Detailed information for compound 1828202

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 268.31 | Formula: C16H16N2O2
  • H donors: 1 H acceptors: 2 LogP: 3.23 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1OC(c2c1c(ncc2)NCc1ccccc1)(C)C
  • InChi: 1S/C16H16N2O2/c1-16(2)12-8-9-17-14(13(12)15(19)20-16)18-10-11-6-4-3-5-7-11/h3-9H,10H2,1-2H3,(H,17,18)
  • InChiKey: VXLRPUBURYXJIK-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens proteasome (prosome, macropain) subunit, beta type, 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) proteasome subunit beta type 1 Get druggable targets OG5_127834 All targets in OG5_127834
Trypanosoma brucei gambiense proteasome beta 6 subunit,20S proteasome beta 6 subunit, putative Get druggable targets OG5_127834 All targets in OG5_127834
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta Get druggable targets OG5_127834 All targets in OG5_127834
Toxoplasma gondii proteasome subunit beta type 1, putative Get druggable targets OG5_127834 All targets in OG5_127834
Entamoeba histolytica proteasome subunit beta type 1, putative Get druggable targets OG5_127834 All targets in OG5_127834
Brugia malayi proteasome subunit beta type 1 Get druggable targets OG5_127834 All targets in OG5_127834
Plasmodium knowlesi proteasome subunit beta type-1, putative Get druggable targets OG5_127834 All targets in OG5_127834
Candida albicans proteasome subunit Get druggable targets OG5_127834 All targets in OG5_127834
Leishmania donovani proteasome beta 6 subunit, putative Get druggable targets OG5_127834 All targets in OG5_127834
Giardia lamblia Proteasome subunit beta type 1 Get druggable targets OG5_127834 All targets in OG5_127834
Plasmodium berghei proteasome subunit beta type-1, putative Get druggable targets OG5_127834 All targets in OG5_127834
Trypanosoma congolense proteasome beta 6 subunit Get druggable targets OG5_127834 All targets in OG5_127834
Plasmodium yoelii proteasome subunit beta type 1-related Get druggable targets OG5_127834 All targets in OG5_127834
Leishmania mexicana proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative Get druggable targets OG5_127834 All targets in OG5_127834
Trypanosoma cruzi proteasome beta 6 subunit, putative Get druggable targets OG5_127834 All targets in OG5_127834
Schistosoma mansoni proteasome subunit beta 1 (T01 family) Get druggable targets OG5_127834 All targets in OG5_127834
Schistosoma japonicum ko:K02732 20S proteasome subunit beta 6, putative Get druggable targets OG5_127834 All targets in OG5_127834
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative Get druggable targets OG5_127834 All targets in OG5_127834
Babesia bovis proteasome A-type and B-type family protein Get druggable targets OG5_127834 All targets in OG5_127834
Echinococcus granulosus proteasome prosome macropain subunit beta Get druggable targets OG5_127834 All targets in OG5_127834
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase Get druggable targets OG5_127834 All targets in OG5_127834
Trypanosoma cruzi proteasome beta 6 subunit, putative Get druggable targets OG5_127834 All targets in OG5_127834
Cryptosporidium parvum proteasome subunit beta type 1, putative Get druggable targets OG5_127834 All targets in OG5_127834
Candida albicans proteasome subunit Get druggable targets OG5_127834 All targets in OG5_127834
Plasmodium falciparum proteasome subunit beta type-1, putative Get druggable targets OG5_127834 All targets in OG5_127834
Leishmania braziliensis proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative Get druggable targets OG5_127834 All targets in OG5_127834
Plasmodium vivax proteasome subunit beta type-1, putative Get druggable targets OG5_127834 All targets in OG5_127834
Cryptosporidium hominis proteasome subunit beta type 1 (20S proteasome alpha subunit F) (20S proteasome subunit beta-6) Get druggable targets OG5_127834 All targets in OG5_127834
