TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 344.161 | Formula: C12H14BrN3O4
H donors: 3 H acceptors: 5 LogP: 0.1 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cc(c2c1ncnc2C)Br
InChi: 1S/C12H14BrN3O4/c1-5-8-6(13)2-16(11(8)15-4-14-5)12-10(19)9(18)7(3-17)20-12/h2,4,7,9-10,12,17-19H,3H2,1H3/t7-,9-,10-,12-/m1/s1
InChiKey: UQQQHAFXXLQKCR-UGKPPGOTSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0402	0.2398	0.3942
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0121	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0045	0.0343
Loa Loa (eye worm)	glycogen phosphorylase	0.011	0.0524	0.4019
Brugia malayi	hypothetical protein	0.0032	0.0025	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0045	0.0343
Leishmania major	thymidine kinase, putative	0.0512	0.3106	1
Schistosoma mansoni	lamin	0.0053	0.0157	0.0215
Schistosoma mansoni	hypothetical protein	0.0047	0.0121	0.0155
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0065	0.0238	0.1588
Echinococcus granulosus	thymidylate kinase	0.0145	0.0747	0.1197
Entamoeba histolytica	glycogen phosphorylase, putative	0.011	0.0524	0.1565
Onchocerca volvulus	Ribonuclease H1 homolog	0.0067	0.0249	0.2905
Trichomonas vaginalis	glycogen phosphorylase, putative	0.011	0.0524	0.1565
Trichomonas vaginalis	inositol monophosphatase, putative	0.0073	0.0287	0.0792
Trichomonas vaginalis	thymidylate kinase, putative	0.0145	0.0747	0.2296
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0103	0.0481	0.3688
Brugia malayi	RNase H family protein	0.0067	0.0249	0.1909
Giardia lamblia	Ribonuclease H	0.0067	0.0249	0.0229
Schistosoma mansoni	hypothetical protein	0.0105	0.0493	0.0773
Schistosoma mansoni	hypothetical protein	0.0035	0.0044	0.0027
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.0057	0.0183	0.0453
Echinococcus multilocularis	musashi	0.0053	0.0157	0.013
Schistosoma mansoni	intermediate filament proteins	0.0053	0.0157	0.0215
Loa Loa (eye worm)	hypothetical protein	0.005	0.0138	0.1062
Trypanosoma brucei	RNA helicase, putative	0.0402	0.2398	0.7688
Echinococcus multilocularis	Glycosyl transferase, family 35	0.011	0.0524	0.0497
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0133	0.067	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0045	0.0343
Trypanosoma brucei	PAB1-binding protein , putative	0.005	0.0138	0.0306
Loa Loa (eye worm)	inositol-1	0.0073	0.0287	0.2204
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0053	0.0157	0.1206
Giardia lamblia	CDC8	0.0145	0.0747	0.1934
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0151	0.1159
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0103	0.0481	0.3688
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0057	0.0182	0.0448
Schistosoma mansoni	hypothetical protein	0.0133	0.067	0.1067
Entamoeba histolytica	Thymidylate kinase, putative	0.0145	0.0747	0.2297
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0139	0.0184
Echinococcus granulosus	lamin dm0	0.0053	0.0157	0.0215
Brugia malayi	RNase H family protein	0.0067	0.0249	0.1909
Brugia malayi	RNase H family protein	0.0067	0.0249	0.1909
Trypanosoma cruzi	thymidylate kinase, putative	0.0145	0.0747	0.2296
Trypanosoma brucei	unspecified product	0.0076	0.0307	0.0858
Schistosoma mansoni	thymidylate kinase	0.0145	0.0747	0.1197
Trichomonas vaginalis	thymidine kinase, putative	0.0512	0.3106	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0045	0.0028
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0139	0.0111
Schistosoma mansoni	phosphoglucomutase	0.0067	0.0249	0.0367
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0139	0.0184
Echinococcus granulosus	thymidine kinase	0.0969	0.604	1
Trichomonas vaginalis	ribonuclease H1, putative	0.0067	0.0249	0.0667
Brugia malayi	hypothetical protein	0.0231	0.1303	1
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0044	0.0027
Schistosoma mansoni	ap endonuclease	0.0057	0.0182	0.0256
