Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1372 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1372 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1372 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1372 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1372 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1372 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1372 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1372 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1372 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1372 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1372 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1372 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED300 (functional) | = 6.1 uM kg-1 | Effective dose causing a homovanillic acid (HVA) concentration three fold the control level in rat striatum | ChEMBL. | 6102606 |
HVA control (functional) | = 180 % | Tested for neuroleptic activity by measuring the increase in homovanillic acid (HVA) level in rat tuberculum olfactorium at dosage of 10 umol/kg | ChEMBL. | 6102606 |
HVA control (functional) | = 240 % | Tested for neuroleptic activity by measuring the increase in homovanillic acid (HVA) level in rat tuberculum olfactorium at dosage of 20 umol/kg | ChEMBL. | 6102606 |
HVA control (functional) | = 250 % | Tested for neuroleptic activity by measuring the increase in homovanillic acid (HVA) level in rat nucleus accumbens at dosage of 10 umol/kg | ChEMBL. | 6102606 |
HVA control (functional) | = 280 % | Tested for neuroleptic activity by measuring the increase in homovanillic acid (HVA) level in rat tuberculum olfactorium at dosage of 30 umol/kg | ChEMBL. | 6102606 |
HVA control (functional) | = 300 % | Tested for neuroleptic activity by measuring the increase in homovanillic acid (HVA) level in rat tuberculum olfactorium at dosage of 50 umol/kg | ChEMBL. | 6102606 |
HVA control (functional) | = 320 % | Tested for neuroleptic activity by measuring the increase in homovanillic acid (HVA) level in rat corpus striatum at dosage of 10 umol/kg | ChEMBL. | 6102606 |
HVA control (functional) | = 350 % | Tested for neuroleptic activity by measuring the increase in homovanillic acid (HVA) level in rat nucleus accumbens at dosage of 20 umol/kg | ChEMBL. | 6102606 |
HVA control (functional) | = 360 % | Tested for neuroleptic activity by measuring the increase in homovanillic acid (HVA) level in rat nucleus accumbens at dosage of 30 umol/kg | ChEMBL. | 6102606 |
HVA control (functional) | = 410 % | Tested for neuroleptic activity by measuring the increase in homovanillic acid (HVA) level in rat corpus striatum at dosage of 20 umol/kg | ChEMBL. | 6102606 |
HVA control (functional) | = 430 % | Tested for neuroleptic activity by measuring the increase in homovanillic acid (HVA) level in rat corpus striatum at dosage of 30 umol/kg | ChEMBL. | 6102606 |
HVA control (functional) | = 510 % | Tested for neuroleptic activity by measuring the increase in homovanillic acid (HVA) level in rat corpus striatum at dosage of 50 umol/kg | ChEMBL. | 6102606 |
HVA control (functional) | = 510 % | Tested for neuroleptic activity by measuring the increase in homovanillic acid (HVA) level in rat nucleus accumbens at dosage of 50 umol/kg | ChEMBL. | 6102606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.