Leishmania infantum proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative Get druggable targets OG5_127834 All targets in OG5_127834
Theileria parva proteasome beat subunit, putative Get druggable targets OG5_127834 All targets in OG5_127834
Neospora caninum hypothetical protein Get druggable targets OG5_127834 All targets in OG5_127834
Trypanosoma brucei proteasome beta 6 subunit Get druggable targets OG5_127834 All targets in OG5_127834

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum proteasome subunit beta type-5 proteasome (prosome, macropain) subunit, beta type, 1 241 aa 194 aa 27.3 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase Fyn 0.0022 0.0856 0.1682
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0064 0.486 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0856 0.0856
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.1352 0.1193
Loa Loa (eye worm) TK/ALK protein kinase 0.0022 0.0856 0.0856
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Loa Loa (eye worm) TK/FER protein kinase 0.0022 0.0856 0.0856
Loa Loa (eye worm) TK/Met protein kinase 0.0022 0.0856 0.0856
Echinococcus granulosus tyrosine protein kinase shark 0.0022 0.0856 0.1682
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Brugia malayi SH2 domain containing protein 0.0022 0.0856 0.0688
Echinococcus granulosus tyrosine kinase 0.0022 0.0856 0.1682
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0022 0.0856 0.1682
Echinococcus multilocularis musashi 0.0027 0.1352 0.2713
Echinococcus multilocularis tyrosine kinase 0.0022 0.0856 0.1682
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0022 0.0856 0.1682
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0022 0.0856 0.1682
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0022 0.0856 0.1682
Echinococcus granulosus tyrosine protein kinase 0.0022 0.0856 0.1682
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Loa Loa (eye worm) RGC/RGC protein kinase 0.0022 0.0856 0.0856
Loa Loa (eye worm) TK/FER protein kinase 0.0022 0.0856 0.0856
Echinococcus granulosus lamin dm0 0.0027 0.1352 0.2713
Brugia malayi bone morphogenetic protein type 1 receptor 0.0022 0.0856 0.0688
Loa Loa (eye worm) hypothetical protein 0.0022 0.0856 0.0856
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0022 0.0856 0.1682
Loa Loa (eye worm) TK/FER protein kinase 0.0022 0.0856 0.0856
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Brugia malayi protein-tyrosine kinase 0.0022 0.0856 0.0688
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Echinococcus multilocularis tyrosine protein kinase shark 0.0022 0.0856 0.1682
Echinococcus multilocularis activin receptor type 0.0022 0.0856 0.1682
Brugia malayi Furin-like cysteine rich region family protein 0.0022 0.0856 0.0688
Loa Loa (eye worm) TK/DDR protein kinase 0.0022 0.0856 0.0856
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Loa Loa (eye worm) proteasome subunit beta type 1 0.0064 0.486 0.486
Echinococcus multilocularis protein kinase 0.0022 0.0856 0.1682
Echinococcus granulosus receptor type guanylyl cyclase 0.0022 0.0856 0.1682
Brugia malayi hypothetical protein 0.0022 0.0856 0.0688
Echinococcus multilocularis tyrosine protein kinase Abl 0.0022 0.0856 0.1682
Loa Loa (eye worm) hypothetical protein 0.0022 0.0856 0.0856
Loa Loa (eye worm) SRC-1 0.0022 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0046
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0022 0.0856 0.1682
Echinococcus granulosus retinal guanylyl cyclase 2 0.0022 0.0856 0.1682
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0022 0.0856 0.1682
Loa Loa (eye worm) transcription factor SMAD2 0.0119 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0856 0.0856
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0022 0.0856 0.1682
Loa Loa (eye worm) hypothetical protein 0.0022 0.0856 0.0856
Brugia malayi Guanylyl cyclase protein 23 0.0022 0.0856 0.0688
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0022 0.0856 0.1682
