TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 325.358 | Formula: C19H19NO4
H donors: 0 H acceptors: 3 LogP: 4.91 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Oc1ccc(cc1)[N+](=O)[O-])CC(c1ccccc1)CC(=C)C
InChi: 1S/C19H19NO4/c1-14(2)12-16(15-6-4-3-5-7-15)13-19(21)24-18-10-8-17(9-11-18)20(22)23/h3-11,16H,1,12-13H2,2H3
InChiKey: AXIIZHNAJOYSJI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.1091	0.345
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.2533	0.8942
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0039	0.1192	0.1174
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0084	0.281	1
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0045	0.1425	0.1445
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0084	0.281	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.281	0.306
Loa Loa (eye worm)	hypothetical protein	0.0084	0.281	0.306
Onchocerca volvulus		0.0084	0.281	0.2291
Loa Loa (eye worm)	hypothetical protein	0.0084	0.281	0.306
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1425	0.1445
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2533	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1425	0.1445
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0084	0.281	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1356	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1356	0.1364
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.1356	0.1091
Toxoplasma gondii	ABC1 family protein	0.0043	0.1356	0.4367
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0084	0.281	0.306
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0249	0.8763	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1425	0.1445
Mycobacterium tuberculosis	Conserved protein	0.0043	0.1356	0.0755
Leishmania major	hypothetical protein, conserved	0.0043	0.1356	1
Mycobacterium leprae	Probable lipase LipE	0.0043	0.1356	0.2805
Loa Loa (eye worm)	hypothetical protein	0.0084	0.281	0.306
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.1356	0.2805
Loa Loa (eye worm)	hypothetical protein	0.0084	0.281	0.306
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1192	0.1174
Mycobacterium tuberculosis	Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase)	0.0092	0.3105	0.2692
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0084	0.281	1
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0084	0.281	0.306
Schistosoma mansoni	neurotransmitter gated ion channel	0.0039	0.1192	0.3835
Mycobacterium ulcerans	beta-lactamase	0.0043	0.1356	0.2805
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.1356	0.1091
Loa Loa (eye worm)	ACC-1 protein	0.0084	0.281	0.306
Schistosoma mansoni	nAChR subunit	0.0039	0.1192	0.3835
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0084	0.281	1
Schistosoma mansoni	neurotransmitter gated ion channel	0.0045	0.1425	0.4721
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0039	0.1192	0.3835
Loa Loa (eye worm)	hypothetical protein	0.0084	0.281	0.306
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1192	0.1174
Plasmodium vivax	apurinic/apyrimidinic endonuclease Apn1, putative	0.0092	0.3105	1
Brugia malayi	Cation transporter family protein	0.0084	0.281	0.306
Echinococcus granulosus	tar DNA binding protein	0.0076	0.2533	0.8942
Brugia malayi	Cation transporter family protein	0.0084	0.281	0.306
Entamoeba histolytica	recQ family helicase, putative	0.0014	0.0297	0.2087
Mycobacterium ulcerans	hypothetical protein	0.0043	0.1356	0.2805
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1356	0.1364
Schistosoma mansoni	nAChR subunit	0.0084	0.281	1
Loa Loa (eye worm)	GABA receptor subunit	0.0045	0.1425	0.1445
Brugia malayi	Cation transporter family protein	0.0084	0.281	0.306
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2533	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1192	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0084	0.281	0.306
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1192	0.1174
Brugia malayi	Pre-SET motif family protein	0.0036	0.1091	0.1056
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1425	0.1445
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.1356	0.4459
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0084	0.281	0.306
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.1091	0.345
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0045	0.1425	0.4721
Onchocerca volvulus		0.0039	0.1192	0.0556
Trichomonas vaginalis	set domain proteins, putative	0.0284	1	1
Trichomonas vaginalis	DNA helicase recq1, putative	0.0026	0.0725	0.0441
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.2533	0.2736
Plasmodium vivax	SET domain protein, putative	0.0036	0.1091	0.2479
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0036	0.1091	0.3515
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0084	0.281	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1192	0.1174
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0084	0.281	1
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0022	0.0614	0.1465
Loa Loa (eye worm)	beta-lactamase	0.0043	0.1356	0.1364
Brugia malayi	beta-lactamase family protein	0.0043	0.1356	0.1364
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.2533	0.2736
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.1356	0.1364
Schistosoma mansoni	nAChR subunit	0.0084	0.281	1
Echinococcus multilocularis	bloom syndrome protein	0.0026	0.0725	0.2054
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.2533	0.2736
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.1356	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1425	0.1445
Loa Loa (eye worm)	hypothetical protein	0.0084	0.281	0.306
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0084	0.281	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.1356	1
