Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin E receptor 1 (subtype EP1), 42kDa | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0095 | 0.3948 | 0.3889 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0108 | 0.4752 | 0.6357 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1592 | 0.0823 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0108 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0099 | 0.4168 | 0.5576 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0067 | 0.2228 | 0.2981 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0108 | 0.4752 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0041 | 0.061 | 0.0817 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0095 | 0.3948 | 0.528 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0032 | 0.0042 | 0.0056 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0152 | 0.7476 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0108 | 0.4752 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0058 | 0.1644 | 0.2199 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0067 | 0.2228 | 0.2941 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0152 | 0.7476 | 1 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0108 | 0.4752 | 0.6357 |
Onchocerca volvulus | 0.0177 | 0.9025 | 0.9285 | |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0102 | 0.4361 | 0.5834 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0073 | 0.2547 | 0.3708 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0102 | 0.4361 | 0.581 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0108 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0102 | 0.4361 | 0.5834 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0152 | 0.7476 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0073 | 0.2588 | 0.3461 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0102 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0102 | 0.4361 | 0.5834 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0085 | 0.3311 | 0.4398 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.8643 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0108 | 0.4752 | 0.6337 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0102 | 0.4361 | 0.4361 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0032 | 0.0042 | 0.0056 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0085 | 0.3311 | 0.443 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0184 | 0.9416 | 1 |
Mycobacterium ulcerans | thioesterase | 0.0085 | 0.3311 | 0.443 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0108 | 0.4752 | 0.6357 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0108 | 0.4752 | 0.6337 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0082 | 0.3131 | 0.4155 |
Mycobacterium ulcerans | polyketide synthase | 0.0102 | 0.4361 | 0.5834 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0066 | 0.2149 | 0.2574 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0082 | 0.3131 | 0.4188 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0067 | 0.2228 | 0.2981 |
Loa Loa (eye worm) | fatty acid synthase | 0.0101 | 0.4277 | 0.4318 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0035 | 0.0229 | 0.0306 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0102 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0102 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0102 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0099 | 0.4168 | 0.5576 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0083 | 0.3214 | 0.4299 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0102 | 0.4361 | 0.581 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0152 | 0.7476 | 1 |
Mycobacterium ulcerans | thioesterase TesA | 0.0085 | 0.3311 | 0.443 |
Brugia malayi | AMP-binding enzyme family protein | 0.0095 | 0.3948 | 0.3948 |
Mycobacterium ulcerans | polyketide synthase | 0.0108 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0082 | 0.3131 | 0.4188 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 30 nM | Antagonist activity human EP1 receptor assessed as inhibition of PGE2-induced effect by reporter gene assay | ChEMBL. | 24252546 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.