TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 387.476 | Formula: C20H29N5O3
H donors: 1 H acceptors: 3 LogP: 2.87 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(c(c1)C)N1CCN([C@H](C1)C)c1noc(n1)[C@@H](NC(=O)C)C
InChi: 1S/C20H29N5O3/c1-6-27-17-7-8-18(13(2)11-17)24-9-10-25(14(3)12-24)20-22-19(28-23-20)15(4)21-16(5)26/h7-8,11,14-15H,6,9-10,12H2,1-5H3,(H,21,26)/t14-,15-/m0/s1
InChiKey: HRSAPEKZOYYIGR-GJZGRUSLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	acetyl-CoA carboxylase alpha	Starlite/ChEMBL	References
Homo sapiens	acetyl-CoA carboxylase beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Brugia malayi	Carboxyl transferase domain containing protein	Get druggable targets OG5_127493	All targets in OG5_127493
Loa Loa (eye worm)	carboxyl transferase domain-containing protein	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania major	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Echinococcus multilocularis	acetyl coenzyme A carboxylase 1	Get druggable targets OG5_127493	All targets in OG5_127493
Candida albicans	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma japonicum	Acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Cryptosporidium parvum	acetyl-CoA carboxylase like biotin dependent carboxylase involved in fatty acid biosynthesis	Get druggable targets OG5_127493	All targets in OG5_127493
Echinococcus granulosus	acetyl coenzyme A carboxylase 1	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium falciparum	biotin carboxylase subunit of acetyl CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Toxoplasma gondii	acetyl-coA carboxylase ACC2	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania braziliensis	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Toxoplasma gondii	acetyl-CoA carboxylase ACC1	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma japonicum	Acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Neospora caninum	hypothetical protein	Get druggable targets OG5_127493	All targets in OG5_127493
Neospora caninum	hypothetical protein	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127493	All targets in OG5_127493
Cryptosporidium hominis	acetyl-CoA carboxylase 2	Get druggable targets OG5_127493	All targets in OG5_127493
Trypanosoma congolense	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium yoelii	acetyl-CoA carboxylase 1 precursor-related	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium knowlesi	biotin carboxylase subunit of acetyl CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania infantum	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium vivax	biotin carboxylase subunit of acetyl CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Trypanosoma cruzi	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania mexicana	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma japonicum	ko:K01946 biotin carboxylase [EC6.3.4.14], putative	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium berghei	biotin carboxylase subunit of acetyl CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma mansoni	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania donovani	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Trypanosoma brucei	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma japonicum	ko:K01961 acetyl-CoA carboxylase [EC6.4.1.2], putative	Get druggable targets OG5_127493	All targets in OG5_127493
Trypanosoma brucei gambiense	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	protein kinase, putative	0.013	0.453	0.422
Schistosoma mansoni	ephrin receptor	0.013	0.453	0.438
Schistosoma mansoni	hypothetical protein	0.013	0.453	0.438
Schistosoma mansoni	protein kinase	0.013	0.453	0.438
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.013	0.453	0.4635
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.013	0.453	0.5
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.013	0.453	0.438
Echinococcus granulosus	epidermal growth factor receptor	0.013	0.453	0.438
Loa Loa (eye worm)	TK protein kinase	0.013	0.453	0.4635
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.453	0.5
Trichomonas vaginalis	STE family protein kinase	0.013	0.453	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.013	0.453	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.013	0.453	0.4635
Loa Loa (eye worm)	TK/ALK protein kinase	0.013	0.453	0.4635
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.013	0.453	1
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.013	0.453	0.422
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.013	0.453	0.438
Entamoeba histolytica	serine/threonine kinase, putative	0.013	0.453	0.5