Echinococcus granulosus	glycine receptor subunit beta	0.0084	0.281	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0084	0.281	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1192	0.1174
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0039	0.1192	0.3835
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2533	0.8942
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0084	0.281	0.306
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0017	0.042	0.1354
Onchocerca volvulus		0.0036	0.1091	0.0447
Onchocerca volvulus		0.0084	0.281	0.2291
Onchocerca volvulus		0.0043	0.1356	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1192	0.1174
Onchocerca volvulus		0.0084	0.281	0.2291
Plasmodium falciparum	apurinic/apyrimidinic endonuclease Apn1, putative	0.0092	0.3105	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.281	0.306
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.1356	0.4459
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0084	0.281	1
Mycobacterium leprae	PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE)	0.0092	0.3105	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.281	0.306
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0039	0.1192	0.3835
Brugia malayi	beta-lactamase	0.0043	0.1356	0.1364
Mycobacterium tuberculosis	Conserved protein	0.0043	0.1356	0.0755
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0084	0.281	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1091	0.1056
Onchocerca volvulus		0.0043	0.1356	0.0731
Echinococcus multilocularis	nAChR subunit	0.0045	0.1425	0.4721
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0084	0.281	0.306
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0084	0.281	0.306
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.1356	0.3468
Brugia malayi	beta-lactamase family protein	0.0043	0.1356	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1192	0.1174
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0084	0.281	0.306
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.1356	0.2805
Loa Loa (eye worm)	hypothetical protein	0.0084	0.281	0.306
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.1356	0.0755
Brugia malayi	Hypothetical 29.7 kDa protein C05D11.5 in chromosome III	0.0024	0.0674	0.0569
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.1356	0.1364
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.1356	0.0755
Onchocerca volvulus		0.0084	0.281	0.2291
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0045	0.1425	0.4721
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0084	0.281	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0034	0.1044	0.327
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1192	0.1174
Echinococcus granulosus	glycine receptor subunit beta	0.0084	0.281	1
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0084	0.281	0.306
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0084	0.281	1
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0084	0.281	0.306
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.1356	0.0755
Echinococcus granulosus	bloom syndrome protein	0.0026	0.0725	0.2054
Schistosoma mansoni	nAChR subunit	0.0039	0.1192	0.3835
Schistosoma mansoni	nAChR subunit	0.0084	0.281	1
Schistosoma mansoni	blooms syndrome DNA helicase	0.002	0.0532	0.1318
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0084	0.281	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0084	0.281	1
Giardia lamblia	Sgs1 DNA helicase, putative	0.0011	0.0186	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0084	0.281	0.306
Schistosoma mansoni	nAChR subunit	0.0084	0.281	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1192	0.1174
Brugia malayi	Pre-SET motif family protein	0.0249	0.8763	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1192	0.1174
Schistosoma mansoni	nAChR subunit	0.0084	0.281	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1425	0.1445
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0084	0.281	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0539	0.0412
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0039	0.1192	0.3835
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0084	0.281	1
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0039	0.1192	0.3835
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.1356	0.2805
Mycobacterium ulcerans	endonuclease IV	0.0092	0.3105	1
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0084	0.281	0.306
Loa Loa (eye worm)	hypothetical protein	0.0092	0.3105	0.3404
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1192	0.1174
Onchocerca volvulus	Putative nachr subunit	0.0084	0.281	0.2291
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0186	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1356	0.1364
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0045	0.1425	0.1445
Echinococcus granulosus	nAChR subunit	0.0084	0.281	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.1356	0.0755
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0084	0.281	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0084	0.281	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0084	0.281	0.306
Loa Loa (eye worm)	hypothetical protein	0.0084	0.281	0.306
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0036	0.1091	0.345
Mycobacterium tuberculosis	Conserved protein	0.0043	0.1356	0.0755
Brugia malayi	hypothetical protein	0.0039	0.1192	0.1174
Loa Loa (eye worm)	LGC-31 protein	0.0084	0.281	0.306
Echinococcus granulosus	histone lysine methyltransferase setb	0.0036	0.1091	0.345
Schistosoma mansoni	nAChR subunit	0.0084	0.281	1
Mycobacterium ulcerans	lipase LipD	0.0043	0.1356	0.2805
Echinococcus multilocularis	nAChR subunit	0.0084	0.281	1
Loa Loa (eye worm)	acetylcholine receptor protein	0.0039	0.1192	0.1174
Trichomonas vaginalis	DNA helicase recq, putative	0.0026	0.0725	0.0441
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0084	0.281	0.306
Loa Loa (eye worm)	RecQ helicase	0.0026	0.0725	0.0629
