Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 2 | Starlite/ChEMBL | References |
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | 0.0679 | 0.2732 | 0.4441 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0679 | 0.2732 | 0.2732 |
Loa Loa (eye worm) | hypothetical protein | 0.0679 | 0.2732 | 0.2732 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0679 | 0.2732 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0679 | 0.2732 | 0.2732 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0679 | 0.2732 | 0.2732 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0679 | 0.2732 | 0.2732 |
Schistosoma mansoni | coup transcription factor | 0.0679 | 0.2732 | 0.3375 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0679 | 0.2732 | 0.2732 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0679 | 0.2732 | 0.3375 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0679 | 0.2732 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0679 | 0.2732 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0679 | 0.2732 | 0.2732 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0679 | 0.2732 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0679 | 0.2732 | 0.2732 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0679 | 0.2732 | 0.2732 |
Loa Loa (eye worm) | hypothetical protein | 0.0679 | 0.2732 | 0.2732 |
Loa Loa (eye worm) | hypothetical protein | 0.1487 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0679 | 0.2732 | 0.3375 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0679 | 0.2732 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.1434 | 0.952 | 0.952 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0679 | 0.2732 | 0.4441 |
Onchocerca volvulus | Bile acid receptor homolog | 0.1487 | 1 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.1059 | 0.6151 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0679 | 0.2732 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0679 | 0.2732 | 0.3375 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0679 | 0.2732 | 0.2732 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0679 | 0.2732 | 0.2732 |
Schistosoma mansoni | thyroid hormone receptor | 0.0679 | 0.2732 | 0.3375 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0679 | 0.2732 | 0.4441 |
Loa Loa (eye worm) | hypothetical protein | 0.0679 | 0.2732 | 0.2732 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0679 | 0.2732 | 0.2732 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0679 | 0.2732 | 0.2732 |
Brugia malayi | nuclear receptor NHR-88 | 0.0679 | 0.2732 | 0.2732 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0679 | 0.2732 | 0.2732 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0679 | 0.2732 | 0.3375 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0679 | 0.2732 | 0.4441 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0679 | 0.2732 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0679 | 0.2732 | 0.2732 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0679 | 0.2732 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0679 | 0.2732 | 0.3375 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0679 | 0.2732 | 0.2732 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0679 | 0.2732 | 0.2732 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.1275 | 0.8096 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0679 | 0.2732 | 0.2732 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0679 | 0.2732 | 0.4441 |
Echinococcus granulosus | FTZ F1 alpha | 0.0679 | 0.2732 | 0.4441 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0679 | 0.2732 | 0.3375 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0679 | 0.2732 | 0.2732 |
Loa Loa (eye worm) | hypothetical protein | 0.0679 | 0.2732 | 0.2732 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0679 | 0.2732 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0679 | 0.2732 | 0.4441 |
Loa Loa (eye worm) | hypothetical protein | 0.0679 | 0.2732 | 0.2732 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0679 | 0.2732 | 0.3375 |
Brugia malayi | steroid hormone receptor | 0.1434 | 0.952 | 0.952 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0679 | 0.2732 | 0.2732 |
Schistosoma mansoni | nuclear hormone receptor | 0.0679 | 0.2732 | 0.3375 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0679 | 0.2732 | 0.2732 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0679 | 0.2732 | 0.4441 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0679 | 0.2732 | 0.2732 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0679 | 0.2732 | 0.2732 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0679 | 0.2732 | 0.3375 |
Brugia malayi | nuclear hormone receptor | 0.0679 | 0.2732 | 0.2732 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0679 | 0.2732 | 0.3375 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0679 | 0.2732 | 0.3375 |
Loa Loa (eye worm) | hypothetical protein | 0.0679 | 0.2732 | 0.2732 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0679 | 0.2732 | 0.4441 |
Loa Loa (eye worm) | hypothetical protein | 0.0679 | 0.2732 | 0.2732 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0679 | 0.2732 | 0.2732 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Emax (binding) | = 77 % | Agonist activity at glucocorticoid receptor in human foreskin fibroblasts assessed as IL-1-mediated IL-6 synthesis at 2 mM after 24 hrs relative to dexamethasone | ChEMBL. | 24239189 |
IC50 (binding) | = 2 nM | Inhibition of glucocorticoid receptor (unknown origin) expressed in baculovirus-infected insect cells by fluorescence polarization assay | ChEMBL. | 24239189 |
IC50 (binding) | = 22 nM | Agonist activity at glucocorticoid receptor in human foreskin fibroblasts assessed as IL-1-mediated IL-6 synthesis after 24 hrs | ChEMBL. | 24239189 |
IC50 (binding) | = 270 nM | Inhibition of mineralocorticoid receptor (unknown origin) expressed in baculovirus-infected insect cells by fluorescence polarization assay | ChEMBL. | 24239189 |
IC50 (binding) | = 620 nM | Inhibition of progesterone receptor (unknown origin) expressed in baculovirus-infected insect cells by fluorescence polarization assay | ChEMBL. | 24239189 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.