Entamoeba histolytica	protein kinase, putative	0.013	0.453	0.5
Echinococcus multilocularis	acetyl coenzyme A carboxylase 1	0.0203	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.013	0.453	0.4635
Leishmania major	protein kinase, putative	0.013	0.453	0.422
Entamoeba histolytica	tyrosine kinase, putative	0.013	0.453	0.5
Echinococcus granulosus	tyrosine protein kinase HCK	0.013	0.453	0.438
Loa Loa (eye worm)	TK/EGFR protein kinase	0.013	0.453	0.4635
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Echinococcus multilocularis	protein kinase	0.013	0.453	0.438
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.013	0.453	0.4635
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Echinococcus granulosus	tyrosine kinase	0.013	0.453	0.438
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Schistosoma mansoni	serine/threonine protein kinase	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.013	0.453	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.013	0.453	0.438
Loa Loa (eye worm)	TK/FER protein kinase	0.013	0.453	0.4635
Echinococcus granulosus	tyrosine protein kinase pr2	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Entamoeba histolytica	protein kinase, putative	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Giardia lamblia	Kinase, NEK	0.013	0.453	0.5
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.013	0.453	0.438
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Brugia malayi	Raf kinase	0.013	0.453	0.4635
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.013	0.453	0.4635
Brugia malayi	Guanylyl cyclase protein 23	0.013	0.453	0.4635
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Loa Loa (eye worm)	TK/FER protein kinase	0.013	0.453	0.4635
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.013	0.453	0.438
Echinococcus granulosus	tyrosine protein kinase Blk	0.013	0.453	0.438
Echinococcus multilocularis	protein KINase family member (kin 25)	0.013	0.453	0.438
Mycobacterium tuberculosis	Probable pyruvate carboxylase Pca (pyruvic carboxylase)	0.0077	0.0535	0.5
Chlamydia trachomatis	biotin carboxylase	0.007	0	0.5
Echinococcus granulosus	integrin linked protein kinase	0.013	0.453	0.438
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.013	0.453	0.438
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.013	0.453	0.438
Loa Loa (eye worm)	RGC/RGC protein kinase	0.013	0.453	0.4635
Brugia malayi	Carboxyl transferase domain containing protein	0.0196	0.9465	1
Echinococcus granulosus	propionyl coenzyme A carboxylase alpha chain	0.0077	0.0535	0.0276
Loa Loa (eye worm)	RGC/RGC protein kinase	0.013	0.453	0.4635
Loa Loa (eye worm)	TK/FER protein kinase	0.013	0.453	0.4635
Loa Loa (eye worm)	TK/FER protein kinase	0.013	0.453	0.4635
Echinococcus multilocularis	FL cytokine receptor	0.013	0.453	0.438
Echinococcus granulosus	retinal guanylyl cyclase 2	0.013	0.453	0.438
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.453	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.013	0.453	0.4635
Brugia malayi	hypothetical protein	0.013	0.453	0.4635
Loa Loa (eye worm)	hypothetical protein	0.013	0.453	0.4635
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Echinococcus multilocularis	epidermal growth factor receptor	0.013	0.453	0.438
Schistosoma mansoni	protein kinase	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Schistosoma mansoni	protein kinase	0.013	0.453	0.438
Echinococcus multilocularis	c src tyrosine kinase	0.013	0.453	0.438
Echinococcus granulosus	retinal guanylyl cyclase 2	0.013	0.453	0.438
Trichomonas vaginalis	protein tyrosine kinase, putative	0.013	0.453	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.013	0.453	0.422
Loa Loa (eye worm)	RGC/RGC protein kinase	0.013	0.453	0.4635
Leishmania major	acetyl-CoA carboxylase, putative	0.0203	1	1
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Onchocerca volvulus		0.013	0.453	1
Entamoeba histolytica	tyrosine kinase, putative	0.013	0.453	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.013	0.453	0.438
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Brugia malayi	bone morphogenetic protein type 1 receptor	0.013	0.453	0.4635
Giardia lamblia	Kinase, NEK	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Schistosoma mansoni	protein kinase	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Onchocerca volvulus		0.013	0.453	1
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Echinococcus granulosus	protein kinase	0.013	0.453	0.438
Loa Loa (eye worm)	TK/RYK protein kinase	0.013	0.453	0.4635
Schistosoma mansoni	protein kinase	0.013	0.453	0.438
Loa Loa (eye worm)	TK/ACK protein kinase	0.013	0.453	0.4635
