Detailed information for compound 1827958

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 308.378 | Formula: C18H20N4O
  • H donors: 2 H acceptors: 2 LogP: 3.12 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)c1c(nn(c1N)C(C)(C)C)c1ccc2c(c1)cccc2
  • InChi: 1S/C18H20N4O/c1-18(2,3)22-16(19)14(17(20)23)15(21-22)13-9-8-11-6-4-5-7-12(11)10-13/h4-10H,19H2,1-3H3,(H2,20,23)
  • InChiKey: JOJOVBICKPOJFI-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II alpha chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Cam kinase protein 1 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Babesia bovis calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calmodulin-domain protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium berghei calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK2B Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calmodulin-domain protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium falciparum calcium-dependent protein kinase 2 Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium falciparum calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium falciparum calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium knowlesi calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II delta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania infantum protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calcium-dependent protein kinase-3 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calmodulin-domain protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii Plasmodium falciparum CDPK2 protein Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis CDPK2 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK2A Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium berghei calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Cryptosporidium hominis calcium-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium yoelii calcium-dept. protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calcium-dependent protein kinase 2, related Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calmodulin-domain protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium knowlesi calcium-dependent protein kinase 5, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II beta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K08794 calcium/calmodulin-dependent protein kinase I, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium knowlesi calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) CAMK/CAMK2 protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calmodulin-like domain protein kinase isoenzyme gamma, related Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium falciparum calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0041 0.1134 0.1131
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.1277 0.1273
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0105 0.0101
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0008 0.0067 0.0639
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0105 0.0105
Echinococcus granulosus c src tyrosine kinase 0.001 0.0146 0.0142
Schistosoma mansoni tyrosine kinase 0.001 0.0146 0.0146
Echinococcus multilocularis c src tyrosine kinase 0.001 0.0146 0.0142
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.1277 0.1273
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0317 1 1
Entamoeba histolytica protein kinase, putative 0.0021 0.0502 0.5065
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.1277 0.1273
Echinococcus multilocularis mitogen activated protein kinase 0.0317 1 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0317 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0502 0.0502
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.1277 0.1273
Trichomonas vaginalis CMGC family protein kinase 0.0317 1 1
Brugia malayi SRC-1 0.0045 0.1277 0.1273
Loa Loa (eye worm) hypothetical protein 0.0009 0.0105 0.0101
Schistosoma mansoni tyrosine kinase 0.0006 0.0004 0.0004
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0021 0.0503 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.1277 0.1273
Echinococcus granulosus growth factor receptor bound protein 2 0.0009 0.0105 0.0101
Echinococcus multilocularis tyrosine protein kinase Blk 0.0041 0.1134 0.1131
Echinococcus multilocularis tyrosine protein kinase HCK 0.0036 0.0988 0.0985
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.1134 0.1131
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0317 1 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0317 1 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.001 0.0146 0.0142
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0009 0.0105 0.0101
Entamoeba histolytica protein kinase, putative 0.0021 0.0502 0.5065
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.1277 0.1273
Trichomonas vaginalis CMGC family protein kinase 0.0317 1 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0021 0.0503 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.1277 0.1273
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0009 0.0105 0.0101
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0021 0.0502 0.0499
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0021 0.0502 0.0499
Schistosoma mansoni protein kinase 0.0021 0.0502 0.0502
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0105 0.0101
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.001 0.0146 0.0142
Echinococcus multilocularis mitogen activated protein kinase 3 0.0317 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.1277 0.1273