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0045	0.0017
Schistosoma mansoni	ap endonuclease	0.0057	0.0182	0.0256
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0133	0.067	0.1067
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0057	0.0182	0.1953
Onchocerca volvulus		0.0047	0.0121	0.1092
Trypanosoma brucei	ingi protein (ORF1)	0.0076	0.0307	0.0858
Onchocerca volvulus		0.0053	0.0157	0.1602
Schistosoma mansoni	glycogen phosphorylase	0.011	0.0524	0.0824
Brugia malayi	thymidylate kinase	0.0145	0.0747	0.5736
Echinococcus multilocularis	inositol monophosphatase 1	0.0073	0.0287	0.026
Entamoeba histolytica	thymidine kinase, putative	0.0512	0.3106	1
Trichomonas vaginalis	thymidine kinase, putative	0.0512	0.3106	1
Schistosoma mansoni	thyroid hormone receptor	0.0143	0.0738	0.1181
Echinococcus granulosus	thymidine kinase	0.0969	0.604	1
Leishmania major	ribonuclease H1, putative	0.0067	0.0249	0.0667
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0045	0.0343
Schistosoma mansoni	inositol monophosphatase	0.0073	0.0287	0.0431
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0057	0.0182	0.0154
Leishmania major	hypothetical protein, conserved	0.0057	0.0183	0.0453
Echinococcus multilocularis	thymidine kinase	0.0969	0.604	0.6029
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0139	0.0184
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0073	0.0287	0.0792
Schistosoma mansoni	phosphoglucomutase	0.0067	0.0249	0.0367
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0139	0.1065
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0073	0.0287	0.0792
Onchocerca volvulus		0.0053	0.0157	0.1602
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.1303	0.1279
Brugia malayi	exodeoxyribonuclease III family protein	0.0057	0.0182	0.1396
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0045	0.0343
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0057	0.0182	0.1396
Schistosoma mansoni	inositol monophosphatase	0.0073	0.0287	0.0431
Brugia malayi	beta-lactamase	0.0035	0.0045	0.0343
Trypanosoma brucei	hypothetical protein, conserved	0.0076	0.0307	0.0858
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0057	0.0182	0.0714
Plasmodium vivax	ataxin-2 like protein, putative	0.005	0.0138	0.1334
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.1303	0.2121
Entamoeba histolytica	glycogen phosphorylase, putative	0.0047	0.0123	0.0258
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0073	0.0287	0.0792
Loa Loa (eye worm)	hypothetical protein	0.007	0.0271	0.208
Trichomonas vaginalis	glycogen phosphorylase, putative	0.011	0.0524	0.1565
Echinococcus multilocularis	transfer RNA-Ile	0.0969	0.604	0.6029
Trichomonas vaginalis	thymidylate kinase, putative	0.0145	0.0747	0.2296
Schistosoma mansoni	hypothetical protein	0.0166	0.0882	0.1421
Schistosoma mansoni	glycogen phosphorylase	0.0047	0.0123	0.0159
Schistosoma mansoni	lipoxygenase	0.0054	0.0165	0.0228
Trypanosoma brucei	thymidylate kinase, putative	0.0145	0.0747	0.2296
Trypanosoma cruzi	thymidine kinase, putative	0.0512	0.3106	1
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0045	0.0343
Echinococcus multilocularis	ribonuclease H1	0.0067	0.0249	0.0221
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0045	0.0343
Brugia malayi	beta-lactamase family protein	0.0035	0.0045	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0045	0.0343
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0044	0.0027
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0054	0.0165	0.0138
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0028	0.0215
Schistosoma mansoni	thyroid hormone receptor	0.0143	0.0738	0.1181
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0139	0.0184
Mycobacterium leprae	probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK)	0.0145	0.0747	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0053	0.0157	0.1206
