Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0253 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1245 | 0.1245 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0367 | 0.0367 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0253 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0253 | 1 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.014 | 0.5339 | 0.5339 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.2002 | 0.2002 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0253 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1245 | 0.1245 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 0.5339 | 0.5339 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0367 | 0.0367 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.2002 | 0.2002 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0253 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0253 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0253 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0367 | 0.0367 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0253 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0253 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0253 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0253 | 1 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 0.5339 | 0.5339 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0367 | 0.0367 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0367 | 0.0367 |
Trypanosoma brucei | protein kinase, putative | 0.0253 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0253 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0367 | 0.0367 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.2002 | 0.2002 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0253 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.2002 | 0.2002 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0253 | 1 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0367 | 0.0367 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0367 | 0.0367 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0253 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0253 | 1 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0367 | 0.0367 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0367 | 0.0367 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0367 | 0.0367 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.1245 | 0.1245 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of TLR2/6 in BALB/c mouse BMDM assessed as downregulation of BLP-stimulated IL-12p40 level at 5 ug/ml preincubated for 18 hrs followed by BLP challenge measured after 24 hrs by ELISA relative to control | ChEMBL. | 24228757 | |
Inhibition (binding) | Inhibition of TLR2/6 in BALB/c mouse BMDM assessed as downregulation of BLP-stimulated IL-6 level at 5 ug/ml preincubated for 18 hrs followed by BLP challenge measured after 24 hrs by ELISA relative to control | ChEMBL. | 24228757 | |
Inhibition (binding) | Inhibition of TLR4 in BALB/c mouse BMDM assessed as downregulation of LPS-stimulated IL-6 level at 5 ug/ml preincubated for 18 hrs followed by LPS challenge measured after 24 hrs by ELISA relative to control | ChEMBL. | 24228757 | |
Inhibition (binding) | Inhibition of TLR4 in BALB/c mouse BMDM assessed as downregulation of LPS-stimulated IL-12p40 level at 5 ug/ml preincubated for 18 hrs followed by LPS challenge measured after 24 hrs by ELISA relative to control | ChEMBL. | 24228757 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.