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.013	0.453	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.013	0.453	0.438
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Plasmodium vivax	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.0147	0.5775	1
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.453	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.013	0.453	0.5
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.013	0.453	0.438
Echinococcus multilocularis	tyrosine protein kinase csk	0.013	0.453	0.438
Loa Loa (eye worm)	TK/FER protein kinase	0.013	0.453	0.4635
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Onchocerca volvulus		0.013	0.453	1
Echinococcus granulosus	tyrosine kinase	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Loa Loa (eye worm)	TK/Met protein kinase	0.013	0.453	0.4635
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.013	0.453	0.438
Entamoeba histolytica	tyrosine kinase, putative	0.013	0.453	0.5
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Entamoeba histolytica	protein kinase, putative	0.013	0.453	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.013	0.453	0.4635
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.013	0.453	0.5
Echinococcus multilocularis	receptor type guanylyl cyclase	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.013	0.453	0.438
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.013	0.453	0.438
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.013	0.453	0.4635
Loa Loa (eye worm)	hypothetical protein	0.013	0.453	0.4635
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.013	0.453	0.422
Onchocerca volvulus		0.013	0.453	1
Onchocerca volvulus		0.013	0.453	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.013	0.453	0.438
Echinococcus multilocularis	epidermal growth factor receptor	0.013	0.453	0.438
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.013	0.453	0.5
Entamoeba histolytica	hypothetical protein	0.013	0.453	0.5
Echinococcus multilocularis	protein kinase	0.013	0.453	0.438
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.013	0.453	0.438
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.453	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.013	0.453	0.438
Echinococcus multilocularis	insulin receptor	0.013	0.453	0.438
Leishmania major	hypothetical protein, conserved	0.013	0.453	0.422
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Entamoeba histolytica	protein kinase, putative	0.013	0.453	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.013	0.453	0.5
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.013	0.453	0.4635
Echinococcus granulosus	tyrosine protein kinase csk	0.013	0.453	0.438
Brugia malayi	Furin-like cysteine rich region family protein	0.013	0.453	0.4635
Echinococcus multilocularis	activated cdc42 kinase 1	0.013	0.453	0.438
Echinococcus granulosus	epidermal growth factor receptor	0.013	0.453	0.438
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.013	0.453	0.5
Trypanosoma brucei	protein kinase, putative	0.013	0.453	0.422
Echinococcus granulosus	c src tyrosine kinase	0.013	0.453	0.438
Schistosoma mansoni	protein kinase	0.013	0.453	0.438
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.013	0.453	0.438
Echinococcus multilocularis	ephrin type A receptor 4 A	0.013	0.453	0.438
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.013	0.453	0.438
Echinococcus granulosus	receptor type guanylyl cyclase	0.013	0.453	0.438
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Echinococcus granulosus	kinase suppressor of Ras 1	0.013	0.453	0.438
Wolbachia endosymbiont of Brugia malayi	Acetyl/propionyl-CoA carboxylase, alpha subunit	0.0077	0.0535	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.013	0.453	0.438
Entamoeba histolytica	hypothetical protein	0.013	0.453	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.013	0.453	0.438
Echinococcus multilocularis	natriuretic peptide receptor 1	0.013	0.453	0.438
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.013	0.453	0.5
Entamoeba histolytica	protein kinase, putative	0.013	0.453	0.5
Toxoplasma gondii	acetyl-CoA carboxylase ACC1	0.0203	1	1
Entamoeba histolytica	protein kinase, putative	0.013	0.453	0.5
Brugia malayi	hypothetical protein	0.013	0.453	0.4635
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Loa Loa (eye worm)	TK protein kinase	0.013	0.453	0.4635
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Echinococcus granulosus	activated cdc42 kinase 1	0.013	0.453	0.438
Entamoeba histolytica	hypothetical protein	0.013	0.453	0.5