Echinococcus granulosus	glycogen phosphorylase	0.011	0.0524	0.0824
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0045	0.0028
Wolbachia endosymbiont of Brugia malayi	thymidylate kinase	0.0145	0.0747	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0143	0.0738	0.0712
Giardia lamblia	Glycogen phosphorylase	0.011	0.0524	0.1169
Trichomonas vaginalis	ap endonuclease, putative	0.0057	0.0182	0.0448
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0121	0.0155
Giardia lamblia	Thymidine kinase	0.0512	0.3106	1
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0054	0.0165	0.0228
Toxoplasma gondii	thymidylate kinase	0.0145	0.0747	1
Schistosoma mansoni	lamin	0.0053	0.0157	0.0215
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0073	0.0287	0.0793
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0057	0.0182	0.0448
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0065	0.0238	0.2753
Loa Loa (eye worm)	hypothetical protein	0.0231	0.1303	1
Echinococcus multilocularis	thymidylate kinase	0.0145	0.0747	0.0721
Leishmania major	hypothetical protein, conserved	0.005	0.0138	0.0306
Echinococcus multilocularis	glycogen phosphorylase	0.011	0.0524	0.0497
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0047	0.0123	0.1121
Entamoeba histolytica	glycogen phosphorylase, putative	0.011	0.0524	0.1565
Schistosoma mansoni	thymidylate kinase	0.0145	0.0747	0.1197
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0047	0.0123	0.0647
Echinococcus multilocularis	lamin	0.0053	0.0157	0.013
Brugia malayi	intermediate filament protein	0.0053	0.0157	0.1206
Trypanosoma cruzi	thymidine kinase, putative	0.0512	0.3106	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0139	0.0111
Entamoeba histolytica	glycogenphosphorylase, putative	0.0047	0.0123	0.0258
Echinococcus multilocularis	lamin dm0	0.0053	0.0157	0.013
Echinococcus multilocularis	glycogen phosphorylase	0.011	0.0524	0.0497
Onchocerca volvulus	Glycogen phosphorylase homolog	0.011	0.0524	0.6816
Echinococcus granulosus	Thymidine kinase 2 mitochondrial	0.0969	0.604	1
Trichomonas vaginalis	thymidine kinase, putative	0.0512	0.3106	1
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0028	0.0215
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.0057	0.0183	0.0453
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0044	0.0016
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0057	0.0182	0.0256
Schistosoma mansoni	hypothetical protein	0.0145	0.0747	0.1197
Toxoplasma gondii	ribonuclease HI protein	0.0067	0.0249	0.2905
Schistosoma mansoni	glycogen phosphorylase	0.011	0.0524	0.0824
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0073	0.0287	0.3451
Mycobacterium ulcerans	thymidylate kinase	0.0145	0.0747	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0138	0.0306
Toxoplasma gondii	LsmAD domain-containing protein	0.005	0.0138	0.1334
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0225	0.1263	1
Brugia malayi	Inositol-1	0.0073	0.0287	0.2204
Echinococcus granulosus	intermediate filament protein	0.0053	0.0157	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0481	0.3688
Echinococcus granulosus	Glycosyl transferase family 35	0.011	0.0524	0.0824
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.0271	0.208
Trypanosoma cruzi	ribonuclease H1, putative	0.0067	0.0249	0.0667
Echinococcus multilocularis	geminin	0.0166	0.0882	0.0857
Echinococcus granulosus	inositol monophosphatase 1	0.0073	0.0287	0.0431
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0057	0.0182	0.1127
Trypanosoma brucei	thymidylate kinase, putative	0.0145	0.0747	0.2296
Onchocerca volvulus	Putative thymidylate kinase	0.0145	0.0747	1
Trypanosoma cruzi	ribonuclease H1, putative	0.0067	0.0249	0.0667
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0076	0.0307	0.0858
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0028	0.0215
Brugia malayi	beta-lactamase family protein	0.0035	0.0045	0.0343
