TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 478.391 | Formula: C22H21Cl2N3O3S
H donors: 2 H acceptors: 3 LogP: 4.6 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cc1ccc(c(c1)Cl)Cl)Nc1ccc(cc1)S(=O)(=O)Nc1cccc(c1)N(C)C
InChi: 1S/C22H21Cl2N3O3S/c1-27(2)18-5-3-4-17(14-18)26-31(29,30)19-9-7-16(8-10-19)25-22(28)13-15-6-11-20(23)21(24)12-15/h3-12,14,26H,13H2,1-2H3,(H,25,28)
InChiKey: NVIDWEOWVGJFSK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	Starlite/ChEMBL	References
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	Starlite/ChEMBL	References
Trypanosoma brucei gambiense	ATP-dependent phosphofructokinase,6-phospho-1-fructokinase		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C)	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania mexicana	6-phospho-1-fructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	hypothetical protein	Get druggable targets OG5_126758	All targets in OG5_126758
Brugia malayi	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C)	Get druggable targets OG5_126758	All targets in OG5_126758
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	Get druggable targets OG5_126758	All targets in OG5_126758
Brugia malayi	phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Entamoeba histolytica	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Echinococcus granulosus	6 phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania donovani	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Echinococcus multilocularis	6 phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania major	ATP-dependent phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Loa Loa (eye worm)	phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C)	Get druggable targets OG5_126758	All targets in OG5_126758
Loa Loa (eye worm)	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	Get druggable targets OG5_126758	All targets in OG5_126758
Entamoeba histolytica	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Mycobacterium ulcerans	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Entamoeba histolytica	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma brucei gambiense	ATP-dependent phosphofructokinase,6-phospho-1-fructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma japonicum	ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania infantum	ATP-dependent phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Brugia malayi	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma mansoni	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma congolense	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C)	Get druggable targets OG5_126758	All targets in OG5_126758
Loa Loa (eye worm)	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma mansoni	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania braziliensis	ATP-dependent phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.0265	0.0283
Trichomonas vaginalis	phosphofructokinase, putative	0.0197	0.4881	0.7438
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0019	0.0203	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0036	0.065	0.0596
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0053	0.1097	0.5
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.0265	0.0283
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.0265	0.0283
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0019	0.0203	0.0146
Schistosoma mansoni	hypothetical protein	0.0036	0.065	0.0694
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.0265	0.0209
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.0265	0.0209
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0559	0.0596
Loa Loa (eye worm)	6-phosphofructokinase	0.0197	0.4881	0.4852
Toxoplasma gondii	phosphofructokinase PFKII	0.0053	0.1097	0.3067
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0265	0.0209
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0374	0.0588
Brugia malayi	hypothetical protein	0.0112	0.2636	0.2594
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0053	0.1097	1
Brugia malayi	ecdysteroid receptor	0.0022	0.0265	0.0209
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	0.0265	0.0209
Schistosoma mansoni	z-protein (S1r protein)	0.0019	0.0203	0.0216
Brugia malayi	Pre-SET motif family protein	0.0228	0.5712	0.5687
Echinococcus granulosus	Protein son of sevenless	0.0014	0.0057	0.0061
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0014	0.0057	0.0061
Toxoplasma gondii	6-phosphofructokinase	0.0053	0.1097	0.3067
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0203	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0137	0.0081
Brugia malayi	6-phosphofructokinase	0.0197	0.4881	0.4852
Echinococcus multilocularis	segment polarity protein dishevelled	0.0019	0.0203	0.0216
Schistosoma mansoni	hypothetical protein	0.0367	0.9368	1
Schistosoma mansoni	dishevelled	0.0019	0.0203	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0265	0.0209
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0137	0.0147
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0559	0.0596
Entamoeba histolytica	hypothetical protein	0.0112	0.2636	0.5346
Entamoeba histolytica	phosphofructokinase, putative	0.0197	0.4881	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0265	0.0209
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.0265	0.0209
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0112	0.2636	0.2814
Echinococcus granulosus	ras GTP exchange factor	0.0014	0.0057	0.0061
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.0265	0.0283
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0203	0.0216
Plasmodium vivax	6-phosphofructokinase, putative	0.0053	0.1097	1
Loa Loa (eye worm)	transcription factor SMAD2	0.014	0.3387	0.3349
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0203	0.0216
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0559	0.0596
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0265	0.0283
Loa Loa (eye worm)	6-phosphofructokinase	0.0197	0.4881	0.4852
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0265	0.0209
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0265	0.0209