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Entamoeba histolytica	protein kinase, putative	0.013	0.453	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.013	0.453	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.013	0.453	0.4635
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.013	0.453	0.4635
Toxoplasma gondii	STE kinase	0.013	0.453	0.422
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.013	0.453	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.013	0.453	0.438
Entamoeba histolytica	tyrosine kinase, putative	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Entamoeba histolytica	ankyrin repeat protein	0.013	0.453	0.5
Trypanosoma brucei	acetyl-CoA carboxylase	0.0203	1	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.013	0.453	0.438
Toxoplasma gondii	acetyl-coA carboxylase ACC2	0.0203	1	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.013	0.453	0.4635
Entamoeba histolytica	protein kinase, putative	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.013	0.453	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Loa Loa (eye worm)	hypothetical protein	0.013	0.453	0.4635
Brugia malayi	C-terminal src kinase protein 1	0.013	0.453	0.4635
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.013	0.453	0.438
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.013	0.453	0.438
Echinococcus granulosus	tyrosine kinase	0.013	0.453	0.438
Schistosoma mansoni	ephrin receptor	0.013	0.453	0.438
Echinococcus multilocularis	tyrosine protein kinase pr2	0.013	0.453	0.438
Loa Loa (eye worm)	TK/FER protein kinase	0.013	0.453	0.4635
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.013	0.453	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.013	0.453	0.5
Loa Loa (eye worm)	hypothetical protein	0.013	0.453	0.4635
Trypanosoma cruzi	protein kinase, putative	0.013	0.453	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.013	0.453	0.4635
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.013	0.453	0.438
Brugia malayi	SH2 domain containing protein	0.013	0.453	0.4635
Echinococcus multilocularis	integrin linked protein kinase	0.013	0.453	0.438
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Schistosoma mansoni	serine/threonine RGC	0.013	0.453	0.438
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Echinococcus granulosus	tyrosine protein kinase Fyn	0.013	0.453	0.438
Echinococcus granulosus	tyrosine protein kinase Srms	0.013	0.453	0.438
Entamoeba histolytica	serine/threonine kinase, putative	0.013	0.453	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.013	0.453	0.438
Echinococcus granulosus	tyrosine protein kinase	0.013	0.453	0.438
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Echinococcus granulosus	natriuretic peptide receptor 1	0.013	0.453	0.438
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Onchocerca volvulus		0.013	0.453	1
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Loa Loa (eye worm)	TK protein kinase	0.013	0.453	0.4635
Trypanosoma cruzi	protein kinase, putative	0.013	0.453	1
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Schistosoma mansoni	protein kinase	0.013	0.453	0.438
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.013	0.453	0.438
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.013	0.453	0.438
Entamoeba histolytica	tyrosine kinase, putative	0.013	0.453	0.5
Mycobacterium leprae	Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP)	0.0077	0.0535	0.5
Mycobacterium ulcerans	acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1	0.0077	0.0535	0.5
Entamoeba histolytica	protein kinase, putative	0.013	0.453	0.5
Loa Loa (eye worm)	TK/CSK protein kinase	0.013	0.453	0.4635
Mycobacterium ulcerans	bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3	0.0077	0.0535	0.5
Schistosoma mansoni	protein kinase	0.013	0.453	0.438
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.013	0.453	0.4635
Loa Loa (eye worm)	carboxyl transferase domain-containing protein	0.0196	0.9465	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.013	0.453	0.438
Onchocerca volvulus		0.013	0.453	1
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.013	0.453	0.438
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Entamoeba histolytica	tyrosine kinase, putative	0.013	0.453	0.5
Entamoeba histolytica	hypothetical protein	0.013	0.453	0.5
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.013	0.453	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.013	0.453	0.438
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Entamoeba histolytica	tyrosin kinase, putative	0.013	0.453	0.5
