 0.0033 | 0.0032 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.001 | 0.0001 | 0.0001 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0001 | 0.0001 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0063 | 0.0169 | 0.0834 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.0033 | 0.2145 |
Schistosoma mansoni | patched 1 | 0.0055 | 0.0145 | 0.0145 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3153 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3153 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.3153 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.3153 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0155 | 0.0898 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0055 | 0.0145 | 0.0143 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0135 | 0.0397 | 0.2359 |
Echinococcus granulosus | acetylcholinesterase | 0.3153 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.0155 | 0.3808 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0063 | 0.0169 | 0.0834 |
Echinococcus multilocularis | bloom syndrome protein | 0.002 | 0.0033 | 0.0032 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC50 (functional) | = 0.05 uM | In vitro antiviral activity against human rhinovirus-1A using plaque reduction assay | ChEMBL. | 8230114 |
MIC50 (functional) | = 0.41 uM | Minimum inhibitory concentration which inhibits 80% of serotypes was determined | ChEMBL. | 8230114 |
MIC50 (functional) | = 0.5 uM | In vitro antiviral activity against human rhinovirus-14 using plaque reduction assay | ChEMBL. | 8230114 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.