Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | Starlite/ChEMBL | References |
Homo sapiens | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.215 | 0.4685 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0415 | 0.459 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 0.1076 | 0.2344 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0415 | 0.459 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0415 | 0.459 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.1485 | 0.3236 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0415 | 0.459 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0415 | 0.459 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0415 | 0.459 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0415 | 0.459 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0415 | 0.459 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0415 | 0.459 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0219 | 0.221 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0415 | 0.459 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0415 | 0.459 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0219 | 0.221 | 0.4814 |
Brugia malayi | MH2 domain containing protein | 0.0126 | 0.1076 | 0.2344 |
Brugia malayi | MAP kinase sur-1 | 0.0415 | 0.459 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0 | 0.5 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0219 | 0.221 | 0.4814 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0415 | 0.459 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0415 | 0.459 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0219 | 0.221 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | dual specificity | 0.0219 | 0.221 | 0.221 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0415 | 0.459 | 1 |
Echinococcus granulosus | dual specificity | 0.0219 | 0.221 | 0.4814 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0415 | 0.459 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0243 | 0.2504 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0 | 0.5 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0219 | 0.221 | 0.4814 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0415 | 0.459 | 0.459 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0415 | 0.459 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0 | 0.5 |
Onchocerca volvulus | 0.016 | 0.1485 | 1 | |
Brugia malayi | hypothetical protein | 0.016 | 0.1485 | 0.3236 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.215 | 0.4685 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0219 | 0.221 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0415 | 0.459 | 0.459 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0415 | 0.459 | 1 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0219 | 0.221 | 0.4814 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0219 | 0.221 | 0.4814 |
Brugia malayi | Protein kinase domain containing protein | 0.0219 | 0.221 | 0.4814 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0219 | 0.221 | 0.4814 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0415 | 0.459 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 0.1076 | 0.2344 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0219 | 0.221 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.027 uM | Cytotoxicity against human SW620 cells | ChEMBL. | 24239188 |
IC50 (binding) | = 0.005 uM | Inhibition of DYRK1A (unknown origin) | ChEMBL. | 24239188 |
IC50 (binding) | = 0.008 uM | Inhibition of DYRK1B (unknown origin) | ChEMBL. | 24239188 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24239188 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.