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Entamoeba histolytica	tyrosin kinase, putative	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Echinococcus granulosus	fibroblast growth factor receptor 4	0.013	0.453	0.438
Echinococcus multilocularis	kinase suppressor of Ras 1	0.013	0.453	0.438
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.453	0.5
Schistosoma mansoni	acetyl-CoA carboxylase	0.0203	1	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.013	0.453	0.438
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Loa Loa (eye worm)	TK/FER protein kinase	0.013	0.453	0.4635
Loa Loa (eye worm)	hypothetical protein	0.013	0.453	0.4635
Schistosoma mansoni	serine/threonine protein kinase	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Loa Loa (eye worm)	SRC-1	0.013	0.453	0.4635
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Schistosoma mansoni	tyrosine protein kinase	0.013	0.453	0.438
Brugia malayi	Immunoglobulin I-set domain containing protein	0.013	0.453	0.4635
Loa Loa (eye worm)	TK protein kinase	0.013	0.453	0.4635
Mycobacterium tuberculosis	Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie	0.0077	0.0535	0.5
Echinococcus granulosus	activin receptor type	0.013	0.453	0.438
Entamoeba histolytica	cysteine surface protein, putative	0.013	0.453	0.5
Entamoeba histolytica	hypothetical protein	0.013	0.453	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.013	0.453	0.438
Entamoeba histolytica	protein kinase, putative	0.013	0.453	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.013	0.453	0.422
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.013	0.453	0.438
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Entamoeba histolytica	hypothetical protein	0.013	0.453	0.5
Schistosoma mansoni	pyruvate carboxylase	0.0077	0.0535	0.0276
Trichomonas vaginalis	CAMK family protein kinase	0.013	0.453	0.5
Loa Loa (eye worm)	hypothetical protein	0.013	0.453	0.4635
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Echinococcus multilocularis	tyrosine kinase	0.013	0.453	0.438
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.013	0.453	0.438
Entamoeba histolytica	receptor protein kinase, putative	0.013	0.453	0.5
Schistosoma mansoni	protein kinase	0.013	0.453	0.438
Echinococcus granulosus	raf serine:threonine protein kinase	0.013	0.453	0.438
Echinococcus granulosus	tyrosine protein kinase Src64B	0.013	0.453	0.438
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.013	0.453	0.438
Echinococcus multilocularis	tyrosine protein kinase csk	0.013	0.453	0.438
Loa Loa (eye worm)	hypothetical protein	0.013	0.453	0.4635
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.013	0.453	0.438
Echinococcus granulosus	tyrosine protein kinase shark	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Loa Loa (eye worm)	TK protein kinase	0.013	0.453	0.4635
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.013	0.453	0.4635
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.013	0.453	0.4635
Echinococcus multilocularis	tyrosine kinase	0.013	0.453	0.438
Loa Loa (eye worm)	RGC/RGC protein kinase	0.013	0.453	0.4635
Loa Loa (eye worm)	TK/FER protein kinase	0.013	0.453	0.4635
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Onchocerca volvulus		0.013	0.453	1
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Trypanosoma cruzi	acetyl-CoA carboxylase	0.0126	0.4177	0.9117
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.013	0.453	1
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.013	0.453	0.438
Entamoeba histolytica	tyrosine kinase, putative	0.013	0.453	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.013	0.453	0.5
Onchocerca volvulus		0.013	0.453	1
Onchocerca volvulus		0.013	0.453	1
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Brugia malayi	ephrin receptor 1 precursor	0.013	0.453	0.4635
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Echinococcus multilocularis	propionyl coenzyme A carboxylase alpha chain	0.0077	0.0535	0.0276
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.013	0.453	0.438
Echinococcus granulosus	insulin receptor	0.013	0.453	0.438
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.013	0.453	0.438
Entamoeba histolytica	tyrosin kinase, putative	0.013	0.453	0.5
Entamoeba histolytica	protein kinase, putative	0.013	0.453	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.013	0.453	0.4635
Loa Loa (eye worm)	hypothetical protein	0.013	0.453	0.4635
Loa Loa (eye worm)	TK/FER protein kinase	0.013	0.453	0.4635
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Onchocerca volvulus		0.013	0.453	1
Entamoeba histolytica	tyrosine kinase, putative	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.013	0.453	0.438
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.013	0.453	0.422