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0022 0.0856 0.1682
Loa Loa (eye worm) TK/ACK protein kinase 0.0022 0.0856 0.0856
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0022 0.0856 0.1682
Loa Loa (eye worm) hypothetical protein 0.0022 0.0856 0.0856
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Echinococcus multilocularis tyrosine kinase 0.0022 0.0856 0.1682
Echinococcus granulosus lamin 0.0027 0.1352 0.2713
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0064 0.486 1
Loa Loa (eye worm) TK/FER protein kinase 0.0022 0.0856 0.0856
Echinococcus granulosus retinal guanylyl cyclase 2 0.0022 0.0856 0.1682
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0022 0.0856 0.1682
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0064 0.486 1
Echinococcus granulosus tyrosine protein kinase csk 0.0022 0.0856 0.1682
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Loa Loa (eye worm) TK/FER protein kinase 0.0022 0.0856 0.0856
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0064 0.486 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0022 0.0856 0.1682
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0022 0.0856 0.1682
Loa Loa (eye worm) hypothetical protein 0.0027 0.1352 0.1352
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Loa Loa (eye worm) hypothetical protein 0.0022 0.0856 0.0856
Echinococcus granulosus activated cdc42 kinase 1 0.0022 0.0856 0.1682
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0064 0.486 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.1352 0.1239
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0022 0.0856 0.1682
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0022 0.0856 0.0856
Echinococcus granulosus retinal guanylyl cyclase 2 0.0022 0.0856 0.1682
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Loa Loa (eye worm) TK/EPH protein kinase 0.0022 0.0856 0.0856
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0022 0.0856 0.1682
Loa Loa (eye worm) TK/FER protein kinase 0.0022 0.0856 0.0856
Loa Loa (eye worm) TK protein kinase 0.0022 0.0856 0.0856
Echinococcus granulosus intermediate filament protein 0.0027 0.1352 0.2713
Echinococcus multilocularis insulin receptor 0.0022 0.0856 0.1682
Echinococcus multilocularis transfer RNA-Thr 0.0022 0.0856 0.1682
Brugia malayi ephrin receptor 1 precursor 0.0022 0.0856 0.0688
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Echinococcus granulosus tyrosine protein kinase Blk 0.0022 0.0856 0.1682
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 1 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0022 0.0856 0.1682
Echinococcus granulosus raf serine:threonine protein kinase 0.0022 0.0856 0.1682
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0022 0.0856 0.1682
Echinococcus multilocularis activated cdc42 kinase 1 0.0022 0.0856 0.1682
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0022 0.0856 0.0688
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Loa Loa (eye worm) TK protein kinase 0.0022 0.0856 0.0856
Brugia malayi C-terminal src kinase protein 1 0.0022 0.0856 0.0688
Loa Loa (eye worm) TK/FER protein kinase 0.0022 0.0856 0.0856
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0022 0.0856 0.0688
Echinococcus granulosus insulin receptor 0.0022 0.0856 0.1682
Echinococcus granulosus tyrosine protein kinase csk 0.0022 0.0856 0.1682
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0064 0.486 1
Echinococcus granulosus epidermal growth factor receptor 0.0022 0.0856 0.1682
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0022 0.0856 0.0856
Echinococcus granulosus natriuretic peptide receptor 1 0.0022 0.0856 0.1682
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0022 0.0856 0.0856
Loa Loa (eye worm) TK/FER protein kinase 0.0022 0.0856 0.0856
Echinococcus multilocularis kinase suppressor of Ras 1 0.0022 0.0856 0.1682
Loa Loa (eye worm) TK/FER protein kinase 0.0022 0.0856 0.0856
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0022 0.0856 0.1682
