Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dihydrofolate reductase | 0.2151 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.021 | 0.0223 | 0.0223 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0231 | 0.033 | 0.033 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1731 | 0.7884 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1731 | 0.7884 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0231 | 0.033 | 0.033 |
Schistosoma mansoni | dihydrofolate reductase | 0.2151 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2151 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.033 | 0.011 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1731 | 0.7884 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2151 | 1 | 0.5 |
Onchocerca volvulus | 0.021 | 0.0223 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0231 | 0.033 | 0.011 |
Echinococcus multilocularis | thymidylate synthase | 0.021 | 0.0223 | 0.0223 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1731 | 0.7884 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2151 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.021 | 0.0223 | 0.0223 |
Echinococcus granulosus | dihydrofolate reductase | 0.2151 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1731 | 0.7884 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.2151 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1731 | 0.7884 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2151 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.