Echinococcus granulosus tyrosine kinase 0.0041 0.1134 0.1131
Plasmodium falciparum calcium-dependent protein kinase 2 0.0021 0.0503 0.5
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0021 0.0502 0.0499
Schistosoma mansoni protein kinase 0.0021 0.0502 0.0502
Loa Loa (eye worm) TK protein kinase 0.0041 0.1134 0.1131
Echinococcus granulosus NCK adaptor protein 0.0009 0.0105 0.0101
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.1093 0.109
Trichomonas vaginalis CMGC family protein kinase 0.0317 1 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.1277 0.1273
Schistosoma mansoni tyrosine kinase 0.001 0.0146 0.0146
Echinococcus granulosus tyrosine protein kinase Blk 0.0041 0.1134 0.1131
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0317 1 1
Brugia malayi protein-tyrosine kinase 0.0041 0.1134 0.1131
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0021 0.0502 0.0499
Schistosoma mansoni serine/threonine protein kinase 0.0317 1 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0317 1 0.5
Giardia lamblia Kinase, CMGC MAPK 0.0317 1 0.5
Schistosoma mansoni tyrosine kinase 0.0045 0.1277 0.1277
Schistosoma mansoni tyrosine kinase 0.0045 0.1277 0.1277
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0021 0.0502 0.0499
Trypanosoma brucei protein kinase, putative 0.0317 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.001 0.0146 0.0146
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0021 0.0503 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.001 0.0146 0.0142
Trichomonas vaginalis CMGC family protein kinase 0.0317 1 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.1277 0.1273
Plasmodium vivax calcium-dependent protein kinase, putative 0.0021 0.0503 0.5
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.1277 0.1273
Echinococcus granulosus calcium dependent protein kinase 0.0018 0.0399 0.0395
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0105 0.0105
Schistosoma mansoni adapter molecule crk 0.0009 0.0105 0.0105
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0021 0.0503 0.5
Schistosoma mansoni nck2/grb4 0.0009 0.0105 0.0105
Echinococcus granulosus tyrosine protein kinase Lyn 0.0049 0.1381 0.1377
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0317 1 0.5
Echinococcus multilocularis calcium dependent protein kinase 0.0018 0.0399 0.0395
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.1277 0.1273
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0021 0.0502 0.0499
Brugia malayi Tyrosine-protein kinase abl-1 0.001 0.0146 0.0142
Loa Loa (eye worm) hypothetical protein 0.0021 0.0502 0.0499
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0009 0.0105 0.0105
Onchocerca volvulus 0.0008 0.0063 1
Schistosoma mansoni protein kinase 0.0021 0.0502 0.0502
Plasmodium falciparum calcium-dependent protein kinase 5 0.0021 0.0503 0.5
Plasmodium falciparum calcium-dependent protein kinase 1 0.0021 0.0503 0.5
Brugia malayi Cam kinase protein 1 0.0021 0.0502 0.0499
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0317 1 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0021 0.0502 0.0499
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.1093 0.109
Loa Loa (eye worm) SRC-1 0.0045 0.1277 0.1273
Loa Loa (eye worm) TK protein kinase 0.0036 0.0988 0.0985
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0021 0.0502 0.0499
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.1277 0.1273
Plasmodium falciparum calcium-dependent protein kinase 3 0.0021 0.0503 0.5
Echinococcus multilocularis growth factor receptor bound protein 2 0.0009 0.0105 0.0101
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0021 0.0502 0.0499
Echinococcus granulosus mitogen activated protein kinase 0.0317 1 1
Echinococcus multilocularis NCK adaptor protein 0.0009 0.0105 0.0101
Echinococcus granulosus tyrosine protein kinase HCK 0.0036 0.0988 0.0985
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0317 1 0.5
Schistosoma mansoni tyrosine kinase 0.0006 0.0004 0.0004
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.1277 0.1273
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.1277 0.1273
Entamoeba histolytica protein kinase, putative 0.0036 0.0988 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0021 0.0502 0.0499
Brugia malayi Sex muscle abnormal protein 5 0.0009 0.0105 0.0101
Echinococcus multilocularis tyrosine protein kinase Srms 0.0041 0.1134 0.1131
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0021 0.0502 0.0499
Entamoeba histolytica protein kinase, putative 0.0008 0.0067 0.0639
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.1277 0.1273
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0317 1 0.5

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.26 uM Inhibition of Toxoplasma gondii proliferation ChEMBL. 24494061
IC50 (binding) = 0.002 uM Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrate ChEMBL. 24494061
IC50 (binding) = 0.002 uM Inhibition of recombinant Toxoplasma gondii CDPK1 using Syntide 2 as substrate assessed as decrease in depletion of ATP after 90 mins by Kinase glo luciferase assay LITERATURE. 27780638
IC50 (binding) = 1.3 uM Inhibition of Src (unknown origin) ChEMBL. 24494061
IC50 (binding) = 1.32 uM Inhibition of human SRC using Ac-EIYGEFKKK as substrate after 90 mins by Kinase glo luciferase assay LITERATURE. 27780638

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Toxoplasma gondii ChEMBL23 24494061

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.