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.1352 0.1352
Loa Loa (eye worm) RGC/RGC protein kinase 0.0022 0.0856 0.0856
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0022 0.0856 0.1682
Loa Loa (eye worm) TK/FER protein kinase 0.0022 0.0856 0.0856
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Loa Loa (eye worm) RGC/RGC protein kinase 0.0022 0.0856 0.0856
Brugia malayi integrin-linked kinase 0.0022 0.0856 0.0688
Loa Loa (eye worm) TK/FER protein kinase 0.0022 0.0856 0.0856
Echinococcus granulosus tyrosine protein kinase Srms 0.0022 0.0856 0.1682
Echinococcus granulosus tyrosine protein kinase pr2 0.0022 0.0856 0.1682
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0022 0.0856 0.1682
Loa Loa (eye worm) TK protein kinase 0.0022 0.0856 0.0856
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Loa Loa (eye worm) TK protein kinase 0.0022 0.0856 0.0856
Loa Loa (eye worm) TK protein kinase 0.0022 0.0856 0.0856
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0022 0.0856 0.1682
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0022 0.0856 0.0856
Schistosoma mansoni lamin 0.0027 0.1352 0.1239
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0022 0.0856 0.1682
Echinococcus granulosus tyrosine protein kinase ABL1 0.0022 0.0856 0.1682
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0022 0.0856 0.1682
Brugia malayi hypothetical protein 0.0022 0.0856 0.0688
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0064 0.486 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0022 0.0856 0.0688
Echinococcus granulosus tyrosine protein kinase csk 0.0022 0.0856 0.1682
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0022 0.0856 0.1682
Loa Loa (eye worm) hypothetical protein 0.0022 0.0856 0.0856
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0022 0.0856 0.1682
Loa Loa (eye worm) hypothetical protein 0.0022 0.0856 0.0856
Echinococcus multilocularis natriuretic peptide receptor 1 0.0022 0.0856 0.1682
Echinococcus multilocularis tyrosine protein kinase pr2 0.0022 0.0856 0.1682
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0022 0.0856 0.0688
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0022 0.0856 0.0688
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0022 0.0856 0.0688
Giardia lamblia Proteasome subunit beta type 1 0.0064 0.486 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0022 0.0856 0.1682
Loa Loa (eye worm) TK/FER protein kinase 0.0022 0.0856 0.0856
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0022 0.0856 0.1682
Brugia malayi Raf kinase 0.0022 0.0856 0.0688
Echinococcus multilocularis protein tyrosine kinase 0.0022 0.0856 0.1682
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0022 0.0856 0.1682
Loa Loa (eye worm) hypothetical protein 0.0026 0.1306 0.1306
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.018 0.018
Echinococcus multilocularis protein kinase 0.0022 0.0856 0.1682
Trypanosoma brucei proteasome beta 6 subunit 0.0064 0.486 1
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0022 0.0856 0.1682
Loa Loa (eye worm) TK protein kinase 0.0022 0.0856 0.0856
Echinococcus multilocularis tyrosine protein kinase csk 0.0022 0.0856 0.1682
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0022 0.0856 0.1682
Loa Loa (eye worm) TK/INSR protein kinase 0.0022 0.0856 0.0856
Echinococcus granulosus tyrosine protein kinase Src42A 0.0022 0.0856 0.1682
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0022 0.0856 0.1682
Loa Loa (eye worm) TK/FER protein kinase 0.0022 0.0856 0.0856
Loa Loa (eye worm) TK protein kinase 0.0022 0.0856 0.0856
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.0856 0.0688
Echinococcus granulosus fibroblast growth factor receptor 4 0.0022 0.0856 0.1682
Loa Loa (eye worm) TK/RYK protein kinase 0.0022 0.0856 0.0856
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Echinococcus granulosus activin receptor type 0.0022 0.0856 0.1682