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0203	0.0216
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0137	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0265	0.0209
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.0265	0.0209
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0203	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0391	1	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.0265	0.0283
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.0265	0.0209
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0374	0.0657
Schistosoma mansoni	hypothetical protein	0.0017	0.0137	0.0147
Trichomonas vaginalis	phosphofructokinase, putative	0.0053	0.1097	0.1603
Schistosoma mansoni	hypothetical protein	0.0367	0.9368	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0265	0.0209
Echinococcus granulosus	6 phosphofructokinase	0.0197	0.4881	0.5211
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0228	0.5712	0.5687
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0559	0.0504
Schistosoma mansoni	aldehyde dehydrogenase	0.013	0.3117	0.3327
Plasmodium vivax	SET domain protein, putative	0.0033	0.0559	0.2551
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0265	0.0283
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0053	0.1097	0.1603
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0265	0.0283
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0013	0.0039	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0203	0.0146
Onchocerca volvulus	Protein ultraspiracle homolog	0.0022	0.0265	0.0209
Trichomonas vaginalis	phosphofructokinase, putative	0.0053	0.1097	0.1603
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0137	0.0147
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0265	0.0209
Schistosoma mansoni	hypothetical protein	0.0017	0.0137	0.0147
Trichomonas vaginalis	phosphofructokinase, putative	0.0197	0.4881	0.7438
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.0265	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1091	0.104
Schistosoma mansoni	ras GTP exchange factor	0.0014	0.0057	0.0061
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0019	0.0203	0.0146
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.0265	0.0283
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0137	0.0081
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0137	0.0081
Echinococcus multilocularis	son of sevenless 1	0.0014	0.0057	0.0061
Echinococcus granulosus	GPCR family 2	0.0017	0.0137	0.0147
Brugia malayi	phosphofructokinase	0.0197	0.4881	0.4852
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.0265	0.0209
Brugia malayi	hypothetical protein	0.0017	0.0134	0.0077
Schistosoma mansoni	dep domain containing protein	0.0019	0.0203	0.0216
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.013	0.3117	0.3327
Schistosoma mansoni	coup transcription factor	0.0022	0.0265	0.0283
Schistosoma mansoni	6-phosphofructokinase	0.0197	0.4881	0.5211
Leishmania major	ATP-dependent phosphofructokinase	0.0197	0.4881	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0265	0.0209
Loa Loa (eye worm)	DIX domain-containing protein	0.0019	0.0203	0.0146
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0374	0.0657
Trichomonas vaginalis	phosphofructokinase, putative	0.0053	0.1097	0.1603
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0391	1	1
Echinococcus multilocularis	segment polarity protein dishevelled	0.0019	0.0203	0.0216
Entamoeba histolytica	phosphofructokinase, putative	0.0197	0.4881	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0022	0.0265	0.0209
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0559	0.0596
Brugia malayi	steroid hormone receptor	0.0022	0.0265	0.0209
Echinococcus granulosus	rap guanine nucleotide exchange factor 6	0.0014	0.0057	0.0061
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0014	0.0057	0.0061
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.0265	0.0283
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0137	0.0147
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0197	0.4881	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.0265	0.0283
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.0265	0.0283
Brugia malayi	hypothetical protein	0.0019	0.0203	0.0146
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0265	0.0209
Echinococcus granulosus	geminin	0.0367	0.9368	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.0265	0.0283
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0053	0.1097	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.065	0.0596
Echinococcus granulosus	segment polarity protein dishevelled	0.0019	0.0203	0.0216
Onchocerca volvulus		0.026	0.6543	0.6523
Brugia malayi	regulator of G-protein signaling egl-10	0.0019	0.0203	0.0146
Brugia malayi	DIX domain containing protein	0.0019	0.0203	0.0146
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.0265	0.0283
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.0265	0.0283
Brugia malayi	MH2 domain containing protein	0.014	0.3387	0.3349
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0019	0.0203	0.0216
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.1091	0.104
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0203	0.0146
Trichomonas vaginalis	phosphofructokinase, putative	0.0197	0.4881	0.7438
Plasmodium vivax	6-phosphofructokinase, putative	0.0053	0.1097	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0265	0.0209
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0197	0.4881	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0265	0.0209
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.0265	0.0209
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.0265	0.0283
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0197	0.4881	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0265	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0203	0.0146
Loa Loa (eye worm)	MH2 domain-containing protein	0.014	0.3387	0.3349
Onchocerca volvulus		0.0022	0.0265	0.0209
Trichomonas vaginalis	phosphofructokinase, putative	0.0053	0.1097	0.1603
Echinococcus multilocularis	ras GTP exchange factor	0.0014	0.0057	0.0061