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Loa Loa (eye worm)	TK protein kinase	0.013	0.453	0.4635
Entamoeba histolytica	hypothetical protein	0.013	0.453	0.5
Loa Loa (eye worm)	TK/EPH protein kinase	0.013	0.453	0.4635
Entamoeba histolytica	receptor protein kinase, putative	0.013	0.453	0.5
Loa Loa (eye worm)	hypothetical protein	0.013	0.453	0.4635
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.013	0.453	0.438
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.013	0.453	0.5
Schistosoma mansoni	protein kinase	0.013	0.453	0.438
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.013	0.453	0.438
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.013	0.453	0.438
Schistosoma mansoni	methylcrotonyl-CoA carboxylase	0.0077	0.0535	0.0276
Onchocerca volvulus		0.013	0.453	1
Entamoeba histolytica	protein kinase, putative	0.013	0.453	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Loa Loa (eye worm)	hypothetical protein	0.013	0.453	0.4635
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Echinococcus multilocularis	tyrosine protein kinase Srms	0.013	0.453	0.438
Echinococcus multilocularis	tyrosine protein kinase Blk	0.013	0.453	0.438
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.013	0.453	0.5
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Entamoeba histolytica	hypothetical protein	0.013	0.453	0.5
Loa Loa (eye worm)	protein kinase domain-containing protein	0.013	0.453	0.4635
Entamoeba histolytica	tyrosine kinase, putative	0.013	0.453	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.013	0.453	0.5
Loa Loa (eye worm)	hypothetical protein	0.013	0.453	0.4635
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.013	0.453	1
Toxoplasma gondii	protein kinase	0.013	0.453	0.422
Echinococcus granulosus	protein tyrosine kinase	0.013	0.453	0.438
Loa Loa (eye worm)	TK/FER protein kinase	0.013	0.453	0.4635
Loa Loa (eye worm)	hypothetical protein	0.013	0.453	0.4635
Entamoeba histolytica	serine/threonine kinase, putative	0.013	0.453	0.5
Schistosoma mansoni	protein kinase	0.013	0.453	0.438
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Brugia malayi	SH2 domain containing protein	0.013	0.453	0.4635
Loa Loa (eye worm)	TK/INSR protein kinase	0.013	0.453	0.4635
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.013	0.453	0.438
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Entamoeba histolytica	tyrosine kinase, putative	0.013	0.453	0.5
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.013	0.453	0.4635
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.013	0.453	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.013	0.453	0.5
Loa Loa (eye worm)	TK protein kinase	0.013	0.453	0.4635
Trichomonas vaginalis	TK family protein kinase	0.013	0.453	0.5
Brugia malayi	Receptor family ligand binding region containing protein	0.013	0.453	0.4635
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.013	0.453	0.4635
Entamoeba histolytica	hypothetical protein	0.013	0.453	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.013	0.453	0.438
Entamoeba histolytica	hypothetical protein	0.013	0.453	0.5
Schistosoma mansoni	methylcrotonyl-CoA carboxylase	0.0077	0.0535	0.0276
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.013	0.453	0.438
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Echinococcus multilocularis	activin receptor type	0.013	0.453	0.438
Entamoeba histolytica	tyrosine kinase, putative	0.013	0.453	0.5
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.013	0.453	0.5
Giardia lamblia	Kinase	0.013	0.453	0.5
Entamoeba histolytica	hypothetical protein	0.013	0.453	0.5
Entamoeba histolytica	protein kinase, putative	0.013	0.453	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.013	0.453	0.5
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Brugia malayi	hypothetical protein	0.013	0.453	0.4635
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Brugia malayi	integrin-linked kinase	0.013	0.453	0.4635
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Schistosoma mansoni	protein tyrosine kinase	0.013	0.453	0.438
Entamoeba histolytica	tyrosine kinase, putative	0.013	0.453	0.5
Onchocerca volvulus		0.013	0.453	1
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Loa Loa (eye worm)	TK protein kinase	0.013	0.453	0.4635
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.013	0.453	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.013	0.453	0.4635
Loa Loa (eye worm)	TK/ROR protein kinase	0.013	0.453	0.4635
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Onchocerca volvulus		0.013	0.453	1