Echinococcus multilocularis lamin dm0 0.0027 0.1352 0.2713
Echinococcus multilocularis epidermal growth factor receptor 0.0022 0.0856 0.1682
Echinococcus multilocularis tyrosine protein kinase HCK 0.0022 0.0856 0.1682
Echinococcus multilocularis tyrosine protein kinase csk 0.0022 0.0856 0.1682
Loa Loa (eye worm) hypothetical protein 0.0022 0.0856 0.0856
Echinococcus granulosus tyrosine protein kinase Src64B 0.0022 0.0856 0.1682
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0022 0.0856 0.1682
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0022 0.0856 0.0856
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0022 0.0856 0.0856
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0022 0.0856 0.1682
Echinococcus multilocularis raf serine:threonine protein kinase 0.0022 0.0856 0.1682
Loa Loa (eye worm) TK/CSK protein kinase 0.0022 0.0856 0.0856
Echinococcus granulosus c src tyrosine kinase 0.0022 0.0856 0.1682
Loa Loa (eye worm) hypothetical protein 0.0022 0.0856 0.0856
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0022 0.0856 0.1682
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Brugia malayi Tyrosine-protein kinase PR2 0.0022 0.0856 0.0688
Brugia malayi hypothetical protein 0.0022 0.0856 0.0688
Echinococcus granulosus protein kinase 0.0022 0.0856 0.1682
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Loa Loa (eye worm) serine/threonine protein kinase 0.0022 0.0856 0.0856
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0022 0.0856 0.0688
Echinococcus multilocularis receptor type guanylyl cyclase 0.0022 0.0856 0.1682
Loa Loa (eye worm) TK/FER protein kinase 0.0022 0.0856 0.0856
Loa Loa (eye worm) TK/FER protein kinase 0.0022 0.0856 0.0856
Loa Loa (eye worm) TK/FAK protein kinase 0.0022 0.0856 0.0856
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0022 0.0856 0.0856
Echinococcus multilocularis integrin linked protein kinase 0.0022 0.0856 0.1682
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0022 0.0856 0.1682
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0064 0.486 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0022 0.0856 0.1682
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0022 0.0856 0.1682
Echinococcus multilocularis tyrosine protein kinase 0.0022 0.0856 0.1682
Brugia malayi proteasome subunit beta type 1 0.0064 0.486 0.4765
Loa Loa (eye worm) TK protein kinase 0.0022 0.0856 0.0856
Echinococcus granulosus tyrosine kinase 0.0022 0.0856 0.1682
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0022 0.0856 0.0856
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0022 0.0856 0.1682
Echinococcus granulosus kinase suppressor of Ras 1 0.0022 0.0856 0.1682
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Brugia malayi SRC-1 0.0022 0.0856 0.0688
Echinococcus multilocularis tyrosine protein kinase Srms 0.0022 0.0856 0.1682
Loa Loa (eye worm) TK/FER protein kinase 0.0022 0.0856 0.0856
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0022 0.0856 0.1682
Onchocerca volvulus 0.0027 0.1352 1
Echinococcus granulosus integrin linked protein kinase 0.0022 0.0856 0.1682
Echinococcus multilocularis tyrosine protein kinase Blk 0.0022 0.0856 0.1682
Plasmodium vivax proteasome subunit beta type-1, putative 0.0064 0.486 1
Onchocerca volvulus 0.0027 0.1352 1
Loa Loa (eye worm) TK protein kinase 0.0022 0.0856 0.0856
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0022 0.0856 0.1682
Echinococcus multilocularis epidermal growth factor receptor 0.0022 0.0856 0.1682
Brugia malayi intermediate filament protein 0.0027 0.1352 0.1193
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0022 0.0856 0.0856
Echinococcus multilocularis ephrin type A receptor 4 A 0.0022 0.0856 0.1682
Loa Loa (eye worm) hypothetical protein 0.0022 0.0856 0.0856
Echinococcus granulosus activated cdc42 kinase 1 0.0022 0.0856 0.1682
Brugia malayi SH2 domain containing protein 0.0022 0.0856 0.0688
Echinococcus granulosus protein tyrosine kinase 0.0022 0.0856 0.1682