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.1091	0.104
Entamoeba histolytica	hypothetical protein	0.0112	0.2636	0.5346
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.1091	0.104
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.0265	0.0283
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0137	0.0147
Schistosoma mansoni	transcription factor LCR-F1	0.0112	0.2636	0.2814
Schistosoma mansoni	hypothetical protein	0.0112	0.2636	0.2814
Brugia malayi	nuclear hormone receptor	0.0022	0.0265	0.0209
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0559	0.0596
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.013	0.3117	0.6085
Echinococcus granulosus	rap guanine nucleotide exchange factor 1	0.0014	0.0057	0.0061
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.0265	0.0283
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0527	0.0562
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0053	0.1097	0.5
Brugia malayi	Pre-SET motif family protein	0.0033	0.0559	0.0504
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.0265	0.0283
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.0265	0.0209
Echinococcus multilocularis	6 phosphofructokinase	0.0197	0.4881	0.5211
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.0265	0.0209
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.0265	0.0209
Schistosoma mansoni	dishevelled	0.0019	0.0203	0.0216
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0197	0.4881	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.0265	0.0283
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0019	0.0203	0.0146
Trichomonas vaginalis	phosphofructokinase, putative	0.0053	0.1097	0.1603
Trichomonas vaginalis	phosphofructokinase, putative	0.0053	0.1097	0.1603
Entamoeba histolytica	hypothetical protein	0.0112	0.2636	0.5346
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.0265	0.0209
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.0265	0.0283
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0137	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0265	0.0209
Echinococcus multilocularis	rap guanine nucleotide exchange factor 6	0.0014	0.0057	0.0061
Brugia malayi	6-phosphofructokinase	0.0197	0.4881	0.4852
Echinococcus multilocularis	Protein son of sevenless	0.0014	0.0057	0.0061
Echinococcus multilocularis	geminin	0.0367	0.9368	1
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0265	0.0283
Schistosoma mansoni	hypothetical protein	0.0017	0.0137	0.0147
Echinococcus granulosus	son of sevenless 1	0.0014	0.0057	0.0061
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0265	0.0283
Onchocerca volvulus		0.0033	0.0559	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0374	0.0319
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.0265	0.0283
Schistosoma mansoni	aldehyde dehydrogenase	0.013	0.3117	0.3327
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.0265	0.0209
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.0265	0.0283
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.0265	0.0209
Echinococcus granulosus	segment polarity protein dishevelled	0.0019	0.0203	0.0216
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0112	0.2636	0.2814
Toxoplasma gondii	aldehyde dehydrogenase	0.013	0.3117	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	0.0265	0.0283
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.0265	0.0209
Brugia malayi	hypothetical protein	0.0026	0.0374	0.0319
Schistosoma mansoni	hypothetical protein	0.0017	0.0137	0.0147
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0014	0.0057	0.0061
Echinococcus multilocularis	rap guanine nucleotide exchange factor 1	0.0014	0.0057	0.0061
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.0265	0.0209
Entamoeba histolytica	phosphofructokinase, putative	0.0197	0.4881	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0559	0.0596
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.0265	0.0283
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0019	0.0203	0.0216
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0559	0.1221
Brugia malayi	hypothetical protein	0.0019	0.0203	0.0146
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0053	0.1097	0.5
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0019	0.0203	0.0146
Trichomonas vaginalis	phosphofructokinase, putative	0.0197	0.4881	0.7438
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0265	0.0209
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0265	0.0283
Loa Loa (eye worm)	phosphofructokinase	0.0197	0.4881	0.4852
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0265	0.0283
Mycobacterium ulcerans	6-phosphofructokinase	0.0197	0.4881	1
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0197	0.4881	1
Onchocerca volvulus		0.0019	0.0203	0.0146
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0053	0.1097	0.3067
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0014	0.0057	0.0061
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0265	0.0209
Trichomonas vaginalis	set domain proteins, putative	0.026	0.6543	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.013	0.3117	0.3327
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0559	0.0596
Onchocerca volvulus	Bile acid receptor homolog	0.0022	0.0265	0.0209
Entamoeba histolytica	hypothetical protein	0.0112	0.2636	0.5346
Schistosoma mansoni	6-phosphofructokinase	0.0197	0.4881	0.5211
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0265	0.0209
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0053	0.1097	0.2155

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.8 uM	Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay	ChEMBL.	24900769
IC50 (binding)	= 11.6 uM	Inhibition of Trypanosoma cruzi PFK	ChEMBL.	24900769
Inhibition (binding)	> 80 %	Inhibition of Trypanosoma cruzi PFK at 57 uM	ChEMBL.	24900769
Inhibition (binding)	> 80 %	Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate at 57 uM by luciferase based luminescence assay	ChEMBL.	24900769

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3108866

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1827459