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Schistosoma mansoni	serine/threonine protein kinase	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Entamoeba histolytica	protein kinase, putative	0.013	0.453	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.013	0.453	0.438
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.013	0.453	0.438
Entamoeba histolytica	protein kinase, putative	0.013	0.453	0.5
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Trichomonas vaginalis	AGC family protein kinase	0.013	0.453	0.5
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Mycobacterium ulcerans	pyruvate carboxylase	0.0077	0.0535	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.013	0.453	0.438
Trypanosoma brucei	Flagellum attachment zone protein 20	0.013	0.453	0.422
Echinococcus multilocularis	tyrosine protein kinase csk	0.013	0.453	0.438
Onchocerca volvulus	Tyrosine kinase homolog	0.013	0.453	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.013	0.453	0.438
Brugia malayi	SRC-1	0.013	0.453	0.4635
Giardia lamblia	Protein 21.1	0.013	0.453	0.5
Echinococcus multilocularis	tyrosine protein kinase	0.013	0.453	0.438
Echinococcus granulosus	tyrosine protein kinase Lyn	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Entamoeba histolytica	protein kinase, putative	0.013	0.453	0.5
Onchocerca volvulus		0.013	0.453	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.013	0.453	0.438
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Entamoeba histolytica	protein kinase, putative	0.013	0.453	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.013	0.453	0.438
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Toxoplasma gondii	protein kinase domain-containing protein	0.013	0.453	0.422
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.013	0.453	0.4635
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.013	0.453	0.4635
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.013	0.453	0.438
Brugia malayi	Protein kinase domain containing protein	0.013	0.453	0.4635
Mycobacterium ulcerans	acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2	0.0077	0.0535	0.5
Plasmodium falciparum	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.0147	0.5775	1
Brugia malayi	protein-tyrosine kinase	0.013	0.453	0.4635
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.013	0.453	0.438
Entamoeba histolytica	protein kinase, putative	0.013	0.453	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.013	0.453	0.438
Entamoeba histolytica	ankyrin repeat protein	0.013	0.453	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.013	0.453	0.4635
Loa Loa (eye worm)	TK protein kinase	0.013	0.453	0.4635
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.453	0.5
Trypanosoma brucei	Pseudokinase, putative	0.013	0.453	0.422
Loa Loa (eye worm)	TK/FER protein kinase	0.013	0.453	0.4635
Brugia malayi	Tyrosine-protein kinase PR2	0.013	0.453	0.4635
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.013	0.453	0.438
Echinococcus multilocularis	heat shock protein 70	0.013	0.453	0.438
Entamoeba histolytica	tyrosine kinase, putative	0.013	0.453	0.5
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Loa Loa (eye worm)	TK/FER protein kinase	0.013	0.453	0.4635
Loa Loa (eye worm)	TK/FAK protein kinase	0.013	0.453	0.4635
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.013	0.453	0.438
Loa Loa (eye worm)	TK protein kinase	0.013	0.453	0.4635
Entamoeba histolytica	protein kinase, putative	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.013	0.453	0.4635
Loa Loa (eye worm)	hypothetical protein	0.013	0.453	0.4635
Trichomonas vaginalis	TKL family protein kinase	0.013	0.453	0.5
Echinococcus multilocularis	protein tyrosine kinase	0.013	0.453	0.438
Schistosoma mansoni	tyrosine kinase	0.013	0.453	0.438
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.013	0.453	0.438
Entamoeba histolytica	protein kinase domain containing protein	0.013	0.453	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
CL (ADMET)	= 16 microL/min/mg	Intrinsic clearance in human liver microsomes	ChEMBL.	24294923
IC50 (binding)	= 5.4 nM	Inhibition of human ACC2 expressed in CHOK1 cells assessed as acetylCoA to malonylCoA conversion after 1 hr by LC-MS/MS analysis	ChEMBL.	24294923
IC50 (binding)	= 24 nM	Inhibition of human ACC2 assessed as acetylCoA to malonylCoA conversion after 10 mins by LC-MS/MS analysis	ChEMBL.	24294923
IC50 (binding)	= 386 nM	Inhibition of human ACC1 assessed as acetylCoA to malonylCoA conversion after 10 mins by LC-MS/MS analysis	ChEMBL.	24294923

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3110092

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1828522