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0186	0.0599
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.1356	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.1356	0.1091
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.1356	0.1091
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0084	0.281	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.1356	0.4459
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0084	0.281	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.1356	0.0755
Brugia malayi	hypothetical protein	0.0039	0.1192	0.1174
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2533	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1192	0.1174
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0084	0.281	1
Brugia malayi	TAR-binding protein	0.0076	0.2533	0.2736
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1425	0.1445
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0084	0.281	1
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0039	0.1192	0.1174
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0084	0.281	0.306
Loa Loa (eye worm)	hypothetical protein	0.0084	0.281	0.306
Brugia malayi	hypothetical protein	0.0039	0.1192	0.1174
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0084	0.281	0.306
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1192	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1356	0.1364
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2533	0.8942
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0039	0.1192	0.3835
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0045	0.1425	0.1445
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.1091	0.345
Echinococcus granulosus	nAChR subunit	0.0045	0.1425	0.4721
Onchocerca volvulus		0.0084	0.281	0.2291
Onchocerca volvulus		0.0039	0.1192	0.0556
Loa Loa (eye worm)	hypothetical protein	0.0084	0.281	0.306
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0039	0.1192	0.1174
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0039	0.1192	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0674	0.0569
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.1356	0.0755
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0039	0.1192	0.1174
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0084	0.281	0.306
Brugia malayi	RNA binding protein	0.0076	0.2533	0.2736
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0084	0.281	0.306
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0045	0.1425	0.1445
Onchocerca volvulus		0.0039	0.1192	0.0556
Brugia malayi	DNA-(Apurinic or apyrimidinic site) lyase	0.0092	0.3105	0.3404
Loa Loa (eye worm)	hypothetical protein	0.0084	0.281	0.306
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0084	0.281	1
Onchocerca volvulus		0.0084	0.281	0.2291
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0275	0.9705	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1192	0.1174
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0039	0.1192	0.1174
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0084	0.281	1
Schistosoma mansoni	acetylcholine receptor-related	0.0039	0.1192	0.3835
Onchocerca volvulus		0.0045	0.1425	0.0805
Trichomonas vaginalis	esterase, putative	0.0043	0.1356	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0084	0.281	0.306
Loa Loa (eye worm)	hypothetical protein	0.0084	0.281	0.306
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0084	0.281	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0036	0.1091	0.345
Loa Loa (eye worm)	hypothetical protein	0.0084	0.281	0.306
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0084	0.281	0.306
Brugia malayi	hypothetical protein	0.0039	0.1192	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1425	0.1445
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0084	0.281	0.306
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0039	0.1192	0.1174
Entamoeba histolytica	hypothetical protein	0.0045	0.1425	1
Brugia malayi	Bloom's syndrome protein homolog	0.0026	0.0725	0.0629
Loa Loa (eye worm)	RNA binding protein	0.0076	0.2533	0.2736
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0084	0.281	0.306
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0084	0.281	0.306
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1425	0.1445
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1356	0.1364
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0084	0.281	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0084	0.281	1
Brugia malayi	hypothetical protein	0.0039	0.1192	0.1174
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0084	0.281	1
Loa Loa (eye worm)	ACC-1 protein	0.0084	0.281	0.306
Loa Loa (eye worm)	hypothetical protein	0.0084	0.281	0.306
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0084	0.281	0.306
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0039	0.1192	0.1174
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.1091	0.345
Schistosoma mansoni	nAChR subunit	0.0084	0.281	1
Toxoplasma gondii	endonuclease IV APN	0.0092	0.3105	1
Onchocerca volvulus		0.0043	0.1356	0.0731
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.1356	0.0755
Chlamydia trachomatis	endonuclease IV	0.0092	0.3105	0.5
Brugia malayi	excitatory GABA receptor EXP-1A	0.0084	0.281	0.306
Schistosoma mansoni	neurotransmitter gated ion channel	0.0039	0.1192	0.3835
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.1356	0.4459
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.1356	0.1091
Onchocerca volvulus		0.0045	0.1425	0.0805

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (ADMET)	= 0.162 min-1	Deacylation rate constant(Kd fast) was determined by proflavin displacement assay	ChEMBL.	2002457
Kd (ADMET)	= 0.162 min-1	Deacylation rate constant(Kd slow) was determined by proflavin displacement assay	ChEMBL.	2002457

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 18272