Loa Loa (eye worm) intermediate filament protein 0.0027 0.1352 0.1352
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.0856 0.0688
Loa Loa (eye worm) TK protein kinase 0.0022 0.0856 0.0856
Echinococcus granulosus tyrosine protein kinase HCK 0.0022 0.0856 0.1682
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Echinococcus granulosus epidermal growth factor receptor 0.0022 0.0856 0.1682
Loa Loa (eye worm) TK/ABL protein kinase 0.0022 0.0856 0.0856
Schistosoma mansoni lamin 0.0027 0.1352 0.1239
Echinococcus multilocularis lamin 0.0027 0.1352 0.2713
Echinococcus granulosus tyrosine protein kinase Lyn 0.0022 0.0856 0.1682
Loa Loa (eye worm) RGC/RGC protein kinase 0.0022 0.0856 0.0856
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0022 0.0856 0.1682
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0022 0.0856 0.1682
Echinococcus granulosus tyrosine protein kinase Fyn 0.0022 0.0856 0.1682
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0022 0.0856 0.1682
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0022 0.0856 0.1682
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0064 0.486 1
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Loa Loa (eye worm) TK/FER protein kinase 0.0022 0.0856 0.0856
Loa Loa (eye worm) protein kinase domain-containing protein 0.0022 0.0856 0.0856
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Echinococcus multilocularis heat shock protein 70 0.0022 0.0856 0.1682
Brugia malayi Receptor family ligand binding region containing protein 0.0022 0.0856 0.0688
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0022 0.0856 0.1682
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Loa Loa (eye worm) TK/EGFR protein kinase 0.0022 0.0856 0.0856
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0064 0.486 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0022 0.0856 0.1682
Echinococcus granulosus ephrin type A receptor 4 A 0.0022 0.0856 0.1682
Echinococcus multilocularis protein KINase family member (kin 25) 0.0022 0.0856 0.1682
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0022 0.0856 0.1682
Brugia malayi Protein kinase domain containing protein 0.0022 0.0856 0.0688
Echinococcus granulosus tyrosine kinase 0.0022 0.0856 0.1682
Echinococcus multilocularis FL cytokine receptor 0.0022 0.0856 0.1682
Echinococcus multilocularis c src tyrosine kinase 0.0022 0.0856 0.1682

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.6 uM Inhibition of 20s immunoproteasome beta 1 subunit caspase-like activity in human blood monocytes using Z-LLE-betaNA as substrate at 2 uM preincubated for 2 mins followed by substrate addition by fluorescence assay ChEMBL. 24534487
IC50 (binding) = 11.6 uM Inhibition of 20s proteasome beta 1 subunit caspase-like activity in human HeLa cells using Z-nLPnLD as substrate after 17 hrs by chemiluminescence assay ChEMBL. 24534487
Inhibition (binding) Inhibition of human calpain-1 using Suc-LLVY-AMC as substrate by fluorescence assay ChEMBL. 24534487
Inhibition (binding) Inhibition of 20s immunoproteasome beta 5 subunit chymotrypsin-like activity in human blood monocytes using Suc-LLVY-AMC as substrate at 100 to 2000 nM preincubated for 2 mins followed by substrate addition by fluorescence assay ChEMBL. 24534487
Inhibition (binding) Inhibition of human cathepsin B using Z-RR-AMC as substrate by fluorescence assay ChEMBL. 24534487
Inhibition (binding) Inhibition of 20s immunoproteasome beta 2 subunit trypsin-like activity in human blood monocytes using Boc-LRR-AMC as substrate at 100 to 2000 nM preincubated for 2 mins followed by substrate addition by fluorescence assay ChEMBL. 24534487
Inhibition (ADMET) = 35 % Cytotoxicity against human HeLa cells assessed as inhibition of mitochondrial dehydrogenase activity at 50 uM after 18 to 72 hrs by XTT assay relative to control ChEMBL. 24534487

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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