Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0779 | 0.0779 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0224 | 0.8197 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0699 | 0.0853 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0224 | 0.8197 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0224 | 0.8197 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.1316 | 0.1606 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0265 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0779 | 0.0779 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0224 | 0.8197 | 0.7924 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0224 | 0.8197 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0779 | 0.0779 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.1316 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0054 | 0.0699 | 0.0853 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0224 | 0.8197 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.1316 | 0.1606 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0224 | 0.8197 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0224 | 0.8197 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0779 | 0.0779 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0068 | 0.1316 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.5697 | 0.5697 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0224 | 0.8197 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0224 | 0.8197 | 0.7924 |
Echinococcus granulosus | muscleblind protein | 0.0167 | 0.5697 | 0.5045 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0224 | 0.8197 | 0.7924 |
Brugia malayi | Muscleblind-like protein | 0.0167 | 0.5697 | 0.5697 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0224 | 0.8197 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0224 | 0.8197 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.1316 | 0.5 |
Brugia malayi | MAP kinase sur-1 | 0.0224 | 0.8197 | 0.8197 |
Onchocerca volvulus | 0.0054 | 0.0699 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.5697 | 0.5697 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0224 | 0.8197 | 0.8197 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0224 | 0.8197 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0167 | 0.5697 | 0.5045 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0224 | 0.8197 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0054 | 0.0699 | 0.0699 |
Echinococcus multilocularis | muscleblind protein | 0.0167 | 0.5697 | 0.5045 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0265 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0224 | 0.8197 | 0.7924 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0224 | 0.8197 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0224 | 0.8197 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0224 | 0.8197 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.1316 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.