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0073	0.0287	0.0792
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0045	0.0028
Trypanosoma cruzi	thymidylate kinase, putative	0.0145	0.0747	0.2296
Loa Loa (eye worm)	intermediate filament protein	0.0053	0.0157	0.1206
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0067	0.0249	0.1183
Chlamydia trachomatis	thymidylate kinase	0.0145	0.0747	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0139	0.0184
Treponema pallidum	ribonuclease H (rnhA)	0.0067	0.0249	0.1183
Trichomonas vaginalis	ap endonuclease, putative	0.0057	0.0182	0.0448
Mycobacterium tuberculosis	Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK)	0.0145	0.0747	0.577
Echinococcus granulosus	ribonuclease H1	0.0067	0.0249	0.0367
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0073	0.0287	0.0792
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0057	0.0182	0.0448
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0073	0.0287	0.1862
Echinococcus granulosus	lamin	0.0053	0.0157	0.0215
Brugia malayi	hypothetical protein	0.0035	0.0044	0.0341
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0057	0.0182	0.1953
Echinococcus multilocularis	thymidine kinase	0.0969	0.604	0.6029
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0028	0.0215
Schistosoma mansoni	hypothetical protein	0.007	0.0271	0.0404
Echinococcus granulosus	glycogen phosphorylase	0.011	0.0524	0.0824
Schistosoma mansoni	hypothetical protein	0.0166	0.0882	0.1421
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0073	0.0287	0.0792
Schistosoma mansoni	thymidine kinase	0.0969	0.604	1
Treponema pallidum	thymidylate kinase (tmk)	0.0145	0.0747	1
Toxoplasma gondii	exonuclease III APE	0.0057	0.0182	0.1953
Plasmodium falciparum	thymidylate kinase	0.0145	0.0747	1
Echinococcus granulosus	geminin	0.0166	0.0882	0.1421
Brugia malayi	carbohydrate phosphorylase	0.011	0.0524	0.4019
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0045	0.0343
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0139	0.1065
Schistosoma mansoni	phosphoglucomutase	0.0067	0.0249	0.0367
Loa Loa (eye worm)	thymidylate kinase	0.0145	0.0747	0.5736
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0057	0.0182	0.0449
Plasmodium vivax	thymidylate kinase, putative	0.0145	0.0747	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0157	0.1206
Trypanosoma brucei	ribonuclease H1	0.0067	0.0249	0.0667
Trypanosoma brucei	thymidine kinase	0.0512	0.3106	1
Entamoeba histolytica	glycogen phosphorylase, putative	0.0047	0.0123	0.0258
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0103	0.0481	0.3688
Leishmania major	thymidylate kinase-like protein	0.0145	0.0747	0.2296
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0138	0.0306
Brugia malayi	hypothetical protein	0.005	0.0138	0.1062
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0057	0.0182	0.0448
Trypanosoma brucei	ingi protein (ORF1)	0.0076	0.0307	0.0858
Giardia lamblia	Deoxynucleoside kinase	0.0396	0.2363	0.7461
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0073	0.0287	0.3451

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		Antibacterial activity against Escherichia coli CCM 3954 after 24 hrs	ChEMBL.	24397620
Activity (functional)		Antifungal activity against Candida albicans after 48 hrs	ChEMBL.	24397620
Activity (functional)		Antibacterial activity against multi-resistant Escherichia coli C/16702 after 24 hrs	ChEMBL.	24397620
CC50 (ADMET)	= 35.61 uM	Cytotoxicity against human HuH7 cells infected with Hepatitis C virus subtype 1b	ChEMBL.	24397620
IC50 (functional)	= 19.6 uM	Cytostatic activity against p53-deficient human HCT116 cells after 72 hrs by MTT assay	ChEMBL.	24397620

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	24397620

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3127044

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1828189